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Biochemistry & Molecular Biology
Dina Mostafa Mohammed, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Mohamed El-Sherbiny, Wael A. Mahdi, Sultan Alshehri, Hasnaa A. Ebrahim, Amr Farouk
Summary: This study aims to examine the potential impact of key flavors and their nanocapsules on health and diseases, such as type 2 diabetes mellitus. The results showed that these flavors and nanocapsules have a potential anti-hyperglycemic effect and improved the rat health without any health drawbacks.
Article
Biochemistry & Molecular Biology
Dina Mostafa Mohammed, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Mohamed El-Sherbiny, Wael A. Mahdi, Sultan Alshehri, Hasnaa A. Ebrahim, Amr Farouk
Summary: This study aims to examine the potential impact of key flavors and their nanocapsules on health and diseases, such as type 2 diabetes mellitus (T2DM). The findings suggest that these flavors and nanocapsules may have a beneficial effect on T2DM without any health drawbacks.
Article
Biochemistry & Molecular Biology
Amir Taldaev, Anastasiya D. Savina, Vera V. Olicheva, Sergey V. Ivanov, Roman P. Terekhov, Igor R. Ilyasov, Anastasiya K. Zhevlakova, Irina A. Selivanova
Summary: Oxidative stress is a key factor in the development of diabetes and its complications. In this study, the protective properties of taxifolin spheroidal form (TS) were examined in a rat model of diabetes. Treatment with TS for 4 weeks resulted in a significant decrease in fasting blood glucose levels and feed intake in diabetic rats. TS also showed a protective effect on the pancreas and liver against the cytotoxic action of streptozotocin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Wan Seok Kang, Woo Kwon Jung, Su-Bin Park, Hyung Rae Kim, Junghyun Kim
Summary: The DPP4 inhibitor gemigliptin demonstrates protective effects against salivary dysfunction in diabetes by mediating antioxidant, anti-apoptotic, and salivary secretion mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Nutrition & Dietetics
Shiqi Zhang, Lanlan Tang, Fanshu Xu, Yonghai Hui, Hongjia Lu, Xiong Liu
Summary: Capsaicin exhibits significant hypoglycemic effects by activating the TRPV1 channel, which is lost when the channel is blocked. The hypoglycemic effect of capsaicin is partially attributed to the combined up-regulation of TRPV1 receptors and PDX-1.
FRONTIERS IN NUTRITION
(2021)
Article
Food Science & Technology
Maojun Yao, Hui Teng, Qiyan Lv, Huifang Gao, Tengming Guo, Yiwen Lin, Sihai Gao, Meihu Ma, Lei Chen
Summary: DHM exhibits significant anti-hyperglycemic and anti-hyperinsulinemic effects, possibly through the regulation of the AMPK/Akt/GSK-3 beta signaling pathway.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Environmental Sciences
Noha Osama El-Shaer, Ahmed Medhat Hegazy, Marwa H. H. Muhammad
Summary: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia, and NLRP3-mediated pyroptosis may contribute to the development of diabetic complications. Quercetin, a natural flavonoid, has been reported to have antioxidant effects on different tissues, but its effects on NLRP3-mediated pyroptosis in diabetic lung are unclear. This study aimed to evaluate the protective effects of quercetin on lung function, oxidative stress, and NLRP3-mediated pyroptosis in Wister rats with STZ-induced DM.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Rui Zhang, Xiaojun Zhou, Qiqi Sheng, Qian Zhang, Tianyue Xie, Chunmei Xu, Zhiwei Zou, Jianjun Dong, Lin Liao
Summary: The study showed that Gliquidone can lower fasting blood glucose and increase insulin sensitivity in diabetic Sur1-- rats, mainly by increasing hepatic glycogen storage and decreasing gluconeogenesis. However, its effects were still weaker compared to metformin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kuang-I. Cheng, Hung-Chen Wang, Kuang-Yi Tseng, Yi-Hsuan Wang, Chung-Yu Chang, Yi-Jing Chen, Chung-Sheng Lai, Dar-Ren Chen, Lin-Li Chang
Summary: Oral cilostazol can attenuate the responses of mechanical allodynia and has the potential to treat diabetic neuropathy by attenuating NaV and glial cell dysregulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Qingying Si, Jinxiu Guo, Xiumei Yang, Yujin Guo, Linlin Wu, Dadi Xie, Pei Jiang
Summary: This study investigated the metabolic alterations in streptozotocin-induced diabetic rats using gas chromatography-mass spectrometry analysis. The results showed differential expression of metabolites in the serum, heart, liver, kidney, cortex, renal lipid, hippocampus, and brown fat tissues of diabetic rats compared to control rats. Metabolic pathway analysis revealed that these alterations mainly involved amino acid metabolism, organic acid metabolism, sugar metabolism, and lipid metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Physical
Alaa A. A. Aljabali, Bahaa Al-Trad, Lina Al Gazo, Ghada Alomari, Mazhar Al Zoubi, Walhan Alshaer, Khalid Al-Batayneh, Bahja Kanan, Kaushik Pal, Murtaza M. Tambuwala
Summary: The study investigated the effects of gold nanoparticles (AuNPs) on an animal model of diabetic cardiomyopathy (DCM). The results indicated that AuNPs reduced the pathological conditions associated with DCM, suggesting a therapeutic potential for AuNPs in the treatment of early DCM. Further research is needed to explore the mechanisms by which AuNPs may prevent the development of DCM.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Abdulaziz M. F. Shayea, Waleed M. Renno, Bedoor Qabazard, Willias Masocha
Summary: This study demonstrated the protective properties of hydrogen sulfide (H2S) in diabetic neuropathy, showing that it can prevent the development of neuropathy-related behavior and suppress apoptosis activation pathways and inflammation in the spinal cord.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Nurdiana Samsulrizal, Yong-Meng Goh, Hafandi Ahmad, Sulaiman Md Dom, Nur Syimal'ain Azmi, Noor Syaffinaz NoorMohamad Zin, Mahdi Ebrahimi
Summary: Ficus deltoidea can significantly increase bone mineral density, promote osteogenesis, and inhibit bone oxidative stress, potentially serving as a therapy for diabetic osteoporosis.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jun Su, Chongting Gao, Ling Xie, Ying Fan, Yilan Shen, Qunwei Huang, Niansong Wang, Youhua Xu, Nizhi Yang, Dingkun Gui
Summary: Astragaloside II (AS II), a novel saponin from Astragalus membranes, shows protective effects on podocyte injury and mitochondrial dysfunction in diabetic nephropathy (DN) by ameliorating albuminuria, renal histopathology, podocyte apoptosis, and restoring the expression of mitochondrial dynamics-related and autophagy-related proteins. Furthermore, AS II increases the expression of PINK1 and Parkin associated with mitophagy, and facilitates antioxidative stress ability via regulation of Nrf2 and Keap1 pathway, providing a potential therapeutic strategy for the treatment of DN.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ken Muramatsu, Satoshi Shimo, Toru Tamaki, Masako Ikutomo, Masatoshi Niwa
Summary: The study reveals a decrease in conduction velocity of the corticospinal tract in the lumbar spinal cord of diabetic animals, along with atrophy of fibers and an increased g-ratio.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
