Cellular Programming and Reprogramming: Sculpting Cell Fate for the Production of Dopamine Neurons for Cell Therapy

Direct Reprogramming of Mouse and Human Fibroblasts into Multipotent Neural Stem Cells with a Single Factor

(2012) Karen L. Ring et al.   Cell Stem Cell

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors

(2012) E. Metzakopian et al.   DEVELOPMENT

GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area

(2012) Stefanie Reyes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Small molecules enable highly efficient neuronal conversion of human fibroblasts

(2012) Julia Ladewig et al.   NATURE METHODS

Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease

(2012) Eunju Shin et al.   NEUROBIOLOGY OF DISEASE

A cytoarchitectonic and chemoarchitectonic analysis of the dopamine cell groups in the substantia nigra, ventral tegmental area, and retrorubral field in the mouse

(2011) YuHong Fu et al.   Brain Structure & Function

Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells

(2011) Xinjian Liu et al.   CELL RESEARCH

Transcription Factor-Induced Lineage Selection of Stem-Cell-Derived Neural Progenitor Cells

(2011) Lia Panman et al.   Cell Stem Cell

Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts

(2011) Jongpil Kim et al.   Cell Stem Cell

miR-371-3 Expression Predicts Neural Differentiation Propensity in Human Pluripotent Stem Cells

(2011) Hyesoo Kim et al.   Cell Stem Cell

Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

(2011) Samuele Marro et al.   Cell Stem Cell

Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cells

(2011) I. Jaeger et al.   DEVELOPMENT

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

(2011) Qiaolin Deng et al.   DEVELOPMENT

Efficient Generation of A9 Midbrain Dopaminergic Neurons by Lentiviral Delivery of LMX1A in Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

(2011) A. Sánchez-Danés et al.   HUMAN GENE THERAPY

Lmx1a and Lmx1b Function Cooperatively to Regulate Proliferation, Specification, and Differentiation of Midbrain Dopaminergic Progenitors

(2011) C. H. Yan et al.   JOURNAL OF NEUROSCIENCE

Pitx3 Is a Critical Mediator of GDNF-Induced BDNF Expression in Nigrostriatal Dopaminergic Neurons

(2011) C. Peng et al.   JOURNAL OF NEUROSCIENCE

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

(2011) Massimiliano Caiazzo et al.   NATURE

Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults

(2011) Daniel Alvarez-Fischer et al.   NATURE NEUROSCIENCE

Cell Therapeutics in Parkinson’s Disease

(2011) Olle Lindvall et al.   Neurotherapeutics

Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors

(2011) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ES cell-derived renewable and functional midbrain dopaminergic progenitors

(2011) S. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Graft-Induced Dyskinesias in Parkinson's Disease: What Is It All About?

(2010) Roger A. Barker et al.   Cell Stem Cell

Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells

(2010) Christopher A. Fasano et al.   Cell Stem Cell

Cell reprogramming gets direct

(2010) Cory R. Nicholas et al.   NATURE

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP

(2010) Michela Di Salvio et al.   NATURE NEUROSCIENCE

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

(2010) G. Hargus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective cell death in neurodegeneration: Why are some neurons spared in vulnerable regions?

(2010) K.L. Double et al.   PROGRESS IN NEUROBIOLOGY

Direct Conversion of C. elegans Germ Cells into Specific Neuron Types

(2010) B. Tursun et al.   SCIENCE

Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Patients with Neural Transplants

(2010) M. Politis et al.   Science Translational Medicine

Foxa2 and Nurr1 Synergistically Yield A9 Nigral Dopamine Neurons Exhibiting Improved Differentiation, Function and Cell Survival

(2010) Hyun-Seob Lee et al.   STEM CELLS

Wnt1-lmx1a Forms a Novel Autoregulatory Loop and Controls Midbrain Dopaminergic Differentiation Synergistically with the SHH-FoxA2 Pathway

(2009) Sangmi Chung et al.   Cell Stem Cell

Multiple roles of  -catenin in controlling the neurogenic niche for midbrain dopamine neurons

(2009) M. Tang et al.   DEVELOPMENT

Epigenetic reprogramming and induced pluripotency

(2009) K. Hochedlinger et al.   DEVELOPMENT

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development

(2009) Wei Lin et al.   DEVELOPMENTAL BIOLOGY

Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon

(2009) Tomoya Nakatani et al.   DEVELOPMENTAL BIOLOGY

Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model

(2009) Ana Muñoz et al.   EXPERIMENTAL NEUROLOGY

Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis

(2009) Marie E. Jönsson et al.   EXPERIMENTAL NEUROLOGY

Wnt2 Regulates Progenitor Proliferation in the Developing Ventral Midbrain

(2009) Kyle M. Sousa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal cell replacement in Parkinson’s disease

(2009) E. Hedlund et al.   JOURNAL OF INTERNAL MEDICINE

FGF8 Signaling Regulates Growth of Midbrain Dopaminergic Axons by Inducing Semaphorin 3F

(2009) K. Yamauchi et al.   JOURNAL OF NEUROSCIENCE

Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

(2009) B. Kadkhodaei et al.   JOURNAL OF NEUROSCIENCE

Shh dependent and independent maintenance of basal midbrain

(2009) Ariadna Perez-Balaguer et al.   MECHANISMS OF DEVELOPMENT

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

A Novel Combination of Factors, Termed SPIE, which Promotes Dopaminergic Neuron Differentiation from Human Embryonic Stem Cells

(2009) Tandis Vazin et al.   PLoS One

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells

(2009) S. Friling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embryonic Stem Cells with GFP Knocked into the Dopamine Transporter Yield Purified Dopamine Neuronsin vitroand from Knock-in Mice

(2009) Wenbo Zhou et al.   STEM CELLS

Human embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Improve Recovery after Cervical Spinal Cord Injury

(2009) Jason Sharp et al.   STEM CELLS

A critical evaluation of the Braak staging scheme for Parkinson's disease

(2008) Robert E. Burke et al.   ANNALS OF NEUROLOGY

Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration

(2008) T. Carlsson et al.   BRAIN

Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease

(2008) Rosario Sanchez-Pernaute et al.   BRAIN

Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon

(2008) D. Omodei et al.   DEVELOPMENT

Effects on Differentiation of Embryonic Ventral Midbrain Progenitors by Lmx1a, Msx1, Ngn2, and Pitx3

(2008) L. Roybon et al.   JOURNAL OF NEUROSCIENCE

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

(2008) Ivar Mendez et al.   NATURE MEDICINE

Mediators of reprogramming: transcription factors and transitions through mitosis

(2008) Dieter Egli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unique Properties of Mesoprefrontal Neurons within a Dual Mesocorticolimbic Dopamine System

(2008) Stephan Lammel et al.   NEURON

Review: Familial Parkinson's disease – genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease

(2008) Carola Schiesling et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Wnt5a Regulates Ventral Midbrain Morphogenesis and the Development of A9–A10 Dopaminergic Cells In Vivo

(2008) Emma R. Andersson et al.   PLoS One

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

(2008) M. Wernig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embryonic Stem Cell-Derived Pitx3-Enhanced Green Fluorescent Protein Midbrain Dopamine Neurons Survive Enrichment by Fluorescence-Activated Cell Sorting and Function in an Animal Model of Parkinson's Disease

(2008) Eva Hedlund et al.   STEM CELLS

The Role of Lmx1a in the Differentiation of Human Embryonic Stem Cells into Midbrain Dopamine Neurons in Culture and After Transplantation into a Parkinson's Disease Model

(2008) Jingli Cai et al.   STEM CELLS

Bone morphogenetic protein-7 reduces toxicity induced by high doses of methamphetamine in rodents

(2007) J. Chou et al.   NEUROSCIENCE