Article
Oncology
Nathaniel Deboever, Kyle G. Mitchell, Hope A. Feldman, Tina Cascone, Boris Sepesi
Summary: The management strategy for non-small-cell lung cancer (NSCLC) has changed due to advancements in cancer biology and the development of novel systemic therapies. Surgical resection remains the best option for cure or disease control, with reduced morbidity due to improved techniques. Patient-centered discussions and promising therapies like immune checkpoint inhibitors have improved outcomes. The field of thoracic oncology has rapidly evolved, with the expansion of indications for surgery to include advanced and metastatic disease. Careful patient selection and timing of multi-modality therapy are crucial.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dolly Y. Wu, Alberto de Hoyos, Dat T. Vo, Helena Hwang, Ann E. Spangler, Stephen J. Seiler
Summary: The study analyzed the accuracy of clinical non-small cell lung cancer staging and tumor length measurements by comparing SEER and non-SEER cases. Results showed that there were disagreements between clinical and pathological staging and lengths, with reasons including the use of family-category descriptors instead of subcategories.
ACADEMIC RADIOLOGY
(2021)
Review
Medicine, General & Internal
Jone Miren Del Campo, Sergio Maroto, Leyre Sebastian, Xavier Vaillo, Sergio Bolufer, Francisco Lirio, Julio Sesma, Carlos Galvez
Summary: Uniportal VATS has become a popular approach in minimally invasive thoracic surgery since its introduction in 2011. It is not only used for treatment, but also for the examination and diagnosis of suspicious solitary undiagnosed nodules and the surgical staging of NSCLC. This article reviews the accuracy of uniportal VATS for NSCLC diagnosis and staging and provides technical details and recommendations for its safe performance.
Review
Oncology
Virginia Leiro-Fernandez, Alberto Fernandez-Villar
Summary: Accurate staging of mediastinal lymph nodes is crucial for planning treatments for lung cancer patients. While computed tomography and positron emission tomography are commonly used for mediastinal staging, surgical techniques provide higher accuracy, especially in cases where further confirmation is needed for negative results.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Elizabeth G. Dunne, Cameron N. Fick, David R. Jones
Summary: This article discusses the importance of EBUS-FNA in the staging of non-small cell lung cancer and the use of EBUS alone or in combination with confirmatory mediastinoscopy. The study concludes that EBUS alone is noninferior to EBUS with confirmatory mediastinoscopy, supporting the current practice of forgoing confirmatory mediastinoscopy after negative EBUS findings.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
John V. Heymach, David Harpole, Tetsuya Mitsudomi, Janis M. Taube, Gabriella Galffy, Maximilian Hochmair, Thomas Winder, Ruslan Zukov, Gabriel Garbaos, Shugeng Gao, Hiroaki Kuroda, Gyula Ostoros, Tho V. Tran, Jian You, Kang-Yun Lee, Lorenzo Antonuzzo, Zsolt Papai-Szekely, Hiroaki Akamatsu, Bivas Biswas, Alexander Spira, Jeffrey Crawford, Ha T. Le, Mike Aperghis, Gary J. Doherty, Helen Mann, Tamer M. Fouad, Martin Reck, AEGEAN Invest
Summary: In resectable non-small-cell lung cancer patients, perioperative durvalumab plus neoadjuvant chemotherapy showed significantly improved event-free survival and pathological complete response compared to neoadjuvant chemotherapy alone, with a similar safety profile.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Juntang Guo, Leilei Shen, Zhipeng Ren, Yang Liu, Chaoyang Liang
Summary: This study evaluated the survival outcomes and risk factors of postoperative unsuspected SCLC. Surgery and adjuvant therapy showed promising results in patients, particularly those in stage I, stage II, and some of stage IIIA. N stage was found to be associated with overall survival.
Article
Public, Environmental & Occupational Health
Xianghui Yang, Liyong Deng, Min Li, Yongjie Zhou, Guihua Wang
Summary: This study evaluated the association between socioeconomic status (SES) factors and cancer-specific survival (CSS) in patients with non-small cell lung cancer (NSCLC). A novel TNM-SES staging system was proposed, which showed superior predictive value compared to the traditional TNM stage.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Aaron R. Dezube, Suden Kucukak, Luis E. De Leon, Daniel C. Wiener, Matthew M. Rochefort, Michael T. Jaklitsch
Summary: This study compared the rates of discordant data in non-small cell lung cancer between the SEER and NCDB databases, revealing higher levels of data errors and outliers in the NCDB.
ANNALS OF THORACIC SURGERY
(2022)
Letter
Medicine, General & Internal
Wilson W. L. Li, Stefan M. van der Heide, Ad F. T. M. Verhagen, Nasser Altorki, Xiaofei Wang, Thomas E. Stinchcombe
Summary: Altorki et al. found similar survival between peripheral stage IA non-small-cell lung cancer patients who underwent lobar resection and those who underwent sublobar resection. However, sublobar resection had a higher incidence of locoregional recurrence, without having the benefits of lower operative mortality, lower risk of complications, higher quality of life, and carrying a probable added risk of adverse events for recurrent disease treatment.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Oncology
Natalia Motas, Veronica Manolache, Marco Scarci, Victor Nimigean, Vanda Roxana Nimigean, Laurentiu Simion, Madalina Cristiana Mizea, Oana Gabriela Trifanescu, Bianca Galateanu, Mirela Gherghe, Cristina Mirela Capsa, Diego Gonzalez-Rivas, Mihnea Dan Davidescu
Summary: Salvage surgery for small-cell lung cancer (SCLC) is a relatively new and rare concept, but it can be considered as an alternative treatment in selected patients with limited disease. It has similar postoperative morbidity to salvage surgery for non-small cell lung cancer (NSCLC), with no postoperative mortality, and a median estimated overall survival of 92% at 2 years and 66% at 5 years. Salvage lung resection for SCLC offers good local control and a favorable survival outcome.
Article
Oncology
Monica Casiraghi, Giulia Sedda, Ester Del Signore, Gaia Piperno, Patrick Maisonneuve, Francesco Petrella, Filippo de Marinis, Lorenzo Spaggiari
Summary: Patients with stage I SCLC may be the best candidates for surgery in a multidisciplinary setting. However, patients with stage II and III should be carefully selected for surgery due to their worse survival outcomes, and alternative therapies should be considered.
Review
Oncology
Yi-Hsing Chen, Ue-Cheung Ho, Lu-Ting Kuo
Summary: Oligometastatic non-small-cell lung cancer (NSCLC) is a distinct group of patients that could benefit from curative-intent treatment to improve clinical outcomes. Various treatment procedures have been developed for different oligometastatic sites. The proposed uniform definition for oligometastases and ongoing trials may enhance patient selection and evaluation of treatment effectiveness.
Article
Medicine, General & Internal
Charles M. Rudin, Elisabeth Brambilla, Corinne Faivre-Finn, Julien Sage
Summary: Small-cell lung cancer is a type of lung cancer characterized by high proliferative rate, early metastasis, and poor prognosis, strongly associated with tobacco carcinogens. Most patients are diagnosed with metastatic disease, with only a small fraction having potentially curative earlier-stage disease. Genomic profiling reveals extensive chromosomal rearrangements and high mutation burden in SCLC, often involving inactivation of TP53 and RB1 tumor suppressor genes.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Article
Cardiac & Cardiovascular Systems
Bor-Shiuan Shyr, Chien-Sheng Huang, Hui-Shan Chen, Po-Kuei Hsu, Chao-Hua Chiu, Han-Shui Hsu, Chun-Ming Tsai, Yuh-Min Chen
Summary: This study aimed to investigate the impact of primary lung resection and systemic treatment on disease progression and survival in patients with oligometastatic NSCLC. The results showed no significant differences in perioperative complications, hospital length of stay, disease progression, overall death, median PFS, and OS between patients who received primary lung resection and systemic treatment. It was also found that patients with single-organ metastasis had significantly longer PFS and OS than those with oligometastases. Nonsolitary metastasis was identified as the only independent predictor of PFS.
ANNALS OF THORACIC SURGERY
(2022)
Article
Respiratory System
Kirsten A. Freeman
Summary: As a new surgeon, understanding the transitions and challenges ahead, building a support network, and focusing on clinical competence are key to thriving in the first years of your career.
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Keith S. Naunheim, Joseph J. Platz
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Fatima G. Wilder, Jason J. Han
Summary: Mentorship plays a crucial role in a successful career in cardiothoracic surgery, and finding a mentor and establishing a fruitful mentor-mentee relationship requires self-reflection, alignment of goals, open communication, and regular feedback. There are various resources available in the cardiothoracic surgery community to aid members in finding and maintaining successful mentoring relationships.
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Jennifer L. Perri, Tom C. Nguyen
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Melanie A. Edwards
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Rachel Kim, Nahush A. Mokadam
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
William A. Baumgartner
Summary: The author enjoys spending time with their family in retirement and emphasizes the importance of staying active and connected. Mentoring, editing, and documenting family history are also meaningful activities for the author. The author misses the interactions with colleagues but believes retirement can be greatly enjoyed with proper preparation.
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Sarah Khalil, Anna Olds, Kristine Chin, Cherie P. Erkmen
THORACIC SURGERY CLINICS
(2024)
Editorial Material
Respiratory System
Ourania Preventza
Summary: Making a professional transition during a surgeon's mid-career is challenging. It is a crucial phase where experience, repetition, and judgment are developed through extensive practice. This phase involves deciding one's future, helping others shape theirs, and moving into the senior phase of a career.
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Himanshu J. Patel, Stefanie L. Peters, Barbara Hamilton, Andrew C. Chang
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Robert James Cerfolio
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Marko T. Boskovski, Elaine E. Tseng
Summary: The promotion process at academic institutions is clearly defined, and promotion criteria vary based on academic tracks. Promotion packets include multiple components.
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Russell Seth Martins, Kostantinos Poulikidis, Faiz Y. Bhora
Summary: This article emphasizes the importance of financial literacy for new attending surgeons, including establishing a financial team, obtaining appropriate insurance, and planning for retirement. It also reminds surgeons to strike a balance between personal life goals and long-term financial obligations.
THORACIC SURGERY CLINICS
(2024)
