Article
Microbiology
Chongyang Wang, Ruochen Hu, Liuyuan Duan, Qili Hou, Mengqing Yang, Ting Wang, Haijin Liu, Sa Xiao, Ruyi Dang, Juan Wang, Xinglong Wang, Shuxia Zhang, Zengqi Yang
Summary: This study showed that pseudorabies virus (PRV) infection activates the Wnt/beta-catenin signaling pathway, leading to enhanced virus proliferation and regulation of virus-induced autophagy. Inhibitors of this pathway can reduce PRV titers, while stimulation of the pathway can enhance PRV proliferation. These findings provide potential targets for the development of antiviral agents against PRV.
VETERINARY MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gaoyang Chen, Shang Wang, Canling Long, Zhenmin Wang, Xin Chen, Wanze Tang, Xiaoqin He, Zhiteng Bao, Baoyu Tan, William W. Lu, Zhizhong Li, Dazhi Yang, Guozhi Xiao, Songlin Peng
Summary: Bone remodeling is a dynamic process involving bone formation and resorption. PiRNA-63049, through the Wnt2b/13-β-catenin signaling pathway, has been shown to inhibit bone formation, making it a potential target for increasing bone formation in disorders such as postmenopausal osteoporosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Huawei Xu, Zhibin Hao, Yujie Wang, Deng Zhang, Jie Li, Ling Chen, Ninghua Yao, Binbin Qian, Xiaobo Peng, Xianbao Zhan
Summary: Gastric cancer, a prevalent tumor globally, is often fatal due to peritoneal metastasis. However, the underlying mechanism of peritoneal metastasis remains unclear. Our study using organoids derived from malignant ascites of gastric cancer patients revealed that the interaction between exfoliated cancer cells and the liquid tumor microenvironment plays a crucial role in peritoneal metastasis.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Jianping Chen, Dandan Wang, Hongqiang Chen, Jin Gu, Xiao Jiang, Fei Han, Jia Cao, Wenbin Liu, Jinyi Liu
Summary: Our study reveals that TMEM196 functions as a novel suppressor of lung cancer metastasis through the Wnt/beta-catenin signaling pathway. TMEM196 mRNA and protein expression levels are significantly decreased in lung cancer tissues and cells. Low expression of TMEM196 is associated with poor prognosis in clinical patients. TMEM196 strongly inhibits tumor metastasis and progression in vitro and in vivo. Mechanistically, TMEM196 inhibits the Wnt signaling pathway and represses beta-catenin promoter transcription. Silencing TMEM196 results in upregulation of beta-catenin and downstream target genes MMP2 and MMP7. Inhibition of beta-catenin expression attenuates the antimetastatic effect of TMEM196 in lung cancer cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Yuxia Yao, Xiangji Li, Baohong Xu, Li Luo, Qingdong Guo, Xingyu Wang, Lan Sun, Zheng Zhang, Peng Li
Summary: This study demonstrates that increased exposure to deoxycholic acid (DCA) after cholecystectomy (XGB) can promote the progression of colon cancer (CC) by inhibiting FXR expression and enhancing the Wnt-beta-catenin pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Veterinary Sciences
Bo Wang, Shanshan Wang, Manyi Ding, Han Lu, Hao Wu, Yao Li
Summary: This study found that moderate dietary supplementation of quercetin has a positive effect on calcium and phosphorus metabolism in broilers, and this effect is mediated through the regulation of the Wnt signaling pathway.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Environmental Sciences
Zhihao Lv, Hao Xu, Xuezhe Si, Shushuo Xu, Xinxiao Li, Ning Li, Qiang Zhou, Meiyu Chang, Sanqiao Yao, Haibin Li
Summary: Silicosis is an occupational lung disease caused by long-term inhalation of free silica dust. The Wnt signaling pathway has been found to be associated with the development of silicosis fibrosis, suggesting it as a potential target for treatment.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Junchang Zhang, Han Wang, Jing Wu, Cheng Yuan, Songyao Chen, Shuhao Liu, Mingyu Huo, Changhua Zhang, Yulong He
Summary: This study found that GALNT1 overexpression in gastric cancer promotes the activation of the Wnt/β-catenin signaling pathway via abnormal O-glycosylation of CD44, enhancing malignancy. This provides a new strategy for gastric cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Yuxuan Li, Lutian Yao, Jing Lu
Summary: IL-35 inhibits adipogenesis by regulating the proliferation, cytotoxicity, and differentiation of adipocytes. It suppresses the expression of PPAR gamma and C/EBP alpha, and also influences the Wnt/beta-actin pathway through the regulation of Axin2 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jian Zhang, Peiyan Wang, Miao Song, Xuliang Zhang, Siming Huo, Jiayu Du, Bo Li, Zheng Cao, Yanfei Li
Summary: The present study investigated the effect of T-2 toxin on osteoblast differentiation and mineralization by treating MC3T3-E1 cells with different concentrations of T-2 toxin. The results showed that T-2 toxin at 4 and 8 nM significantly inhibited cell viability and impaired osteoblastic differentiation and mineralization. The activation of the Wnt signaling pathway mitigated the T-2 toxin-induced damage, while the inhibition of autophagy exacerbated it. Our findings also revealed a positive feedback loop between the Wnt signaling pathway and autophagy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Oncology
Yujing Liu, Chunyan Wang, Peiqiu Cheng, Shengan Zhang, Wenjun Zhou, Yangxian Xu, Hanchen Xu, Guang Ji
Summary: This study found that low FHL1 expression is associated with poor patient survival in colorectal cancer. Experimental results indicate that FHL1 acts as a tumor suppressor in CRC, primarily by inhibiting cell proliferation through regulating the Wnt/beta-catenin signaling pathway.
Article
Biotechnology & Applied Microbiology
Zongting Shi, Jun He, Jian He, Yuan Xu
Summary: This study found that appropriate hydrostatic pressure can enhance the viability and proteoglycan synthesis of human nucleus pulposus cells (HNPCs), while inhibiting apoptosis. On the other hand, high hydrostatic pressure promotes apoptosis of HNPCs.
Review
Cell Biology
Ian James Bell, Matthew Sheldon Horn, Terence John Van Raay
Summary: The non-canonical Wnt signaling pathways have different roles in cancer and development, involving calcium and Vangl2. Cells tend to choose non-canonical Wnt signaling over canonical Wnt signaling when presented with a choice, but this occurs rarely in vivo.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Guocheng Li, Wenwen Xu, Xuelin Li, Mengzhu Chen, Yong Shi, Mingming Wei, Danhong Peng
Summary: This study reveals that SIRT7 is overexpressed in ovarian cancer and promotes its development by suppressing GATA4 and activating the Wnt signaling pathway. Therefore, the SIRT7/GATA4/Wnt axis may serve as a potential therapeutic target for ovarian cancer.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shiu-Min Cheng, Shin-Da Lee
Summary: This study aimed to clarify the therapeutic effects of exercise training on neural BDNF/TrkB signaling and apoptotic pathways in diabetic cerebral cortex. The results showed that exercise training could provide neuroprotective effects by enhancing the neural BDNF/TrkB signaling pathway and preventing Fas/FasL-mediated and mitochondria-initiated apoptotic pathways in the diabetic cerebral cortex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
