Review
Pharmacology & Pharmacy
Ariela Hoxha, Daniela Tormene, Elena Campello, Paolo Simioni
Summary: This study conducted a systematic review on the additional treatments used in refractory and high-risk antiphospholipid antibody syndrome (APS) pregnancies. The results showed that combination therapy with IVIG and PEX achieved a 100% live birth rate in refractory APS pregnancies, while Pravastatin, IA, and PEX showed higher live birth rates in high-risk APS pregnancies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rositsa Dacheva, Ekaterina Kurteva, Vladimira Boyadzhieva, Rumen Stoilov, Dobroslav Kyurkchiev, Nikolay Stoilov
Summary: This article reports a rare case of TA presenting with acute aortic dissection, along with atypical ANCA positivity and positive antiphospholipid antibodies.
Article
Cardiac & Cardiovascular Systems
Jacqueline J. J. Tao, Sanjana Adurty, Debra D'Angelo, Maria T. T. DeSancho
Summary: Women with antiphospholipid syndrome (APS) are at an increased risk of adverse pregnancy outcomes. This retrospective cohort study evaluated clinical, serologic, and treatment factors in pregnant women with APS to predict outcomes. The study found that treatment with aspirin plus low molecular weight heparin (LMWH) was associated with a higher odds of live birth compared to no antithrombotic use or aspirin alone.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Immunology
Giuseppe Barilaro, Emmanuel Coloma-Bazan, Alejandro Chacur, Carlo Della Rocca, Albert Perez-Isidro, Estibaliz Ruiz-Ortiz, Odette Vinas, Dolors Tassies Penella, Joan Carles Reverter, Alicia Molina Andujar, Ricard Cervera, Gerard Espinosa
Summary: The purpose of this study was to analyze the persistence of antiphospholipid antibodies (aPL) over time in patients with antiphospholipid syndrome (APS) and its association with clinical recurrence. The results showed that more than half of the patients maintained persistent positive aPLs over a long-term follow-up, and these patients were more prone to experience recurrence of clinical manifestations.
AUTOIMMUNITY REVIEWS
(2022)
Article
Medicine, General & Internal
Siobhan Quenby, Katie Booth, Louise Hiller, Arri Coomarasamy, Paulien G. de Jong, Eva N. Hamulyak, Luuk J. Scheres, Thijs F. van Haaps, Lauren Ewington, Mariette Gojjin, Shreeya Tewary, Saskia Middeldorp
Summary: The use of low-molecular-weight heparin (LMWH) did not increase livebirth rates in women with recurrent pregnancy loss and inherited thrombophilia. Therefore, the use of LMWH is not recommended in these women.
Review
Medicine, General & Internal
Eunyoung Emily Lee, Jong Kwan Jun, Eun Bong Lee
Summary: The treatment strategies for Antiphospholipid syndrome (APS) and asymptomatic women positive for antiphospholipid antibodies (aPL) depend on the patient's clinical subtype and pregnancy status, consideration may be given to the use of aspirin, low-dose aspirin, or low molecular weight heparin if necessary, emphasizing the importance of personalized treatment.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Clinical Neurology
Sirisha Nouduri, Rajiv Padmanabhan, Richard Hicks, Mary-Alice Abbott, Dennis O'Brien, Gottfried Schlaug
Summary: Mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes, and other features (MELAS syndrome) are characterized by a rare condition caused by mutations in maternally inherited mitochondrial DNA. This article reports a case of a patient with MELAS and a potential Antiphospholipid Antibody Syndrome (APLAS). The patient presented with neurologic symptoms at different time points and was diagnosed with MELAS and APLAS based on laboratory and imaging studies.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Jin Zhang, Cheng Li, Xiaorong Han, Zhongbo Chen, Binay Kumar Adhikari, Yinghui Wang, Yonggang Wang, Jian Sun
Summary: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by vascular thrombosis and pregnancy complications. Digestive system involvement in APS may result from autoimmune or thrombotic mechanisms, with the liver being the most commonly affected organ. This review discusses the clinical manifestations of APS in the digestive system, along with the epidemiology, pathophysiology, and treatment strategies for these patients.
ANNALS OF MEDICINE
(2021)
Article
Hematology
Romain Stammler, Yann Nguyen, Cecile Yelnik, Veronique Le Guern, Marc Lambert, Romain Paule, Eric Hachulla, Luc Mouthon, Anastasia Dupre, Felix Ackermann, Virginie Dufrost, Denis Wahl, Bertrand Godeau, Gaelle Leroux, Ygal Benhamou, Estibaliz Lazaro, Eric Daugas, Holy Bezanahary, Arsene Mekinian, Jean-Charles Piette, Nathalie Morel, Nathalie Costedoat-Chalumeau
Summary: This study analyzed the prevention of catastrophic antiphospholipid syndrome (CAPS), focusing on anticoagulation before CAPS episodes. The results indicated that the major precipitating factors of CAPS were infections, pregnancy, and surgery. Among patients with previous APS diagnosis, the proportion of using vitamin K antagonists (VKA) was low and many patients had a subtherapeutic international normalized ratio (INR) below 2, suggesting suboptimal anticoagulation management. These findings strongly suggest that inadequate anticoagulation can trigger CAPS.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Microbiology
Marc Emmenegger, Sreedhar Saseendran F. Kumar, Vishalini J. Emmenegger, Tomas J. Malinauskas, Thomas Buettner, Laura Rose, Peter Schierack, Martin B. Sprinzl, Clemens Sommer, Karl B. Lackner, Adriano Aguzzi, Dirk B. Roggenbuck, Katrin B. M. Frauenknecht
Summary: SARS-CoV-2 infection can lead to diverse symptoms, with some patients developing hypercoagulation and autoantibody responses. Research has shown that infection with SARS-CoV-2 can result in the production of autoantibodies, particularly IgM antibodies targeting coagulation proteins. Further investigation is needed to explore the relationship between SARS-CoV-2 infection, autoantibody production, and disease severity.
Review
Rheumatology
Zikica Jovicic, Sanja Dragasevic, Ana Petkovic, Snezana Plesinac, Aleksandra Sokic Milutinovic, Maja Stojanovic
Summary: Takayasu arteritis (TA) is a large vessel vasculitis that mainly affects females below the age of 40. The association between antiphospholipid syndrome (APS) and TA is rarely reported, and there is limited data on pregnancy outcomes in patients with both TA and APS. Active Crohn's disease (CD) may also contribute to decreased fertility rate.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Cecilia Nalli, Daniele Lini, Laura Andreoli, Francesca Crisafulli, Micaela Fredi, Maria Grazia Lazzaroni, Viktoria Bitsadze, Antonia Calligaro, Valentina Canti, Roberto Caporali, Francesco Carubbi, Cecilia Beatrice Chighizola, Paola Conigliaro, Fabrizio Conti, Caterina De Carolis, Teresa Del Ross, Maria Favaro, Maria Gerosa, Annamaria Iuliano, Jamilya Khizroeva, Alexander Makatsariya, Pier Luigi Meroni, Marta Mosca, Melissa Padovan, Roberto Perricone, Patrizia Rovere-Querini, Gian Domenico Sebastiani, Chiara Tani, Marta Tonello, Simona Truglia, Dina Zucchi, Franco Franceschini, Angela Tincani
Summary: The study found that decreased complement levels before pregnancy are associated with an increased risk of adverse pregnancy outcomes in women with triple antiphospholipid antibodies positivity, while this trend was not observed in those with single or double positivity. Complement levels are cost-effective and easy to measure, making them a potentially useful tool for identifying pregnant women at risk of pregnancy loss.
Article
Immunology
Annika Kits, Mattia Russel Pantalone, Christopher Illies, Aleksandra Antovic, Anne-Marie Landtblom, Ellen Iacobaeus
Summary: This case report presents a 53-year-old male patient with rheumatoid arthritis who developed fatal acute hemorrhagic encephalomyelitis (AHEM) following the second dose of the COVID-19 vaccine. The patient also showed signs of multiorgan thromboembolic disease and antiphospholipid syndrome. The report highlights the diagnostic challenges and suggests a possible causal relationship with the COVID-19 vaccine.
Article
Public, Environmental & Occupational Health
Pedro C. Hallal, Mariangela F. Silveira, Ana M. B. Menezes, Bernardo L. Horta, Aluisio J. D. Barros, Lucia C. Pellanda, Gabriel D. Victora, Odir A. Dellagostin, Claudio J. Struchiner, Marcelo N. Burattini, Marilia A. Mesenburg, Nadege Jacques, Luis Paulo Vidaletti, Emanuele L. Ambros, Evelise M. Berlezi, Helena Schirmer, Jane D. P. Renner, Kaue Collares, Maria Leticia R. Ikeda, Thiago M. Ardenghi, Patricia de Gasperi, Fernando P. Hartwig, Fernando C. Barros, Cesar G. Victora
Summary: The spread of SARS-CoV-2 in the Brazilian State of Rio Grande do Sul over 6 months was slow compared to other regions in Brazil. Older adults were less likely to be infected compared to younger participants, and the proportion of the population leaving home daily increased during this period. Future surveys will continue to monitor the spread of the pandemic.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2021)
Review
Medicine, General & Internal
Marco Capecchi, Maria Abbattista, Alessandro Ciavarella, Mario Uhr, Cristina Novembrino, Ida Martinelli
Summary: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies and thrombosis or obstetrical complications. Anticoagulant therapy is the mainstay of treatment, but its optimal intensity and risk stratification for thrombosis are still unclear.
JOURNAL OF CLINICAL MEDICINE
(2022)
