Article
Pharmacology & Pharmacy
Masato Takase, Tomohiro Nakamura, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Akira Narita, Takumi Hirata, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N. Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa
Summary: This study found that a higher body fat percentage is associated with hypertension, even in non-obese individuals. Reducing both FMI and FFMI may play an important role in preventing hypertension. However, the relationship between FFMI and hypertension in the lowest FMI group might be weak for men.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Geriatrics & Gerontology
Marie-Theres Huemer, Alina Bauer, Agnese Petrera, Markus Scholz, Stefanie M. Hauck, Michael Drey, Annette Peters, Barbara Thorand
Summary: This study utilized proteomic profiling to identify novel biomarkers associated with low muscle mass, high fat mass, and their combination. Key findings included previously unknown biomarkers such as kallikrein-6, CCL28, and NT-proBNP as potential indicators of declining health status related to muscle and fat composition. The high-throughput proteomics approach accelerated biomarker discovery in muscle research.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Nutrition & Dietetics
Minhua Tang, Qi Zhao, Kangqi Yi, Yiling Wu, Yu Xiang, Maryam Zaid, Shuheng Cui, Xuyan Su, Yuting Yu, Genming Zhao, Yonggen Jiang
Summary: This study aimed to assess the association between metabolic phenotypes based on body mass index (BMI) and waist circumference (WC) and the risk of stroke among Chinese community residents. The study found that metabolic abnormalities were associated with an increased risk of stroke, highlighting the importance of maintaining normal body weight and improving metabolic health in preventing cerebrovascular diseases.
Article
Medicine, General & Internal
Tham T. Nguyen, Minh H. Nguyen, Yen H. Nguyen, Thao T. P. Nguyen, Manh H. Giap, Tung D. X. Tran, Thu T. M. Pham, Khue M. Pham, Kien T. Nguyen, Vinh-Tuyen T. Le, Chien-Tien Su, Tuyen Van Duong
Summary: This study explored the association between health literacy (HL) and hypertension, and investigated whether body mass index (BMI), body fat percentage (PBF), and visceral fat (VF) mediated this association. The results showed that the prevalence of hypertension was relatively high. People with better HL were less likely to have hypertension. PBF partially mediated the association between HL and hypertension. Strategic approaches are needed to improve people's HL and reduce body fat, which can help manage hypertension in rural and suburban areas.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Bjorn Gerdle, Olof Dahlqvist Leinhard, Eva Lund, Ann Bengtsson, Peter Lundberg, Bijar Ghafouri, Mikael Fredrik Forsgren
Summary: Obesity is a risk factor for fibromyalgia and worsens the clinical presentation. Fibromyalgia patients have low physical conditioning, and obesity exacerbates this. Body composition and physical capacity variables are correlated with clinical variables in fibromyalgia. Obesity should be considered in the clinical management of fibromyalgia patients.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Orthopedics
Mohammad Mehdi Khaleghi, Hadi Emamat, Maryam Marzban, Akram Farhadi, Ali Jamshidi, Negin Ghasemi, Azar Falahatzadeh, Zahrasadat Jalaliyan, Hasan Malekizadeh, Iraj Nabipour, Bagher Larijani
Summary: Dysmobility Syndrome (DS) is a condition characterized by the accumulation of clinical risk factors for functional disability. This study found that fat distribution in different body areas is associated with the development of DS in older adults, particularly in the limbs. Higher fat mass in the limbs, especially the legs, is linked to a greater risk of DS, while a higher android-to-gynoid fat mass ratio is associated with a lower risk. Screening fat mass distribution in older individuals can help diagnose DS and improve their quality of life.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Health Care Sciences & Services
Maja R. Radojcic, Romain S. Perera, Lingxiao Chen, Tim D. Spector, Deborah J. Hart, Manuela L. Ferreira, Nigel K. Arden
Summary: The study on 19-year BMI patterns found that trajectories of increase overweight-to-obese were bidirectionally related to knee and multi-site pain, while women with BMI above 40 had an increased mortality risk.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Geriatrics & Gerontology
Katsuhiko Ohori, Toshiyuki Yano, Satoshi Katano, Hidemichi Kouzu, Suguru Honma, Kanako Shimomura, Takuya Inoue, Yuhei Takamura, Ryohei Nagaoka, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Tomoyuki Ishigo, Ayako Watanabe, Akiyoshi Hashimoto, Tetsuji Miura
Summary: The study retrospectively analyzed data from 198 HF patients and found that higher body fat mass was associated with lower short-term cardiac event risk in HF patients, while muscle wasting was not significantly associated with cardiac events.
Article
Medicine, General & Internal
Paivi E. Korhonen, Tuija Mikkola, Hannu Kautiainen, Johan G. Eriksson
Summary: This study found that both fat mass and lean mass index are positively associated with blood pressure levels, independently of other factors. Lean body mass is shown to be an important determinant of blood pressure levels, with a magnitude similar to fat mass. Excess muscle mass may not be beneficial to cardiovascular health.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Rheumatology
Romain S. Perera, Lingxiao Chen, Deborah J. Hart, Tim D. Spector, Nigel K. Arden, Manuela L. Ferreira, Maja R. Radojcic
Summary: This study aimed to investigate the relationship between weight and back pain in middle-aged women. The results showed that weight, BMI, and total fat mass were directly associated with back pain, indicating the importance of mechanical loading effect.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Clinical Neurology
Xiaoxi Li, Yining Wang, Youyou Zhang, Yubo Ma, Faming Pan, Laura Laslett, Guoqi Cai
Summary: Back pain is a common musculoskeletal problem, and there is increasing evidence linking obesity to musculoskeletal pain. This study aims to evaluate the role of weight, BMI, and abdominal circumference in the risk of back pain over a 96-month period.
Article
Medicine, General & Internal
Israel Gotsman, Andre Keren, Offer Amir, Donna R. Zwas
Summary: The study found that increased body composition indices, including body mass index, fat-free mass index, and fat mass index, were associated with better survival in patients with heart failure. The strongest association was seen with fat-free mass index, showing a graded increase in survival.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Takashi Shimada, Shotaro Chubachi, Shiro Otake, Kaori Sakurai, Mamoru Sasaki, Hiroaki Iijima, Naoya Tanabe, Kazuya Tanimura, Kaoruko Shimizu, Toru Shirahata, Masaru Suzuki, Susumu Sato, Hidetoshi Nakamura, Koichiro Asano, Koichi Fukunaga
Summary: This study investigated the different impacts of fat mass index (FMI) and fat-free mass index (FFMI) on emphysema, pulmonary function, and health-related quality of life in chronic obstructive pulmonary disease (COPD) patients. The study found that FMI and FFMI have different effects on the clinical manifestations of COPD, with both low fat and muscle mass contributing to severe emphysema, and only low muscle mass contributing to worse health-related quality of life.
RESPIRATORY MEDICINE
(2023)
Article
Health Care Sciences & Services
Daniel F. Mcwilliams, Bin Yue, Stephanie L. Smith, Joanne Stocks, Michael Doherty, Ana M. Valdes, Weiya Zhang, Aliya Sarmanova, Gwen S. Fernandes, Kehinde Akin-Akinyosoye, Michelle Hall, David A. Walsh
Summary: Knee pain is associated with lower muscle strength, and both peripheral and central neurological mechanisms contribute to OA pain. Understanding the relative contributions of pain mechanisms to muscle strength might help future treatments.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Reshma Aziz Merchant, Santhosh Seetharaman, Lydia Au, Michael Wai Kit Wong, Beatrix Ling Ling Wong, Li Feng Tan, Matthew Zhixuan Chen, Shu Ee Ng, John Tshon Yit Soong, Richard Jor Yeong Hui, Sing Cheer Kwek, John E. Morley
Summary: This study found that higher FFMI and lower FM/FFM in the high BMI group were associated with better functional outcomes. The prevalence of low muscle mass was higher in the normal BMI group. Females had significantly higher FMI and FM/FFM, while males had significantly higher FFMI. Additionally, the highest FFMI tertile group had better physical function and lower prevalence of sarcopenic obesity and sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2021)