Journal
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 120, Issue 3, Pages 99-111Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/13813455.2014.940352
Keywords
alpha-linolenic acid; dietary enrichment; insulin resistance; pregnancy
Funding
- Moshe Ishai Center for the Investigation of Natural Food on the Quality of Human Health Grant
- Research Authority of Tel Aviv University
- Minerva Foundation, Germany
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Objective: Our objective was to test the contribution of dietary enrichment in essential or saturated fatty acids, in normocaloric diets, on the lipid accumulation and insulin resistance in the adult offspring in a C57Bl6/J mice model. Methods: Pregnant mothers were fed normocaloric diets containing 6% fat enriched in essential fatty acids (EFA): alpha-linolenic (ALA-18:3, n-3), linoleic (LA-18:2, n-6), or saturated fatty acids (SFA). After a washing-out period with regular diet, the offspring received a high-fat diet before euthanization. Results: Adult mice fed maternal ALA showed lower body weight gain and lower liver fat accumulation, lower HOMA index and lower stearoyl-CoA desaturase (SCD1) activity than those fed maternal SFA. Conclusion: The results observed using this novel model suggest that ALA in maternal diet may have the potential to inhibit insulin resistance in adult offspring.
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