Review
Clinical Neurology
Paul G. Harch
Summary: This systematic review examines the evidence for hyperbaric oxygen therapy in Persistent Postconcussion Syndrome using a dose-analysis based on the scientific definition of hyperbaric oxygen therapy. The results suggest that hyperbaric oxygen therapy at 1.5 ATA can significantly improve symptoms and cognitive function in patients with mild traumatic brain injury Persistent Postconcussion Syndrome, with positive and negative results found at different doses of oxygen and pressure.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Martijn de Neeling, Dirk Liessens, Bart Depreitere
Summary: Mild traumatic brain injury (mTBI) has a high incidence worldwide, and long-term persistent postconcussion symptoms (PPCS) are predicted by psychological and psychiatric factors. Anxiety, depressive symptoms, and emotional distress early after injury can predict PPCS burden and functional outcome. Coping styles, preinjury psychiatric disorders and mental health also correlate with PPCS burden and functional outcome.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Kaisa Maki, Taina Nybo, Marja Hietanen, Antti Huovinen, Ivan Marinkovic, Harri Isokuortti, Susanna Melkas
Summary: Perceived injustice is associated with self-reported symptoms in patients with mild traumatic brain injury (mTBI). Our results suggest that perceived injustice could be a relevant construct to consider in clinical management of patients with mTBI, and it could be a potential target for psychological interventions promoting recovery after mTBI.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Clinical Neurology
Barry M. Miskin, Lee A. Fox, Hussam Abou-Al-Shaar, Othman Bin-Alamer, Aaron Goertz, Conner T. Lipin, Nicole Fertig, Nevada Cox
Summary: This study evaluated the safety and outcomes of hyperbaric oxygen therapy (HBOT) in managing the long-term sequelae of traumatic brain injury (TBI). The results showed that TBI patients who underwent 40 sessions of HBOT at 1.5 atmosphere absolute experienced significant improvements in cognitive and physical function, as well as increased cerebral blood flow and oxygen metabolism. HBOT was considered a safe and effective modality in the treatment of the long-term sequelae of TBI.
WORLD NEUROSURGERY
(2023)
Article
Multidisciplinary Sciences
Mohammed M. Alnawmasi, Sieu K. Khuu
Summary: This study investigated the impact of TBI on the allocation and maintenance of visual attention to multiple moving targets using a multiple object tracking task. The results showed that patients with mild TBI had greater deficits in maintaining visual attention and detecting targets, particularly when the tracking load and distraction increased.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Clinical
Josh W. Faulkner, Deborah L. Snell, Alice Theadom, Susan Mahon, Suzanne Barker-Collo
Summary: The study found that psychological flexibility significantly affects postconcussion symptoms and functional status in individuals with mTBI, serving as an important treatment target in mTBI interventions. Researchers suggest that psychological flexibility is a psychological mechanism that contributes to recovery outcomes in individuals with mTBI.
REHABILITATION PSYCHOLOGY
(2021)
Article
Medicine, General & Internal
Sophia Wagberg, Britt-Marie Stalnacke, Beatrice M. M. Magnusson
Summary: This study evaluates post-TBI symptoms and disabilities seven to eight years after mild TBI (mTBI), showing that women and individuals with repeated TBI experience more severe symptoms and functional decline. These findings have implications for clinical practice and research, and should be considered in rehabilitation and follow-up plans.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anesthesiology
Cayden Peixoto, Derrick Matthew Buchanan, Richard Nahas
Summary: Missed diagnosis of mTBI is common in patients presenting to the ED after MVC, and these patients are at risk of developing chronic pain syndromes. Better screening for mTBI is needed, especially in patients with loss of consciousness, altered mental state, posttraumatic amnesia, or postinjury headache, who are at increased risk of PCS.
Article
Cell Biology
Ruslan Prus, Olena Appelhans, Maksim Logash, Petro Pokotylo, Grzegorz Jozef Nowicki, Barbara Slusarska
Summary: Traumatic brain injury is a serious issue in modern medicine, with our study showing that mild TBI causes different histological changes in the livers of adult and juvenile rats. The most significant changes were observed on days 5-7, with compensatory phenomena prevailing on days 14-21 in both groups.
Article
Multidisciplinary Sciences
Eli Fried, Uri Balla, Merav Catalogna, Eran Kozer, Adi Oren-Amit, Amir Hadanny, Shai Efrati
Summary: This study aimed to evaluate the prevalence of persistent post-concussion syndrome (PPCS) in children after mild traumatic brain injury (mTBI) and identify high-risk factors. The results showed that 25% of children may suffer from PPCS, but it is often underdiagnosed in the pediatric population. Screening guidelines should be implemented to identify and treat these children in a timely manner.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Roh-Eul Yoo, Seung Hong Choi, Sung-Won Youn, Moonjung Hwang, Eunkyung Kim, Byung-Mo Oh, Ji Ye Lee, Inpyeong Hwang, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn
Summary: This study found that mTBI patients with PCS had lower average MVF in the bilateral cerebral WM compared to controls, as well as significantly decreased myelin volume in the corpus callosum and brainstem. Total myelin volume was also reduced in these patients. Additionally, there was a significant correlation between myelin volume and neuropsychological test scores only in the bilateral cerebral WM and verbal learning test.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Sung Ho Jang, Eun Bi Choi, Young Seo Lee
Summary: This study examined the incidence and characteristics of physical disabilities in patients with postconcussion syndrome (PCS) after a mild traumatic brain injury (mTBI). It found that approximately 5% of patients with PCS after mTBI had definite physical disabilities, with most of them showing mild quadriparesis.
Article
Clinical Neurology
Molly Cairncross, Chantel T. Debert, Cindy Hunt, Mark T. Bayley, Paul Comper, Tharshini Chandra, Noah D. Silverberg
Summary: This study aimed to establish clinical normative data for the Fear Avoidance Behavior after Traumatic Brain Injury Questionnaire (FAB-TBI) and found that females reported more fear avoidance behavior than males, suggesting that FAB-TBI normative data should be stratified by sex. Higher symptom burden and loss of consciousness were also associated with higher FAB-TBI scores.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2021)
Article
Clinical Neurology
Ido Ben Zvi, Oren Shaia Harel, Amos Douvdevani, Penina Weiss, Chen Cohen, Eynat Ben Ari, Gal Gross, Yehonatan Menndel, David Felzensztein, Noa Schwartz, Shani Berkowitz, Michael Drescher, Sagi Harnof
Summary: This study suggests that circulating cell-free DNA (cfDNA) can be used as a potential biomarker for screening postconcussion syndrome (PCS) in the emergency room. The results show a correlation between cfDNA levels and cognitive performance status, indicating the potential of cfDNA as an early predictor of PCS.
JOURNAL OF NEUROSURGERY
(2022)
Article
Psychology, Clinical
Shannon L. Edmed, Karen A. Sullivan, Alicia C. Allan, Simon S. Smith
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2015)
Article
Anesthesiology
S. L. Edmed, K. M. Moss, J. Warren, J. Kenardy
EUROPEAN JOURNAL OF PAIN
(2018)
Meeting Abstract
Clinical Neurology
S. Edmed, K. Rossa, J. Kenardy, V. Anderson, S. Smith
Article
Neurosciences
Shannon L. Edmed, Karen A. Sullivan
Article
Psychology, Clinical
Shannon L. Edmed, Karen A. Sullivan
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2014)
Article
Psychiatry
Shannon Edmed, Karen Sullivan
PSYCHIATRY RESEARCH
(2012)