Review
Cell & Tissue Engineering
Weitao Zheng, Hanluo Li, Kanghong Hu, Liming Li, Mingjian Bei
Summary: Chondromalacia patellae, also known as runner's knee, is a joint disease that typically occurs in young patients and is characterized by anterior knee pain. Various factors contribute to its development, and clinical indications include quadriceps wasting, patellofemoral crepitus, and effusion. Cell-based therapies, particularly using mesenchymal stem cells, have shown promise in treating CMP.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell & Tissue Engineering
Abdelrahman M. Elhusseiny, Mohammad Soleimani, Taher K. Eleiwa, Reem H. ElSheikh, Charles R. Frank, Morteza Naderan, Ghasem Yazdanpanah, Mark Rosenblatt, Ali R. Djalilian
Summary: The regeneration of corneal epithelium relies on limbal epithelial stem cells (LESCs) residing in the limbus, which are regulated by the limbal niche. Disruption to LESCs or their niche can lead to limbal stem cell deficiency (LSCD), impacting corneal and visual function.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Xue Sun, Xiaosheng Fang, Yahan Li, Dongyue Lu, Xin Wang
Summary: ALCL, a rare and highly invasive non-Hodgkin's lymphoma, has traditionally been treated with chemotherapy regimens, but dose-intensive chemotherapy and stem cell transplantation have shown some progress in improving patient survival. With accumulating clinical cases and advancements in our understanding of ALCL biology, new targeted drugs and immunotherapies are providing opportunities for certain patients with ALCL. This review focuses on the current use of traditional therapy and the treatment prospects of these new drugs in ALCL.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Clinical Neurology
Peter Alping, Joachim Burman, Jan Lycke, Thomas Frisell, Fredrik Piehl
Summary: This study compares the safety outcomes of different induction therapies for multiple sclerosis patients. It found a higher incidence of thyroid disease in patients treated with alemtuzumab and AHSCT, with a higher incidence of infection in AHSCT-treated patients compared to both alemtuzumab and noninduction therapies. The incidence of nonthyroid autoimmune disease was low for both therapies.
Review
Cell Biology
Guoyang Zhou, Yongjie Wang, Shiqi Gao, Xiongjie Fu, Yang Cao, Yucong Peng, Jianfeng Zhuang, Junwen Hu, Anwen Shao, Lin Wang
Summary: Cell therapy, especially stem cell therapy, is considered a novel and potential therapeutic strategy to improve stroke outcome through mechanisms such as cell differentiation, cell replacement, immunomodulation, neural circuit reconstruction, and protective factor release. Despite promising results from clinical and preclinical studies, some key issues in cell therapy, such as optimal parameters, require further research and exploration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Ahmed Lotfy, Aya Elgamal, Anna Burdzinska, Ayman A. Swelum, Reham Soliman, Ayman A. Hassan, Gamal Shiha
Summary: Autoimmune hepatitis is a chronic inflammatory liver disease, and adult stem cells (ASCs) have been investigated as potential therapies with positive effects. Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) interact with immune response pathways and are potentially valuable in treating autoimmune diseases like autoimmune hepatitis.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Elisabetta Bretto, Davide Giuseppe Ribaldone, Gian Paolo Caviglia, Giorgio Maria Saracco, Elisabetta Bugianesi, Simone Frara
Summary: Inflammatory bowel disease (IBD) refers to a group of chronic, relapsing inflammatory disorders of the gastrointestinal tract, including Crohn's disease and ulcerative colitis. The global incidence and prevalence of IBD have been increasing, and although the specific causes are still unknown, immunological, genetic, and environmental factors are believed to play a role. The development of biologic therapies in the past few decades has greatly improved the treatment of IBD, but there is still no definitive cure and some patients may not respond well to available therapies. However, emerging therapies targeting new pathogenic mechanisms show promising efficacy and safety in early clinical trials, and their potential significance in shaping future treatment options is being emphasized.
Review
Pharmacology & Pharmacy
Katelin M. Allan, Nigel Farrow, Martin Donnelley, Adam Jaffe, Shafagh A. Waters
Summary: Prognosis of CF patients varies significantly despite advances in targeted therapies improving CFTR function. Lung tissue destruction remains a major cause of morbidity and mortality. Challenges in gene therapy and cell-based therapy for CF treatment need to be addressed through further research and development.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Maryam Zare Moghaddam, Mohammad Javad Mousavi, Somayeh Ghotloo
Summary: Cell-based therapy, including stem cells and non-stem cells, is considered as a therapeutic option for treating autoimmune diseases. The unique properties of stem cells, such as differentiation ability, can influence diseases caused by immunological abnormalities. The efficacy and related issues of cell-based therapy are evaluated and discussed through the assessment of different types of stem cells and non-stem cells.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Hematology
Sridevi Surapally, Daniel G. Tenen, John A. Pulikkan
Summary: This review focuses on the key role of CBF beta-SMMHC in AML and recent advances in therapeutic strategies targeting CBF beta-SMMHC in inv(16) AML.
Review
Endocrinology & Metabolism
G. Basile, M. M. F. Qadir, F. Mauvais-Jarvis, A. Vetere, V Shoba, A. E. Modell, R. L. Pastori, H. A. Russ, B. K. Wagner, J. Dominguez-Bendala
Summary: Stem cell therapies are emerging as a viable alternative for treating insulin dependent diabetes. Clinical trials using human embryonic stem cell-derived (3-like cells show promising results. Meanwhile, research on inducing pancreatic cell regeneration through pharmacological means is also promising. However, achieving a permanent cure for diabetes still faces challenges and requires interventions to restore immune balance.
MOLECULAR METABOLISM
(2022)
Review
Immunology
Dragana Odobasic, Stephen R. Holdsworth
Summary: Anti-myeloperoxidase vasculitis (MPO-AAV) is a life-threatening autoimmune disease that causes severe inflammation of small blood vessels, especially in the kidneys. Current treatments are partially effective and toxic, so there is an urgent need for more targeted and less harmful therapies. Tolerogenic dendritic cells, regulatory T cells, and stem cells have emerged as new and safer options for treating various autoimmune diseases due to their unique and selective immunosuppressive capacity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Engineering, Biomedical
Yaron Bram, Duc-Huy T. Nguyen, Vikas Gupta, Jiwoon Park, Chanel Richardson, Vasuretha Chandar, Robert E. Schwartz
Summary: Liver disease is a significant clinical issue affecting 600 million people worldwide. Liver transplantation, although the gold standard treatment for liver failure, currently meets less than 10% of the global demand due to a shortage of available organs. Cell- and tissue-based therapies offer a promising alternative to organ transplantation.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021
(2021)
Article
Oncology
Anh Nguyen, Gary Johanning, Yihui Shi
Summary: CAR-T cell therapy, through combination with small molecule drugs and other immunotherapy, is emerging as a promising approach to overcome challenges in targeting solid tumors and improve treatment outcomes.
Review
Chemistry, Medicinal
Muhammad Umer, Dinesh K. K. Kalra
Summary: Fabry disease is a rare genetic disorder that affects the metabolism of glycosphingolipids. It results in the accumulation of globotriaosylceramide in lysosomes due to a deficiency of the alpha-galactosidase A enzyme. This disease affects multiple organs, mainly the kidneys, heart, and cerebrovascular system. Early diagnosis and treatment are crucial in preventing irreversible tissue damage, organ failure, and life-threatening complications that can significantly impact life expectancy. This review focuses on the current and emerging treatment options for Fabry disease.
Article
Biology
V. Sivakamasundari, Petra Kraus, Wenjie Sun, Xiaoming Hu, Siew Lan Lim, Shyam Prabhakar, Thomas Lufkin
Article
Clinical Neurology
Petra Kraus, V Sivakamasundari, Victoria Olsen, Victoria Villeneuve, Abbey Hinds, Thomas Lufkin
Article
Anatomy & Morphology
Kangning Li, Devin Kapper, Brittany Youngs, Victoria Kocsis, Sumona Mondal, Petra Kraus, Thomas Lufkin
JOURNAL OF ANATOMY
(2019)
Article
Neurosciences
Li Guan, Wing Shan Yu, Smeeta Shrestha, Yu Zuan Or, Thomas Lufkin, Ying-Shing Chan, Valerie Chun Ling Lin, Lee Wei Lim
BRAIN RESEARCH BULLETIN
(2020)
Article
Biotechnology & Applied Microbiology
Kangning Li, Lara Varden, Althea Henderson, Thomas Lufkin, Petra Kraus
Summary: A simple sequential protocol combining RNA in situ hybridization (RISH) and immunohistochemistry (IHC) was developed for simultaneous analysis of multiple transcripts and proteins to characterize heterogeneous cell populations at the single cell level. The protocol was demonstrated on bovine intervertebral disc cells, providing insights into mechanotransduction, stemness, and cell proliferation.
BIOTECHNOLOGY LETTERS
(2021)
Article
Orthopedics
Shaghayegh Basatvat, Frances C. Bach, Marcos N. Barcellona, Abbie L. Binch, Conor T. Buckley, Brian Bueno, Nadeen O. Chahine, Ana Chee, Laura B. Creemers, Stefan Dudli, Bailey Fearing, Stephen J. Ferguson, Jennifer Gansau, Benjamin Gantenbein, Rahul Gawri, Juliane D. Glaeser, Sibylle Grad, Julien Guerrero, Lisbet Haglund, Paula A. Hernandez, Judith A. Hoyland, Charles Huang, James C. Iatridis, Svenja Illien-Junger, Liufang Jing, Petra Kraus, Lisanne T. Laagland, Gernot Lang, Victor Leung, Zhen Li, Thomas Lufkin, Josette C. van Maanen, Emily E. McDonnell, Chris J. Panebianco, Steven M. Presciutti, Sanjna Rao, Stephen M. Richardson, Sarah Romereim, Tara C. Schmitz, Jordy Schol, Lori Setton, Dmitriy Sheyn, Joseph W. Snuggs, Y. Sun, Xiaohong Tan, Marianna A. Tryfonidou, Nam Vo, Dong Wang, Brandon Williams, Rebecca Williams, S. Tim Yoon, Christine L. Le Maitre
Summary: This study aims to standardize the extraction and expansion techniques for nucleus pulposus (NP) cells, in order to reduce variability between laboratories and improve comparability of results. The most commonly used methods for NP cell extraction, expansion, and re-differentiation were identified through a global survey. Recommended protocols for NP cell culture in different species were provided to support harmonization and cross-lab comparisons.
Article
Nanoscience & Nanotechnology
John C. Hadynski, Jaren Diggins, Zachary Goad, Monu Joy, Steven Dunckel, Petra Kraus, Thomas Lufkin, Mario Wriedt
Summary: This study presents a fluorescence-based detection platform using a metal-organic framework (MOF) that can accurately and rapidly recognize specific targets of the SARS-CoV-2 genome, providing an alternative avenue for innovative detection methods for diverse viral genomes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Public, Environmental & Occupational Health
Ankita Samanta, Thomas Lufkin, Petra Kraus
Summary: Intervertebral disc degeneration (IVDD) is a normal part of aging and can have implications on physical health, mental health, and socioeconomic status. Current therapies primarily focus on symptom management rather than addressing the underlying causes or mechanical function of the disc. Various therapeutic modalities have been developed to improve clinical outcomes and quality of life.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biology
Petra Kraus, Ankita Samanta, Sina Lufkin, Thomas Lufkin
Summary: Pain and lifestyle changes are common consequences of intervertebral disc degeneration (IVDD). Extracellular vesicles, such as exosomes, derived from stem cells provide a new approach for treating IVDD.
Article
Biochemistry & Molecular Biology
Leon Lufkin, Ankita Samanta, DeVaun Baker, Sina Lufkin, JesslynHope Schulze, Benjamin Ellis, Jillian Rose, Thomas Lufkin, Petra Kraus
Summary: Regenerative medicine aims to repair degenerate tissue using minimally invasive procedures. Adipose tissue-derived stem cells are a convenient choice for many therapies, with intervertebral disc degeneration presenting a significant global burden. Assessing stromal cells from adipose and IVD tissues, it was suggested that Glis1 and OAA could provide survival tools for NP cells in the harsh niche conditions of the avascular IVD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, Research & Experimental
Wing Shan Yu, Li Guan, Shawn Zheng Kai Tan, Smeeta Shrestha, Yu Zuan Or, Thomas Lufkin, Valerie C. L. Lin, Lee Wei Lim
Summary: This study investigates the effects of TTC9A on social anxiety and aggressive behaviors in female mice. Female Ttc9a-/- mice show social and non-social anxiety-like behaviors, as well as a reduction in aggressive behavior.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Veterinary Sciences
Kangning Li, Devin Kapper, Sumona Mondal, Thomas Lufkin, Petra Kraus
VETERINARY SCIENCES
(2019)
Article
Cell Biology
Petra Kraus, Rachel Yerden, Victoria Kocsis, Thomas Lufkin
Review
Cell Biology
Petra Kraus, Thomas Lufkin
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Petra Kraus, Rachel Yerden, Darren Sipes, Shantanu Sur, Thomas Lufkin