Review
Clinical Neurology
Daniel Chih Yung Cheng, James L. Ganner, Christopher J. Gordon, Craig L. Phillips, Ronald R. Grunstein, Maria Comas
Summary: Combined melatonin and bright light therapies have significant effects on improving sleep and circadian outcomes, with better efficacy in elderly populations compared to patients with delayed sleep-wake phase disorder. Adverse effects of melatonin in elderly populations should be carefully considered, and future studies should further investigate the separate and combined effects of these therapies in different target populations.
SLEEP MEDICINE REVIEWS
(2021)
Article
Geriatrics & Gerontology
Tsung-Hsing Lin, Cheng-Chia Yang, Shih-Yu Lee, Ching-Mao Chang, I-Ju Tsai, Cheng-Yu Wei, Chun-Pai Yang
Summary: This study aims to explore the effects of light therapy on migraine patients with sleep disturbances. The study design is a 2-year randomized, double-blind, placebo-controlled clinical trial that includes assessments on headache frequency and severity, subjective and objective sleep disturbances, as well as quality of life and serum biomarkers. The results of this study will provide evidence for the use of light therapy in migraine prevention.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Chuen-Ru Liu, Yiing Mei Liou, Jwo-Huei Jou
Summary: The use of bright ambient light intervention significantly improves sleep quality and circadian rhythms in elderly patients with dementia, especially in terms of sleep efficiency and sleep duration.
Article
Oncology
Alicia Bao, Qiuhong Zhao, Ruchi Kudalkar, Jose Rodriguez, Nidhi Sharma, Naresh Bumma, Srinivas S. Devarakonda, Abdullah M. Khan, Elvira Umyarova, Ashley E. Rosko, Don Benson, Francesca Cottini
Summary: In patients with multiple myeloma undergoing autologous stem cell transplant, a gap between induction therapy and transplant allows for stem cell mobilization. However, some patients experience disease progression during this interval, which can impact response to transplant.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hartmut Goldschmidt, Marc-Andrea Baertsch, Jana Schlenzka, Natalia Becker, Christina Habermehl, Thomas Hielscher, Marc-Steffen Raab, Jens Hillengass, Sandra Sauer, Carsten Mueller-Tidow, Steffen Luntz, Anna Jauch, Dirk Hose, Anja Seckinger, Peter Brossart, Martin Goerner, Stefan Klein, Martin Schmidt-Hieber, Peter Reimer, Ullrich Graeven, Roland Fenk, Mathias Haenel, Hans Martin, Hans W. Lindemann, Christoph Scheid, Axel Nogai, Hans Salwender, Richard Noppeney, Britta Besemer, Katja Weisel
Summary: The efficacy of salvage high-dose chemotherapy and autologous stem cell transplantation (sHDCT/ASCT) for relapsed and/or refractory multiple myeloma (RRMM) has not been clearly defined in the era of continuous novel agent treatment, however, patients who received this treatment may have benefited.
Article
Immunology
Rui Zhao, Jing Zhao, Yichuan Song, Wenxuan Fu, Qingtao Wang, Rui Zhang
Summary: This study aimed to find laboratory indicators that could predict disease progression in newly diagnosed multiple myeloma patients who underwent autologous stem cell transplantation (ASCT). The results showed that certain inflammation-related indicators, such as ANC, NLR, SIRI, and LMR, can serve as potential biomarkers for predicting the progression-free survival (PFS) of these patients.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lu Huang, Xi Chen, Qian Tao, Xiaoli Wang, Xiaodan Huang, Yunwei Fu, Yan Yang, Shijie Deng, Song Lin, Kwok-Fai So, Xingrong Song, Chaoran Ren
Summary: Light in the environment greatly impacts brain functions, including sleep. Bright light treatment has a beneficial effect on stress-related diseases. However, the effect of bright light treatment on stress-induced sleep alterations and the underlying mechanism are poorly understood.
Review
Medicine, General & Internal
Juan Liang, Ying Yang, Peijie He, Oscar Onayi Mandizadza, Wanjun Zhang, Shengyun Lin, Conghua Ji
Summary: This study systematically summarized the quality and evidence of multiple meta-analyses on the treatment of MM, including autologous stem cell transplantation. The findings revealed that the included meta-analyses were affected by possible bias and lacked protocol and registration. The methodological quality of the meta-analyses ranged from very low to moderate, and most outcome indicators were of low quality.
Article
Biology
Lisa M. Wu, Heiddis B. Valdimarsdottir, Ali Amidi, Kathryn J. Reid, Sonia Ancoli-Israel, Katrin Bovbjerg, Rina S. Fox, Lauren Walker, Amreen Matharu, Erin T. Kaseda, John P. Galvin, Kehinde Adekola, Gary Winkel, Frank Penedo, William H. Redd
Summary: This double-blind randomized controlled trial examined the efficacy of bright light therapy on cognition in hematopoietic stem cell transplant survivors. The results showed significant improvements in objective and self-reported cognitive function in both the bright white light and dim red light conditions, with no significant differences between the two groups.
JOURNAL OF BIOLOGICAL RHYTHMS
(2022)
Article
Oncology
Julia Kuypers, Natalie Simmance, Hang Quach, Katherine Hastie, Nicole Kiss
Summary: This study investigated the associations between nutritional status, nutrition support type, and clinical outcomes in adults with multiple myeloma post stem cell transplantation. The results showed that participants who received parenteral nutrition had shorter platelet engraftment time but longer hospital stay, and inadequate energy intake for >= 7 days did not impact clinical outcomes.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Huixing Zhou, Yuan Jian, Juan Du, Junru Liu, Zhiyao Zhang, Guangzhong Yang, Guorong Wang, Ying Tian, Yanchen Li, Yin Wu, Wenming Chen, Weijun Fu, Juan Li, Wen Gao
Summary: This study aimed to establish a predictive nomogram for early relapse after autologous stem cell transplantation in multiple myeloma patients. The nomogram showed higher accuracy compared to other staging systems, suggesting its potential for modifying post-ASCT strategies for high-risk patients.
Article
Multidisciplinary Sciences
Melissa A. St Hilaire, Maria L. Amundadottir, Shadab A. Rahman, Shantha M. W. Rajaratnam, Melanie Ruger, George C. Brainard, Charles A. Czeisler, Marilyne Andersen, Joshua J. Gooley, Steven W. Lockley
Summary: This study investigates the contributions of different wavelengths of monochromatic light to human melatonin suppression and circadian resetting responses. The results show that, initially, short-wavelength (S) cones and long- and medium-wavelength (L+M) cones have a significant contribution, while the contribution of melanopsin-containing intrinsically-photosensitive retinal ganglion cells (ipRGCs) becomes dominant over time. The first few minutes of light exposure play a crucial role in the phase resetting response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Lakshmi Yarlagadda, Sravani Gundarlapalli, Richa Parikh, Reid D. Landes, Mathew Kottarathara, Yetunde Ogunsesan, Shadiqul Hoque, Angel A. Mitma, Clyde Bailey, Kerri M. Hill, Sharmilan Thanendrarajan, Monica Graziutti, Meera Mohan, Maurizio Zangari, Frits van Rhee, Guido Tricot, Carolina Schinke
Summary: Multiple Myeloma (MM) is a common cancer of the bone marrow that remains incurable despite advancements in therapy. While Daratumumab has improved survival rates, heavily pretreated patients who progress on this treatment have poor clinical outcomes. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) may be a viable treatment option for selected patients who are refractory to Daratumumab.
Review
Plant Sciences
Elaine Tobin
Summary: The author, a successful woman in the field of science, was motivated by her family background to pursue education and adventure, which led to strong support and accomplishments in her career. She not only had an interest in science, but also a strong interest and involvement in politics.
ANNUAL REVIEW OF PLANT BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Beatriz Bano-Otalora, Franck Martial, Court Harding, David A. Bechtold, Annette E. Allen, Timothy M. Brown, Mino D. C. Belle, Robert J. Lucas
Summary: The study reveals an impact of daytime light intensity on SCN physiology and the amplitude of circadian rhythms, with lower daytime irradiance leading to a marked reduction in the amplitude of spontaneous activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cardiac & Cardiovascular Systems
Mariana G. Figueiro, Young-Hwa Goo, Ryan Hogan, Barbara Plitnick, Jeong-Kyung Lee, Kiran Jahangir, Mousumi Moulik, Vijay K. Yechoor, Antoni Paul
Summary: Research shows that mimicking light-dark patterns experienced by rotating shift workers leads to larger and more vulnerable atherosclerotic plaques in low-density lipoprotein receptor knockout mice, indicating a valuable model for further studies on the deleterious effects of shift work on the vasculature.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Xuekai Xiong, Yayu Lin, Jeongkyung Lee, Antonio Paul, Vijay Yechoor, Mariana Figueiro, Ke Ma
Summary: Chronic shiftwork disrupts the circadian clock, resulting in adipocyte hypertrophy and adipose tissue inflammation and fibrosis in mice. This disruption also impairs insulin signaling and suppresses the mTOR pathway, highlighting a potential link between circadian misalignment and insulin resistance.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Neurosciences
Mark S. Rea, Rohan Nagare, Mariana G. Figueiro
Summary: This study introduces a revised computational model of circadian phototransduction, characterizing the spectral sensitivity of the retinal circuit and defining circadian light, which rectifies spectral power distribution into a single, instantaneous photometric quantity. The study also characterizes the circuit's response characteristic to circadian light and defines a more complete instantaneous photometric quantity representing the circadian stimulus.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Mark S. Rea, Rohan Nagare, Mariana G. Figueiro
Summary: This paper explores the neural circuits underlying phototransduction for the central pacemaker of the human circadian system, adhering to orthodox retinal neuroanatomy and neurophysiology. Proposed mechanisms are offered to explain the high threshold and subadditive response to polychromatic light exhibited by the human circadian phototransduction circuit. A companion paper provides a computational model for predicting psychophysical data associated with nocturnal melatonin suppression, while staying within the constraints of the neurophysiology and neuroanatomy offered in this paper.
FRONTIERS IN NEUROSCIENCE
(2021)
Correction
Neurosciences
Mark S. Rea, Rohan Nagare, Mariana G. Figueiro
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Dinne S. Christensen, Robert Zachariae, Ali Amidi, Lisa M. Wu
Summary: This study found significant associations between sleep disturbances and higher allostatic load, as well as between long sleep duration and higher allostatic load. However, no associations were found for short sleep duration or sleep duration in general. Future research should focus on identifying mechanisms and directionality in longitudinal studies.
SLEEP MEDICINE REVIEWS
(2022)
Review
Oncology
Priya Kaur, Nihal E. Mohamed, Maddison Archer, Mariana G. Figueiro, Natasha Kyprianou
Summary: Circadian rhythm disruption is associated with genitourinary cancer development and unfavorable outcomes. Manipulating circadian rhythms may have potential benefits in the detection and treatment of GU cancers.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Lisa M. Wu, Heiddis B. Valdimarsdottir, Ali Amidi, Kathryn J. Reid, Sonia Ancoli-Israel, Katrin Bovbjerg, Rina S. Fox, Lauren Walker, Amreen Matharu, Erin T. Kaseda, John P. Galvin, Kehinde Adekola, Gary Winkel, Frank Penedo, William H. Redd
Summary: This double-blind randomized controlled trial examined the efficacy of bright light therapy on cognition in hematopoietic stem cell transplant survivors. The results showed significant improvements in objective and self-reported cognitive function in both the bright white light and dim red light conditions, with no significant differences between the two groups.
JOURNAL OF BIOLOGICAL RHYTHMS
(2022)
Article
Geriatrics & Gerontology
Terri L. Blackwell, Mariana G. Figueiro, Gregory J. Tranah, Jamie M. Zeitzer, Kristine Yaffe, Sonia Ancoli-Israel, Deborah M. Kado, Kristine E. Ensrud, Nancy E. Lane, Yue Leng, Katie L. Stone
Summary: This study found that older men with worse alignment of activity and light had lower levels of cognition and increased rates of cognitive decline. However, there was no association between phasor angle and cognition. Interventions that improve the alignment of light and activity may help slow cognitive decline in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Neurosciences
Mark S. Rea, Rohan Nagare, Andrew Bierman, Mariana G. Figueiro
Summary: Modeling the effects of light and dark patterns on circadian phase is crucial in clinical and organizational settings. This study analyzed the Kronauer99 model using a well-established framework from experimental psychology and found that revising the model significantly reduced prediction uncertainty.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Oncology
Sonali S. Dasari, Maddison Archer, Nihal E. Mohamed, Ashutosh K. Tewari, Mariana G. Figueiro, Natasha Kyprianou
Summary: This study discusses the relationship between circadian rhythm disruption and racial disparities in African American prostate cancer, emphasizing the importance of integrating circadian-related therapies to improve current treatment methods for prostate cancer.
Article
Clinical Neurology
Anne Sophie L. Helligsoe, Louise T. Henriksen, Line Kenborg, Yasmin Lassen-Ramshad, Lisa M. Wu, Jeanette F. Winther, Henrik Hasle, Ali Amidi
Summary: This study examined neurocognitive function in childhood brain tumor survivors and its associations with quality of life (QoL) and symptom burden. The majority of survivors exhibited overall neurocognitive impairment, reduced QoL, and high symptom burden.
NEURO-ONCOLOGY PRACTICE
(2023)
Letter
Oncology
Ali Amidi, Lene Haldbo-Classen, Jesper F. Kallehauge, Lisa M. Wu, Robert Zachariae, Yasmin Lassen-Ramshad, Slavka Lukacova, Morten Hoyer
Meeting Abstract
Psychology, Multidisciplinary
Rebecca N. Mindel, Alejandro Vega, Natalie Stern, William Holden, Kathryn Sommer, Ariella Hoffman-Peterson, Jason N. Chen, Mariana G. Figueiro, William H. Redd, Heiddis Valdimarsdottir
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Article
Construction & Building Technology
L. Sahin, M. G. Figueiro
Summary: The study showed that a lighting intervention could help promote circadian alignment, improve sleep quality, and reduce subjective sleepiness among railway shift workers, especially when they were off duty.
LIGHTING RESEARCH & TECHNOLOGY
(2022)