Article
Allergy
Juliette Caron, Sahara Graf, Christine Delebarre-Sauvage
Summary: Among patients with immediate hypersensitivity reactions to iodinated contrast media, the rate of confirmed allergic patients by positive skin tests was 8.1%. Despite negative skin test results, 12.5% of re-exposed patients experienced recurrent hypersensitivity reactions. Additional investigations on pure intradermal tests to contrast media and development of drug provocation tests could provide a safety net for detecting recurrent reactors. Agreement among allergists is necessary to standardize practices.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Dermatology
Jidapa Triwatcharikorn, Natthiya Pholmoo, Narumol Ratanasutiranont, Pawinee Rerknimitr, Jettanong Klaewsongkram
Summary: Drug-induced immune complex-mediated vasculitis is primarily diagnosed based on medical history, clinical setting, and laboratory evidence. Skin test with delayed reading can play a potential role in diagnosing some instances of immune complex-mediated hypersensitivity reactions.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Oncology
Lisha Li, Lianglu Wang, Kai Guan, Jun Liu, Daobin Zhou, Yanbin Zhang, Yan Zhang
Summary: The study evaluated the incidence and severity of immediate hypersensitivity reactions to rituximab in patients with hematological malignancies using skin testing screening and desensitization. Results showed that this approach may have potential to control the occurrence and severity of immediate HSRs during the first exposure. The intradermal test results could serve as a useful predictor for immediate HSR to rituximab.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Allergy
Cosby A. Stone, Jason A. Trubiano, Elizabeth J. Phillips
Summary: This study found that cross-reactivity of cephalosporins is based on shared R1 groupings, and increasing time since the original reaction and having a penicillin allergy label (PAL) with unknown cephalosporin tolerance predicted a lower likelihood of positive skin testing.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Allergy
Danielle E. Novack, Melinda Braskett, Scott D. Worswick, Brandon L. Adler
Summary: A systematic review was conducted to assess the utility and safety of patch testing in SJS/TEN. The results showed that patch testing is useful and safe in this condition. Antiepileptic drugs had the highest positivity rate. Large-scale studies with standardized methodology are needed to obtain reproducible data on patch testing in SJS/TEN.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Allergy
Marie-Line M. Van der Poorten, Mark Walschot, Margaretha Faber, Jessy Elst, Athina L. Van Gasse, Leander De Puysseleyr, Christel M. Mertens, Margo M. Hagendorens, Lene H. Garvey, Vito Sabato, Didier G. Ebo
Summary: This study confirms that evaluation of drug allergy for suspected POH can be performed before 6 weeks after the event, and there is no maximal upper time limit disclosing ex vivo and in vitro testing.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Multidisciplinary Sciences
Hannah L. Miller, Prabhakar Sairam Andhey, Melissa K. Swiecki, Bruce A. Rosa, Konstantin Zaitsev, Alexandra-Chloe Villani, Makedonka Mitreva, Maxim N. Artyomov, Susan Gilfillan, Marina Cella, Marco Colonna
Summary: This study revealed that depletion of pDCs in mice through injection of diphtheria toxin can enhance Th2-dependent skin inflammation, independent of reduced IFN-I. Additionally, treatment with DT alters the representation of conventional dendritic cells in the skin-draining lymph nodes, leading to Th2-driven contact hypersensitivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Allergy
Natalijia Novak, Wenming Peng, Mirjam C. Naegeli, Christina Galvan, Isabel Kolm-Djamei, Charlotte Brueggen, Beatriz Cabanillas, Peter Schmid-Grendelmeier, Alba Catala
Summary: COVID-19 caused by SARS-CoV-2 can lead to respiratory symptoms as well as skin lesions and vascular system abnormalities in some patients. Understanding and identifying these skin manifestations and vascular changes are crucial for diagnosis and treatment of COVID-19 patients.
Review
Dermatology
Anton C. de Groot
Summary: This article introduces the diagnostic method of patch testing for delayed cutaneous adverse drug reactions, provides tools and information for performing patch tests safely and properly.
Article
Multidisciplinary Sciences
Luciane Nunes de Sousa Casavechia, Antonio Carlos Meireles, Evandro Schapira, Rodrigo Antonio Brant Fernandes, Arthur Gustavo Fernandes
Summary: The study aimed to compare the rates of postoperative infectious endophthalmitis before and after the introduction of intracameral antibiotic prophylaxis with cefuroxime (ATB-P IC) in cataract surgery. The results showed a significantly lower rate of endophthalmitis in the group with ATB-P IC compared to the control group without the protocol.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Yitian Zhou, Kristi Krebs, Lili Milani, Volker M. Lauschke
Summary: Cost-effectiveness of preemptive HLA genotyping varies significantly across countries and regions, with some regions showing lower cost-effectiveness of testing for HLA alleles.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Najah Ben Fadhel, Fares Aroua, Zohra Chadli, Haifa Ben Romdhane, Amel Chaabane, Mounira Sahtout, Naceur A. Boughattas, Nadia Ben Fredj, Karim Aouam
Summary: This study emphasizes the importance of allergy work-up in diagnosing beta-lactam hypersensitivity. Most patients were excessively labelled as beta-lactam allergic, which could increase healthcare costs and lead to the development of drug resistance by the use of wide-spectrum antibiotics.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Immunology
Monika Majewska-Szczepanik, Anna Strzepa, Katarzyna Marcinska, Marian Szczepanik
Summary: The contact hypersensitivity response (CHS) is a mouse model that mimics allergic contact dermatitis in humans. Experiments in mice showed that applying a protein antigen to the skin before inducing CHS effectively reduces the inflammatory response. Epicutaneous immunization also suppresses inflammatory response in various mouse models of autoimmune diseases. This suggests that EC immunization could be a therapeutic approach for T cell-mediated diseases in humans.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Editorial Material
Dermatology
Sarah Fleming, Ian R. White, Louise Cunningham, Karen Eustace
Summary: Hypersensitivity reactions to corticosteroids present a clinical paradox due to their anti-inflammatory and immunomodulatory effects. This case report discusses a patient with positive patch test results to the corticosteroid series.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Allergy
Maria Luisa Somoza, Ana Prieto-Moreno Pfeifer, Laura Martin-Pedraza, Laura Victorio Puche, Angel Esteban Rodriguez, Natalia Blanca-Lopez, Abel Eva Fernandez Gonzalez, Enrique Fernandez-Caldas, Miriam Moran Morales, Francisco Javier Fernandez-Sanchez, Jose Damian Lopez Sanchez, Jose Luis Subiza Garrido-Lestache, Gabriela Canto, Miguel Blanca
Summary: The study showed that SPT with peach peel extract and Pru p 3 sIgE were effective predictors of peach fruit allergy, while the sIgE to Pru p 1, Pru p 4, and Pru p 7 had negligible role in predicting anaphylaxis.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2021)
Letter
Allergy
Jessy Elst, Marie-Line M. van Der Poorten, Athina L. Van Gasse, Christel Mertens, Margo M. Hagendorens, Didier G. Ebo, Vito Sabato
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Allergy
Didier G. Ebo, Jessy Elst, Nele Moonen, Marie-Line M. van der Poorten, Athina L. Van Gasse, Lene H. Garvey, Chris H. Bridts, Christel Mertens, Margo M. Hagendorens, Vito Sabato
Summary: This study explored cross-reactivity between chlorhexidine (CHX) and structurally similar compounds using a passive mast cell activation test (pMAT). Results showed that some CHX-allergic patients exhibited mast cell degranulation responses to alexidine (ALX) and octenidine (OCT), while polyhexamethylene biguanide (PHMB) directly activated mast cells via occupation of MRGPRX2.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Review
Pharmacology & Pharmacy
Didier G. Ebo, Michiel Beyens, Kevin Heremans, Marie-Line M. van der Poorten, Athina L. Van Gasse, Christel Mertens, Michel Van Houdt, Vito Sabato, Jessy Elst
Summary: Immediate hypersensitivity reactions are challenging to diagnose due to their wide range of clinical presentations and uncertain mechanisms. These reactions can be caused by activation and degranulation of specific and nonspecific mast cells and basophils. Degranulation of these cells leads to the release of inflammatory mediators, which can vary depending on the trigger.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Medicine, General & Internal
Michiel Beyens, Jessy Elst, Marie-Line van der Poorten, Athina Van Gasse, Alessandro Toscano, Anke Verlinden, Katrien Vermeulen, Marie-Berthe Maes, J. N. G. Hanneke Oude Elberink, Didier Ebo, Vito Sabato
Summary: Mastocytosis is a complex multisystem disorder characterized by abnormal activation or accumulation of mast cells. The disease is often associated with mutations in the KIT gene and has varied clinical presentations. A new genetic trait related to mastocytosis has also been discovered recently.
ACTA CLINICA BELGICA
(2023)
Letter
Allergy
Jessy Elst, Marie-Line M. van der Poorten, Alessandro Toscano, Athina L. Van Gasse, Christel Mertens, Michiel Beyens, Margo M. Hagendorens, Didier G. Ebo, Vito Sabato
Letter
Allergy
Didier G. Ebo, Jessy Elst, Christel Mertens, Marie-Line M. van der Poorten, Athina L. Van Gasse, Michel Van Houdt, Margo M. Hagendorens, Vito Sabato
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Medicine, General & Internal
D. G. Ebo, M. M. van der Poorten, A. L. Van Gasse, R. Schrijvers, C. Hermans, M. Bartiaux, F. Haerynck, J. Willekens, H. Lapeere, M. Moutschen, O. Michel, V. Sabato
Summary: This paper assessed the alignment of Belgian clinical practice in hereditary angioedema (HAE) with the updated international guideline and identified opportunities for optimization. The main action points to further optimize the Belgian clinical practice of HAE include working towards total disease control, informing patients about new long-term prophylactic therapies, ensuring availability of on-demand therapy, implementing a more comprehensive assessment in daily clinical practice, and expanding the existing patient registry.
ACTA CLINICA BELGICA
(2023)
Article
Allergy
M. Pascal, S. M. Edelman, A. Nopp, C. Moebs, W. J. Geilenkeuser, E. F. Knol, D. G. Ebo, C. Mertens, M. H. Shamji, A. F. Santos, S. Patil, B. Eberlein, C. Mayorga, H. J. Hoffmann
Editorial Material
Anesthesiology
Didier G. Ebo, Marie-Line M. van der Poorten, Philip M. Hopkins
Summary: We evaluate the diagnostic approach used in the Japanese Epidemiologic Study for Perioperative Anaphylaxis (JESPA) and caution against over-reliance on less sensitive and specific diagnostic tests in cases where clinical data indicate a likely immediate perioperative hypersensitivity reaction.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Review
Allergy
Cristobalina Mayorga, Adriana Ariza, Rosa Munoz-Cano, Vito Sabato, Inmaculada Dona, Maria J. Torres
Summary: Immediate drug hypersensitivity reactions (IDHRs) are burdensome and diagnosing the right phenotype and endotype at early stages is crucial due to the diverse mechanisms involved in drug-immune system interactions.
Article
Allergy
D. G. Ebo, H. P. Rihs, C. H. Mertens, A. L. Van Gasse, M. L. van Der Poorten, M. M. Hagendorens, V. Sabato, J. Elst
