Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo−/−mice

Review of high-dose intravenous vitamin C as an anticancer agent

(2014) Michelle K Wilson et al.   Asia-Pacific Journal of Clinical Oncology

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response

(2014) Caroline Kuiper et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer

(2014) Caroline Kuiper et al.   Frontiers in Oncology

Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations

(2013) Anitra C Carr et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine

(2013) Emily A. Minor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

(2013) Peter J. Ratcliffe   JOURNAL OF PHYSIOLOGY-LONDON

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Vitamin C is dispensable for oxygen sensing in vivo

(2011) K. J. Nytko et al.   BLOOD

The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C

(2011) James M May   BRITISH JOURNAL OF PHARMACOLOGY

Dietary ascorbate intake affects steady state tissue concentrations in vitamin C–deficient mice: tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit)

(2010) Margreet CM Vissers et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

HIF1A Overexpression Is Associated with Poor Prognosis in a Cohort of 731 Colorectal Cancers

(2010) Yoshifumi Baba et al.   AMERICAN JOURNAL OF PATHOLOGY

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

(2010) Emily Flashman et al.   BIOCHEMICAL JOURNAL

Guidelines for the welfare and use of animals in cancer research

(2010) P Workman et al.   BRITISH JOURNAL OF CANCER

Redox-modulatory vitamins and minerals that prospectively predict mortality in older British people: the National Diet and Nutrition Survey of people aged 65 years and over

(2010) Christopher J. Bates et al.   BRITISH JOURNAL OF NUTRITION

Low Ascorbate Levels Are Associated with Increased Hypoxia-Inducible Factor-1 Activity and an Aggressive Tumor Phenotype in Endometrial Cancer

(2010) C. Kuiper et al.   CANCER RESEARCH

Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES)

(2009) Rosemary L Schleicher et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Vitamin C: update on physiology and pharmacology

(2009) J Mandl et al.   BRITISH JOURNAL OF PHARMACOLOGY

Vitamin C Requirements in Parenteral Nutrition

(2009) Mette M. Berger   GASTROENTEROLOGY

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

(2008) Johanna Myllyharju   ANNALS OF MEDICINE

Estimated prevalence and predictors of vitamin C deficiency within UK's low-income population

(2008) A. Mosdol et al.   JOURNAL OF PUBLIC HEALTH

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA