Journal
PATHOGENS AND DISEASE
Volume 68, Issue 2, Pages 44-51Publisher
OXFORD UNIV PRESS
DOI: 10.1111/2049-632X.12043
Keywords
interleukin-17-producing gamma delta T-cells; acute; Pseudomonas aeruginosa; pulmonary infection
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Funding
- Natural Science Foundation of Shanghai [10ZR1419300]
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Interleukin (IL)-17-producing T-lymphocytes play a crucial role in inflammation, yet the potential roles of the cells in acute bacterial pulmonary infection remain unclear. Here, we investigated the role of IL-17-producing T-cells in a mouse model of acute Pseudomonas aeruginosa pulmonary infection. Results showed that augmentation of IL-17, IL-22 and IL-23 was associated with the development of acute bacterial pulmonary infection. However, IL-17 was markedly reduced following the blockade of T-cell activity in vivo. The levels of the chemokines, including granulocyte colony-stimulating factor (G-CSF), keratinocyte chemoattractant (KC), macrophage inflammatory protein-1 (MIP-1) and macrophage inflammatory protein (MIP-2), were also noticeably decreased in the anti- T Cell Receptor(TCR) mice after 8h infection. Following the depletion of T-cells, the bacterial load was consistently increased. Anti-TCR-treated mice had changes similar to those in the the anti-IL-17-treated mice. The mRNA and protein levels of IL-22 and IL-23, and the mRNA level of RORt were all markedly decreased in the anti-TCR mice. Overall, our results demonstrated that at the early stage of acute P.aeruginosa pulmonary infection, T-cells are the major source of IL-17 and play a pivotal role in the host immune response and defense against bacteria.
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