Article
Environmental Sciences
Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Rupa Lavarti, G. K. Jhanani, Ruangwong On-uma, Kumchai Jutamas, Wongchai Anupong
Summary: This study found that the methanol leaf extract of Tarenna asiatica has the potential to synthesize zinc oxide nanoparticles, which show larvicidal and pupicidal activity against Aedes aegypti larvae. These findings are significant for the development of mosquito repellents.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Muthuraman Ramanathan, Monikandon Sukumaran, Mathiyazhagan Narayanan, Natarajan Devarajan, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Nguyen Thuy Lan Chi, Mythili Saravanan, Kathirvel Brindhadevi
Summary: This study aimed to isolate significant compounds from the crude ethyl acetate extract of Cymodocea serrulata and evaluate their larvicidal and pupicidal activity against Culex quinquefasciatus. The results showed that fraction 7a had strong larvicidal and pupicidal activities and could be used as a mosquito vector control agent.
PROCESS BIOCHEMISTRY
(2022)
Article
Entomology
Xinxin Gao, Jihong Zhang, Qilian Qin, Peipei Wu, Huan Zhang, Qian Meng
Summary: Energy metabolism is crucial in insect metamorphosis, particularly in the larval-pupal stage of holometabolous insects. In this study, metabolome and transcriptome analyses were conducted to elucidate the metabolic changes and regulatory mechanisms during larval-pupal metamorphosis of the cotton bollworm, Helicoverpa armigera. The findings revealed that aerobic glycolysis supported cell proliferation and lipid synthesis during the feeding stage, while triglyceride degradation and acylcarnitine accumulation were activated during non-feeding stages. This study provides valuable insights into the metabolic regulation mechanism of lepidopteran larvae during their final stage of development.
Article
Entomology
Jian-Jian Wu, Min-Di Cheng, Long-Ji Ze, Chen-Hui Shen, Lin Jin, Guo-Qing Li
Summary: FTZ-F1 plays a crucial regulatory role in molting in insects, and the functions of two isoforms were confirmed through RNA interference.
Article
Physiology
Qi Wang, Liang Zhong, Yong Wang, Shengwei Zheng, Yumeng Bian, Junhao Du, Ruisheng Yang, Wei Liu, Li Qin
Summary: Melanism plays important roles in defense, immunoreactions, and body color in insects. During the larval-pupal metamorphosis of the Chinese oak silkworm, the expression of key genes TH and DDC, involved in dopamine synthesis, is regulated, affecting pupal melanization.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Plant Sciences
Kristina M. Alois, Gideon C. Sangiwa, Chrian M. Marciale, Mtabazi G. Sahini
Summary: The crude extracts of Aristolochia elegans leaves collected from Tanzania were analyzed using GC-MS, with Caryophyllene identified as the main component. The larvicidal activity of the extracts against Anopheles gambiae larvae showed potential for control and further research into natural larvicides.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Entomology
Larissa Komo, Damien Charabidze
Summary: Studies have investigated the impact of environmental factors on blowfly larvae development, particularly on the allocation of speed between feeding and post-feeding stages, and the compensatory effect. Results showed different blowfly species have distinct developmental strategies and speed allocations. Developmental speed more often accumulates through life stages and results in larger variability in later development instars.
JOURNAL OF INSECT PHYSIOLOGY
(2021)
Article
Agronomy
Yu Chen, Hong Tang, Wei Zhou, Chang Li, Yi-Nan Chen, Qing Zhang, Kai-Yun Fu, Wen-Chao Guo, Ji-Feng Shi
Summary: This study provides a comprehensive understanding of the functional specialization of chitinase genes during the molting process of Leptinotarsa decemlineata, identifying potential targets for RNAi-based pest management strategies.
PEST MANAGEMENT SCIENCE
(2023)
Article
Entomology
Jian-Jian Wu, Li-Li Mu, Wei-Nan Kang, Long-Ji Ze, Chen-Hui Shen, Lin Jin, Ahmad Ali Anjum, Guo-Qing Li
Summary: The study successfully demonstrated the control of Henosepilachna vigintioctopunctata larvae using RNAi technology, indicating its environmental friendliness. By targeting the ecdysone receptor gene, high efficacy was achieved in laboratory and greenhouse settings.
Article
Biochemistry & Molecular Biology
Mathiyazhagan Narayanan, S. Priya, Devarajan Natarajan, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Ramakrishnan Krishnan, Nguyen Thuy Lan Chi, Arivalagan Pugazhendhi
Summary: This research demonstrates the ability of aqueous leaf extract of Aristolochia bracteolata to synthesize silver nanoparticles with high quality and their larvicidal potential against Culex quinquefasciatus mosquito vector.
PROCESS BIOCHEMISTRY
(2022)
Article
Entomology
Afroja Rahman, Sarayut Pittarate, Vivekanandhan Perumal, Julius Rajula, Malee Thungrabeab, Supamit Mekchay, Patcharin Krutmuang
Summary: This study demonstrates the significant larvicidal and antifeedant activity of CuO NPs against Spodoptera frugiperda. CuO NPs can be considered as effective and pollution-free green nano-insecticides for controlling S. frugiperda.
Article
Biochemistry & Molecular Biology
Xiaoran Qian, Kai Chen, Lijuan Chen, Hongsheng Song, Zhongjie Zhang
Summary: This study identified the ps homologue gene in B. mori and found that PS plays an essential role in maintaining the dynamic balance of apoptosis and proliferation during metamorphosis. Loss-of-function analysis of Bmps using the binary transgenic CRISPR/cas9 system revealed delayed developmental time and abnormal appendages in Bmps-depleted animals, along with affected apoptosis and proliferation related pathways and the Hippo pathway.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jingjing Li, Letong Yin, Jingxiu Bi, David Stanley, Qili Feng, Qisheng Song
Summary: In this study, the authors investigated the role of the TGF-beta receptor gene Sax in development using the red flour beetle as a model organism. The results showed that knockdown of Sax prolonged developmental duration and decreased pupation and adult emergence. Additionally, knockdown of Sax suppressed the 20E signaling pathway. Topical application of 20E partially rescued the defects caused by Sax knockdown.
Article
Developmental Biology
Rishav Mitra, Shlesha Richhariya, Siddharth Jayakumar, Dimple Notani, Gaiti Hasan
Summary: In fruit fly larvae, the IP3/Ca2+ signals in specific interneurons drive the expression of Set2 gene, essential for pupariation in the absence of dietary protein. This signal-controlled expression of Set2 upregulates key Ca2+-signaling genes through a positive-feedback loop, regulating gene expression for the transition from larval to pupal stages.
Article
Agronomy
Zhong-Jian Shen, Fang Zhu, Yan-Jun Liu, Zhen Li, Timothy W. Moural, Xiao-Ming Liu, Xiaoxia Liu
Summary: The study investigates the regulatory functions of dopamine (DA) and its associated non-coding RNA in the metamorphosis of the cotton bollworm, Helicoverpa armigera. It is found that DA deficiency inhibits larval-pupal metamorphosis in H. armigera. The study suggests that DA pathway genes and their microRNAs could be used as a novel target for H. armigera management.
PEST MANAGEMENT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Antony Stalin, Ding Lin, Johnson Josephine Princy, Yue Feng, Haiping Xiang, Savarimuthu Ignacimuthu, Yuan Chen
Summary: Single nucleotide polymorphisms (SNPs) are common genetic variations in human genomes and act as markers for susceptibility to complex traits and diseases. This study focused on the non-synonymous SNPs (nsSNPs) in the PPARG gene, which plays a role in lipid metabolism and insulin production. Mutations in PPARG were found to be associated with cancer, insulin resistance, and lipodystrophy, and molecular dynamics simulations showed significant differences in protein structure compared to the wild-type PPARG.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Antony Stalin, Ding Lin, Balakrishnan Senthamarai Kannan, Yue Feng, Yanjing Wang, Wei Zhao, Savarimuthu Ignacimuthu, Dong-Qing Wei, Yuan Chen
Summary: A novel acute viral pneumonia caused by SARS-CoV-2 emerged at the end of 2019, leading to a severe crisis. In silico virtual screening was used to identify potential drug targets through the analysis of conserved amino acid regions.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Pachaiyappan Saravana Kumar, Appadurai Daniel Reegan, Karunakaran Rajakumari, Antony Cruz Asharaja, Kedike Balakrishna, Savarimuthu Ignacimuthu
Summary: This study evaluated the larvicidal and pupicidal activities of 22 crude extracts of soil actinomycetes on Culex quinquefasciatus and Aedes aegypti, and identified a compound with significant activity, suggesting its potential as an effective biopesticide in integrated mosquito management programs.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Agronomy
Pachaiyappan Saravana Kumar, Gopal Nattudurai, Villianur Ibrahim Hairul Islam, Savarimuthu Ignacimuthu
Summary: Foods contaminated with fungi and their toxins can cause infections in developing countries. Due to the resistance of fungal pathogens to current antifungal agents, there is a need to find new environmentally friendly antimicrobial agents. Plant essential oils, which contain antifungal volatile substances, have the potential to replace chemical fungicides in food protection.
Article
Pharmacology & Pharmacy
Subramanian Mutheeswaran, Antony Mariappan, Kamaraj Ragavendran, Vedapuri Porchezhiyan, Poovan Elankani, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Savarimuthu Ignacimuthu
Summary: An ethnobotanical survey was conducted in Sathuragiri hills, India, revealing 139 medicinally useful plant species. The study highlighted the importance of Fabaceae, Euphorbiaceae, and Apocynaceae families, which contained numerous important medicinal plants. Dermatological ailments, gastrointestinal problems, joint pain, fever, and poisonous bites were among the important diseases treated by these species. The study emphasized the need for conservation of these medicinal plants and local knowledge.
ADVANCES IN TRADITIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Sanmugapriya Nagul Kumar, Santhaanam Sylvester Darvin, Erenius Toppo, Vedapuri Porchezhian, Perumal Pandikumar, Michael Gabriel Paulraj, Savarimuthu Ignacimuthu
Summary: This study investigated the therapeutic effect of mangiferin on NASH, showing that mangiferin can lower liver lipid levels, reduce inflammation, and increase the expression of related genes, indicating its potential for treating NASH.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
P. Saravana Kumar, Yu Li, Meijun He, P. Yuvaraj, K. Balakrishna, S. Ignacimuthu
Summary: This study introduced an effective method to isolate the antifungal compound ricinine from Ricinus communis (L.). Ricinine showed significant antifungal activity against a range of pathogenic fungi, making it a potential agent for controlling plant and skin fungal infections. The study provides new insights for large-scale isolation and identification of ricinine, as well as other potentially useful alkaloids.
JOURNAL OF BIOLOGICALLY ACTIVE PRODUCTS FROM NATURE
(2022)
Article
Biochemistry & Molecular Biology
M. R. Lima Mirabel Louis, Vedham Pushpa Rani, Padma Krishnan, Appadurai Daniel Reegan, Kedike Balakrishna, Savarimuthu Ignacimuthu, Soosaimanickam Maria Packiam, Rajan Maheswaran, Osamu Shirota
Summary: This study presents the larvicidal activities of three active constituents from the methanolic extract of unripe fruit peel of Persea americana against three mosquito species. The three compounds showed the highest larvicidal activity against Anopheles stephensi, and also exhibited certain larvicidal activity against Aedes aegypti and Culex quinquefasciatus.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Parasitology
K. Buvanesvaragurunathan, J. Ganesh, S. Nagul Kumar, V Porchezhiyan, A. Radha, P. Azhahianambi, P. Pandikumar, S. Ignacimuthu
Summary: This study evaluated the in vitro growth inhibitory effect of 18 beta-Glycyrrhetinic acid and its esters against Theileria annulata, the causative agent of Tropical Bovine Theileriosis. The isopropyl ester of 18 beta-GA showed improved anti-theileriosis efficacy, while propyl, ethyl, and benzyl esters also exhibited considerable inhibitory effect.
EXPERIMENTAL PARASITOLOGY
(2022)
Article
Plant Sciences
Santiagu Stephen Irudayaraj, Jacob Jincy, Christudas Sunil, Veeramuthu Duraipandiyan, Savarimuthu Ignacimuthu, Govindasamy Chandramohan, Soosaimanickam Maria Packiam
Summary: This study found that flindersine isolated from Toddalia asiatica leaves has antidiabetic, antilipidemic, and antioxidant effects. Flindersine can reduce blood glucose levels, decrease body weight gain, improve lipid profile and antioxidant markers. Additionally, flindersine can enhance insulin sensitivity and restore the expression of related proteins.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biology
Antony Stalin, Appadurai Daniel Reegan, Munusamy Rajiv Gandhi, R. R. Saravanan, Kedike Balakrishna, Abd El-Latif Hesham, Savarimuthu Ignacimuthu, Ying Zhang
Summary: Embelin and its derivatives, 6-bromoembelin and vilangin, showed strong mosquitocidal activities against larvae and pupae of Aedes aegypti and Culex quinquefasciatus. Among them, vilangin exhibited the highest larvicidal activity. The histopathological results revealed that vilangin caused significant damage to the midgut of mosquito larvae and impaired the peritrophic membrane. The molecular docking and molecular dynamics studies further demonstrated the effectiveness of vilangin in inhibiting acetylcholinesterase activity.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Environmental Sciences
Muthusamy Ramakrishnan, Jaison Arivalagan, Lakkakula Satish, Manikandan Mohan, Johnson Retnaraj Samuel Selvan Christyraj, Sam Aldrin Chandran, Ho-Jong Ju, Anoopa L. John, Thiyagarajan Ramesh, Savarimuthu Ignacimuthu, Kalimuthu Kalishwaralal
Summary: Emerging evidence suggests that selenium plays a beneficial role in plant development and is considered an essential micronutrient. Selenium promotes plant physiological processes and offers stress resistance. Ferroptosis, a unique form of regulated cell death, is prevented by selenium supplementation. More research is needed on plant-specific ferroptosis and selenium-mediated nanofertilizers for large-scale plant biomass production.
Article
Entomology
Muzafar Riyaz, Rauf Ahmad Shah, Ignacimuthu Savarimuthu, Sivasankaran Kuppusamy
Summary: This study sequenced the mitogenomes of two species from the family Erebidae and found that despite different lengths, their gene orders were identical, and both genomes contained 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and an A+T-rich region. Phylogenomic analysis revealed that the superfamily Noctuoidea has a well-supported monophyletic relationship with Notodontidae, Erebidae, Nolidae, Euteliidae, and Noctuidae, and L. dorsigera should be classified within the subfamily Toxocampinae instead of Erebinae.
EUROPEAN JOURNAL OF ENTOMOLOGY
(2023)
Article
Plant Sciences
S. Antony Ceasar, S. Ignacimuthu
Summary: Genome editing tools based on CRISPR/Cas system have the potential to solve agricultural issues and improve food production. The use of genetic engineering in agriculture has allowed for the introduction of specific traits in crops, while CRISPR/Cas system offers a more precise technique for targeted modification of genes in the host plant genome. The delivery of CRISPR reagents has the potential to overcome limitations with traditional transformation methods and produce transgene-free plants. The CRISPR/Cas system is expected to play a key role in future crop breeding.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Rauf Ahmad Shah, Muzafar Riyaz, Savarimuthu Ignacimuthu, Kuppusamy Sivasankaran
Summary: In this study, the complete mitogenomes of Sympis rufibasis, Lacera noctilio, Oxyodes scrobiculata, Mocis undata, and Artena dotata were newly sequenced using next-generation sequencing methods. The analysis of these mitogenomes revealed a common gene order and characteristics unique to Noctuoidea moths. Additionally, the phylogenetic analyses provided insights into the tribe and subfamily relationships within the Erebidae.
BIOCHEMICAL GENETICS
(2023)
