Article
Gastroenterology & Hepatology
Ferdinando D'Amico, David T. Rubin, Paulo Gustavo Kotze, Fernando Magro, Britta Siegmund, Taku Kobayashi, Pablo A. Olivera, Peter Bossuyt, Lieven Pouillon, Edouard Louis, Eugeni Domenech, Subrata Ghosh, Silvio Danese, Laurent Peyrin-Biroulet
Summary: Consistency in FC measurement is crucial for the treatment of IBD patients, requiring standardization of measurement methods and result interpretation; quantitative tests should be preferred for measuring FC, with the same method used whenever possible and factors influencing FC levels taken into account.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Medicine, General & Internal
Anastasia Katsoula, Georgios Axiaris, Afroditi Mpitouli, Maria Palatianou, Angeliki Christidou, Nikolaos Dimitriadis, Andreas Nakos, Ploutarchos Pastras, Panagiotis Kourkoulis, Pantelis Karatzas, Miltiadis Moutzoukis, Charalampos Zlatinoudis, Athanasios Philippidis, Anastasia Kourikou, Georgios Kokkotis, Antonios Gklavas, Angeliki Machaira, Aikaterini Mantaka, Persefoni Talimtzi, Evaggelia Anagnostopoulou, Ioannis E. Koutroubakis, Ioannis Papaconstantinou, Georgios Bamias, Spilios Manolakopoulos, Nicoletta Mathou, Konstantina Paraskeva, Andreas Protopappas, Eftychia Tsironi, Konstantinos H. H. Katsanos, Dimitrios K. K. Christodoulou, Georgios Papatheodoridis, Georgios Michalopoulos, Georgios Theocharis, Christos Triantos, Ioannis Pachiadakis, Konstantinos Soufleris, Nikolaos Viazis, Gerassimos J. Mantzaris, Georgios Tribonias, Maria Tzouvala, Angeliki Theodoropoulou, Konstantinos Karmiris, Evanthia Zampeli, Spyridon Michopoulos, Anna-Bettina Haidich, Olga Giouleme
Summary: The aim of this study was to validate the content of IBD-Disk in a Greek cohort of IBD patients. The results showed good correlation and consistency between the scores of IBD-Disk and IBD-DI at baseline and follow-up. Female gender and extraintestinal manifestations were significantly associated with a higher IBD-Disk total score. Therefore, the Greek version of IBD-Disk was proven to be a reliable and valid tool for assessing IBD-related disability.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Fabio Salvatore Macaluso, Giuseppina Liguori, Massimo Galli
Summary: Vaccination is crucial in managing patients with inflammatory bowel disease (IBD), yet vaccination rates are low due to lack of awareness among healthcare providers and patients. Current evidence-based recommendations for vaccines and prevention of infectious diseases in IBD patients should be widely promoted and implemented.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Nutrition & Dietetics
Marlijne C. G. de Graaf, Corinne E. G. M. Spooren, Evelien M. B. Hendrix, Martine A. M. Hesselink, Edith J. M. Feskens, Agnieszka Smolinska, Daniel Keszthelyi, Marieke J. Pierik, Zlatan Mujagic, Daisy M. A. E. Jonkers
Summary: The study found that diet quality was lower in patients with IBD and IBS, and was associated with intestinal inflammation and gastrointestinal symptoms to varying degrees.
Article
Infectious Diseases
Puo-Hsien Le, Cheng-Tang Chiu, Pai-Jui Yeh, Yu-Bin Pan, Cheng-Hsun Chiu
Summary: This study retrospectively evaluated the role of Clostridium innocuum (CI) infection in patients with inflammatory bowel disease (IBD). The results showed that CI infection may lead to poorer clinical remission in ulcerative colitis, which should be considered in the treatment approach.
JOURNAL OF INFECTION
(2022)
Article
Pediatrics
Amy A. Howk, Savannah R. Smith, Karunesh Polireddy, Cary G. Sauer, Subra Kugathasan, Julie Glasson, Alfred Chahine
Summary: This retrospective cohort study assessed the correlation between preoperative perioperative nutrition score (PONS) and postoperative outcomes in pediatric inflammatory bowel disease (IBD) patients. The results showed that PONS positive patients had a higher risk of postoperative infections, longer hospital stays, and more readmissions. This highlights the high prevalence of malnutrition in pediatric IBD patients and the need for standardized nutritional evaluation to improve preoperative nutritional status and postoperative outcomes.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Medicine, General & Internal
Katarzyna Bak-Drabik, Michalina Malik, Karolina Gwozdziewicz, Anna Jarzumbek, Helena Krakowczyk, Monika Glowinkowska, Piotr Adamczyk
Summary: The aim of this study was to assess pulmonary function in children with inflammatory bowel disease (IBD). Differences in spirometric and oscillometry parameters were observed between the IBD group and the control group. However, there was no correlation between pulmonary function abnormalities and disease activity or immunosuppressive therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Lorenzo Norsa, Roberto Berni Canani, Remi Duclaux-Loras, Emeline Bequet, Jutta Koeglmeier, Richard K. Russell, Holm H. Uhlig, Simon Travis, Jennifer Hollis, Sibylle Koletzko, Giusi Grimaldi, Giuseppe Castaldo, Astor Rodrigues, Jaques Deflandre, Lukasz Dembinski, Neil Shah, Peter Heinz-Erian, Andreas Janecke, Saara Leskinen, Satu Wedenoja, Ritva Koskela, Alain Lachaux, Kaija-Leena Kolho, Frank M. Ruemmele
Summary: A significant proportion of patients with Congenital Chloride Diarrhoea develop Inflammatory Bowel Disease, which may require surgery for treatment failure or colon cancer.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Tenghui Zhang, Yi Xu, Yao Yao, Lingling Jin, Haoxin Liu, Yan Zhou, Lili Gu, Qing Ji, Weiming Zhu, Jianfeng Gong
Summary: The study investigated the effectiveness of perioperative dexamethasone in reducing postoperative ileus in patients undergoing elective surgery for inflammatory bowel disease (IBD). The results showed that a single, intravenous 8-mg dose of dexamethasone significantly reduced the incidence of prolonged postoperative ileus, decreased postoperative pain intensity, and shortened postoperative length of stay for IBD patients.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Environmental Sciences
Oliwia Zakerska-Banaszak, Liliana Lykowska-Szuber, Michal Walczak, Joanna Zuraszek, Aleksandra Zielinska, Marzena Skrzypczak-Zielinska
Summary: The effectiveness of thiopurine drugs in inflammatory bowel disease (IBD) has been confirmed for more than 50 years. Despite controversies over their cytotoxic properties and adverse effects, thiopurines are still widely used for maintaining remission in Crohn's disease and ulcerative colitis. Further research is needed to explore the modulation of thiopurine action in combination therapy and their interaction with the gut microbiota.
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Edyta Maria Tulewicz-Marti, Konrad Lewandowski, Grazyna Rydzewska
Summary: Bone mineral alterations are common in patients with inflammatory bowel disease (IBD), especially in those with Crohn's disease (CD). This may be due to poor absorption, making CD patients vulnerable to changes in bone mineralization. Vitamin D supplementation is crucial, especially when taking corticosteroids.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Lev Lichtenstein, Benjamin Koslowsky, Ami Ben Ya'acov, Irit Avni-Biron, Baruch Ovadia, Ofer Ben-Bassat, Timna Naftali, Uri Kopylov, Yael Haberman, Hagar Eran, Rami Eliakim, Adi Lahat-Zok, Ayal Hirsch, Eran Zittan, Nitsan Maharshak, Matti Waterman, Eran Israeli, Idan Goren, Jacob Ollech, Henit Yanai, Bella Ungar, Benjamin Avidan, Dana Ben Hur, Bernardo Melamud, Ori Segol, Zippora Shalem, Iris Dotan, Selwyn Odes, Shomron Ben-Horin, Yf'at Snir, Yael Milgrom, Efrat Broide, Eran Goldin, Shmuel Delgado, Yulia Ron, Nathaniel Cohen, Eran Maoz, Maya Zborovsky, Safwat Odeh, Naim Abu Freha, Eyal Shachar, Yehuda Chowers, Tal Engel, Hila Reiss-Mintz, Arie Segal, Adar Zinger, Ariella Bar-Gil Shitrit
Summary: The use of immunosuppressive therapy in IBD patients does not worsen the severity of COVID-19, and in fact, patients receiving biologics have milder infection course. Treatment can be postponed until recovery from COVID-19.
Review
Gastroenterology & Hepatology
Jeremy Lagrange, Patrick Lacolley, Denis Wahl, Laurent Peyrin-Biroulet, Veronique Regnault
Summary: Patients with inflammatory bowel diseases (IBD) have an increased risk of thrombosis, with reasons including increased platelet reactivity and continuous coagulation activation. Additionally, fibrinogen levels are increased and fibrin clots are denser in these patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Joana Franco Lacerda, Ana Catarina Lagos, Elisabete Carolino, Ana Santos Silva-Herdade, Manuel Silva, Catarina Sousa Guerreiro
Summary: The study aimed to evaluate the effect of food components on intestinal permeability and inflammatory markers in individuals with IBD. While the specific impact of food components was inconclusive, there was a trend observed in the reduction of inflammatory parameters and gastrointestinal symptom prevalence. More controlled intervention studies with diet plans including potentially beneficial food components for intestinal barrier integrity are warranted.