Article
Medicine, General & Internal
Angela M. Boutte, Bharani Thangavelu, Jeffrey Nemes, Christina R. LaValle, Mike Egnoto, Walter Carr, Gary H. Kamimori
Summary: This study aimed to evaluate the association between concussion-like symptoms and serum levels of neurotrauma biomarkers among military and law enforcement personnel. The results suggest that long-term exposure to LLOP during occupational training may affect serum levels of neurotrauma biomarkers. Assessing biomarkers and symptoms in healthy individuals may be beneficial for military occupational medicine risk management.
Article
Neurosciences
Rany Vorn, Rosanne Naunheim, Chen Lai, Chelsea Wagner, Jessica M. Gill
Summary: This study aimed to identify acute biomarkers related to blast injury in military personnel exposed to blast-related training. The findings indicate that serum concentrations of tau, NfL, and p-tau181 were significantly elevated after repetitive blast exposure, suggesting axonal injury.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Matthew A. Tovar, Randy S. Bell, Chris J. Neal
Summary: Mass casualty incidents due to bombing-related terrorism pose a significant threat to global society. A study compared blast injury patterns between military and civilian victims of terrorist bombings, finding differences in demographics and injury distribution. Military casualties were younger, predominantly male, and reported higher rates of head/neck injuries compared to civilians, while both groups had similar rates of instantaneous fatalities and injuries to the chest, lumbar spine, and extremities.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Shadi Bsat, Charbel Moussalem, Sarah Kawtharani, Mohamad Nabih El Houshiemy, Adham Halaoui, Tatiana Saba, Marwan Najjar, Hazem Assi, Jana Baajour, Ibrahim El-Houcheimi, George Abi Saad, Houssein Darwish
Summary: This paper discusses the significance of the Beirut blast in the era of COVID-19, emphasizing the role of healthcare providers and the challenges they faced, as well as looking ahead to the importance of preparing for similar events in the future.
WORLD NEUROSURGERY
(2022)
Article
Critical Care Medicine
Emily Ashworth, David Baxter, Iain Gibb, Mark Wilson, Anthony M. J. Bull
Summary: The aim of this study was to investigate head and spinal injuries caused by underbody blast (UBB) and develop hypotheses on the injury mechanisms. They identified five injury constellations and proposed mitigation strategies or clinical treatments.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Neuroimaging
Carl Trolle, Estee Goldberg, Clas Linnman
Summary: This study conducted a systematic review and meta-analysis to investigate cervical spinal cord atrophy after spinal cord injury. The results showed that the level of injury and time since injury influenced the atrophy, and more severe atrophy was observed in more rostral injuries. The study suggests the need for larger and longitudinal studies, data sharing, and standardized protocols.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Rita Campos-Pires, Bee Eng Ong, Mariia Koziakova, Eszter Ujvari, Isobel Fuller, Charlotte Boyles, Valerie Sun, Andy Ko, Daniel Pap, Matthew Lee, Lauren Gomes, Kate Gallagher, Peter F. Mahoney, Robert Dickinson
Summary: This study investigates the effects of repeated mild blast traumatic brain injury (mbTBI) on rats and identifies specific brain regions that are particularly sensitive to repeated blast exposure. The findings suggest that repeated exposure to blast can lead to functional impairments and neuronal loss in certain brain regions. The reasons for this sensitivity may include exposure to stronger shockwaves or proximity to tissue density transitions. This study provides insights into the mechanisms of injury sensitization and potential new treatments.
Review
Biochemistry & Molecular Biology
Annika Guntermann, Katrin Marcus, Caroline May
Summary: Infections and autoimmune reactions are major factors in the immune response after traumatic spinal cord injury, but there is controversy over how autoantibodies affect the neuronal and functional outcome in patients.
BIOLOGICAL CHEMISTRY
(2023)
Article
Neurosciences
Lanier Heyburn, Rania Abutarboush, Samantha Goodrich, Rodrigo Urioste, Andrew Batuure, Jaimena Wheel, Donna M. Wilder, Peethambaran Arun, Stephen T. Ahlers, Joseph B. Long, Venkatasivasai Sujith Sajja
Summary: Repeated exposure to low-level blast overpressure experienced by military personnel may lead to deficits in behavior and cognition, with cumulative effects on the brain. Research findings indicate different changes in inflammatory, cerebrovascular, and neurodegeneration-related proteins between the 8.5 psi BOP group and the 10 psi BOP group, suggesting varying impacts of blast overpressure on the brain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Julian Seelig, Raban Arved Heller, Patrick Haubruck, Qian Sun, Georg Jochen Klingenberg, Julian Hackler, Helena Lucia Crowell, Volker Daniel, Arash Moghaddam, Lutz Schomburg, Bahram Biglari
Summary: The serum levels of SELENBP1 are related to the degree of neurological impairment in patients with TSCI and offer information on remission odds. The correlation of SELENBP1 with CCL2 levels establishes a novel connection between selenium metabolism and immune cell activation, which may have implications for neurological damage and regeneration processes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Michael F. Almeida, Thuvan Piehler, Kelly E. Carstens, Meilan Zhao, Mahsa Samadi, Serena M. Dudek, Christopher J. Norton, Catherine M. Parisian, Karen L. G. Farizatto, Ben A. Bahr
Summary: Explosive shockwaves and blast exposures are associated with injuries common in military service and increased risk for dementia. Blast-induced changes in neuronal circuitries were identified, with explosions leading to reductions in synaptic markers linked to cognitive disorders without causing neuronal loss.
Article
Ophthalmology
Matthew M. Harper, Nickolas Boehme, Laura M. Dutca, Michael G. Anderson
Summary: This study examined the influence of genetic background on the retinal ganglion cell (RGC) response to blast-mediated traumatic brain injury (TBI) in mice. It found significant differences in RGC response between different genetic backgrounds, indicating a strong dependency of RGC response on genetic factors.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Orthopedics
Anais Chataigneau, Alexia Milaire, Paul-Vincent Martin, Julien Danis, Fabrice Bazile, Nicolas de l'Escalopier, Laurent Mathieu
Summary: This study evaluated the functional outcomes of hindfoot blast injuries in French service personnel, comparing amputated patients with non-amputated patients. The results showed better long-term functional outcomes in the amputated group.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Clinical Neurology
Michael R. Miller, Alicia DiBattista, Maitray A. Patel, Mark Daley, Catherine Tenn, Ann Nakashima, Shawn G. Rhind, Oshin Vartanian, Maria Y. Shiu, Norleen Caddy, Michelle Garrett, Doug Saunders, Ingrid Smith, Rakesh Jetly, Douglas D. Fraser
Summary: This study identified candidate biomarkers for chronic blast exposure in military personnel using metabolomics profiling. These biomarkers may aid in surveillance and care for military personnel and could potentially be used for point-of-care screening.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrey Khaitin
Summary: Neurotrauma can lead to the disconnection of axons, impacting both neurons and surrounding glial cells. Calcium signaling plays a crucial role in post-axotomy events, affecting the survival or degeneration of neurons and glial cells. Future research should focus on understanding the survival mechanisms of remote glial cells from the lesion site after axotomy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Meeting Abstract
Sport Sciences
Gary H. Kamimori, Uade Da Silva
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2016)
Article
Mechanics
G. H. Kamimori, L. A. Reilly, C. R. LaValle, U. B. Olaghere Da Silva
Article
Neurosciences
Clinton E. Canal, Uade B. Olaghere da Silva, Paul J. Gresch, Erin E. Watt, Elaine Sanders-Bush, David C. Airey
PSYCHOPHARMACOLOGY
(2010)
Article
Neurosciences
Uade B. Olaghere da Silva, Michael V. Morabito, Clinton E. Canal, David C. Airey, Ronald B. Emeson, Elaine Sanders-Bush
FRONTIERS IN NEUROSCIENCE
(2010)
Meeting Abstract
Geriatrics & Gerontology
A Bernardo, UB Olaghere-Dasilva, AK Bruchey, JL Zhao, MP McDonald
NEUROBIOLOGY OF AGING
(2004)
Meeting Abstract
Geriatrics & Gerontology
A Bernardo, UB Olaghere-DaSilva, M Jablonski, JL Zhao, JS Penn, MP McDonald
NEUROBIOLOGY OF AGING
(2004)
Article
Neurosciences
SC Gammie, UB Olaghere-da Silva, RJ Nelson