Review
Biochemistry & Molecular Biology
Nuri Gueven, Pranathi Ravishankar, Rajaraman Eri, Emma Rybalka
Summary: Idebenone is widely described as an antioxidant drug, but there is a significant discrepancy between its pharmacokinetics and achievable tissue levels in target tissues, casting doubt on our current understanding. A new framework has been proposed based on recent discoveries to explain its mode of action, providing a rational approach for testing its effects in novel indications.
Article
Chemistry, Medicinal
Zahra Oskouei, Soghra Mehri, Fatemeh Kalalinia, Hossein Hosseinzadeh
Summary: D-galactose induces aging and memory impairment, while thymoquinone shows neuroprotective effects in rats. Thymoquinone improves memory and learning deficits caused by D-galactose, reduces oxidative stress and neuroinflammation, and enhances memory and learning abilities.
PHYTOTHERAPY RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Doaa Ibrahim, Sara E. Shahin, Leena S. Alqahtani, Zeinab Hassan, Fayez Althobaiti, Sarah Albogami, Mohamed Mohamed Soliman, Rania M. S. El-Malt, Helal F. Al-Harthi, Nada Alqadri, Mohamed Tharwat Elabbasy, Marwa Abd El-Hamid
Summary: This study investigates the effects of thymol and thymoquinone on the growth, immune response, antioxidant capacity, and resistance to Aeromonas sobria in Nile tilapia. The results show that the dietary inclusion of thymol and thymoquinone significantly improves the growth rate and feed conversion ratio of tilapia, and provides defense against A. sobria infection. Furthermore, the expression of genes related to digestion, antioxidant enzymes, inflammation, and autophagy is influenced by the dietary inclusion of thymol and thymoquinone. Overall, this study highlights the potential benefits of thymol and thymoquinone in enhancing fish productivity and health in aquaculture.
Review
Food Science & Technology
Masood Sadiq Butt, Muhammad Imran, Ali Imran, Muhammad Sajid Arshad, Farhan Saeed, Tanweer Aslam Gondal, Mohammad Ali Shariati, Syed Amir Gilani, Tabussam Tufail, Ishtiaque Ahmad, Nadir Ali Rind, Mohamad Fawzi Mahomoodally, Saiful Islam, Zaffar Mehmood
Summary: Thymoquinone, an important bioactive component, has been shown to have various pharmacological properties such as anti-cancer and anti-diabetic effects. It regulates apoptotic genes, decreases phosphorylation of NF-kappa B and IKK alpha/beta, and lowers metastasis and ERK1/2 and PI3K activities.
FOOD SCIENCE & NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Juveriya Farooq, Rokeya Sultana, Tahreen Taj, Syed Mohammed Basheeruddin Asdaq, Abdulkhaliq J. Alsalman, Mohammed Al Mohaini, Maitham A. Al Hawaj, Mehnaz Kamal, Saad Alghamdi, Mohd. Imran, Haleema Shahin, Ruheena Tabassum
Summary: Chemotherapeutic drugs can cause toxicities, but thymoquinone has a protective effect against these toxicities.
Review
Nutrition & Dietetics
Arslan Shaukat, Arsalan Zaidi, Haseeb Anwar, Nadeem Kizilbash
Summary: This review examines the pharmacological and pharmacokinetic properties of Nigella sativa (NS) as a herbal diabetes medication. It discusses the efficacy and safety of NS in diabetes management, as well as its interaction with oxidative stress.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Eser Ciftci, Vedat Turkoglu, Zehra Bas
Summary: GR, a specific antioxidant enzyme, was purified from human erythrocytes with affinity chromatography method. Thymoquinone and lycopene compounds were found to inhibit GR activity, with non-competitive inhibition types and specific Ki values calculated. This study suggests a potential therapeutic effect of these compounds on cancer disease.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Toxicology
F. Shahid, Z. Farooqui, T. Alam, S. Abidi, I Parwez, F. Khan
Summary: The study demonstrates that TQ has a protective effect against CP-induced hepatotoxicity and can alleviate the adverse effects of CP on liver function in rats.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tayfun Ceylan, Ali Tugrul Akin, Derya Karabulut, Fazile Canturk Tan, Mehmet Taskiran, Birkan Yakan
Summary: The aim of this study was to investigate the effects of TQ on brain damage caused by NP. The results showed that treatment with TQ improved the behavioral impairment and brain damage caused by NP exposure.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biology
Atef M. Al-Attar
Summary: The study investigated the potential protective effects of curcumin and thymoquinone against thioacetamide-induced hematological and biochemical alterations in male rats. The results showed that treatment with curcumin, thymoquinone, and their combination could inhibit these alterations, with the most protective effect observed in mice treated with both curcumin and thymoquinone. The findings suggest that the protective effects of curcumin and thymoquinone are attributed to their antioxidant properties.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Multidisciplinary Sciences
Fabiha Zaheen Khan, Md Shaki Mostaid, Mohd Nazmul Hasan Apu
Summary: Black cumin and its main bioactive compound, thymoquinone (TQ), have potential effects in preventing and treating Alzheimer's disease through antioxidative, anti-inflammatory, antiapoptotic properties, and inhibiting altered signaling pathways.
Article
Biochemistry & Molecular Biology
Marwa M. M. Qadri, Mohammad Firoz Alam, Zenat A. A. Khired, Reem O. O. Alaqi, Amani A. A. Khardali, Moudi M. M. Alasmari, Ahmad S. S. Alrashah, Hisham M. A. Muzafar, Abdullah M. M. Qahl
Summary: Chemotherapy-induced kidney damage, particularly in the context of CFZ treatment, remains a significant concern in cancer therapy. This study investigated the potential protective effect of Thymoquinone (TQ) against CFZ-induced nephrotoxicity in rats. The findings demonstrated that TQ administration significantly mitigated the negative effects of CFZ treatment on kidney function and oxidative stress, suggesting that TQ may serve as a potential therapeutic agent for preventing CFZ-induced kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mohammad A. Alzohairy, Amjad Ali Khan, Mohammed A. Alsahli, Saleh A. Almatroodi, Arshad Husain Rahmani
Summary: This study demonstrated that thymoquinone (TQ) has significant therapeutic effects against Benzopyrene (B(a)P)-induced lung injury, including reducing lipid profile, inflammatory markers, oxidative stress, and increasing antioxidant enzyme levels, as well as decreasing apoptosis rate.
Article
Food Science & Technology
Majid Aminzare, Saeideh Soltan Ahmadi, Hassan Hassanzad Azar, Nasser Nikfarjam, Shahin Roohinejad, Ralf Greiner, Reza Tahergorabi
Summary: The present study aimed to fabricate, characterize, and evaluate the antimicrobial and antioxidant properties of zein/polyvinyl alcohol nanofibers containing thymoquinone and electrosprayed with resveratrol nanoparticles. The results showed that incorporating thymoquinone in nanofibers along with resveratrol nanoparticles increased their antibacterial and free radical scavenging activities. The best results were obtained with nanofibers containing 4% thymoquinone and 2% resveratrol.
FOOD SCIENCE & NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Zakia Akter, Faiza Rafa Ahmed, Mousumi Tania, Md Asaduzzaman Khan
Summary: Thymoquinone exhibits anti-inflammatory and immunomodulatory activities in cancer cells, targeting and modulating inflammatory molecules to play a significant role in anticancer activities beyond its chemopreventive role. Further attention is needed to study its role in immunotherapeutics and its development as a future anticancer drug.
CURRENT MEDICINAL CHEMISTRY
(2021)
