Controlling HIV-1: Non-Coding RNA Gene Therapy Approaches to a Functional Cure

Promoter Targeting RNAs: Unexpected Contributors to the Control of HIV-1 Transcription

(2015) Kazuo Suzuki et al.   Molecular Therapy-Nucleic Acids

RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice

(2015) Saki Shimizu et al.   Molecular Therapy-Nucleic Acids

Novel RNA Duplex Locks HIV-1 in a Latent State via Chromatin-mediated Transcriptional Silencing

(2015) Chantelle Ahlenstiel et al.   Molecular Therapy-Nucleic Acids

The rise of regulatory RNA

(2014) Kevin V. Morris et al.   NATURE REVIEWS GENETICS

More on Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32/Delta32 Mutation

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies

(2014) Angela Battistini et al.   Viruses-Basel

Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

(2014) Richard Brad Jones et al.   PLoS Pathogens

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

(2014) Datsen George Wei et al.   PLoS Pathogens

Preclinical safety and efficacy of an anti–HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor

(2014) Orit Wolstein et al.   Molecular Therapy-Methods & Clinical Development

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA

(2013) A. Singh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

CCR5 as a Natural and Modulated Target for Inhibition of HIV

(2013) Bryan Burke et al.   Viruses-Basel

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

Serious Non-AIDS events: Immunopathogenesis and interventional strategies

(2013) Denise C Hsu et al.   AIDS Research and Therapy

Promoter Targeting shRNA Suppresses HIV-1 Infection In vivo Through Transcriptional Gene Silencing

(2013) Kazuo Suzuki et al.   Molecular Therapy-Nucleic Acids

Preclinical In Vivo Evaluation of the Safety of a Multi-shRNA-based Gene Therapy Against HIV-1

(2013) Mireille Centlivre et al.   Molecular Therapy-Nucleic Acids

Activation of Latent HIV-1 Expression by Protein Kinase C Agonists. A Novel Therapeutic Approach to Eradicate HIV-1 Reservoirs

(2012) Gonzalo Sanchez-Duffhues et al.   CURRENT DRUG TARGETS

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Impact of treatment with raltegravir during primary or chronic HIV infection on RNA decay characteristics and the HIV viral reservoir

(2011) Kersten K. Koelsch et al.   AIDS

Non-coding RNAs as regulators of gene expression and epigenetics

(2011) M. U. Kaikkonen et al.   CARDIOVASCULAR RESEARCH

A Randomized, Placebo-Controlled Trial of Abacavir Intensification in HIV-1–Infected Adults With Virologic Suppression on a Protease Inhibitor–Containing Regimen

(2011) Scott M. Hammer et al.   HIV CLINICAL TRIALS

HDAC inhibitors in HIV

(2011) Fiona Wightman et al.   IMMUNOLOGY AND CELL BIOLOGY

Editorial: Hijacking the IL-7/IL-7R system in HIV infection

(2011) M. Paiardini   JOURNAL OF LEUKOCYTE BIOLOGY

The functional role of long non-coding RNA in human carcinomas

(2011) Ewan A Gibb et al.   Molecular Cancer

Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells

(2011) Chantelle L. Ahlenstiel et al.   NUCLEIC ACIDS RESEARCH

Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific

(2011) Kazuo Suzuki et al.   RNA Biology

Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy

(2010) Steven A Yukl et al.   AIDS

Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation

(2010) K. Allers et al.   BLOOD

Short‐Course Raltegravir Intensification Does Not Reduce Persistent Low‐Level Viremia in Patients with HIV‐1 Suppression during Receipt of Combination Antiretroviral Therapy

(2010) D. McMahon et al.   CLINICAL INFECTIOUS DISEASES

Antiretroviral Intensification and Valproic Acid Lack Sustained Effect on Residual HIV-1 Viremia or Resting CD4+ Cell Infection

(2010) Nancie M. Archin et al.   PLoS One

RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

(2010) D. L. DiGiusto et al.   Science Translational Medicine

The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-Infected Patients on Antiretroviral Therapy: A Randomized Controlled Trial

(2010) Rajesh T. Gandhi et al.   PLOS MEDICINE

Short Communication: Activation of Latent HIV Type 1 Gene Expression by Suberoylanilide Hydroxamic Acid (SAHA), an HDAC Inhibitor Approved for Use to Treat Cutaneous T Cell Lymphoma

(2009) Leonard C. Edelstein et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Potent Activity of a Nucleoside Reverse Transcriptase Inhibitor, 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine, against Human Immunodeficiency Virus Type 1 Infection in a Model Using Human Peripheral Blood Mononuclear Cell-Transplanted NOD/SCID Janus Kinase 3 Knockout Mice

(2009) S. Hattori et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

(2009) S. Shimizu et al.   BLOOD

Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in cutaneous T cell lymphoma

(2009) Ulrike Heider et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells

(2009) Xavier Contreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

No Evidence for Decay of the Latent Reservoir in HIV‐1–Infected Patients Receiving Intensive Enfuvirtide‐Containing Antiretroviral Therapy

(2009) Rajesh T. Gandhi et al.   JOURNAL OF INFECTIOUS DISEASES

Retroviral delivery of promoter-targeted shRNA induces long-term silencing of HIV-1 transcription

(2009) Makoto Yamagishi et al.   MICROBES AND INFECTION

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells

(2009) Ronald T Mitsuyasu et al.   NATURE MEDICINE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells

(2009) Peter G. Hawkins et al.   NUCLEIC ACIDS RESEARCH

Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy

(2009) J. B. Dinoso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells

(2008) Seiji Okada et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Closed Chromatin Architecture Is Induced by an RNA Duplex Targeting the HIV-1 Promoter Region

(2008) Kazuo Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noncoding RNA in development

(2008) Paulo P. Amaral et al.   MAMMALIAN GENOME

Promoter-targeted siRNAs Induce Gene Silencing of Simian Immunodeficiency Virus (SIV) Infection In Vitro

(2008) Heidi GW Lim et al.   MOLECULAR THERAPY

Lentiviral Vector Design for Multiple shRNA Expression and Durable HIV-1 Inhibition

(2008) Olivier ter Brake et al.   MOLECULAR THERAPY

Small non-coding RNAs in animal development

(2008) Giovanni Stefani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA