Article
Immunology
Yimeng Zhang, Zikang Guo, Lisong Wang, Ying Zhan, Jin Qu, Xinwei Lei
Summary: Fat metaplasia in axial spondyloarthritis (axSpA) patients predicts backfill progression, suggesting an important mechanism in this disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Dominik Deppe, Kay-Geert Hermann, Fabian Proft, Denis Poddubnyy, Felix Radny, Mikhail Protopopov, Marcus R. Makowski, Torsten Diekhoff
Summary: In patients with axSpA, SWI depicts erosions and sclerosis more accurately than T1 spin echo MRI at 1.5T.
Article
Immunology
Liudan Tu, Churong Lin, Ya Xie, Xiaohong Wang, Qiujing Wei, Yanli Zhang, Jieruo Gu
Summary: This study found that patients with radiographic axial spondyloarthritis (r-axSpA) showed more active inflammatory and chronic structural damages on MRI compared to non-radiographic axial spondyloarthritis (nr-axSpA) patients, especially in terms of fat metaplasia and ankylosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seok Hahn, Ji Soo Song, Eun Jung Choi, Jang Gyu Cha, Yunjung Choi, Young Ju Song, InSeong Kim, Eun Hae Park
Summary: This study evaluated the diagnostic performance of ultrashort echo time (UTE) imaging for detecting bone erosion in axial spondyloarthropathy (SpA) compared to T1WI and 3D DESS sequences. The results showed that UTE imaging has higher specificity and all observers had the highest confidence in interpreting UTE imaging for detecting bone erosion.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Medicine, General & Internal
Yun-Sic Bang, He Won Hwang, Hanwool Bae, Young-Soon Choi, Youngsu Lim, Jungmin Yi, Hyunhae Kim, Min-Ying Su, Young Uk Kim
Summary: This study found that using the sacroiliac joint cross-sectional area (SIJA) as a morphological parameter for evaluating ankylosing spondylitis (AS) can accurately diagnose AS. AS patients had significantly lower sacroiliac joint thickness (SIJT) and SIJA compared to the control group, and the SIJA parameter had higher sensitivity.
Editorial Material
Rheumatology
Denis Poddubnyy, Torsten Diekhoff, Xenofon Baraliakos, Kay Geert A. Hermann, Joachim Sieper
Summary: This article discusses whether MRI can replace radiographs for diagnostic evaluation and classification of axial spondyloarthritis, and provides answers to specific questions based on current data.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Raphael Micheroli, Seraphina Kissling, Kristina Buerki, Pascale Exer, Rene Braem, Michael J. Nissen, Burkhard Moeller, Michael Andor, Oliver Distler, Almut Scherer, Adrian Ciurea
Summary: The study findings suggest that TNFi can decelerate the radiographic progression of SIJ in patients with axSpA, especially when used for at least 1 year.
Article
Rheumatology
Walter P. Maksymowych, Mikkel Ostergaard, Robert Landewe, William Barchuk, Ke Liu, Chantal Tasset, Leen Gilles, Thijs Hendrikx, Robin Besuyen, Xenofon Baraliakos
Summary: The study found that filgotinib significantly reduced SI joint erosion and increased backfill scores in AS patients, suggesting potential prognostic implications for ankylosis development.
Article
Rheumatology
Marie Wetterslev, Mikkel Ostergaard, Inge J. Sorensen, Ulrich Weber, Anne G. Loft, Gina Kollerup, Lars Juul, Gorm Thamsborg, Ole R. Madsen, Jakob M. Moller, Susanne J. Pedersen
Summary: This study aimed to combine the SPARCC SIJ structural score into three versions of a novel axSpA MRI SIJ Composite Structural Damage Score (CSDS) and test these in patients with axSpA. The results showed that CSDS stepwise and CSDS hierarchical demonstrated good construct validity and responsiveness, supporting further validation in larger clinical trials. The potential clinical implication is the assessment of SIJ damage progression by a composite score.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Juergen Braun
Summary: Inflammatory back pain is a common symptom of axial spondyloarthritis caused by inflammation in the axial skeleton. The sacroiliac joints are often affected in early stages, while the spine is affected later on. Both inflammation and structural changes can impact function and mobility. Clinical trials often focus on pain, disease activity, function, mobility, and global health, as well as radiographic progression in the axial skeleton of axSpA patients.
Review
Physiology
Clement Prati, Thierry Lequerre, Benoit Le Goff, Bernard Cortet, Hechmi Toumi, Anne Tournadre, Hubert Marotte, Eric Lespessailles
Summary: A detailed anatomical description of the sacroiliac joint is crucial for understanding spondyloarthropathy, as sacroiliitis is its earliest and most common sign. Additionally, understanding the histopathology and immunological mechanisms of sacroiliac entheses is essential for comprehending the disease causation. This review focuses on the anatomical, histological, and immunohistological observations related to the development of sacroiliitis and discusses the sequencing of enthesitis, synovitis, and subchondral bone changes in spondyloarthropathy.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Rheumatology
Kay Geert A. Hermann, Katharina Ziegeler, Virginie Kreutzinger, Denis Poddubnyy, Fabian Proft, Dominik Deppe, Juliane Greese, Joachim Sieper, Torsten Diekhoff
Summary: This study proposes a data-driven definition for structural changes in the sacroiliac (SI) joints in the context of axial spondyloarthritis (axSpA) imaging. Evaluation of 546 individuals with SI joint CTs showed that ankylosis and/or erosions of the middle and dorsal joint portions had the best diagnostic performance. Sclerosis and ventrally located erosions had lower specificity on SI joint CT imaging.
Article
Orthopedics
Ming-Shan Du, Xuan-Qi Xiong, He Liu, Xin Qin, Xiao-Fei Hu, Wei Chen
Summary: This study investigated the value of MRI Dixon sequence in diagnosing marrow edema of the sacroiliac joint in AS patients. The water-fat ratio under the sacroiliac joints was significantly higher in the case group compared to the healthy control group, and positively correlated with SPARCC, BASFI, and BASDAI scores.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Rheumatology
Katharina Ziegeler, Virginie Kreutzinger, Fabian Proft, Denis Poddubnyy, Kay Geert A. Hermann, Torsten Diekhoff
Summary: This study found that patients with mechanical joint disease had the highest proportion of atypical joints, with females showing significantly higher proportions than males, and symptomatic joint disease males having significantly higher proportions of atypical joints compared to controls.
Article
Rheumatology
Alexandre Terrier, Olivier Fakih, Mickael Chouk, Clement Prati, Daniel Wendling, Sebastien Aubry, Frank Verhoeven
Summary: This study aimed to compare the SBAC-SI differences in AS, OCI, and DISH. The results showed that SBAC-SI was significantly higher in the OCI group compared to the AS group, which could help distinguish between these two diseases. In AS, the disease duration was negatively correlated with SBAC-SI, and HLA B27 was associated with lower SBAC-SI.
Letter
Rheumatology
Walter P. Maksymowych, Robert G. W. Lambert, Mikkel ostergaard, Xenofon Baraliakos
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Desiree van der Heijde, Maxime Dougados, Walter P. Maksymowych, Gina Bergman, Sean P. Curtis, Anjela Tzontcheva, Susan Huyck, George Philip, Joachim Sieper
Summary: In this study, the long-term efficacy and safety of golimumab (GLM) in patients with non-radiographic axial spondyloarthritis (nr-axSpA) were evaluated. It was found that GLM treatment provided sustained improvement in clinical efficacy at 52 weeks and was well tolerated.
Article
Rheumatology
Uta Kiltz, Annelies Boonen, Desiree van der Heijde, Wilson Bautista-Molano, Ruben Burgos Vargas, Praveena Chiowchanwisawakit, Bassel El-Zorkany, Inna Gaydukova, Pal Geher, Laure Gossec, Michele Gilio, Simeon Grazio, Jieruo Gu, Muhammad Asim Khan, Tae-Jong Kim, Walter P. Maksymowych, Helena Marzo-Ortega, Victoria Navarro-Compan, Salih Ozgocmen, Dimos Patrikos, Fernando Manuel Pimentel-Santos, John Reveille, Michael Schirmer, Simon Stebbings, Filip Van den Bosch, Ulrich Weber, Juergen Braun
Summary: This study developed an Environmental contextual factors (EF) Item Set (EFIS) to accompany the Assessment of SpondyloArthritis international Society Health Index (ASAS HI), aiming to interpret ASAS HI results by exploring the interaction between health conditions and contextual factors.
Article
Rheumatology
Walter P. Maksymowych, Mikkel Ostergaard, Robert Landewe, William Barchuk, Ke Liu, Chantal Tasset, Leen Gilles, Thijs Hendrikx, Robin Besuyen, Xenofon Baraliakos
Summary: The study found that filgotinib significantly reduced SI joint erosion and increased backfill scores in AS patients, suggesting potential prognostic implications for ankylosis development.
Article
Rheumatology
Walter P. Maksymowych, Robert G. W. Lambert, Liron Caplan, Filip E. van den Bosch, Mikkel ostergaard
Summary: The current RCT design does not fully utilize MRI to select nr-axSpA patients who best demonstrate differences in clinical response rates between active drug and placebo therapies. Future studies should incorporate revised patient inclusion criteria based on expanded MRI evaluation and data-driven definitions of a positive MRI to improve discrimination between therapies.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Rheumatology
Desiree van der Heijde, Lianne S. Gensler, Walter P. Maksymowych, Robert Landewe, Martin Rudwaleit, Lars Bauer, Thomas Kumke, Mindy Kim, Simone Emanuele Auteri, Bengt Hoepken, Atul Deodhar
Summary: The 52-week results from the C-axSpAnd study demonstrate the long-term safety and efficacy of Certolizumab pegol (CZP) in patients with active non-radiographic axial spondyloarthritis (nr-axSpA). CZP treatment for up to 3 years is well tolerated and leads to sustained clinical improvement.
Article
Rheumatology
Victoria Navarro-Compan, Anne Boel, Annelies Boonen, Philip J. Mease, Maxime Dougados, Uta Kiltz, Robert B. M. Landewe, Xenofon Baraliakos, Wilson Bautista-Molano, Praveena Chiowchanwisawakit, Hanne Dagfinrud, Lara Fallon, Marco Garrido-Cumbrera, Lianne Gensler, Bassel Kamal ElZorkany, Nigil Haroon, Yu Heng Kwan, Pedro M. Machado, Walter Maksymowych, Anna Molto, Natasha de Peyrecave, Denis Poddubnyy, Mikhail Protopopov, Sofia Ramiro, In-Ho Song, Salima van Weely, Desiree van der Heijde
Summary: This study aims to define the instruments for the Assessment of SpondyloArthritis international Society-Outcomes Measures in Rheumatology core domain set for axial spondyloarthritis (axSpA). The study selected core outcome instruments through a systematic literature review and assessment of the instruments' psychometric properties. Additionally, the study endorsed additional instruments to enhance the evaluation of axSpA trials.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Mikhail Protopopov, Fabian Proft, Stephanie Wichuk, Pedro M. Machado, Robert G. Lambert, Ulrich Weber, Susanne Juhl Pedersen, Mikkel Ostergaard, Joachim Sieper, Martin Rudwaleit, Xenofon Baraliakos, Walter P. Maksymowych, Denis Poddubnyy
Summary: This study compares the ability of MRI and conventional radiography to detect structural lesions indicative of axSpA.
Article
Rheumatology
Desiree van der Heijde, Atul Deodhar, Walter P. Maksymowych, Joachim Sieper, Filip Van den Bosch, Tae-Hwan Kim, Mitsumasa Kishimoto, Andrew J. Ostor, Bernard Combe, Yunxia Sui, Yuanyuan Duan, Peter K. Wung, In-Ho Song
Summary: Upadacitinib 15 mg once daily demonstrated sustained and consistent efficacy in the long-term treatment of active ankylosing spondylitis. It effectively inhibited radiographic progression and no new safety concerns were identified in the clinical trial.
Article
Rheumatology
Walter P. Maksymowych, Xenofon Baraliakos, Robert G. Lambert, Robert Landewe, David Sandoval, Hilde Carlier, Jeffrey Lisse, Xiaoqi Li, Maja Hojnik, Mikkel Ostergaard
Summary: Ixekizumab treatment in patients with non-radiographic axial spondyloarthritis showed significant reductions in erosions and increases in fat lesions and backfill in the sacroiliac joints, suggesting an early repair process.
LANCET RHEUMATOLOGY
(2022)
Review
Rheumatology
Ying-Ying Leung, Tatiana V. Korotaeva, Liliana Candia, Susanne Juhl Pedersen, Wilson Bautista Molano, Eric M. Ruderman, Radjesh Bisoendial, Rodolfo Perez-Alamino, Wendy Olsder, Burkhard Moeller, Simeon Grazio, Tania Gudu, Girish M. Mody, Carlos Pineda, Helena Raffayova, Sherry Rohekar, Claudia Goldenstein-Schainberg, Sergio R. Gutierrez Urena, Julio Cesar Casasola Vargas, Bhowmik Meghnathi, Roopa Prasad, Pascal Richette, Jose Roberto S. Miranda, Nikolas Malliotis, Ulla Lindqvist, David Simon, Amara Ezeonyeli, Enrique R. Soriano, Oliver FitzGerald
Summary: The objective of this study was to provide evidence for the efficacy and safety of therapeutic options for the peripheral arthritis domain of PsA for the revised 2021 GRAPPA treatment recommendations. Evidence was derived from new RCTs and recommendations were made for different patient groups based on their treatment history and response. Different classes of therapeutic options were strongly recommended for different patient groups.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Helena Port, Signe Holm Nielsen, Peder Frederiksen, Sofie Falkenlove Madsen, Anne-Christine Bay-Jensen, Inge Juul Sorensen, Bente Jensen, Anne Gitte Loft, Ole Rintek Madsen, Mikkel Ostergaard, Susanne Juhl Pedersen
Summary: This study investigated whether extracellular matrix (ECM) blood-based biomarkers reflect the pharmacodynamic effect and response to TNF-a inhibitor therapy in patients with axial spondyloarthritis (axSpA). The results showed that ECM metabolites exhibited a pharmacodynamic effect and were associated with ASDAS response.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Walter P. Maksymowych, Jacob L. Jaremko, Susanne J. Pedersen, Iris Eshed, Ulrich Weber, Andrew McReynolds, Paul Bird, Stephanie Wichuk, Robert G. Lambert
Summary: This study compared the performance of two new web-based MRI scoring systems (KIMRISS and MOAKS) in quantification of bone marrow lesions (BML) and synovitis-effusion (S-E). The results showed that KIMRISS had higher reliability and usability in evaluating BML and synovitis. Both methods should be further compared in clinical trials of new therapies for OA.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Medicine, General & Internal
Atul Deodhar, Filip Van den Bosch, Denis Poddubnyy, Walter P. Maksymowych, Desiree van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Ricardo Blanco, Yuanyuan Duan, Yihan Li, Aileen L. Pangan, Peter Wung, In-Ho Song
Summary: Upadacitinib demonstrates significant efficacy and safety in patients with non-radiographic axial spondyloarthritis.
Article
Rheumatology
Philip C. Robinson, Walter P. Maksymowych, Lianne S. Gensler, Stephen Hall, Martin Rudwaleit, Bengt Hoepken, Lars Bauer, Thomas Kumke, Mindy Kim, Natasha de Peyrecave, Atul Deodhar
Summary: This study demonstrates that CZP treatment can provide clinical responses in patients with nr-axSpA across MRI+/CRP+, MRI-/CRP+, and MRI+/CRP- subgroups.
ACR OPEN RHEUMATOLOGY
(2022)