Article
Ophthalmology
Jing Na He, Tsz Kin Ng, Shi Yao Lu, Pancy Oi Sin Tam, Poemen P. Chan, Clement C. Tham, Chi Pui Pang, Li Jia Chen, Wai Kit Chu
Summary: This study investigated the association between the ANGPT2 gene and primary open-angle glaucoma (POAG) in the Chinese population. The results showed that the SNP rs11775442 was associated with normal tension glaucoma (NTG) in the Hong Kong cohort, while rs13269021 was associated with NTG in males in the Shantou cohort. Further studies are needed to confirm the association between the ANGPT2 locus and NTG in Chinese males.
Article
Multidisciplinary Sciences
Younhea Jung, Kyungdo Han, Kyoung Ohn, Da Ran Kim, Jung Moon
Summary: The study found that diabetes status is associated with an increased risk of glaucoma development in postmenopausal women, a relationship that remained consistent even after subgroup analyses.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Ruiqi Pang, Jieting Peng, Kai Cao, Yunxiao Sun, Xue-Ting Pei, Diya Yang, Zhong-Lin Lu, Ningli Wang
Summary: This study aimed to evaluate the association between contrast sensitivity function (CSF) and glaucomatous structural damage in primary open-angle glaucoma (POAG). The researchers found that full spatial frequency contrast sensitivity impairment, especially at low spatial frequencies, is a characteristic change in POAG. They also concluded that contrast sensitivity can be a potential functional endpoint for measuring the severity of glaucoma.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Geriatrics & Gerontology
Yichao Qiu, Jian Yu, Li Tang, Jun Ren, Mingxi Shao, Shengjie Li, Yunxiao Song, Wenjun Cao, Xinghuai Sun
Summary: The study revealed that lower E2 levels were significantly associated with POAG in female patients, especially in premenopausal subjects; in addition, PROG, LH, FSH, and TESTO might also play a role in the pathogenesis of POAG.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Yi Lin, Xiaomin Zhu, Wangdu Luo, Bingcai Jiang, Qianyi Lin, Min Tang, Xiangji Li, Lin Xie
Summary: Using a two-sample Mendelian randomization study, this research investigates the causal relationship between obesity and primary open-angle glaucoma (POAG). The results show that there is a positive effect of body mass index (BMI), waist circumference, and hip circumference on the risk of POAG. The findings suggest that obesity may increase the risk of POAG, providing guidance for its prevention and treatment.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Liyuan Wang, Tianyang Yu, Xiaohui Zhang, Xiaojun Cai, He Sun
Summary: This study analyzed and studied the transcription profile of POAG tissue samples, identified multiple differentially expressed genes associated with POAG, and constructed a competing RNA regulatory network. Additionally, the study revealed the immune desert status of AH tissue in POAG patients and a potential biomarker for POAG.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Ophthalmology
Elnaz Ezzati Amini, Yousef Moradi
Summary: This systematic review and meta-analysis provide evidence for the association between Helicobacter pylori infection and Primary Open-Angle Glaucoma. Through a comprehensive search and evaluation of relevant studies, the authors identified eligible research. The results show a significant correlation between H. pylori infection and Primary Open-Angle Glaucoma.
Article
Ophthalmology
Eunoo Bak, Young Kook Kim, Ahnul Ha, Young Soo Han, Jin-Soo Kim, Jinho Lee, Yong Woo Kim, Sung Uk Baek, Jin Wook Jeoung, Ki Ho Park
Summary: In patients with moderate-stage primary open-angle glaucoma, differences in intereye visual field defect (VFD) asymmetry were associated with varying rates of progression, with unilateral VFD eyes showing the fastest progression. Greater intereye MD asymmetry index and intereye hemifield visual-sensitivity asymmetry index were significant risk factors for glaucoma progression.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Jon Klokk Slettedal, Leiv Sandvik, Amund Ringvold
Summary: The study investigated the relationship between lifespan and cause of death among patients with open-angle glaucoma and pseudoexfoliation syndrome. It found that patients with primary open-angle glaucoma had a reduced lifespan due to neoplasia and cardiovascular disease, while those with pseudoexfoliation syndrome did not show such reductions. This highlights the differences between primary open-angle glaucoma and pseudoexfoliation glaucoma as distinct disease entities.
Review
Genetics & Heredity
Grace Kuang, Rebecca Salowe, Joan O'Brien
Summary: Both AD and POAG are neurodegenerative diseases with complex pathophysiologies, and there are similarities between them at various aspects. Researchers have shown increasing interest in exploring the underlying connections between AD and POAG due to their resemblance in neurodegenerative processes. By studying a multitude of genes in each condition, with overlapping genes of interest, a better understanding of genetic factors can be achieved to identify relationships and common pathways of the diseases. Establishing a genetic connection between AD and POAG could lead to the development of targeted strategies for both diseases, benefitting researchers, clinicians, and patients. This paper aims to summarize the genetic associations between AD and POAG, discuss common mechanisms, explore potential applications, and provide a review.
Article
Health Care Sciences & Services
Wei-Yang Lu, Ci-Wen Luo, Shyan-Tarng Chen, Yu-Hsiang Kuan, Shun-Fa Yang, Han-Yin Sun
Summary: The study found that comorbidities such as hypotension, sleep disturbances, peptic ulcers, and allergic rhinitis are more highly associated with NTG than POAG.
Review
Biochemistry & Molecular Biology
Saray Tabak, Sofia Schreiber-Avissar, Elie Beit-Yannai
Summary: Reactive oxygen species (ROS) play a key role in the pathogenesis of primary open-angle glaucoma (POAG), damaging trabecular meshwork cells and inducing apoptosis of retinal ganglion cells. Certain microRNAs (miRNAs) have been identified as potential therapeutic targets for regulating inflammatory and degenerative processes in POAG patients, offering promise for lowering or preventing oxidative stress injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Jian Wu, Caixia Lin, Chenlong Yang, Lijie Pan, Hongyi Liu, Sirui Zhu, Shuwen Wei, Xu Jia, Qi Zhang, Ziyu Yu, Xiaofang Zhao, Weihai Liu, Yehong Zhuo, Ningli Wang
Summary: The study aims to identify novel biomarkers and potential therapeutic targets for primary open-angle glaucoma (POAG). Through gene expression analysis and functional enrichment analysis, it was found that POAG is associated with immune-related pathways, oxidative stress, and endoplasmic reticulum stress. FN1, GPX3, and VAV3 were confirmed as key genes in POAG through single-cell validation. These biomarkers may serve as potential therapeutic targets for POAG, and further research is needed to uncover the mechanisms underlying the expression variations of these genes in POAG.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Medicine, General & Internal
Antonio Maria Fea, Martina Menchini, Alessandro Rossi, Chiara Posarelli, Lorenza Malinverni, Michele Figus
Summary: The study investigated the efficacy and safety of the XEN63 implant in open-angle glaucoma patients, showing significant reduction in intraocular pressure and the need for hypotensive medications, with good short-term safety profile.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Alexandru Lavric, Valentin Popa, Hidenori Takahashi, Rossen M. Hazarbassanov, Siamak Yousefi
Summary: This study aimed to identify the association between corneal parameters and visual field damage using machine learning. Results showed that corneal parameters can predict visual functional loss caused by glaucoma, providing insights for glaucoma prediction.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Mohammed S. Hamid, Autumn Valicevic, Brianne Brenneman, Leslie M. Niziol, Joshua D. Stein, Paula Anne Newman-Casey
Summary: The study aimed to assess the feasibility of using automated text parsing to screen physician notes in the electronic health record for identifying glaucoma patients with poor medication compliance. It was found that text parsing could identify a larger proportion of patients who self-reported poor medication adherence compared to automated EHR extraction alone, but was limited by the small number of patients identified. Optimizing the documentation of medication adherence is necessary to maximize the utility of this automated approach in identifying medication noncompliance.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Swati Upadhyaya, Anushri Agarwal, Venkatesh Rengaraj, Kavitha Srinivasan, Paula Anne Newman Casey, Emily Schehlein
Summary: The study aimed to evaluate the sensitivity and specificity of a portable non-mydriatic fundus camera for assessing glaucoma. The results showed high sensitivity and specificity of the camera for diagnosing glaucoma remotely, suggesting it as an effective tool for community outreach programs.
Article
Ophthalmology
Paula Anne Newman-Casey, Lindsey De Lott, Juno Cho, Dena Ballouz, Lyna Azzouz, Sahal Saleh, Maria A. Woodward
Summary: The study evaluated the initial utilization, safety, and patient experience with tele-ophthalmology during the COVID-19 pandemic, finding that when appropriately triaged, tele-ophthalmology can safely reduce the volume of in-person visits and promote social distancing. A hybrid model of eye care combining ancillary testing with video or phone visits is seen as a promising model of care.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Angela R. Elam, David Sidhom, Peter Ugoh, Chris A. Andrews, Lindsey B. De Lott, Maria A. Woodward, Paul P. Lee, Paula Anne Newman-Casey
Summary: Disparities were found in how patients accessed eye care during the COVID-19 pandemic, with older patients more likely to receive in-person care and non-White patients less likely to access care. There were significant variations in neighborhood median household income by race, with Black individuals having the lowest estimated mean income.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Carrie A. Karvonen-Gutierrez, Michelle M. Hood, Sayoko Moroi, David C. Musch, Navasuja Kumar, Sarah Dougherty Wood
Summary: The objective of this study was to measure the burden of vision impairment and ocular conditions in late-life women. The study found that black women and those with greater economic strain or less education had a higher prevalence of vision impairment. However, most participants were unaware of their ocular diagnosis. This highlights the need for increased vision services and access to optimal vision correction to reduce disparities across sociodemographic groups.
SEMINARS IN OPHTHALMOLOGY
(2022)
Article
Genetics & Heredity
Lilia T. Popova, Rebhi O. Abuzaitoun, Maria Fernanda Abalem, Chris A. Andrews, Alison M. Mondul, Gabrielle D. Lacy, David C. Musch, K. Thiran Jayasundera
Summary: The number of symptoms, rather than the duration of symptoms, is an independent risk factor for vision-related anxiety in patients with Inherited Retinal Diseases. Patients with more symptoms are at higher risk for vision-related anxiety. Having symptoms for longer than 25 years may reduce this anxiety.
OPHTHALMIC GENETICS
(2023)
Article
Ophthalmology
Olivia J. Killeen, Leslie M. Niziol, Juno Cho, Michele Heisler, Ken Resnicow, Deborah Darnley-Fisch, David C. Musch, Paul P. Lee, Paula Anne Newman-Casey
Summary: An evaluation was conducted to assess the effectiveness of the Support, Educate, Empower (SEE) glaucoma coaching program in improving medication adherence among poorly adherent patients with glaucoma. The study found that medication adherence decreased in the year after the program ended but remained higher than baseline adherence. The findings suggest that intermittent reinforcement sessions might be necessary to maintain long-term medication adherence.
OPHTHALMOLOGY GLAUCOMA
(2023)
Article
Medicine, Research & Experimental
Paula Anne Newman-Casey, Ken Resnicow, Suzanne Winter, Leslie M. Niziol, Deborah Darnley-Fisch, Nauman Imami, Phalatha McHaney-Conner, David C. Musch, Jamie Mitchell, Michele Heisler
Summary: The purpose of this study is to improve glaucoma medication adherence among those with medically treated glaucoma and poor self-reported adherence using the Support, Educate, Empower personalized coaching program. The study is a two-site randomized controlled trial enrolling 230 participants with poor self-reported glaucoma medication adherence. The primary outcome is the proportion of prescribed doses taken on schedule during the 6-month period.
Article
Ophthalmology
Jay K. Rathinavelu, Kelly W. Muir, Nadya T. Majette, Sandra Woolson, Maren K. Olsen, Kathryn Flaharty, Paula Anne Newman-Casey, Miriam Kirshner
Summary: This study used qualitative analysis of structured interviews to compare barriers and facilitators of medication adherence among participants in the intervention group. The results showed that a difficult schedule was the most common barrier for low adherence, while the use of smart bottle was the most cited facilitator for high adherence.
OPHTHALMOLOGY GLAUCOMA
(2023)
Article
Ophthalmology
Paula Anne Newman-Casey, Leslie M. Niziol, Angela R. Elam, Amanda K. Bicket, Olivia Killeen, Denise John, Sarah Dougherty Wood, David C. Musch, Jason Zhang, Leroy Johnson, Martha Kershaw, Maria A. Woodward
Summary: The MI-SIGHT program aims to engage people at high risk of glaucoma and assesses first-year outcomes and costs. Telemedicine eye disease detection programs effectively identify high rates of pathology in low-income community clinics.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
David J. Miller, Leslie M. Niziol, Angela R. Elam, Michele Heisler, Paul P. Lee, Kenneth Resnicow, David C. Musch, Deborah Darnley-Fisch, Jamie Mitchell, Paula Anne Newman-Casey
Summary: The purpose of this study was to investigate whether demographic, clinical, or psychosocial factors moderate the change in medication adherence in the SEE program for patients with glaucoma. The results showed that lower income, fewer glaucoma medications, and increased glaucoma-related distress were associated with greater improvements in medication adherence through the SEE program. These findings indicate that the SEE program can enhance glaucoma self-management even among patients with social and psychological barriers to medication adherence.
OPHTHALMOLOGY GLAUCOMA
(2022)
Article
Ophthalmology
Juno Cho, Leslie M. Niziol, Paul P. Lee, Michele Heisler, Ken Resnicow, David C. Musch, Paula Anne Newman-Casey
Summary: This study aimed to assess the accuracy of 5 subjective self-assessment tools and pharmacy refill data in predicting medication nonadherence among glaucoma patients. The results showed that a single-item adherence question demonstrated the highest accuracy and sensitivity in predicting nonadherence.
OPHTHALMOLOGY GLAUCOMA
(2022)