Article
Health Care Sciences & Services
Vasileios Papatsimpas, Sotiria Vrouva, Marianna Papadopoulou, George Papathanasiou, Daphne Bakalidou
Summary: The study aims to investigate the effect of different exercise programs on cognitive functions and functionality of individuals with mild Alzheimer's disease. A randomized controlled trial will be conducted involving aerobic and resistance exercise interventions. Participants will be assessed at baseline and after 12 weeks. The primary outcome will measure the effect of exercise programs on cognitive functions using various cognitive tests. The secondary outcomes will assess the effect on functionality, depression, physical activity, and compliance with the intervention. Exercise is a low-cost and low-risk intervention.
Article
Chemistry, Medicinal
Omid Reza Tamtaji, Reza Heidari-soureshjani, Zatollah Asemi, Ebrahim Kouchaki
Summary: The study aimed to investigate the effects of spirulina intake on cognitive function and metabolic status in patients with Alzheimer's disease (AD). A randomized, double-blind, controlled clinical trial was conducted involving 60 AD patients. The results showed that spirulina intake for 12 weeks significantly improved cognitive function and glucose homeostasis, while reducing high-sensitivity C-reactive protein levels. These findings suggest that spirulina may have beneficial effects in AD patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Neurosciences
Patricio Solis-Urra, Cristina Molina-Hidalgo, Yolanda Garcia-Rivero, Claudia Costa-Rodriguez, Jose Mora-Gonzalez, Beatriz Fernandez-Gamez, Marcos Olvera-Rojas, Andrea Coca-Pulido, Angel Toval, Dario Bellon, Alessandro Sclafani, Isabel Martin-Fuentes, Eva Maria Trivino-Ibanez, Carlos de Teresa, Haiqing Huang, George Grove, Charles H. Hillman, Arthur F. Kramer, Andres Catena, Francisco B. Ortega, Manuel Gomez-Rio, Kirk I. Erickson, Irene Esteban-Cornejo
Summary: Alzheimer's disease is the leading cause of dementia globally and has significant socio-economic impact. Physical exercise has been proposed as an effective non-pharmaceutical intervention to improve cognitive function and delay dementia progression. This randomized controlled trial aims to investigate the effects of a 24-week resistance exercise program on executive function and related brain and molecular biomarkers in cognitively normal older adults, aged 65-80 years. The findings from this study will contribute to a better understanding of the mechanisms involved in exercise-mediated cognitive improvements in aging populations.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Aladdin H. Shadyab, Andrea Z. LaCroix, Howard H. Feldman, Christopher H. van Dyck, Ozioma C. Okonkwo, Steven P. Tam, J. Kaci Fairchild, Kathleen A. Welsh-Bohmer, Genevieve Matthews, Daniel Bennett, Alexandre A. Shadyab, Kimberly A. Schafer, Rosemary H. Morrison, Sean A. Kipperman, Jennifer Mason, Donna Tan, Ronald G. Thomas, Carl W. Cotman, Laura D. Baker
Summary: Effective recruitment strategies for older adults with MCI into nonpharmacological intervention trials are lacking. However, mass mailings of infographic materials significantly increased recruitment rates in this 18-month exercise trial, accounting for 52% of randomized participants. Other sources included memory clinic rosters, electronic health records, and national/local registries.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Vasileios Papatsimpas, Sotiria Vrouva, George Papathanasiou, Marianna Papadopoulou, Christina Bouzineki, Sophia Kanellopoulou, Dimitra Moutafi, Daphne Bakalidou
Summary: This randomized controlled trial investigated the effect of 12 weeks of therapeutic exercise on cognitive function and daily activities in patients with mild Alzheimer's disease. The results showed significant improvement in cognitive function and daily activities for both the aerobic and resistance exercise group and the resistance exercise group compared to the control group. However, there were no significant differences between the two exercise groups in any of the outcome measures.
Article
Medicine, Research & Experimental
Dereck Salisbury, Tom Plocher, Fang Yu
Summary: This study aims to test the synergistic efficacy of an exergame intervention (simultaneous moderate-intensity aerobic cycling and cognitive training) on cognition and aerobic fitness in community-dwelling older adults with SCD. The study will evaluate the efficacy of exergame in older adults with SCD and assess the distraction effect of exergame on aerobic fitness. Data will be analyzed using ANOVA following intention-to-treat, providing effect-size estimates for future trials in AD prevention research.
Article
Nutrition & Dietetics
Pirjo Komulainen, Jaakko Tuomilehto, Kai Savonen, Reija Mannikko, Maija Hassinen, Timo A. Lakka, Tuomo Hanninen, Vesa Kiviniemi, David R. Jacobs, Miia Kivipelto, Rainer Rauramaa
Summary: The study indicated that a combination of at least moderate-intensity aerobic exercise and a healthy diet may improve cognition in middle-aged and older individuals over a 4-year period. However, neither aerobic nor resistance exercise alone, resistance training alone, nor resistance exercise with a healthy diet showed significant effects on cognition.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Neurosciences
Fang Yu, David M. Vock, Lin Zhang, Dereck Salisbury, Nathaniel W. Nelson, Lisa S. Chow, Glenn Smith, Terry R. Barclay, Maurice Dysken, Jean F. Wyman
Summary: The study found that for older adults with mild-to-moderate Alzheimer's disease, exercise may help reduce the decline in global cognition. However, aerobic exercise did not show superior cognitive effects compared to stretching, possibly due to the lack of power in the pilot trial.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Teresa Liu-Ambrose, Jennifer C. Davis, Ryan S. Falck, John R. Best, Elizabeth Dao, Kristin Vesely, Cheyenne Ghag, Caterina Rosano, C. L. Hsu, Larry Dian, Wendy Cook, Kenneth M. Madden, Karim M. Khan
Summary: The study aimed to investigate the impact of the Otago Exercise Program on the rate of subsequent falls in older adults, and found that exercise significantly reduced the rate of moderate injurious falls and improved processing speed. Further analysis revealed that improved processing speed played a mediating role in the effect of exercise on the rate of moderate injurious falls.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Yotam Lavy, Tzvi Dwolatzky, Zeev Kaplan, Jonathan Guez, Doron Todder
Summary: The study found that using an EEG-based neurofeedback system can significantly improve memory performance in patients with mild cognitive impairment (MCI), with this improvement lasting for at least one month.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Rehabilitation
Xiaoqian Wang, Jiawei Wu, Haoran Zhang, Guohua Zheng
Summary: The study suggests that regular Baduanjin training may be an effective and safe intervention to improve cognitive frailty and executive function in community-dwelling older adults with cognitive frailty.
CLINICAL REHABILITATION
(2023)
Article
Behavioral Sciences
Shuyu Huo, Lin Cheng, Shuying Li, Fulu Xu
Summary: This study aimed to investigate the effects of eszopiclone on sleep quality and cognitive function in elderly patients with Alzheimer's disease. The results showed that eszopiclone effectively improved sleep quality, sleep progression, and cognitive function in these patients.
BRAIN AND BEHAVIOR
(2022)
Article
Neurosciences
Julia Maria Falkenreck, Michelle Celine Kunkler, Anja Ophey, Hannah Weigert, Andrea Friese, Petra Jahr, Gereon Nelles, Elke Kalbe, M. Cristina Polidori
Summary: This study compared the short-term effects of multicomponent cognitive training with general health counseling on cognitive abilities and health-related quality of life in healthy adults. The results showed that multicomponent cognitive training did not have a significant impact on overall cognition, but there were improvements in some cognitive subtests and quality of life measures that were clinically meaningful.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Cell Biology
Susana Lopez-Ortiz, Pedro L. Valenzuela, Maria M. Seisdedos, Javier S. Morales, Tomas Vega, Adrian Castillo-Garcia, Robert Nistic, Nicola Biagio Mercuri, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano
Summary: This study systematically evaluated the effects of exercise interventions on patients with Alzheimer's disease in terms of cognitive function, physical function, functional independence, and neuropsychiatric symptoms. The results suggest that exercise interventions can have significant benefits in multiple domains for patients with AD.
AGEING RESEARCH REVIEWS
(2021)
Article
Geriatrics & Gerontology
Kathryn L. Gwizdala, Robert Brouillete, Robbie Beyl, William Johnson, Callie Hebert, Leah Carter, Melissa Harris, Robert L. Newton, Owen T. Carmichael
Summary: This study aimed to investigate the effects of increasing physical activity on cognitive function in older African Americans. The results showed that a healthy aging education program improved cognitive function, while a physical activity intervention did not. Inadequate dosage or duration of physical activity and social stimulation within the successful aging group may have contributed to these results.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Mu Bai, Xin Sui, Changli Zhou, Yuewei Li, Jinwei Li, Ruitong Gao, Zhen Du, Linqi Xu, Feng Li
BIOMED RESEARCH INTERNATIONAL
(2020)
Review
Oncology
Ruitong Gao, Tianzhuo Yu, Lu Liu, Jiasi Bi, Huiying Zhao, Yujia Tao, Feng Li, Lirong Guo
JOURNAL OF CANCER SURVIVORSHIP
(2020)
Article
Medicine, General & Internal
Linqi Xu, Wenji Xiong, Jinwei Li, Hongyu Shi, Meidi Shen, Xin Zhang, Yue Pang, Yuanyuan Ni, Wei Zhang, Yuewei Li, Lirong Guo, Shuang Zhang, Lijing Zhao, Feng Li
Article
Medicine, General & Internal
Qinqin Cao, Linqi Xu, Shujuan Wen, Feng Li
Summary: The study aimed to investigate the adherence to home- and exercise-based cardiac rehabilitation in patients undergoing PCI and explore the factors affecting this adherence. Results showed that only 64.66% of patients had good adherence, with factors such as shared decision-making, age, CAD knowledge, and self-management behavior identified as key factors affecting patient adherence.
PATIENT PREFERENCE AND ADHERENCE
(2021)
Article
Psychiatry
Yue Pang, Xin Zhang, Ruitong Gao, Linqi Xu, Meidi Shen, Hongyu Shi, Yuewei Li, Feng Li
Summary: Web-based self-management is an effective therapy for reducing depressive symptoms, especially for patients with moderate-to-severe depression. Interventions based on cognitive behavioral therapy (CBT) are highly effective. Longer intervention time leads to greater improvement in depression status.
Review
Medicine, General & Internal
Ruitong Gao, Hui Guo, Fei Li, Yandi Liu, Meidi Shen, Linqi Xu, Tianzhuo Yu, Feng Li
Summary: This study aimed to assess the impact of educational interventions based on gain and loss frames on the health behaviors and beliefs of patients with chronic diseases. The findings suggest that integrating message framing into health education can enhance communication effectiveness and promote positive health behaviors and beliefs in patients with chronic diseases. However, due to the limited number of included articles, further research is needed to support the conclusions.
Article
Medicine, General & Internal
Linqi Xu, Jinwei Li, Xin Zhang, Yue Pang, Tianzhuo Yu, Xiaoqian Lian, Tianyue Yu, Lanyu Zhu, Qian Tong, Feng Li
Summary: This study aims to explore whether a mobile health-based gamification intervention can improve physical activity participation and related outcomes in patients with coronary heart disease. The intervention will incorporate principles from behavioral economics and use a smartphone app (WeChat applet) to deliver the intervention. The study will be a randomized controlled trial with three arms and will last for 12 weeks, with a 12-week follow-up period. The primary outcome is physical activity participation, and secondary outcomes include biomedical and lifestyle-related risk factors, motivation, enjoyment, competence, autonomy, relatedness, social support, mental health, and patient satisfaction and perceptions.
Article
Medicine, General & Internal
Ruitong Gao, Hui Guo, Yandi Liu, Yue Pang, Xin Zhang, Xiaoqian Lian, Tianyue Yu, Lanyu Zhu, Feng Li
Summary: This study aims to explore the effectiveness of diabetes education based on message framing on self-management behavior. A single-blind, three-arm randomized controlled trial will be conducted involving 84 participants. The primary outcome is self-management behavior, and secondary outcomes include self-efficacy, patient activation, diabetes-related knowledge and attitude, quality of life, and blood glucose level.
Article
Mathematical & Computational Biology
Hongyu Shi, Li Wang, Ting Zeng, Yuewei Li, Haiyan Xu, Xin Sui, Ruitong Gao, Feng Li
Summary: This study investigated the relationship between depression, alexithymia, and social support in patients with colorectal cancer (CRC) and identified the main factors influencing depression in these patients. The results showed that education level and family monthly income were the main factors affecting depression in CRC patients. Alexithymia was positively correlated with depression, while social support was negatively correlated with alexithymia and depression. In addition, alexithmia partially mediated the relationship between social support and depression.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Nursing
Ruitong Gao, Hui Guo, Yandi Liu, Yue Pang, Xin Zhang, Xiaoqian Lian, Tianyue Yu, Lanyu Zhu, Feng Li
Summary: This study investigates the impact of message framing in diabetes education on self-management behavior in people with type 2 diabetes. It suggests that message framing can effectively enhance self-management behavior and that the choice of appropriate message framing should be based on the level of patient activation.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2023)
Review
Geriatrics & Gerontology
Yuejin Wu, Haiyan Xu, Xin Sui, Ting Zeng, Xin Leng, Yuewei Li, Feng Li
Summary: A systematic review found that group reminiscence interventions are beneficial in improving depressive symptoms and life satisfaction in older adults with intact cognition or mild cognitive impairment, but the effect on quality of life is uncertain.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Geriatrics & Gerontology
Yuejin Wu, Xin Zhang, Tianzhuo Yu, Xin Sui, Yuewei Li, Haiyan Xu, Ting Zeng, Xin Leng, Lijing Zhao, Feng Li
Summary: This study aims to confirm the effectiveness of reminiscence therapy combined with memory specificity training in improving autobiographical memory and depressive symptoms in older adults. The study will enroll 78 older adults aged 65 years or older with a score of ≥11 on the Geriatric Depression Scale and randomly assign them to different groups. The primary outcome measure is self-reported depressive symptoms, and secondary outcome measures include measures of autobiographical memory, rumination, and social engagement.
Article
Multidisciplinary Sciences
Bing Liang, Yuejin Wu, Jiaxin Zhang, Shumin Hao, Feng Li
Summary: This study successfully translated the Graded Chronic Pain Scale-Revised into simplified Chinese and demonstrated its favorable psychometric properties in China. The scale addresses the shortcomings of domestic chronic pain assessment tools and provides a valuable instrument for evaluating the severity of chronic pain in Chinese clinical practice.
