Review
Chemistry, Multidisciplinary
Huu Van Le, Didier Le Cerf
Summary: Hyaluronic acid-based colloidal polyelectrolyte complexes (PECs), due to their high biocompatibility and simple preparation process, have a wide range of applications in the biomedical field. This review aims to provide a comprehensive understanding of the preparation process and various biomedical applications of colloidal PECs from hyaluronic acid complexed with polycations.
Article
Biotechnology & Applied Microbiology
Jianfeng Bao, Hui Tu, Jing Li, Yanbo Dong, Le Dang, Korjova Elena Yurievna, Fengshou Zhang, Lei Xu
Summary: Magnetic nanoparticles mediated magnetic hyperthermia therapy has great potential in the treatment of various diseases, but the existing materials have low heating efficiency and short circulation time. In this study, a highly efficient magnetic-thermal conversion nanoplatform was constructed, which successfully encapsulated and released the chemotherapy drug for synergetic magnetic-thermal/chemo cancer therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lucia Cardo, Lydia Martinez-Parra, Michele Cesco, Begona M. Echeverria-Beistegui, Marta Martinez-Moro, Natalia Herrero-Avarez, Marta-Beraza Cabrerizo, Susana Carregal-Romero, Pedro Ramos-Cabrer, Jesus Ruiz-Cabello, Maurizio Prato
Summary: Carbon Dots (CDs) are luminescent quasi-spherical nanoparticles with various applications. New gadolinium-doped CDs, Gd@CNDs, are presented as multifunctional probes for MRI. These Gd@CNDs show good homogeneity, stability, and biocompatibility, making them potential candidates for both MR and fluorescence imaging.
Article
Pharmacology & Pharmacy
Weijie Zhang, Zhongyue Zhang, Shitong Lou, Zhiwei Chang, Baohong Wen, Tao Zhang
Summary: This paper reports the synthesis of hyaluronic acid-stabilized Fe3O4 nanoparticles, which exhibit good colloidal stability and targeting ability, and demonstrate effectiveness as contrast agents for MRI in both in vitro and in vivo models.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ruru Zhang, Kuan Lu, Li Xiao, Xuelan Hu, Wu Cai, Linjiang Liu, Yan Liu, Weihua Li, Hui Zhou, Zhiyuan Qian, Sixia Wang, Can Chen, Jianfeng Zeng, Mingyuan Gao
Summary: This study utilized ultrasmall iron oxide nanoparticles in combination with magnetic resonance imaging (MRI) to achieve early and noninvasive diagnosis of atherosclerotic plaques. The experiment demonstrated that the nanoparticles could enhance the signal at the plaque sites, providing a means for dynamic evaluation over a specific time frame.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biophysics
Chiara Turrina, Max Schoenen, Davide Milani, Anna Klassen, Diana M. Rojas Gonzalez, Gerhard Cvirn, Petra Mela, Sonja Berensmeier, Ioana Slabu, Sebastian P. Schwaminger
Summary: Coated iron oxide nanoparticles have potential applications in nanomedicine, such as imaging, magnetic hyperthermia, and drug delivery. This study demonstrates the importance of coating material and thickness in influencing the behavior and performance of these nanoparticles in the human body, and highlights their potential in nanomedicine.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xiyang Sun, Ye Xu, Qingkui Guo, Ning Wang, Bin Wu, Chen Zhu, Wen Zhao, Wenliang Qiang, Min Zheng
Summary: This study successfully constructed a targeted nanoprobe that can efficiently load the photosensitive drug ICG into lung cancer cells. The nanoprobe not only has excellent ICG loading and stability, but also improves the efficiency of thermal conversion and singlet oxygen generation, resulting in optimal photothermal/photodynamic therapy effects.
Article
Chemistry, Physical
Maria Martinez-Negro, Guillermo Gonzalez-Rubio, Emilio Aicart, Katharina Landfester, Andres Guerrero-Martinez, Elena Junquera
Summary: This article discusses the formation of protein corona (PC) on colloidal nanoparticles (NPs) and its impact on the biological behavior of NPs. The focus is on the mechanisms of PC formation and strategies to control PC formation to ensure the successful application of NPs in medicine.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Review
Oncology
Federico Bruno, Vincenza Granata, Flavia Cobianchi Bellisari, Ferruccio Sgalambro, Emanuele Tommasino, Pierpaolo Palumbo, Francesco Arrigoni, Diletta Cozzi, Francesca Grassi, Maria Chiara Brunese, Silvia Pradella, Maria Luisa Mangoni di S. Stefano, Carmen Cutolo, Ernesto Di Cesare, Alessandra Splendiani, Andrea Giovagnoni, Vittorio Miele, Roberto Grassi, Carlo Masciocchi, Antonio Barile
Summary: This article introduces the application of magnetic resonance imaging in the field of nanomedicine and the characteristics of nanoparticles as diagnostic and therapeutic tools. Imaging techniques play an important role in studying the properties of nanoconstructs and their interactions with the biological environment.
Article
Nanoscience & Nanotechnology
Harald Unterweger, Christina Janko, Tamara Folk, Iwona Cicha, Noemi Kovacs, Gyula Gyebnar, Ildiko Horvath, Domokos Mathe, Kang H. Zheng, Bram F. Coolen, Erik Stroes, Janos Szebeni, Christoph Alexiou, Laszlo Dezsi, Stefan Lyer
Summary: This study compared a new iron oxide-based contrast agent, SPIONDex, with conventional contrast agents ferucarbotran and ferumoxytol. The results demonstrate that SPIONDex has better biocompatibility and immunocompatibility, and does not trigger allergic reactions. In a rat model, SPIONDex showed liver imaging properties comparable to the other two agents but with faster clearance. These findings suggest that SPIONDex is a promising candidate for further clinical translation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Maghsoud Amirfarhangi Anbardan, Siamak Alipour, Gholam Reza Mahdavinia, Parisa Fathi Rezaei
Summary: The magnetic nanocarriers composed of chitosan/hyaluronic acid complexed with kappa-carrageenan were successfully synthesized and demonstrated as an efficient drug delivery system. The nanodelivery system showed high drug loading capacity and responsive drug release behavior under pH stimuli, while exhibiting no inhibitory effect on cell growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Hana Bunzen, Daniel Jirak
Summary: This review discusses the usage of metal-organic frameworks (MOFs) and composite materials based on them as contrast agents for magnetic resonance imaging (MRI). It summarizes the progress in this field over the last five years and provides an overview of MOF-based materials for heteronuclear MRI.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Nanoscience & Nanotechnology
Hana Bunzen, Daniel Jirak
Summary: This review discusses the usage of metal-organic frameworks (MOFs) and composite materials based on them as contrast agents for magnetic resonance imaging (MRI). MOFs, with their design variety and high metal ion density, have been studied as a promising class of materials for developing MRI contrast agents. The review highlights important studies and classifies the materials into three groups based on their design and structural properties.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Max E. Distler, Kaitlin M. Landy, Kyle J. Gibson, Byeongdu Lee, Steven Weigand, Chad A. Mirkin
Summary: In this study, novel DNA dendrimers were synthesized and characterized, which can break the symmetry in colloidal crystals and enable directional interactions. By modulating the shape anisotropy of the DNA dendrimers, the distribution of nanoparticles within the crystals can be precisely controlled.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier
Summary: NMR-based diffusion methods are valuable tools for nanomedicine characterization and understanding interactions with the biological environment. They provide insights into diffusion phenomena and measurement of self-diffusion and mutual diffusion coefficients. NMR diffusometry spectroscopic and imaging methods have broad applications in nanomedicine, aiding in elucidating important issues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Crystallography
Seung Jae Oh, Yoochan Hong, Ki-Young Jeong, Inhee Maeng, Jin-Suck Suh, Jaemoon Yang, Yong-Min Huh
Summary: In this study, the changes in the molecular structure of polyaniline (PANI) nanoparticles illuminated by a proton beam were investigated using terahertz thermal spectroscopy. The results showed that the molecular structure of PANI nanoparticles can be altered by a proton beam with a particle fluence above a certain threshold.
Article
Chemistry, Analytical
Jaewon Jung, Sung-Min An, Eun-Kyung Lim, Seung-Chul Kim, Beum-Soo An, Sungbaek Seo
Summary: A sensing platform based on PDA was developed to detect testosterone as a potential biomarker of preterm birth. By conjugating anti-T antibodies to PDA assemblies and using a mixture of acetonitrile and distilled water as a solvent, the platform showed over 3.4 times higher sensitivity for detecting T compared to other sex steroid hormones studied.
Article
Biophysics
Jaewoo Lim, Byunghoon Kang, Hye Young Son, Byeonggeol Mun, Yong-Min Huh, Hyun Wook Rho, Taejoon Kang, Jeong Moon, Jae-Jong Lee, Seung Beom Seo, Soojin Jang, Seong Uk Son, Juyeon Jung, Seungjoo Haam, Eun-Kyung Lim
Summary: The newly developed exoNA-sensing chip, based on microfluidic and 3D-nanostructured hydrogels, allows for rapid detection of ERBB2 with high accuracy and selectivity.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Young Han Lee, Kyu-Ho Song, Jaemoon Yang, Won Jun Kang, Keum Sil Lee, Min Jung Kim, Eun-Kyung Kim, Dan Heo, Bo-Young Choe, Jin-Suck Suh
Summary: The study focused on the feasibility of a proposed two-channel Helmholtz loop for PET-MR imaging and found comparable image quality to the standard conventional coil. By optimizing coil design and construction, conducting electromagnetic field simulations, and acquiring images on PET-CT and MR systems, the proposed RF coil showed improvements in signal-to-noise ratio, image uniformity percent, and Hounsfield units, compared to the standard coil.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Medicine, General & Internal
Young Min Kim, In Gyu Kwon, Seung Ho Choi, Sung Hoon Noh, Jaeyoung Chun, Young Hoon Youn, Hyojin Park, Ji Hae Nahm, Jie-Hyun Kim, Yong-Min Huh, Eunji Jang
Summary: This study aimed to identify predictive factors for extragastric recurrence of EGC after curative resection. The results showed that submucosal invasion and metastasis of more than seven lymph nodes were independent predictive factors for extragastric recurrence. The expression levels of SFRP4 and CDX1 may serve as novel predictive markers for extragastric recurrence of EGC after curative resection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemical Research Methods
Byunghoon Kang, Moo-Kwang Shin, Seungmin Han, Ilyoung Oh, Eunjung Kim, Joseph Park, Hye Young Son, Taejoon Kang, Juyeon Jung, Yong-Min Huh, Seungjoo Haam, Eun-Kyung Lim
Summary: Considerable attention is given to drug delivery technology, and nanotechnology has been used to develop various strategies for targeted drug delivery. In this study, a delivery system was designed to control drug release through external magnetic fields, and it demonstrated superior therapeutic efficacy in treating cancer cells.
Article
Biophysics
Jeong Moon, Jayeon Song, Hyowon Jang, Hyunju Kang, Yong-Min Huh, Hye Young Son, Hyun Wook Rho, Mirae Park, Chandana S. Talwar, Kwang-Hyun Park, Euijeon Woo, Jaewoo Lim, Eun-Kyung Lim, Juyeon Jung, Yongwon Jung, Hyun Gyu Park, Taejoon Kang
Summary: In this study, a ligation-free DNA extension method for nucleic acid amplification was developed. This method allows for high sensitivity detection of target RNA and shows potential applications in cancer companion diagnostics and other gene detection platforms.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Jinyoung Kim, Joowon Park, Jisun Ki, Hyun Wook Rho, Yong-Min Huh, Eunjung Kim, Hye Young Son, Seungjoo Haam
Summary: Breast cancer is a common global cancer, and early detection is crucial for improving the 5-year survival rate. In this study, the combination of seed-mediated grown silver nanopillars and surface-enhanced Raman spectroscopy was used for rapid and sensitive detection of circulating miRNA in breast cancer.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seung-Hyun Yang, Yuna Choi, Mirae Park, Hye-Young Son, Yong-Min Huh, Chan Gyu Joo
Summary: This study investigated the potential use of alanine as an MRI contrast agent and measured its relaxation properties in solution. The uptake of alanine in a mouse xenograft model of glioblastoma was measured using MRI and compared with immunohistochemistry staining. Statistically significant differences in ASCT2 distribution were found between regions with strong and weak alanine uptake in MRI.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Sihwa Joo, Ui Jin Lee, Hye Young Son, Moonil Kim, Yong-Min Huh, Tae Geol Lee, Mina Lee
Summary: miRNAs play a crucial role in regulating gene expression and are potential biomarkers for cancer diagnosis. A highly selective miRNA detection method using FRET technology was developed, allowing for accurate measurement of miRNA concentrations and discrimination of nucleotide mismatches.
Article
Chemistry, Analytical
Jiwon Kim, Incheol Heo, Quy Son Luu, Quynh Thi Nguyen, Uyen Thi Do, Nicholas Whiting, Seung-Hyun Yang, Yong-Min Huh, Sun-Joon Min, Jeong Hyun Shim, Won Cheol Yoo, Youngbok Lee
Summary: 29Si silica nanoparticles (SiO2 NPs) show promise as magnetic resonance imaging (MRI) probes, due to their biocompatibility and dispersibility. However, using dynamic nuclear polarization (DNP) for SiO2 NPs has been challenging due to the lack of required electronic defects. In this study, SiO2 NPs were synthesized with selective 29Si isotope enrichment and optimal DNP signal enhancement was achieved by controlling the proportion of 29Si in the shell layer. The effective hyperpolarization depth was found to be less than 10 nm, indicating improved diffusion length for the shell-enriched NPs compared to natural abundance NPs.
ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Seung-Hyun Yang, Kiyoung Jeong, Jaemoon Yang, Hye Young Son, Jin-Suck Suh, Yong-Min Huh, Seung Jae Oh
Summary: This study used magnetic resonance thermometry to investigate the temperature increases and thermal transfer during plasmonic photothermal therapy with gold nanorods. The results showed that MR thermometry can be a useful tool for monitoring the therapy and establishing ideal laser irradiation conditions.
CURRENT APPLIED PHYSICS
(2023)
Article
Multidisciplinary Sciences
Jeongsoo Kim, Seungri Song, Hongseong Kim, Bora Kim, Mirae Park, Seung Jae Oh, Daesuk Kim, Barry Cense, Yong-min Huh, Joo Yong Lee, Chulmin Joo
Summary: In this study, a lens-less polarization-sensitive microscopy method is proposed for complex and birefringence imaging of transparent objects. The method achieves high-resolution imaging without the need for optical lenses or moving parts.
SCIENTIFIC REPORTS
(2023)
Article
Materials Science, Biomaterials
Jong-Woo Lim, Hye Young Son, Yong-Min Huh, Seungjoo Haam
Summary: This study demonstrates that poly(l-arginine) can induce the polarization of macrophages into the tumor-suppressive phenotype, and hyaluronic acid and coated manganese dioxide nanoparticles exhibit efficient anti-cancer effects through upregulating nitric oxide production.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
