Article
Biochemistry & Molecular Biology
Leonardo Augusto dos Santos Escaliante, Bianca Busato, Carmen Lucia de Oliveira Petkowicz, Silvia Maria Suter Correia Cadena, Guilhermina Rodrigues Noleto
Summary: The study investigated the cytotoxic effect of xyloglucan complexed with oxovanadium on hepatocellular carcinoma cells, showing that the complex could intensify its effects on the respiratory chain and reduce mitochondrial membrane potential. Moreover, ATP levels were elevated under complexation, possibly due to enhanced glycolytic flux.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Xingyu Heng, Fangjian Shan, He Yang, Jun Hu, Ruyan Feng, Wende Tian, Gaojian Chen, Hong Chen
Summary: A new strategy is proposed in this study to regulate the efficacy of polysaccharides in promoting dendritic cells (DCs) maturation through the spatial dimension. An anchoring molecule (DMA) is introduced to enhance the confinement effect, which can be turned off by oxidation of DMA. The study reveals that the turn-on and off of confinement effect can regulate DCs maturation by polysaccharides.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Immunology
Yongqiang Liao, Ni Xiao, Xiaoming Wang, Senhua Dai, Guiliang Wang
Summary: In this study, we found that the expression of Thymosin beta 4 x (Tmsb4x) is decreased in patients with septicemia, leading to increased inflammatory response and reduced proportion of dendritic cells (DCs). Restoration of Tmsb4x expression facilitated the differentiation of mononuclear cells into DCs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Laya Zoghi Mofrad, Abolfazl Fateh, Fattah Sotoodehnejadnematalahi, Dariush Norouzian Sham Asbi, Seyed Davar Siadat
Summary: Probiotics such as A. muciniphila and its outer membrane vesicles (OMVs) play an important role in immunomodulation by regulating dendritic cell (DC) maturation and inducing tolerogenic DCs. These probiotics also affect the expression of microRNAs involved in inflammatory and anti-inflammatory pathways.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Environmental Sciences
Zhen-zhong Wu, You-xian Zhang, Jin-yan Yang, Zong-qian Jia
Summary: Elevated vanadium in the environment can have adverse effects on organisms, with plants being the main pathway for vanadium entering the food chain. A study on lettuce growth under vanadium stress found that concentrations of 0.1 mg L-1 V did not significantly impact growth, while >=0.5 mg L-1 V led to marked depression in growth. Vanadium accumulation in plant tissues was highest in roots, and health risks were observed when adults and children consumed lettuce with higher levels of vanadium. Further attention is needed on the potential health risks associated with consuming vegetables grown in vanadium-contaminated soil.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Immunology
Khaled Alharshawi, Holger Fey, Alyx Vogle, Tori Klenk, Miran Kim, Costica Aloman
Summary: Alcoholic liver disease is influenced by the direct effects of alcohol and its metabolites on immune cells and tissue cells, with females being more susceptible. Plasmacytoid dendritic cells play a significant role in chronic alcohol exposure, especially in female mice, and may explain the sex-specific differences in alcoholic liver disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Teresa Pagano, Katia Fecchi, Marina Pierdominici, Elena Ortona, Daniela Peruzzu
Summary: Silibinin exhibits immunosuppressive activity by inhibiting the maturation and activation of human dendritic cells, suggesting its potential application as an adjuvant therapy for autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Leanne C. Helgers, Michel S. Bhoekhan, Dasja Pajkrt, Katja C. Wolthers, Teunis B. H. Geijtenbeek, Adithya Sridhar
Summary: Enterovirus A71 is a causative agent of neurological diseases in young children. Dendritic cells may play a role in the dissemination of the virus, and heparan sulfates and heparin derivatives may be effective in attenuating dissemination.
MICROBIOLOGY SPECTRUM
(2022)
Review
Biochemistry & Molecular Biology
Sara Nava, Daniela Lisini, Simona Frigerio, Anna Bersano
Summary: DCs vaccines have established safety and the ability to induce anti-tumor responses, and combining with other treatments may improve efficacy. Combinatorial approaches of DCs-based immunotherapy with chemotherapy and radiotherapy could be the key to cancer treatment paradigms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marta Toth, Szabolcs Muzsai, Krzysztof Regulski, Timea Szendi-Szatmari, Zsolt Czimmerer, Eva Rajnavolgyi, Marie-Pierre Chapot-Chartier, Attila Bacsi
Summary: The human gut symbiont Lacticaseibacillus (L.) casei has a wide range of immunomodulatory effects on the human host. This study demonstrates that human monocyte-derived dendritic cells (moDCs) can engulf L. casei BL23, and the intact bacterial cell wall and morphology play a key role in this process. The absence of the bacterial cell-wall-degrading enzyme Lc-p75 leads to defective internalization and impaired cytokine secretion by moDCs, resulting in reduced T-cell activation capacity. Formation of short bacterial chains helps to exert the potent immunomodulatory properties of L. casei BL23.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Markus J. Lehtinen, Ritesh Kumar, Bryan Zabel, Sanna M. Makela, Derek Nedveck, Peipei Tang, Sinikka Latvala, Sebastien Guery, Charles R. Budinoff
Summary: The study found that probiotic consortia OL-1 and OL-2 can significantly reduce viral load of SARS-CoV-2 in ferrets, modulate immune response, and stimulate the production of genes and cytokines associated with anti-SARS-CoV-2 immunity in human immune cells.
Article
Biochemistry & Molecular Biology
Sara Monaci, Federica Coppola, Gaia Giuntini, Rossella Roncoroni, Francesco Acquati, Silvano Sozzani, Fabio Carraro, Antonella Naldini
Summary: Hypoxia enhances the expression and secretion of RNASET2 in dendritic cells, which is associated with survival, autophagy, and apoptosis in DCs. The expression of RNASET2 under hypoxia is regulated by the PI3K/AKT pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Christiane Braun, Sebastian Schlaweck, Solveig Nora Daecke, Peter Brossart, Annkristin Heine
Summary: Idelalisib's reduced usage may be linked to its impact on dendritic cells, resulting in impaired T cell immune function and decreased activation of the NFκB pathway in DCs after treatment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Maura B. Bendix, Aileen Houston, Patrick F. Forde, Elizabeth Brint
Summary: Electrochemotherapy (ECT) is a potential treatment for lung cancer, which has traditionally been difficult to treat. This study found that cisplatin at 11 μM is the suggested drug of choice for ECT in lung cancer. Additionally, high electric field strengths used in current ECT protocols negatively impact the survival of immune cells, suggesting a need for modifications to improve therapy outcomes.
BIOELECTROCHEMISTRY
(2022)
Article
Immunology
Tae Jin Yun, Suzu Igarashi, Haoquan Zhao, Oriana A. Perez, Marcus R. Pereira, Emmanuel Zorn, Yufeng Shen, Felicia Goodrum, Adeeb Rahman, Peter A. Sims, Donna L. Farber, Boris Reizis
Summary: Plasmacytoid dendritic cells (pDCs) can recognize live infected cells and produce a unique antiviral immune response, including high amounts of interferons, prolonged and efficient responses to CMV-infected cells, and activation of natural killer cells. Patients with CMV viremia show activated pDCs and increased circulating IFN-I and IFN-III.
SCIENCE IMMUNOLOGY
(2021)
