Journal
CHINESE JOURNAL OF CANCER
Volume 31, Issue 8, Pages 359-363Publisher
SUN YAT SEN UNIV MED SCI WHO
DOI: 10.5732/cjc.012.10087
Keywords
DNA damage response; DNA repair; synthetic lethality; PARP inhibitors
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Funding
- NCI NIH HHS [R01CA133093, R01 CA133093] Funding Source: Medline
- NIEHS NIH HHS [R01 ES016354, R01ES016354] Funding Source: Medline
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The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.
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