Article
Multidisciplinary Sciences
Julie Rondeaux, Deborah Groussard, Sylvanie Renet, Virginie Tardif, Anais Dumesnil, Alphonse Chu, Lea Di Maria, Theo Lemarcis, Manon Valet, Jean-Paul Henry, Zina Badji, Claire Vezier, Delphine Beziau-Gasnier, Annette E. Neele, Menno P. J. de Winther, Dominique Guerrot, Marjorie Brand, Vincent Richard, Eric Durand, Ebba Brakenhielm, Sylvain Fraineau
Summary: Epigenetic regulation of histone H3K27 methylation plays a key role in cardiac repair after myocardial infarction. The authors demonstrate the ectopic EZH2 and cytoplasmic inactive localization of EZH2 during monocyte differentiation and in immunomodulatory cardiac macrophages. Pharmacological inhibition of EZH2 resolves H3K27 methylation, enhances gene expression, and accelerates cardiac inflammatory resolution, preventing infarct expansion and cardiac dysfunction.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Kandasamy Rajamanickam, Venkatasubramanian Leela, Gopalakrishnan Suganya, Sabiha Hayath Basha, Manoharan Parthiban, Pasuvalingam Visha, Ayyasamy Elango
Summary: This study aimed to investigate the molecular and functional responses of bovine monocyte-derived macrophages to thermal and lipopolysaccharide-induced stress. The results showed that the combined stimulation of heat and lipopolysaccharide led to increased apoptosis, reduced mitochondrial membrane potential and cell viability, decreased oxidative and phagocytosis ability, as well as dysregulation of gene expressions related to heat shock, cell signaling, and inflammation.
JOURNAL OF THERMAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Hirokazu Usui, Makio Shozu
Summary: This report presents a case of complete hydatidiform mole (CHM) with genomic DNA identical to the paternal somatic cells and no maternally derived nuclear DNA. The development of CHM into gestational trophoblastic neoplasia was resolved with chemotherapy. The case highlights the importance of accurate selection of round spermatids in assisted reproductive technology.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Jong Youl Kim, Jiwon Kim, Meiying Huang, Renee Kosonen, Jong Eun Lee
Summary: Microglia plays a significant role in the migration of monocyte-derived macrophages in neuroinflammatory conditions caused by microglial activation. The released chemokines by microglia can interact with CCR4 and CCR5 receptors on monocyte-derived macrophages, inducing their migration. CCR4 and CCR5 may be explored as new therapeutic targets for neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Yanni Zeng, Carmen Amador, Chenhao Gao, Rosie M. Walker, Stewart W. Morris, Archie Campbell, Azra Frkatovic, Rebecca A. Madden, Mark J. Adams, Shuai He, Andrew D. Bretherick, Caroline Hayward, David J. Porteous, James F. Wilson, Kathryn L. Evans, Andrew M. McIntosh, Pau Navarro, Chris S. Haley
Summary: This study identified a set of vulnerable/modifiable parent-of-origin effects (POE)-regulated CpGs, and found several factors that significantly modified the POE on these CpGs. Additionally, plasma proteins and health-related phenotypes associated with the methylation level of one of the identified CpGs were also identified.
Article
Biochemistry & Molecular Biology
Stephanie Solier, Michele Mondini, Lydia Meziani, Arnaud Jacquel, Catherine Lacout, Tom Vanden Berghe, Yvon Jule, Jean-Claude Martinou, Gerard Pierron, Julie Riviere, Marc Deloger, Corinne Dupuy, Anny Slama-Schwok, Nathalie Droin, Peter Vandenabeele, Patrick Auberger, Eric Deutsch, Jamel El-Benna, Pham My-Chan Dang, Eric Solary
Summary: Circulating monocytes are recruited to damaged tissues to generate macrophages that modulate disease progression. Activation of caspase-3 and caspase-7, located near mitochondria, is involved in the generation of monocyte-derived macrophages stimulated by Colony-stimulating factor-1 (CSF-1). A non-conventional pathway that involves caspases and activates NOX2 is responsible for CSF1-driven monocyte differentiation, and targeting this pathway may have therapeutic implications for modulating macrophage polarization in damaged tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alfredo Bellon, Vincent Feuillet, Alonso Cortez-Resendiz, Faycal Mouaffak, Lan Kong, L. Elliot Hong, Lilian De Godoy, Therese M. Jay, Anne Hosmalin, Marie-Odile Krebs
Summary: This study used Monocyte-Derived-Neuronal-like Cells (MDNCs) to investigate the dopamine pruning effects in the neuronal development of schizophrenia (SCZ) patients. The results showed that SCZ patients' cells differentiated more efficiently, extended longer neurites, but had less primary neurites. Additionally, medication in patients influenced the pruning effects under dopamine exposure.
MOLECULAR PSYCHIATRY
(2022)
Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kazuki Kai, Masafumi Moriyama, A. S. M. Rafiul Haque, Taichi Hattori, Akira Chinju, Chen Hu, Keigo Kubota, Yuka Miyahara, Noriko Kakizoe-Ishiguro, Shintaro Kawano, Seiji Nakamura
Summary: It was found that oral squamous cell carcinoma cells promote the differentiation of monocytes into CD206(+) TAMs through the production of PAI-1 and IL-8. Positive correlations were observed among CD206(+), PAI-1(+), and IL-8(+) cells in OSCC sections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Giuseppe Rizzo, Julius Gropper, Marie Piollet, Ehsan Vafadarnejad, Anna Rizakou, Sourish Reddy Bandi, Panagiota Arampatzi, Tobias Krammer, Nina DiFabion, Oliver Dietrich, Anahi Paula Arias-Loza, Marco Prinz, Matthias Mack, Kai Schlepckow, Christian Haass, Jean Sebastien Silvestre, Alma Zernecke, Antoine Emmanuel Saliba, Clement Cochain
Summary: The study utilized single-cell immune profiling to map the transition of monocyte/macrophage populations in the infarcted heart, revealing the origin and dynamic changes of cardiac macrophages. In summary, the research provides valuable insights into how these cells can be potentially modulated to enhance post-ischaemic heart repair.
CARDIOVASCULAR RESEARCH
(2023)
Article
Psychiatry
Barbara Risse Quaioto, Aline Ribeiro Borcoi, Suzanny Oliveira Mendes, Paola Cerbino Doblas, Tamires dos Santos Vieira, Ivana Alece Arantes Moreno, Joaquim Gasparini dos Santos, Andre Willian Hollais, Amanda Sgrancio Olinda, Marcele Lorentz Mattos de Souza, Flavia Vitorino Freitas, Julia Assis Pinheiro, Ester Ribeiro Cunha, Bruna Pereira Sorroche, Lidia Maria Rebolho Batista Arantes, Adriana Madeira Alvares-da-Silva
Summary: This study investigated the methylation of the BDNF gene in individuals with depression who were tobacco users. A total of 384 adults from southeastern Brazil were recruited for the study. The results showed a significant interaction between depression and tobacco use on BDNF methylation levels. Individuals with depression and tobacco use had lower levels of BDNF methylation compared to those with or without depression who did not use tobacco. The findings suggest that tobacco use may interfere with BDNF gene methylation in depressed individuals.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Ilaria Campesi, Andrea Montella, Giovanni Sotgiu, Simone Dore, Ciriaco Carru, Angelo Zinellu, Mario Palermo, Flavia Franconi
Summary: This study investigated the influence of sex, smoking habits, and combined oral contraceptives (COC) on cellular inflammatory indexes, as well as their association with endothelial function. The results showed specific effects of COC on different parameters, emphasizing the need for intersectionality in sex and gender studies. Additionally, COC use was found to significantly impact the effects of tobacco smoking.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Caroline B. K. Mathiesen, Asha M. Rudjord-Levann, Monika Gad, Jesper Larsen, Finn Sellebjerg, Anders Elm Pedersen
Summary: Cladribine has shown to reduce the inflammatory potential and phagocytic activity of M1 macrophages without affecting the differentiation or phenotype of these cells in relevant therapeutic concentrations in vitro. This could have a beneficial clinical impact in the treatment of MS by reducing plaque development while leaving M1 macrophages intact for protection against infections.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Denho Ravi, Erato Ntinopoulou, Nessim Guetta, Manuela Weier, Verena Vogel, Barbara Spellerberg, Parham Sendi, Sandrine Gremlich, Thierry Roger, Eric Giannoni
Summary: This study compares the response of newborn and adult macrophages to GBS. The findings show that newborn macrophages exhibit higher levels of cytokine release in response to GBS, and may play a significant role in the progression of GBS infection in newborns.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Jennillee Wallace, Hemil Gonzalez, Reshma Rajan, Srinivas D. Narasipura, Amber K. Virdi, Arnold Z. Olali, Ankur Naqib, Zarema Arbieva, Mark Maienschein-Cline, Lena Al-Harthi
Summary: Combination antiretroviral therapy (cART) has significantly improved the treatment of HIV/AIDS, but it may also affect cell dysregulation and increase susceptibility to comorbidities in persons living with HIV (PLWH).
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Donatella Coradduzza, Adriana Ghironi, Emanuela Azara, Nicola Culeddu, Sara Cruciani, Angelo Zinellu, Margherita Maioli, Maria Rosaria De Miglio, Serenella Medici, Claudio Fozza, Ciriaco Carru
Summary: Lymphomas are a heterogeneous group of neoplastic diseases with complex clinicopathological characteristics. Inflammation plays a significant role in their development, and measuring specific substances in serum may enhance diagnosis and comparison of patient groups.
Article
Biochemistry & Molecular Biology
Donatella Coradduzza, Caterina Arru, Nicola Culeddu, Antonella Congiargiu, Emanuela Gigliola Azara, Antonio Mario Scanu, Angelo Zinellu, Maria Rosaria Muroni, Vincenzo Rallo, Serenella Medici, Ciriaco Carru, Andrea Angius, Maria Rosaria De Miglio
Summary: Colorectal cancer (CRC) is a major public health and socio-economic problem that requires non-invasive screening tests. By using ultra-high-resolution liquid chromatography and mass spectrometry, we profiled eleven polyamines, including spermine and spermidine with their acetylated forms, and evaluated their potential as biomarkers for identifying CRC patients. The statistical models showed good discrimination in distinguishing CRC patients and healthy subjects. Plasma assessment of ornithine and acetylspermine, as well as lymphocyte/platelet ratio, provided helpful information on the progression of CRC. The combined profiles of circulating polyamines and inflammatory indexes, along with innovative technology, could be a valuable tool for discriminating patients from different clinical groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ilaria Campesi, Antonio Brunetti, Giampiero Capobianco, Adriana Galistu, Andrea Montella, Francesca Ieri, Flavia Franconi
Summary: In this study, the researchers investigated the response of male and female human umbilical vein endothelial cells to ionizing radiation and analyzed the influence of antioxidants on sex-dependent differences. The results showed that autophagy was higher in female cells in the absence of radiation. Radiation reduced cell viability and migration in a sex-independent manner, but antioxidants protected the cells and promoted wound closure.
Review
Biochemistry & Molecular Biology
Donatella Coradduzza, Antonella Congiargiu, Zhichao Chen, Angelo Zinellu, Ciriaco Carru, Serenella Medici
Summary: Senescence is a cellular aging process that contributes to the development of age-related complications, while ferroptosis is linked to various disorders. Both pathways play complex roles in aging and disease and require further research for a better understanding and potential interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Maria Carmina Pau, Angelo Zinellu, Arduino A. Mangoni, Panagiotis Paliogiannis, Maria Roberta Lacana, Sara Solveig Fois, Sabrina Mellino, Alessandro G. Fois, Ciriaco Carru, Elisabetta Zinellu, Pietro Pirina
Summary: In this study of 259 OSA patients, specific haematological parameters such as albumin, neutrophil and monocyte counts, and the systemic inflammatory response index were found to be associated with reduced oxygen saturation. These findings suggest that these parameters may serve as promising markers for assessing oxygen saturation in OSA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Giuseppe Seghieri, Elisa Gualdani, Piergiorgio Francia, Ilaria Campesi, Flavia Franconi, Graziano Di Cianni, Paolo Francesconi
Summary: The aim of this study was to examine gender differences in mortality risk among patients with diabetic foot disease (DFD). Using data from Tuscany, Italy, the study found that women with DFD had a lower survival probability compared to men. After initial DFD hospitalizations, men had a significantly higher mortality risk of 18% compared to women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Biagio Di Lorenzo, Maria Carmina Pau, Elisabetta Zinellu, Arduino A. A. Mangoni, Panagiotis Paliogiannis, Pietro Pirina, Alessandro G. G. Fois, Ciriaco Carru, Angelo Zinellu
Summary: Although polysomnography is the gold standard method to diagnose OSAS, there is a search for simpler and cheaper biomarkers. This study reviewed the potential diagnostic role of RDW, a routine hematological parameter, in OSAS. The results suggest that RDW could be a promising biomarker for OSAS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Angelo Zinellu, Federica Sucato, Viviana Piras, Gian Mario Addis, Gabriele Biondi, Maria Antonia Montesu, Arduino A. Mangoni, Ciriaco Carru, Pietro Pirina, Panagiotis Paliogiannis, Alessandro G. Fois, Rosanna Satta
Summary: We retrospectively investigated the association between baseline inflammatory indexes and response to dupilumab in 66 patients with moderate-to-severe atopic dermatitis (AD). We found that the platelet-to-lymphocyte ratio (PLR) was independently associated with early-response. Combining PLR with serum IgE concentrations improved the predictive performance for early-response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biology
Donatella Coradduzza, Antonella Congiargiu, Zhichao Chen, Sara Cruciani, Angelo Zinellu, Ciriaco Carru, Serenella Medici
Summary: Humanin is a mitochondrial-derived peptide with potential therapeutic applications for age-related diseases. It plays a role in protecting against various pathophysiological conditions, including neurodegenerative diseases and metabolic disorders. Humanin improves glucose metabolism, insulin sensitivity, and can increase lifespan and health span in animal models. The mechanisms behind its protective effects are connected with autophagy and cytoprotective activity.
Review
Obstetrics & Gynecology
Jing Wang, Ciriaco Carru, Stefania Sedda, Pier Luigi Fiori, Zhi Li, Zhichao Chen
Summary: This study aimed to determine which exercise-based interventions are preferable for postpartum depression (PPD) management and provide estimates for future evidence. The results showed that all commonly prescribed physical exercises were effective alternatives or complementary treatments for PPD, with pram walking potentially performing better in improving symptoms.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Biochemistry & Molecular Biology
Flavia Franconi, Giampiero Capobianco, Giuseppe Diana, Valeria Lodde, Alberto De Donno, Maria Laura Idda, Andrea Montella, Ilaria Campesi
Summary: This study investigates the sex-specific effects of Ang II on key processes such as endothelial dysfunction, angiotensin II, and autophagy in HUVECs. The results show that Ang II affects the expression of genes, proteins, and miRNAs in a sex-dependent manner. These findings contribute to a better understanding of the mechanisms underlying sex differences in endothelial dysfunction and provide valuable insights for the development of innovative biomarkers and personalized therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ilaria Campesi, Giampiero Capobianco, Antonella Cano, Valeria Lodde, Sara Cruciani, Margherita Maioli, Giovanni Sotgiu, Maria Laura Idda, Mariangela Valentina Puci, Margherita Ruoppolo, Michele Costanzo, Marianna Caterino, Francesca Cambosu, Andrea Montella, Flavia Franconi
Summary: This study found sex-related differences in amniotic fluid and amniotic fluid cells. Inflammation markers and certain metabolites were higher in female amniotic fluid, while other metabolites were higher in male amniotic fluid. Female amniotic fluid cells expressed more estrogen receptors and proteins associated with autophagy, while male amniotic fluid cells expressed more proteins associated with lysosomes.
Article
Biochemistry & Molecular Biology
Rossana Migheli, Giada Lostia, Grazia Galleri, Gaia Rocchitta, Pier Andrea Serra, Ilaria Campesi, Valentina Bassareo, Elio Acquas, Alessandra T. Peana
Summary: This study reveals that Naloxone (NLX) has a protective effect against oxidative stress induced by hydrogen peroxide (H2O2) in PC12 cells. NLX reduces intracellular reactive oxygen species (ROS) production, apoptosis levels, and prevents G2/M phase cell cycle distribution and cellular damage. Electrochemical experiments further confirm the antioxidant properties of NLX.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2023)
Review
Medicine, General & Internal
Xiaofen Wen, Donatella Coradduzza, Jiaxin Shen, Antonio Mario Scanu, Maria Rosaria Muroni, Matteo Massidda, Vincenzo Rallo, Ciriaco Carru, Andrea Angius, Maria Rosaria De Miglio
Summary: Minimal residual disease (MRD) detection offers an effective method for predicting recurrence in colorectal cancer (CRC) and has the potential to revolutionize management for CRC patients. The use of circulating tumor DNA (ctDNA) in MRD detection has shown promising applications in risk stratification, treatment guidance, and early relapse monitoring.
MEDICINA-LITHUANIA
(2023)