Article
Polymer Science
Xiaohua Chang, Dengwen Hu, Liangren Chen, Yaping Wang, Yutian Zhu
Summary: Thermoresponsive block copolymer micelles have potential in biological applications, with studies showing that changes in hydrophobic/hydrophilic block ratio, micelle concentration and addition of salt can alter the cloud point. Increasing the amount of PLGA hydrophobic block significantly decreases the cloud point, while higher micelle concentration and salt addition also lower the cloud point.
Article
Polymer Science
Jidong Dai, Min Liang, Zhigang Zhang, Katrien Bernaerts, Tianzhu Zhang
Summary: By crosslinking nucleation to prepare crystalline 4arm-PLGA, the degradation rate of PLGA can be effectively controlled, promoting cell growth and potentially having ideal performance in tissue engineering.
Article
Chemistry, Physical
Bong-Seop Lee
Summary: In a polymer-based drug delivery system, the polymer material entwines the drug and transports it to the desired target. Poly(lactide-co-glycolide) (PLGA) is a widely utilized controlled-release system for drugs with short half-lives, low stability, easy decomposition, and non-toxic side effects. Supercritical fluid (SCF) technology can be employed to prepare or micronize drug-loaded particles without the need for additional purification or cleaning procedures. The liquid-liquid phase transition behavior of PLGA in several supercritical fluids, including dimethyl ether (DME), CO2, chlorodifluoromethane (HCFC-22), and trifluoromethane (HFC-23), has been investigated. The phase behavior of PLGA is primarily controlled by the lactide-to-glycolide ratio in the copolymer backbone.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Biomedical
Yang Zhou, Yuecheng Cui, Li-Qun Wang
Summary: A dual-sensitive hydrogel was developed by introducing a photocrosslinkable group into triblock copolymers, allowing for excellent shear thinning properties and rapid elastic recovery properties. Through a two-step crosslinking strategy, tissue-like constructs with high shape fidelity can be printed using the dual-sensitive inks.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Engineering, Biomedical
Lucy Geddes, Efrosyni Themistou, James F. Burrows, Fraser J. Buchanan, Louise Carson
Summary: This study aimed to develop an in vitro protocol for assessing the long-term cytotoxicity of bioresorbable polymers. Results showed that PDLLGA samples exhibited increasing cytotoxicity at later degradation stages, while PLLGA samples demonstrated significantly less cytotoxic behavior. Additionally, a new dynamic flow culture methodology was developed and validated to test the cytotoxicity of these degradable materials, along with profiling of inflammatory cytokines released by cells in response to degraded PDLLGA and PLLGA.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Kinam Park, Andrew Otte, Farrokh Sharifi, John Garner, Sarah Skidmore, Haesun Park, Young Kuk Jhon, Bin Qin, Yan Wang
Summary: Injectable long-acting formulations, particularly those based on poly(lactide-co-glycolide) (PLGA), have been utilized for systemic drug delivery for up to 6 months, but the development of clinical products and generics has been slow. The limited understanding of PLGA polymers and the complex variables involved in composition and manufacturing processes hinder the control over formulation properties and drug efficacy. Factors such as formulation composition, manufacturing processes, and surface morphology play crucial roles in determining the pharmacokinetic profile of the formulations, highlighting the importance of proper characterization and control of these parameters for desired drug release kinetics and efficacy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Yihua Pei, Jianping Wang, Nisar Ul Khaliq, Fanfei Meng, Kaoutar A. Oucherif, Jie Xue, Sarena D. Horava, Amy L. Cox, Coralie A. Richard, Monica R. Swinney, Kinam Park, Yoon Yeo
Summary: Poly(lactide-co-glycolide) (PLGA) polymers are commonly used for drug delivery due to their biodegradability and biocompatibility. This study focused on achieving sustained drug release from PLGA microparticles (MPs) for two weeks using meloxicam. By encapsulating meloxicam as a solid and incorporating magnesium hydroxide (Mg(OH)2), the researchers were able to control the drug release kinetics of the MPs. The study demonstrated the feasibility of controlling drug release from PLGA MPs over weeks based on the physical state of the drug and the inclusion of Mg(OH)2 to neutralize the microenvironmental pH of the MPs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biotechnology & Applied Microbiology
Joshua Woo, Jeoung Soo Lee
Summary: The study showed that Lyo. PgP/pGFP polyplexes prepared with 5% sucrose as a lyoprotectant remained stable for up to 6 months and retained transfection efficiency for up to 4 months. This indicates that polyplexes based on Lyo. PgP retain bioactivity during extended storage, potentially facilitating transport to remote regions and less stable settings for gene therapy.
Article
Polymer Science
M. Margarida Cardoso, Ines N. Peca, Telma Lopes, Rui Gardner, A. Bicho
Summary: DWNPs were produced with PLGA and PLLA containing doxorubicin as a model drug. Optical and fluorescence microscopy were used to examine the inner morphology and drug distribution of the double-walled microparticles. The study showed that the double-walled nanoparticles exhibited sustained drug release and the PLLA layer acted as a rate control barrier.
Article
Materials Science, Multidisciplinary
Liuyun Jiang, Yingjun Ma, Shuo Tang, Yan Zhang, Shengpei Su
Summary: In this study, a functionalized hybrid nanohydroxyapatite (n-HA) was proposed to obtain a high-performance poly(lactide-co-glycolide) (PLGA)-based composite. By introducing carboxymethyl-beta-cyclodextrin (CMCD) and zoledronic acid (ZA), the mechanical and degradation properties of PLGA were improved, and the CMCD-ZA-n-HA also exhibited good biocompatibility and the ability to promote bone-like apatite deposition and cell proliferation in vitro.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Lukasz Lamch, Kazimiera A. Wilk, Imre Dekany, Agota Deak, Viktoria Hornok, Laszlo Janovak
Summary: The encapsulation of hydrophilic and amphiphilic drugs in colloidal carrier systems for sustained release is a growing concern. The use of a core-shell approach with nanocarriers can provide a solution for hydrophilic/amphiphilic drugs. Amphiphilic polymers play a key role in stabilizing the system and enhancing the chemical stability and sustained release profiles.
Article
Biochemistry & Molecular Biology
Monika Smiga-Matuszowicz, Jakub Wlodarczyk, Malgorzata Skorupa, Dominika Czerwinska-Glowka, Kaja Folta, Malgorzata Pastusiak, Malgorzata Adamiec-Organisciok, Magdalena Skonieczna, Roman Turczyn, Michal Sobota, Katarzyna Krukiewicz
Summary: This paper introduces a scaffold material made of PLGA/PISEB fibers and confirms its biocompatibility towards HUVEC. During a 12-week hydrolytic degradation process, the PLGA/PISEB fibers swell and disintegrate, resulting in the formation of highly developed structures resembling seaweeds. The change in the scaffold structure is expected to have a positive effect on blood vessel regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zhimin Dong, Yushuang Miao, Huashuai Cui, Qing Huang, Yiguo Li, Zongbao Wang
Summary: The microstructure of PGA and P(GA-co-LA) fibers used as surgical sutures plays a crucial role in determining their properties. Heat-setting at 120 degrees C was found to be more effective in enhancing fiber properties, especially due to crystal formation and perfection. The structural evolution during heating showed different behaviors between PGA and P(GA-co-LA) fibers, with differences in crystallite sizes, unit cell parameters, and crystal structure due to the presence of LA monomers.
Article
Biochemistry & Molecular Biology
Xiao-Ling Wang, Wen-Zheng Zhao, Jia-Ze Fan, Le-Chen Jia, Ya-Nan Lu, Ling-Hui Zeng, Yuan-Yuan Lv, Xiao-Yi Sun
Summary: By utilizing the tumor-targeting property of MSCs, a drug delivery system was developed to improve drug transfer in tumor cells and achieve deep tumor penetration, leading to better therapeutic outcomes.
Article
Biochemistry & Molecular Biology
Gianni Pecorini, Simona Braccini, Gianluca Parrini, Federica Chiellini, Dario Puppi
Summary: Polyhydroxyalkanoates are biopolyesters that can be used as unique scaffolding polymer candidates for tissue engineering due to their biocompatibility, biodegradability, environmental sustainability, processing versatility, and mechanical properties. This study explored the fabrication of tissue engineering scaffolds using a solution-extrusion additive manufacturing technique, called Computer-Aided Wet-Spinning (CAWS), by blending poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(D,L-lactide-co-glycolide) (PLGA). The results showed that the blend composition influenced the morphological, physicochemical, and biological properties of the scaffolds, with increasing PLGA content leading to larger pore size, enhanced wettability, and improved thermal stability. In vitro experiments demonstrated the suitability of the scaffolds for cell colonization and differentiation towards an osteoblastic phenotype, particularly with scaffolds richer in PLGA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Electrical & Electronic
Xinyan Xia, Shiying Guo, Lili Xu, Tingting Guo, Zhenhua Wu, Shengli Zhang
Summary: By combining density functional theory and nonequilibrium Green's function, the study systematically investigates the adsorption and sensing properties of SO2, SO3, and NO2 on 2D pentagonal PdSe2. The results show that PdSe2 monolayer exhibits higher sensitivity to NO2 and SO3 gases, making it a potential gas sensing material with high sensitivity.
IEEE ELECTRON DEVICE LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Yuwei Cai, Qingzhu Zhang, Zhaohao Zhang, Gaobo Xu, Zhenhua Wu, Jie Gu, Junjie Li, Jinjuan Xiang, Huaxiang Yin
Summary: This study investigates the effects of tensile stress and annealing temperature on Zr-doped HfO2 ferroelectric film properties, revealing that tensile stress significantly improves material endurance, while remnant polarization increases with annealing temperature.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Electrical & Electronic
Weixing Huang, Huilong Zhu, Yongkui Zhang, Zhenhua Wu, Qiang Huo, Zhongrui Xiao, Kunpeng Jia
Summary: This study presents a ternary logic inverter based on negative capacitance FETs, achieving a third intermediate state without additional footprints and optimizing noise margin by altering ferroelectric thickness or annealing temperature. The impact of remnant polarization and coercive electric field variations on the ternary logic inverter was examined using experimental data, and a ternary logic 8T SRAM with transmission gate logic was proposed, demonstrating nondestructive read and reliable write operations for all three states.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2021)
Article
Engineering, Electrical & Electronic
Yongkui Zhang, Xuezheng Ai, Xiaogen Yin, Huilong Zhu, H. Yang, G. L. Wang, J. J. Li, A. Y. Du, C. Li, W. X. Huang, L. Xie, Y. Y. Li, Y. B. Liu, Y. B. Zhang, K. P. Jia, Z. H. Wu, X. L. Ma, Q. Z. Zhang, S. J. Mao, G. B. Xu, J. J. Xiang, J. F. Gao, X. B. He, Y. H. Lu, G. B. Bai, J. Zhao, Y. L. Li, T. Yang, J. F. Li, H. X. Yin, H. Radamson, J. Luo, C. Zhao, W. W. Wang, T. C. Ye
Summary: The study presented a new type of vertical nanowire and nanosheet field-effect transistors (FETs) called VSAFETs, fabricated with a specific process, suitable for producing high-performing p-type NS and NW VSAFETs.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2021)
Article
Engineering, Electrical & Electronic
Qihang Yang, Guodong Qi, Weizhuo Gan, Zhenhua Wu, Huaxiang Yin, Tao Chen, Guangxi Hu, Jing Wan, Shaofeng Yu, Ye Lu
Summary: This research develops a transistor compact model (TCM) based on a multigradient neural network (MNN) using the PyTorch framework, which can capture the transistor's DC/AC characteristics and high-order derivatives, and is adaptable to various device types. The study shows that this model significantly accelerates the process of creating novel device compact models and circuit benchmark simulations, providing a rapid solution for early-stage design technology co-optimization (DTCO).
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2021)
Article
Engineering, Electrical & Electronic
Fan Zhang, Yue Peng, Xinran Deng, Jiali Huo, Yan Liu, Genquan Han, Zhenhua Wu, Huaxiang Yin, Yue Hao
Summary: This study proposes a quasi-antiferroelectric (QAFE) model for evaluating the electrical characteristics of negative capacitance Fin field-effect transistor (NC-FinFET) integrated with a QAFE gate insulator. The introduction of QAFE is shown to improve the performance of FinFETs, particularly in terms of on-state current enhancement.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2021)
Article
Chemistry, Multidisciplinary
Jianhua Liu, Kun Luo, Hudong Chang, Bing Sun, Zhenhua Wu
Summary: The study investigated the spin related electrical and thermoelectric properties of monolayer and bilayer MPc (M = Co, Fe, Cu) molecular devices in different spin configurations, revealing significant advantages in designing high-performance electrical and spintronic molecular devices.
Article
Chemistry, Multidisciplinary
Yadong Zhang, Xiaoting Sun, Kunpeng Jia, Huaxiang Yin, Kun Luo, Jiahan Yu, Zhenhua Wu
Summary: The study shows that 2D InSe flakes undergo irreversible degradation when exposed to the atmosphere, affecting the performance of field effect transistors. Using a hard shadow mask instead of lithography can prevent material contamination and achieve high-performance InSe FETs. The InSe FET exhibits low hysteresis, high on/off ratio, relatively high I-on, and low subthreshold swing, suggesting potential for high-performance logic devices.
Article
Chemistry, Multidisciplinary
Shujuan Mao, Jianfeng Gao, Xiaobin He, Weibing Liu, Jinbiao Liu, Guilei Wang, Na Zhou, Yanna Luo, Lei Cao, Ran Zhang, Haochen Liu, Xun Li, Yongliang Li, Zhenhua Wu, Junfeng Li, Jun Luo, Chao Zhao, Wenwu Wang, Huaxiang Yin
Summary: This work investigates low-temperature Schottky source/drain (S/D) MOSFETs as the top-tier devices for 3D sequential integration. The study successfully fabricates complementary Schottky S/D FinFETs with a maximum processing temperature of 500 degrees C. Through source/drain extension engineering, the devices achieve competitive driving capability and switching properties compared to conventional devices. The experimental results demonstrate the excellent performance of the devices in CMOS inverters and ring oscillators.
Article
Engineering, Electrical & Electronic
Z. R. Xiao, Q. Wang, H. L. Zhu, Z. Chen, Y. K. Zhang, J. J. Li, N. Zhou, J. F. Gao, X. Z. Ai, S. S. Lu, W. X. Huang, W. J. Xiong, Z. Z. Kong, J. J. Xiang, Y. Zhang, J. Zhao, J. B. Liu, Y. H. Lu, G. B. Bai, X. B. He, A. Y. Du, Z. H. Wu, T. Yang, J. F. Li, J. Luo, W. W. Wang, T. C. Ye
Summary: In this work, a novel vertical C-shaped-channel nanosheet field-effect-transistor (VCNFET) with precise control of channel thickness and gate length, and a unique integration flow of Dual Side Process (DSP) is proposed. The VCNFETs are fabricated using high quality Si/SiGe epitaxy, atomic layer etching, and self-aligned high-k metal gate (HKMG). The integration flow is compatible with mainstream CMOS technology. The device exhibits excellent performance with perfect subthreshold slope (SS), small drain-induced barrier lowering (DIBL), and remarkably large on/off ratio.
IEEE ELECTRON DEVICE LETTERS
(2022)
Article
Engineering, Electrical & Electronic
Z. R. Xiao, H. L. Zhu, Q. Wang, Z. Chen, Z. Y. Liu, Y. K. Zhang, Z. J. Yan, Y. F. Shi, N. Zhou, J. J. Li, J. F. Gao, X. Z. Ai, S. S. Lu, W. X. Huang, W. J. Xiong, Z. Z. Kong, J. J. Xiang, Y. Zhang, J. Zhao, J. B. Liu, Y. H. Lu, G. B. Bai, X. B. He, A. Y. Du, H. Yang, T. Yang, Z. H. Wu, J. F. Li, J. Luo, W. W. Wang, T. C. Ye
Summary: We presented and demonstrated vertical C-shaped-channel nanosheet field-effect transistors (VCNFETs) with precise control of both channel thickness and gate length. The VCNFETs were fabricated using high-quality Si/SiGe epitaxy and atomic layer deposition for nanometer-scale process control and self-aligned high-k metal gate (HKMG). The integration flow is compatible with mainstream industry processes and can be easily extended to vertically stacked devices. Perfect subthreshold swing (SS), small drain-induced barrier lowering (DIBL), and large I-ON/I-OFF ratios were achieved for both n-and p-VCNFETs.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Chemistry, Multidisciplinary
Hao Chang, Guilei Wang, Hong Yang, Qianqian Liu, Longda Zhou, Zhigang Ji, Ruixi Yu, Zhenhua Wu, Huaxiang Yin, Anyan Du, Junfeng Li, Jun Luo, Chao Zhao, Wenwu Wang
Summary: In this article, an experimental study was conducted on the gate-induced drain leakage (GIDL) current repairing worst hot carrier degradation (HCD) in Si p-FinFETs using an ultra-fast measurement (UFM) technique. It was found that increasing the GIDL bias from 3 V to 4 V achieved a 114.7% V-T recovery ratio from HCD. The over-repair phenomenon of HCD by UFM GIDL was discussed through oxide trap behaviors. The results provide insights into the transistor repairing technique and its implications for the reliable operation of ICs.
Article
Chemistry, Multidisciplinary
Shixin Li, Zhenhua Wu
Summary: FinFET devices and Silicon-On-Insulator (SOI) devices are two mainstream technical routes that come after the planar MOSFET reached its scaling limit. SOI FinFET devices combine the advantages of both FinFET and SOI devices and can be further enhanced by SiGe channels. This study presents an optimization strategy for the Ge fraction in SiGe Channels of SGOI FinFET devices. Simulation results of RO circuits and SRAM cells demonstrate that adjusting the Ge fraction can enhance the performance and power efficiency of different circuits for various applications.
Article
Chemistry, Multidisciplinary
Peng Zhao, Lei Cao, Guilei Wang, Zhenhua Wu, Huaxiang Yin
Summary: In this paper, the impact of ambient temperature on the self-heating effect in stacked nanosheet transistors is investigated. The study shows that as the number of lateral stacks increases, the nanoscale devices exhibit more severe thermal crosstalk issues, and the current performance between n- and p-type nanoscale transistors degrades differently. The findings provide an effective design guide for stacked nanosheet transistors in circuit applications.
Proceedings Paper
Engineering, Multidisciplinary
S. J. Mao, J. B. Liu, Y. Wang, W. B. Liu, Y. P. Hu, H. W. Cui, R. Zhang, H. C. Liu, Z. X. Wang, N. Zhou, Y. K. Zhang, H. Yang, Z. H. Wu, Y. L. Li, J. F. Gao, A. Y. Du, J. F. Li, J. Luo, W. W. Wang, H. X. Yin
Summary: The thermal stability of n-type and p-type contacts on Si and SiGe has been experimentally investigated, revealing that Ti silicide contacts with Ge pre-amorphization implantation (PAI) demonstrate better performance for n-type contacts, while Ti germanosilicide contacts show superior performance for p-type contacts. Therefore, a single Ti contact scheme has been proven to be more suitable for 3D sequential integration.
2022 IEEE INTERNATIONAL RELIABILITY PHYSICS SYMPOSIUM (IRPS)
(2022)
