Article
Clinical Neurology
Pinar Ozcelik, Koray Kocoglu, Vesile Ozturk, Pembe Keskinoglu, Gulden Akdal
Summary: The study revealed differences between vestibular migraine (VM) patients and migraine only (MO) patients in terms of gender, age, comorbid depression, motion sickness history, imbalance symptoms, and headache triggers. Identifying and addressing these differences could assist clinicians in diagnosing and managing VM patients more effectively.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Minping Li, Xue Xu, Weiwei Qi, Yingyin Liang, Yongxin Huang, Haiwei Huang
Summary: Vestibular migraine is gaining attention as an independent disease concept, with a lack of specific laboratory biomarkers causing high misdiagnosis and missed diagnosis rates. Further basic research and clinical trials focusing on specific laboratory biomarkers are needed to develop more detailed and complete diagnostic criteria.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
I. P. Hannigan, S. M. Rosengren, G. K. Bharathy, M. Prasad, M. S. Welgampola, S. R. D. Watson
Summary: The study found that patients with vestibular migraine have higher nystagmus slow-phase velocity and subjective symptoms during caloric testing compared to patients with other vestibular disorders. Combining objective and subjective measures can provide better differentiation of vestibular migraine from Meniere's disease.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Shin C. Beh
Summary: This review explores recent developments in vestibular migraine (VM), including the diagnostic criteria for VM, the wide range of vestibular symptoms and triggers, and the treatment options. The article highlights that many patients with VM experience persistent vestibular symptoms even in the absence of acute attacks, which greatly impacts their quality of life.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Pediatrics
Roberto Teggi, Bruno Colombo, Marco Familiari, Iacopo Cangiano, Mario Bussi, Massimo Filippi
Summary: This study retrospectively analyzed data from 95 pediatric patients with episodic vertigo recruited from 2018 to 2022. Based on the revised criteria by the Barany Society, 28 patients were diagnosed with vestibular migraine of childhood (VMC), 38 patients with probable VMC, and 29 patients with recurrent vertigo of childhood (RVC). The duration of vertigo was significantly longer in the VMC group compared to the probable VMC and RVC groups.
FRONTIERS IN PEDIATRICS
(2023)
Article
Clinical Neurology
Justin L. Hoskin, Terry D. Fife
Summary: The CGRP medications appear to be a decent treatment option for vestibular migraine (VM), with most patients experiencing some level of symptom improvement.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Youjin Shen, Xiaokun Qi
Summary: This study provides an overview of the diagnostic criteria and differential diagnosis of vestibular migraine, emphasizing the importance of accurate diagnosis for appropriate treatment and reducing misdiagnosis.
NEUROLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Mauro Gufoni, Augusto Pietro Casani
Summary: This study aimed to verify the presence of pupillary nystagmus in patients with vestibular migraine and compare it with non-migraine dizzy patients. The results showed that 28 out of 30 vestibular migraine patients had pupillary nystagmus, while only 3 out of 50 non-migraine dizziness patients had it. This suggests that pupillary nystagmus can be considered as an objective sign for diagnosing vestibular migraine.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Young Jae Byun, Dylan A. Levy, Shaun A. Nguyen, Emily Brennan, Habib G. Rizk
Summary: Various treatment modalities have been evaluated for preventative treatment of vestibular migraine, showing improvement in outcome parameters. However, due to significant heterogeneity and lack of standardized reporting, a preferred treatment modality could not be determined. Future randomized controlled trials are needed for more evidence-based treatment.
Article
Clinical Neurology
Stefan Evers
Summary: Martin Luther reported experiencing headache and vertigo attacks. His headache attacks may be diagnosed as migraine, but further evidence is needed. His vertigo attacks may fulfill the criteria for Meniere's disease or vestibular migraine, but more information is required to confirm the diagnoses.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Monica P. Mallampalli, Habib G. Rizk, Amir Kheradmand, Shin C. Beh, Mehdi Abouzari, Alaina M. Bassett, James Buskirk, Claire E. J. Ceriani, Matthew G. Crowson, Hamid Djalilian, Joel A. Goebel, Jeffery J. Kuhn, Anne E. Luebke, Marco Mandala, Magdalena Nowaczewska, Nicole Spare, Roberto Teggi, Maurizio Versino, Hsiangkuo Yuan, Ashley Zaleski-King, Michael Teixido, Frederick Godley
Summary: Vestibular migraine is increasingly recognized as a pathological cause of vestibular disorders, yet it remains underdiagnosed. The pathophysiology of this disorder is still unclear. A multidisciplinary expert workshop identified seven current care gaps that need to be resolved, including a better understanding of symptoms and phenotypes, a lack of diagnostic markers, a better understanding of pathophysiological mechanisms, as well as the need for clear recommendations and outcome measures. Recommendations were made to address these gaps, such as establishing a global registry and conducting trials to validate current treatments.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Jing-Yu Chen, Zhao-Qi Guo, Jun Wang, Dan Liu, E. Tian, Jia-Qi Guo, Wei-Jia Kong, Su-Lin Zhang
Summary: Meniere's disease is a vertigo disorder characterized by recurrent vertigo, fluctuating hearing loss, tinnitus, or ear fullness. It is important to accurately differentiate Meniere's disease from vestibular migraine for effective treatment. Advances in examination technologies have improved the diagnostic accuracy of differentiating vertigo diseases.
JOURNAL OF NEUROLOGY
(2023)
Article
Audiology & Speech-Language Pathology
James G. Naples, Drew Soda, Kahlil Rahman, Michael J. Ruckenstein, Kourosh Parham
Summary: This study evaluated the role of prestin and otolin-1 as biomarkers and found differences in their levels between Meniere's disease and vestibular migraine patients. Furthermore, prestin levels were correlated with word recognition scores in Meniere's disease patients, suggesting a potential role as a marker for inner ear function.
Article
Clinical Neurology
Zhengwei Chen, Lijie Xiao, Haiyan Liu, Qingxiu Zhang, Quan Wang, You Lv, Yujia Zhai, Jun Zhang, Shanshan Dong, Xiue Wei, Liangqun Rong
Summary: VM patients exhibited altered functional connectivity between the thalamus and brain regions involved in pain, vestibular and visual processing. Specifically, there was reduced connectivity in thalamo-pain and thalamo-vestibular pathways, while enhanced connectivity in the thalamo-visual pathway. These findings suggest specific alterations in brain connectivity in VM patients that are related to their clinical features.
Article
Clinical Neurology
Sun-Young Oh, Jin-Ju Kang, Sohui Kim, Jong-Min Lee, Ji-Soo Kim, Marianne Dieterich
Summary: This study found that BTX-A treatment can effectively improve migraine and vertigo symptoms in VM patients who are unresponsive to conventional therapies. Furthermore, changes in functional brain network suggest a dysmodulation of multimodal sensory integration and abnormal cortical processing of vestibular and pain signals in VM patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
S. M. Stoecklein, M. Brandlhuber, S. S. Lause, A. Pomschar, K. Jahn, R. Schniepp, N. Alperin, B. Ertl-Wagner
Summary: This study investigates craniospinal cerebrospinal fluid (CSF) flow rates in patients with normal pressure hydrocephalus using phase-contrast MR imaging. The results show that the maximal systolic CSF flow rate is significantly decreased in patients with normal pressure hydrocephalus compared to healthy controls, suggesting a reduced compliance of the spinal CSF spaces and an ineffective spinal CSF buffer function.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Maria de las Mercedes Ruiz Brunner, Eduardo Cuestas, Florian Heinen, Andreas Sebastian Schroeder
Summary: This study compared growth patterns in children with unilateral and bilateral cerebral palsy (CP) and found that children with bilateral CP had significantly decreased growth in height, weight, and BMI compared to those with unilateral CP. Furthermore, reduced growth in children with bilateral CP was strongly associated with moderate to severe impairment in gross motor function and dysphagia.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Josefine Eder, Silvy Kellerer, Tamara Amberger, Aram Keywan, Julia Dlugaiczyk, Max Wuehr, Klaus Jahn
Summary: There is no synergistic treatment effect when noisy galvanic vestibular stimulation (nGVS) is combined with vestibular rehabilitation training (VRT) in patients with bilateral vestibulopathy (BVP). However, nGVS may be used as a complementary therapeutic option during postural activities in daily life.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Stephanie Schmidle, Alexandra Charlotte de Crignis, Manuela Stuerzer, Joachim Hermsdoerfer, Klaus Jahn, Carmen Krewer
Summary: Posturography is an objective method to interpret postural control systematically. This study aimed to investigate the influence of different stance widths on a set of parameters in healthy older adults. Results showed that outcomes acquired in self-selected stance width provide comparable results to standardized stance widths of 20 and 30 cm.
JOURNAL OF NEUROLOGY
(2022)
Article
Rehabilitation
Jeannine Bergmann, Carmen Krewer, Friedemann Mueller, Klaus Jahn
Summary: The German version of SRP demonstrates excellent reliability and validity in patients with neurological disorders, providing a useful tool for assessing retropulsion. The SRP showed a wide range of scores and good correlations with other clinical balance scales.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Clinical Neurology
Jacob Staisch, Corinna Borner, Magdalena Lang, Ari Hauser, Iris Hannibal, Kristina Huss, Birgit Klose, Matthias F. Lechner, Nico Sollmann, Florian Heinen, Mirjam N. Landgraf, Michaela V. Bonfert
Summary: This study suggests that repetitive neuromuscular magnetic stimulation (rNMS) is safe, feasible, and well-accepted among children and adolescents with headache disorders. There was a significant reduction in headache frequency and intensity during a 3-month follow-up.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Alida Kindt, Yvonne Kraus, David Rasp, Kai M. Foerster, Narges Ahmidi, Andreas W. Flemmer, Susanne Herber-Jonat, Florian Heinen, Heike Weigand, Thomas Hankemeier, Berthold Koletzko, Jan Krumsiek, Juergen Babl, Anne Hilgendorff
Summary: A study found that the use of a novel standardized parenteral nutrition (PN) solution called MUC PREPARE can improve nutritional intake, accelerate termination of parenteral feeding, and positively affect growth in very preterm infants. Infants receiving MUC PREPARE showed improved macro- and micronutrient intake, balanced electrolyte levels, and stable metabolomic profiles. The use of MUC PREPARE also resulted in earlier termination of parenteral feeding and higher weight gain in extremely immature infants. This new standardized PN solution is considered a superior therapeutic strategy for very preterm infants.
Article
Food Science & Technology
Steffen Berweck, Marta Banach, Deborah Gaebler-Spira, Henry G. Chambers, A. S. Schroeder, Thorin L. Geister, Michael Althaus, Angelika Hanschmann, Matteo Vacchelli, Michaela Bonfert, Florian Heinen, Edward Dabrowski
Summary: This study provides safety data of IncobotulinumtoxinA in children/adolescents with spasticity associated with cerebral palsy and sialorrhea associated with neurologic disorders, showing that IncobotulinumtoxinA is safe and well-tolerated with minimal treatment-related adverse events.
Article
Multidisciplinary Sciences
Maria de las Mercedes Ruiz Brunner, Eduardo Cuestas, Rudiger von Kries, Jordan Brooks, Charlotte Wright, Florian Heinen, Andreas Sebastian Schroeder
Summary: This study aimed to analyze the growth patterns of children with CP between countries, compare the differences in growth, and assess the fit of growth charts. A cross-sectional study was conducted on 799 children with CP from Argentina and Germany, aged 2 to 19 years old. The results showed that the decrease in height z-scores (HAZ) with age in Argentina was double that in Germany. Both countries showed decreasing HAZ with age when using the US CP growth charts. Growth differences due to ethnicity, motor impairment, age, and feeding modality were observed, reflecting differences in environment or health care.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Philine Rojczyk, Johanna Seitz-Holland, Elisabeth Kaufmann, Valerie J. Sydnor, Cara L. Kim, Lisa F. Umminger, Tim L. T. Wiegand, Jeffrey P. Guenette, Fan Zhang, Yogesh Rathi, Sylvain Bouix, Ofer Pasternak, Catherine B. Fortier, David Salat, Sidney R. Hinds, Florian Heinen, Lauren J. O'Donnell, William P. Milberg, Regina E. McGlinchey, Martha E. Shenton, Inga K. Koerte
Summary: Sleep disturbances are strongly associated with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD), and poor sleep quality has a compounding effect on white matter (WM) microstructure in veterans with comorbid PTSD+mTBI. Veterans with PTSD and comorbid PTSD+mTBI reported poorer sleep quality than those with mTBI or no history of PTSD or mTBI. Poor sleep quality fully mediated the association between greater PTSD symptom severity and impaired WM microstructure. Sleep-targeted interventions are necessary for improving brain health in veterans with PTSD+mTBI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Engineering, Biomedical
Chiara Hoehler, Emilio Trigili, Davide Astarita, Joachim Hermsdoerfer, Klaus Jahn, Carmen Krewer
Summary: Hybrid neuroprostheses, including robots and electrical stimulation, have shown positive effects on upper limb recovery after stroke, with long-lasting benefits. Among the 32 identified hybrid systems, the majority are exoskeleton devices that actively reinforce movement. The combination of Functional Electrical Stimulation and robotic components can target different levels of impairment and improve upper limb function.
Article
Clinical Neurology
Anja Melder, Esther Wittmann, Lucia Bulubas, Beate Dornheim, Katharina Kerber, Ulrike Vogelmann, Mattia Campana, Jasmin Hubert, Vivien Schmidt, Florian Heinen, Frank Padberg, Mirjam N. Landgraf
Summary: This study is the first-ever investigation of repetitive transcranial magnetic stimulation (rTMS) in Fetal Alcohol Spectrum Disorder (FASD). The results show that rTMS is safe, tolerable, and acceptable in pediatric patients with FASD. However, the individual improvements in functional cerebral domains and quality of life were not significant, and further clinical studies with larger samples are needed to determine effective stimulation protocols and evaluate treatment response.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2023)
Review
Clinical Neurology
Tristan Schmidlechner, Malin Zaddach, Florian Heinen, Sonia Cornell, Georgia Ramantani, Jan Remi, Christian Vollmar, Mathias Kunz, Ingo Borggraefe
Summary: This systematic review showed that children with medically intractable epilepsy experience a mean gain in FSIQ and DQ after surgery. Patients who are seizure-free and ASM-free have higher FSIQ gains. Further research is needed to evaluate individual changes after specific surgery types and their long-term effects.
JOURNAL OF NEUROLOGY
(2023)
Article
Pediatrics
Leonie Grosse, Julian F. Schnabel, Corinna Boerner-Schroeder, Malina A. Spaeh, Anne C. Meuche, Nico Sollmann, Ute Breuer, Birgit Warken, Matthias Hoesl, Florian Heinen, Steffen Berweck, Sebastian A. Schroeder, Michaela V. Bonfert
Summary: This study demonstrates that functional repetitive neuromuscular magnetic stimulation (frNMS) is a safe and well-accepted neuromodulatory approach that could improve the quality of life, especially in regard to activity and participation, of children and adolescents with bilateral spastic cerebral palsy (BSCP).
Article
Pediatrics
Leonie Grosse, Anne C. Meuche, Barbara Parzefall, Corinna Boerner, Julian F. Schnabel, Malina A. Spaeh, Pia Klug, Nico Sollmann, Luisa Klich, Matthias Hoesl, Florian Heinen, Steffen Berweck, Sebastian A. Schroeder, Michaela V. Bonfert
Summary: Non-invasive neurostimulation combined with personalized task-specific physical exercises can improve motor performance in patients with upper motor neuron syndrome. This pilot study demonstrated the feasibility, safety, and practicability of this approach, as well as high satisfaction among patients. The results also showed meaningful benefits on an individual level, supporting further investigation of this intervention.