Article
Cardiac & Cardiovascular Systems
Yader Sandoval, Bradley R. Lewis, Ramila A. Mehta, Olatunde Ola, Jonathan D. Knott, Laura De Michieli, Ashok Akula, Ronstan Lobo, Eric H. Yang, S. Michael Gharacholou, Marshall Dworak, Erika Crockford, Nicholas Rastas, Eric Grube, Swetha Karturi, Scott Wohlrab, David O. Hodge, Tahir Tak, Charles Cagin, Rajiv Gulati, Allan S. Jaffe
Summary: Using a single hs-cTnT below the limit of quantitation of 6 ng/L is a safe and rapid method to identify a substantial number of patients at very low risk for acute myocardial injury and infarction.
Article
Cardiac & Cardiovascular Systems
Manan Pareek, Kristian H. Kragholm, Anna Meta Dyrvig Kristensen, Muthiah Vaduganathan, Jannik L. Pallisgaard, Christina Byrne, Tor Biering-Sorensen, Christina Ji-Young Lee, Anders Nissen Bonde, Martin Bodtker Mortensen, Michael Maeng, Emil L. Fosbol, Lars Kober, Niels Thue Olsen, Gunnar H. Gislason, Deepak L. Bhatt, Christian Torp-Pedersen
Summary: The study found that individuals suspected of acute coronary syndrome who had consecutively elevated high-sensitivity troponin concentrations had the highest risk of death, while those with consecutively normal hsTnT concentrations had very low mortality rates, regardless of changes between measurements.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Pedro Lopez-Ayala, Thomas Nestelberger, Jasper Boeddinghaus, Luca Koechlin, Paul David Ratmann, Ivo Strebel, Juliane Gehrke, Severin Meier, Joan Walter, Maria Rubini Gimenez, Eugenio Mutschler, Oscar Miro, Beatriz Lopez-Barbeito, Francisco Javier Martin-Sanchez, Esther Rodriguez-Adrada, Dagmar I. Keller, L. Kristin Newby, Raphael Twerenbold, Evangelos Giannitsis, Bertil Lindahl, Christian Mueller
Summary: The study validated the ESC NSTEMI guidelines for the observe-zone of the 0/1h hs-cTnT algorithm and proposed new 0/3h criteria, which can more accurately rule out or rule in NSTEMI by measuring hs-cTnT concentrations and changes.
Article
Cardiac & Cardiovascular Systems
Yader Sandoval, Fred S. Apple, Simon A. Mahler, Richard Body, Paul O. Collinson, Allan S. Jaffe
Summary: The guidelines for the evaluation and diagnosis of acute chest pain released by multiple associations in 2021 provide important recommendations, including the use of high-sensitivity cardiac troponin (hs-cTn) as the preferred biomarker, defining myocardial injury with 99th percentile upper reference limits, and utilizing clinical decision pathways. However, the guidelines do not extensively address the details of integrating hs-cTn into clinical practice, and clinicians need to be aware of analytical aspects related to hs-cTn assays and how to best use it with clinical decision pathways.
Article
Cardiac & Cardiovascular Systems
Fred S. Apple, Stephen W. Smith, Jaimi H. Greenslade, Yader Sandoval, William Parsonage, Isuru Ranasinghe, Niranjan Gaikwad, Karen Schulz, Laura Stephensen, Christian W. Schmidt, Brynn Okeson, Louise Cullen
Summary: By using a rapid point-of-care whole-blood hs-cTnI assay, it is possible to safely exclude the possibility of myocardial infarction and expedite discharge from the emergency department.
Article
Cardiac & Cardiovascular Systems
Jeanne du Fay de Lavallaz, Alexandra Prepoudis, Maria Janina Wendebourg, Eva Kesenheimer, Diego Kyburz, Thomas Daikeler, Philip Haaf, Julia Wanschitz, Wolfgang N. Loescher, Bettina Schreiner, Mira Katan, Hans H. Jung, Britta Maurer, Angelika Hammerer-Lercher, Agnes Mayr, Danielle M. Gualandro, Annemarie Acket, Christian Puelacher, Jasper Boeddinghaus, Thomas Nestelberger, Pedro Lopez-Ayala, Noemi Glarner, Samyut Shrestha, Robert Manka, Joanna Gawinecka, Salvatore Piscuoglio, John Gallon, Sophia Wiedemann, Michael Sinnreich, Christian Mueller
Summary: This study aimed to confirm the cardiac specificity of cTnT in patients with various skeletal muscle disorders (SMDs). The results showed that elevations in cTnT concentrations in patients with active chronic SMDs are common and not attributable to cardiac disease, while this phenomenon was not observed for cTnI. The re-expression of cTnT in skeletal muscle may partially explain this.
Article
Medicine, Legal
Michael Moridi, Cecilia Magnusson, Brita Zilg
Summary: Diagnosing acute myocardial infarction (AMI), especially in the early hours after ischemia, is challenging for forensic pathologists. This study investigated the sensitivity and specificity of cardiac Troponin T (cTnT) as a postmortem diagnostic marker for AMI, as well as the impact of postmortem interval (PMI) and cardiopulmonary resuscitation (CPR) on cTnT concentrations.
FORENSIC SCIENCE INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Ayesha Khan, Muhammad S. Saleem, Keith D. Willner, Luke Sullivan, Elsie Yu, Osama Mahmoud, Amro Alsaid, Martin E. Matsumura
Summary: Accelerated diagnostic protocols (ADPs) using high-sensitivity troponin levels have excellent sensitivity and negative predictive value for rapid risk stratification of chest pain patients. Patients discharged following ADP with discordant results had significantly higher rates of major adverse cardiac events, especially among those with a peak hsTnT level between 12 and 51 ng/L. Application of a HEART score of 4 or greater may help in discharge decisions for patients with ADP-discordant troponin series.
Review
Cardiac & Cardiovascular Systems
Thomas E. Kaier, Bashir Alaour, Michael Marber
Summary: The 4th Universal Definition of Myocardial Infarction has sparked debates aiming to define types of myocardial injury from a pathophysiological perspective, with necessary adjustments in clinical guidelines for real-world patient triage.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Brandon R. Allen, Robert H. Christenson, Scott A. Cohen, Richard Nowak, R. Gentry Wilkerson, Bryn Mumma, Troy Madsen, James McCord, Maite Huis In't Veld, Michael Massoomi, Jason P. Stopyra, Cindy Montero, Michael T. Weaver, Kai Yang, Simon A. Mahler
Summary: In a prospective multisite US cohort, an initial hs-cTnT below the LOQ combined with a low-risk HEART score has a 99% NPV for 30-day MACEs. The 0/1-h hs-cTnT algorithm did not achieve an NPV >99% for 30-day MACEs when used alone or with a HEART score.
Review
Cardiac & Cardiovascular Systems
Thomas E. Kaier, Bashir Alaour, Michael Marber
Summary: The 4th Universal Definition of Myocardial Infarction aims to define types of myocardial injury based on their pathophysiology, sparking debates and leading to necessary pragmatic adjustments in clinical guidelines to improve triage of real-world patients.
CARDIOVASCULAR RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Stanely Mainzen Prince Ponnian
Summary: This study assessed the preventive effects of (-) epicatechin on tachycardia, cardiac hypertrophy, and inflammation in myocardial infarction, and found that it improved cardiac function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Weiwei Dong, Zhiyong Yang
Summary: An analysis of lipid profiles and lipid control among US adult survivors of stroke and/or myocardial infarction from 2001-2018 revealed a decrease in total cholesterol, LDL, and triglyceride concentrations, as well as an improvement in lipid control rates. However, variations were observed based on sex and race.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Chemistry, Analytical
Ali Pourali, Mohammad Reza Rashidi, Jaleh Barar, Graciela Pavon-Djavid, Yadollah Omidi
Summary: This article provides insights into recent progress in amperometry/voltammetry biosensors for the detection of AMI biomarkers, highlighting their ability to simultaneously detect multiple biomarkers, provide fast and cost-efficient monitoring tools, and future development directions.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Anita Yovas, Shervin Prince Stanely, Reya Issac, Stanely Mainzen Prince Ponnian
Summary: Beta-caryophyllene was found to have anti-hyperlipidemic and antioxidant effects, which could inhibit the risk of isoproterenol-induced myocardial infarction in rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
