Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle

Proline-rich Akt substrate of 40-kDa contains a nuclear export signal

(2013) Claudia Wiza et al.   CELLULAR SIGNALLING

Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells

(2013) C. Wiza et al.   DIABETOLOGIA

Role of PRAS40 in Akt and mTOR signaling in health and disease

(2012) Claudia Wiza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Tissue-Specific Coupling between Insulin/IGF and TORC1 Signaling via PRAS40 in Drosophila

(2012) Cristina Pallares-Cartes et al.   DEVELOPMENTAL CELL

Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1

(2010) Emmani B.M. Nascimento et al.   CELLULAR SIGNALLING

PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy

(2010) Nirmalya Dey et al.   JOURNAL OF CELLULAR PHYSIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemerin Is a Novel Adipocyte-Derived Factor Inducing Insulin Resistance in Primary Human Skeletal Muscle Cells

(2009) Henrike Sell et al.   DIABETES

Raptor Binds the SAIN (Shc and IRS-1 NPXY Binding) Domain of Insulin Receptor Substrate-1 (IRS-1) and Regulates the Phosphorylation of IRS-1 at Ser-636/639 by mTOR

(2009) Alexandros Tzatsos   JOURNAL OF BIOLOGICAL CHEMISTRY

IRS1-Independent Defects Define Major Nodes of Insulin Resistance

(2008) Kyle L. Hoehn et al.   Cell Metabolism

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE

Regulation of Proline-rich Akt Substrate of 40 kDa (PRAS40) Function by Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation

(2008) Lifu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY