Article
Chemistry, Multidisciplinary
Jipsa Chelora, Yuchao Liang, Wei-Chih Wei, Xiao Cui, Yafang Xiao, Yingpeng Wan, Zhongming Huang, Shuang Tian, Shengliang Li, Yi-Hsuan Huang, Ken-Tsung Wong, Chun-Sing Lee
Summary: The development of small molecule-based nanoparticles that can perform effective photothermal therapy and overcome hypoxia for cancer photodynamic therapy shows promising results in vitro and in vivo studies.
Review
Chemistry, Inorganic & Nuclear
Zhiheng Li, Zhenwu Zhou, Yarui Wang, Jie Wang, Liming Zhou, Hong-Bo Cheng, Juyoung Yoon
Summary: Due to deficiencies in specific accumulation at tumors and undesired activation in normal tissues, many photodynamic therapy (PDT) agents show off-target phototoxicity. To address this issue, activatable photodynamic nano-photosensitizers (nanoPSs) that generate reactive oxygen species (ROS) in response to tumor-associated or external stimuli have been developed. These nanoPSs are in an off-state during delivery and are only activated in targeted lesions, enhancing the accuracy and minimizing side effects. This review discusses the design, work principle, and therapeutic performance of PDT using activatable nanoPSs, categorized by different stimuli and composite materials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Nem Singh, Subin Son, Jusung An, Ilwha Kim, Minhyeok Choi, Na Kong, Wei Tao, Jong Seung Kim
Summary: Finding a personalized nano theranostics solution for cancer diagnosis and therapy is a top challenge in current medicinal science. Porous organic polymers (POPs) show remarkable advantages for cancer theranostics due to their specific physicochemical characteristics. Both crystalline and non-crystalline POPs, such as covalent organic frameworks (COFs), have shown potential applications across various research areas. Early research on nanoscale POPs for theranostics has demonstrated promising applications in drug loading, targeted delivery, stimuli-responsive release, cancer imaging, and combination therapy.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Ziling Zeng, Chi Zhang, Jingchao Li, Dong Cui, Yuyan Jiang, Kanyi Pu
Summary: This study introduces an organic polymer nanoenzyme (SPNK) with near-infrared (NIR) photoactivatable immunotherapeutic effects for photodynamic immunometabolic therapy. By generating singlet oxygen (O-1(2)) upon NIR photoirradiation, SPNK induces immunogenic cell death of cancer and degrades immunosuppressive kynurenine (Kyn), ultimately promoting effector T cell proliferation and infiltration, enhancing systemic antitumor T cell immunity, and inhibiting both primary and distant tumors in living mice.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Bing Lu, Zhecheng Zhang, Danni Jin, Xiaolei Yuan, Jin Wang, Yue Ding, Yang Wang, Yong Yao
Summary: New nanoparticles (Y6 NPs) based on the A-DA ' D-A fused-ring conjugated small molecule Y6 have been developed for the photothermal and photodynamic treatment of cancer. These Y6 NPs demonstrate outstanding light absorption, good photothermal conversion efficiency, and reactive oxygen species generation capability. The high photothermal conversion efficiency and excellent photodynamic activity make them promising for cancer therapy.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Thais P. Pivetta, Caroline E. A. Botteon, Paulo A. Ribeiro, Priscyla D. Marcato, Maria Raposo
Summary: Photodynamic therapy and photothermal therapy are photo-mediated treatments with different mechanisms that cause cancer cell death through the production of reactive oxygen species or heat. The advancement of nanotechnology has significantly improved the effectiveness of these therapies by allowing drug encapsulation, development of various nanoparticles, and surface functionalization.
Article
Biochemical Research Methods
Mingdang Li, Wei Feng, Menglong Zhao, Peiling Dai, Yucheng Zhou, Jiawei Wang, Wen Lv, Shujuan Liu, Qiang Zhao
Summary: The study developed a polymeric therapeutic agent to overcome tumor hypoxia through multiple pathways, achieving capture and controllable release of O-1(2). It displayed promising synergistic anti-tumor and anti-recurrence efficacies under hypoxic environments, suggesting new avenues for the design of treatment platforms in clinical studies.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Engineering, Biomedical
Xiaoyan Liu, Zhaoyou Chu, Benjin Chen, Yan Ma, Lingling Xu, Haisheng Qian, Yue Yu
Summary: In this study, the BUC@ZMS core-shell nanoparticles were developed for tumor-targeted cancer therapy by inducing the death of pancreatic cancer cells through the high production of ROS and increasing the sensitivity of tumor cells to oxidative stress. The in vivo results showed that the BUC@ZMS nanoparticles could accumulate specifically in tumor locations and suppress PDAC without generating obvious toxicity.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Jing Liu, Shasha He, Yingli Luo, Yue Zhang, Xiaojiao Du, Cheng Xu, Kanyi Pu, Jun Wang
Summary: This study reports a smart semiconducting polymer nano-immunomodulator that can achieve precise regulation of photodynamic immunotherapy for cancer in the acidic tumor microenvironment. The release of immunogenic factors and TLR7 agonist at the tumor site activates dendritic cells, leading to strong antitumor activities. Additionally, the nano-immunomodulator can directly eradicate tumors and induce immunogenic cancer cell death. This approach enhances systemic antitumor immune responses, resulting in inhibition of tumor growth and metastasis.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Shengqiang Hu, Lixian Huang, Liuyan Zhou, Tingchan Wu, Shulin Zhao, Liangliang Zhang
Summary: This research focuses on the integration of ratiometric NIR-II fluorescence imaging and chemo-/photodynamic combination therapy for accurate diagnosis and efficient treatment of deep tumors. By conjugating dual-ligands-stabilized gold nanoclusters (cgAuNCs) into down-/up-conversion nanoparticles (D/UCNPs), single-excitation triple-emission nanoassemblies were prepared, enabling simultaneous imaging and therapy upon exposure to an 808 nm laser. The study provides insights into the design of multifunctional nanoplatforms for tumor diagnosis and treatment.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shuo Wang, Zengyi Liu, Yue Tong, Yunqian Zhai, Xiujie Zhao, Xinmin Yue, Yanqi Qiao, Yonghui Liu, Yongmei Yin, Rimo Xi, Wei Zhao, Meng Meng
Summary: In this study, a tetrahedral DNA-based nanosystem was designed to load IR780, improving its solubility and stability for cancer phototherapy. The nanoformulation showed promising results in enhancing tumor targeting and anti-tumor effects of IR780, indicating potential for intravenous administration of IR780 in cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Analytical
Huairong Zhang, Mei Yao, Lu Feng, Zizhen Wei, Yuqi Wang, Wenxiu Han, Shusheng Zhang
Summary: In this study, E. coli was utilized for cancer therapy by using its tumor-targeting, catalytic, and surface-reducing properties. The E-Au@Rf@Lum probe, achieved through the surface reduction of HAuCl4 and carrier modification with riboflavin (Rf) and luminol (Lum) by E. coli, has the ability to emit blue-violet chemiluminescence (CL) for cancer cell imaging. This work opens up a self-amplified therapy modality to tumor through self-illumination, effective penetration, and tumor hypoxia relief.
ANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Greta Avancini, Luca Menilli, Adele Visentin, Celeste Milani, Francesca Mastrotto, Francesca Moret
Summary: Despite improvements in breast cancer treatment, alternative therapies are needed for advanced-stage patients. Photodynamic therapy (PDT) is gaining attention as a selective and low off-target option. Polymeric nanoparticles (NPs) can overcome the solubility and circulation challenges of hydrophobic photosensitizers (PSs).
Review
Oncology
Mahmood Barani, Seyedeh Maryam Hosseinikhah, Abbas Rahdar, Leila Farhoudi, Rabia Arshad, Magali Cucchiarini, Sadanand Pandey
Summary: Bladder cancer is a common cancer in both men and women, and the use of nanotechnology has shown promising potential in improving the diagnosis and treatment of this disease. Nanoparticles offer a novel approach to enhance drug delivery and therapeutic performance, reducing the limitations of conventional cancer therapies. Developing nanosystems that can effectively diagnose and treat bladder cancer is crucial in advancing medical approaches in cancer management.
Review
Nanoscience & Nanotechnology
Yan Yang, Xi Zheng, Lu Chen, Xuefeng Gong, Hao Yang, Xingmei Duan, Yuxuan Zhu
Summary: Cancer is the second leading cause of death in the world and poses a serious threat to human health. Nanomedicine, particularly gold nanoparticles (AuNPs), has emerged as a promising technology for overcoming the limitations of conventional cancer therapies. This review discusses the current achievements and clinical trials of AuNPs in anticancer applications, as well as the challenges in translating basic findings into the clinic, providing a reference for future research.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
