Journal
PATHOGENS AND DISEASE
Volume 67, Issue 2, Pages 132-135Publisher
WILEY-BLACKWELL
DOI: 10.1111/2049-632X.12028
Keywords
Bordetella holmesii; genome; asplenia; opportunistic
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Funding
- NIH [K08 AI101005, T32-AI007531-Saiman, R01 AI092743, R21 AI098654]
- PIDS-St. Jude Children's Research Hospital Fellowship Program in Basic Research
- Louis V. Gerstner, Jr. Scholars Program
- Flight Attendant Medical Research Institute
- Doris Duke Charitable Foundation
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Bordetella holmesii is an emerging opportunistic pathogen that causes respiratory disease in healthy individuals and invasive infections among patients lacking splenic function. We used 16S rRNA gene analysis to confirm B. holmesii as the cause of bacteremia in a child with sickle cell disease. Semiconductor-based draft genome sequencing provided insight into B. holmesii phylogeny and potential virulence mechanisms and also identified a toluene-4-monoxygenase locus unique among bordetellae.
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