Article
Medicine, Research & Experimental
Chan Huang, Xuan Su, Da-Lei Zhou, Bo-Heng Xu, Qing Liu, Xiao Zhang, Tao Tang, Xin-Hua Yang, Zu-Lu Ye, Cai-Yun He
Summary: This study identified several lncRNAs as diagnostic biomarkers for papillary thyroid cancer (PTC) and developed a nomogram model to predict lymph node metastasis (LN) in PTC patients. Additionally, a pathway involving lncMPEG1-1:1/miR-766-5p was discovered to be associated with thyroid cancer progression.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Cell Biology
Christian Sommerauer, Claudia Kutter
Summary: The liver plays important roles in detoxification, energy metabolism, and whole body homeostasis. However, chronic overload of fatty acids and glucose can lead to the development of malignant phenotypes in the liver. The global increase in metabolic dysfunction-associated fatty liver disease (MAFLD) is affecting a significant portion of the population. Noncoding RNAs, including long and short noncoding RNAs, have emerged as potential targets for treatment interventions. The interactions between noncoding RNAs and proteins offer precise ways to target specific cellular pathways.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maryam Nasiri-Aghdam, Texali C. Garcia-Garduno, Luis Felipe Jave-Suarez
Summary: Post-transcriptional modifications to coding and non-coding RNAs play a key role in influencing human mRNA and protein diversity, especially in cancer proliferation. CELF proteins have pleiotropic capabilities in RNA processing, impacting alternative splicing and transcript editing. Understanding the regulation of CELF functions, particularly through noncoding RNAs, is crucial for cancer research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xiaoping Zhang, Yong Zhong, Lin Liu, Chengyou Jia, Haidong Cai, Jianshe Yang, Bo Wu, Zhongwei Lv
Summary: The study found that fasting can inhibit glycolysis and mitochondrial function in papillary thyroid carcinoma (PTC). Fasting significantly increases the expression of lncRNA PRKCQ-AS1 in PTC cells, which leads to suppression of glycolysis and reduced mitochondrial function. PRKCQ-AS1 interacts with IGF2BPs and enhances the expression of PRMT7 mRNA, thereby regulating glycolysis and mitochondrial function in PTC and inhibiting tumor growth.
CELL DEATH & DISEASE
(2023)
Article
Cell & Tissue Engineering
Yuheng Li, Weijia Sun, Jianwei Li, Ruikai Du, Wenjuan Xing, Xinxin Yuan, Guohui Zhong, Dingsheng Zhao, Zizhong Liu, Xiaoyan Jin, Junjie Pan, Youyou Li, Qi Li, Guanghan Kan, Xuan Han, Shukuan Ling, Xiqing Sun, Yingxian Li
Summary: This study reveals the importance of temporal and spatial regulation of HOTAIR in BMSC osteogenic differentiation and bone formation. HOTAIR inhibits BMSC osteogenic differentiation but promotes osteoblast function. In addition, HOTAIR is involved in nucleocytoplasmic translocation and acts as a ceRNA to increase Atf4 protein levels and osteoblast function through binding to miR-214. Furthermore, Bglap-HOTAIR alleviates bone loss induced by unloading.
Article
Cell Biology
Jiaqi Sheng, Yiming Luo, Enjun Lv, Huifang Liang, Haisu Tao, Chengpeng Yu, Dean Rao, Mengyu Sun, Limin Xia, Wenjie Huang
Summary: This study found that LINC01980 was upregulated and associated with poor overall survival in HCC patients. It plays a role in promoting HCC metastasis by competitively binding miR-376b-5p, enhancing E2F5 expression, inducing epithelial-mesenchymal transition, and promoting HCC cell migration and invasion. Additionally, TGF-beta activates LINC01980 transcription through the canonical TGF-beta/SMAD signaling pathway in HCC.
CELLULAR SIGNALLING
(2023)
Article
Cell Biology
Chen Yang, Yiwen Zang, Siqi Wu, Quan Zhou, Yuxi Ou, Qiang Ding, Hao Wang, Zuquan Xiong
Summary: This study demonstrates that the circFTO/miR-514b-3p/DUSP4 axis plays an important role in the development of ccRCC and may serve as a potential biomarker and therapeutic target.
CELL DEATH DISCOVERY
(2022)
Article
Chemistry, Analytical
Isabella T. Whitworth, Katherine B. Henke, Bing Yang, Mark Scalf, Brian L. Frey, David F. Jarrard, Lloyd M. Smith
Summary: RNA-protein interactions are vital for cellular homeostasis, and their identification is crucial for understanding cellular function. This study introduces a new method called hybridization purification of RNA-protein complexes followed by mass spectrometry (HyPR-MS), which enables the characterization of specific RNA-protein complexes in tissue samples. The researchers successfully isolated polyadenylated RNA and the long noncoding RNA MALAT1, and characterized their protein interactomes using this technique, demonstrating its feasibility.
ANALYTICAL CHEMISTRY
(2023)
Article
Genetics & Heredity
Silin Jiang, Xiaohan Ren, Shouyong Liu, Zhongwen Lu, Aiming Xu, Chao Qin, Zengjun Wang
Summary: This study identified differentially expressed RNA-binding proteins in renal papillary cell carcinoma using TCGA database and established a prognostic model. High-risk group showed poor overall survival, and further analysis revealed potential therapeutic drugs for the disease. The research provided new insights into pRCC prognosis and individualized treatment strategies.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Agata M. Gawel, Maciej Ratajczak, Ewa Gajda, Malgorzata Grzanka, Agnieszka Paziewska, Marta Cieslicka, Maria Kulecka, Malgorzata Oczko-Wojciechowska, Marlena Godlewska
Summary: The study revealed enhanced expression of FRMD5 in BRAF V600E thyroid tumor specimens and cells; Depletion of FRMD5 resulted in significant alterations in migration, invasiveness, adhesion, and spheroid formation potential of PTC-derived cells; Knockdown of FRMD5 significantly affected the expression of multidrug resistant genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yunqiu Zhang, Zhonghan Li
Summary: Mechanotransduction is a crucial cellular process involving the response to mechanical signals, which is associated with various physiological conditions and diseases such as cancer. Recent studies have highlighted the significant role of RNA binding proteins in mechanotransduction and cancer metastasis.
Article
Cell Biology
Meichen Liu, Xuelei Ruan, Xiaobai Liu, Weiwei Dong, Di Wang, Chunqing Yang, Libo Liu, Ping Wang, Mengyang Zhang, Yixue Xue
Summary: The study reveals the important roles of BUD13, CDK12, and MBNL1 in the formation of vasculogenic mimicry (VM) in glioblastoma (GBM) and provides a potential target for GBM therapy. Upregulation of BUD13 and CDK12, and downregulation of MBNL1 are associated with VM formation in GBM. Targeting these genes can inhibit VM formation in GBM, offering a potential therapeutic strategy for GBM.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Yu Zhang, Kai-Ning Lu, Jin-Wang Ding, You Peng, Gang Pan, Li-Song Teng, Ding-Cun Luo
Summary: Long noncoding RNAs (lncRNAs) and mRNAs play important roles in different clinical features of papillary thyroid carcinoma (PTC) with or without Hashimoto's thyroiditis (HT). The differentially expressed lncRNAs and mRNAs in PTC/HT (+) tissues suggest the involvement of immune system processes. One lncRNA, ENST00000452578, was found to be negatively correlated with tumor size and could inhibit cell proliferation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Bing Zhong, Zexue Zhao, Xi Jiang
Summary: RP1-59D14.5 acts as a tumor suppressor in prostate cancer (PCa) by activating the Hippo pathway through regulating the miR-147a/LATS1/2 and HUR/CK1/beta TrCP pathways, thus inhibiting the proliferation, migration, and invasion of PCa cells.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Siyi Chen, Aihui Zhang, Na Li, Hongpan Wu, Yaqi Li, Shuai Liu, Qiu Yan
Summary: Protein glycosylation plays an important role in endometrial decidualization, and dysregulation of high-mannose glycan biosynthesis is associated with pregnancy failure. The lncRNA lncNEAT1 inhibits the expression of MAN1A1, a key enzyme in high-mannose glycan biosynthesis, through its interaction with the nucleophosmin-SP1 transcription complex, resulting in impaired endometrial decidualization and embryo implantation potential.
