Review
Medicine, General & Internal
Gisele Abreu Coelho, Philippe-Henri Secretan, Lionel Tortolano, Loic Charvet, Najet Yagoubi
Summary: This review aims to identify and discuss the different stages of chronic wound progression, focusing on the changes in the biochemical composition of the wound microenvironment, particularly in venous leg ulcers (VLUs). It provides detailed information about the pathophysiology of venous ulcers and reviews the known changes in the VLU microenvironment as the VLU evolves. Additionally, it discusses simulating conditions for VLU and highlights potentially relevant simulating media to assess the biological safety of medical devices intended to be in contact with these wounds.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Ian O. Cook, Jayer Chung
Summary: The medical management of PAD aims to reduce the risk of MACE and MALE by optimizing atherosclerotic risk factors, providing appropriate wound care, and managing diabetic foot ulcers, foot infections, gangrene, and chronic non-healing wounds. This review emphasizes the importance of a multi-faceted approach to care, including supervised exercise therapy for intermittent claudication, understanding the disease patterns of smoking and diabetes mellitus, and implementing best practices for diabetic foot ulcer prevention.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Biochemical Research Methods
Nisha Maheshwari, Alessandro Marone, Mirella Altoe, Stephen H. K. Kim, Danielle R. Bajakian, Andreas H. Hielscher
Summary: This study validates the utility of the dynamic vascular optical spectroscopy system (DVOS) in assessing wound healing in peripheral arterial disease (PAD) patients one month after surgery, by recording hemodynamic response to predict long-term wound healing.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Medicine, General & Internal
Kwan Jae Kim, Jin Hong Min, Insool Yoo, Seung Whan Kim, Jinwoong Lee, Seung Ryu, Yeon Ho You, Jung Soo Park, Won Joon Jeong, Yong Chul Cho, Se Kwang Oh, Yong Nam In, Hong Joon Ahn, Chang Shin Kang, Hyunwoo Kyung, Byung Kook Lee, Dong Hun Lee, Dong Hoon Lee
Summary: The study found that ultra-early application of NPWT can reduce edema, promote wound healing, and prevent necrosis in patients with snakebites.
Article
Medicine, General & Internal
Awni Alshurafa, Mohammed Alkhatib, Mohammad Abu-Tineh, Mohamed A. Yassin
Summary: Sickle cell leg ulcers (SCLUs) are chronic and painful complications of sickle cell disease, caused by skin vaso-occlusion, chronic inflammation, and endothelial dysfunction. Managing SCLUs is challenging and various treatments have been attempted, but there are no official recommendations for the best effective treatment. We report a successful case of a 34-year-old male patient with non-transfusion-dependent sickle cell disease, whose chronic left ankle ulcer was completely resolved with hyperbaric oxygen therapy.
FRONTIERS IN MEDICINE
(2023)
Review
Nanoscience & Nanotechnology
Jia-Ying Ji, Dan-Yang Ren, Ying-Zheng Weng
Summary: This review article discusses the recent developments and innovations of antibacterial hydrogels for diabetic chronic wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Dermatology
Ayaka Onoyama, Minoru Hoshiyama, Hiroki Yabe
Summary: This study investigated the psychological factors affecting wound healing in patients with PAD and found that psychological factors were closely associated with wound occurrence and treatment needs. Therefore, the psychological well-being of PAD patients should be taken into consideration during long-term follow-up.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Medicine, General & Internal
Felice Pecoraro, David Pakeliani, Salvatore Bruno, Ettore Dinoto, Francesca Ferlito, Domenico Mirabella, Mario Lachat, Bianca Cudia, Guido Bajardi
Summary: A retrospective analysis of simultaneous hybrid treatments in 45 patients with multilevel PAD and CLTI showed that technical success was 100% without perioperative mortality. The study concluded that hybrid treatments are effective in addressing patients with multilevel PAD and CLTI, with larger studies needed for further validation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Microbiology
Sang Phan, Cafrey He Feng, Raymond Huang, Zeng X. Lee, Yer Moua, Olivia J. Phung, Justin R. Lenhard
Summary: Pseudomonas aeruginosa is commonly found in chronic wound infections worldwide, except in South America, where it is less prevalent. It is the second most common organism in each continent, with Staphylococcus aureus being the most abundant pathogen overall. In Southeast Asia nations including India and Malaysia, P. aeruginosa is the most frequently isolated organism in chronic wound infections. The presence of P. aeruginosa in diabetic foot infections is lower in North America, Europe, and Africa compared to other types of chronic wound infections. The isolation of P. aeruginosa using the Levine wound swab technique may not be a reliable predictor of the patient's clinical course.
Article
Surgery
Olamide Alabi, Nader N. Massarweh, Xinyan Zheng, Luke Brewster, Jialin Mao, Yazan Duwayri
Summary: Lower extremity revascularization (LER) for peripheral artery disease often requires readmission, but it is unclear if the location of readmission affects patient outcomes. This study found that readmission to a different facility after LER was not associated with 90-day mortality or amputation, but readmission for procedure-related complications increased the risk of major amputation. Efforts should focus on understanding post-LER complications and their impact on limb salvage.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Francesca Bartoli-Leonard, Jonas Zimmer, Abhijeet R. R. Sonawane, Katelyn Perez, Mandy E. E. Turner, Shiori Kuraoka, Tan Pham, Feifei Li, Masanori Aikawa, Sasha Singh, Luke Brewster, Elena Aikawa
Summary: The study reveals the significant role of NLRP3 inflammasome activation in peripheral arterial disease (PAD), contributing to macrophage accumulation and calcification in the arteries of PAD patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Dermatology
Yi-Jye Chen, Chih-Yi Hsu, Chih-Hsun Lin
Summary: Chronic leg ulcers are common and may be associated with autoimmune diseases or vasculitis. Chronic leg ulcers related to cutaneous IgG4-related disease are rare. In addition to medication, following wound management principles and providing adjuvant treatments can promote wound healing.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Infectious Diseases
Koko Barrigah-Benissan, Jerome Ory, Albert Sotto, Florian Salipante, Jean-Philippe Lavigne, Paul Loubet
Summary: The study found that the use of iodine antiseptic agents in chronic wound care can promote wound healing and has a better effect compared to saline. However, there is not enough evidence to suggest a significant difference in wound healing with octenidine or polyhexanide. No adverse events were found to be influenced by any antiseptic agents compared to saline during the study.
Article
Surgery
Gabriela Velazquez-Ramirez, Jonathan Krebs, Jeanette M. Stafford, Rebecca Ur, Timothy E. Craven, Ashlee E. Stutsrim, Matthew P. Goldman, Justin B. Hurie, Matthew S. Edwards
Summary: This study investigated the prevalence of chronic opioid use in patients with PAD both preoperatively and postoperatively, with results indicating a rate of approximately 35%. After revascularization, less than 15% of patients with preoperative opioid use terminated chronic opioid use.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Infectious Diseases
Ilaria Cavallo, Ilaria Lesnoni La Parola, Francesca Sivori, Luigi Toma, Tatiana Koudriavtseva, Isabella Sperduti, Daniela Kovacs, Giovanna D'Agosto, Elisabetta Trento, Norma Cameli, Anna Mussi, Alessandra Latini, Aldo Morrone, Fulvia Pimpinelli, Enea Gino Di Domenico
Summary: This study analyzed clinical data and laboratory parameters of patients with infected and noninfected chronic venous leg ulcers (VU). The results showed that infected ulcers had increased size and depth and higher levels of inflammatory cytokines. Hyperhomocysteinemia was more common in infected ulcers, and Gram-negative bacteria and strong biofilm producers were predominant in the infection.
