Article
Medicine, General & Internal
Michelle Prasuhn, Nathalie Rommel, Vinodh Kakkassery, Salvatore Grisanti, Mahdy Ranjbar, Felix Rommel
Summary: A 76-year-old male patient presented with painless bilateral vision loss, and was diagnosed with a rare case of BDUMP caused by lung carcinoma. The ophthalmological diagnosis led to the discovery of an underlying malignant disease in the patient. Multiple dermal and mucosal lesions were uncommonly detected and histopathologically analyzed.
Article
Ophthalmology
Fangyu Zhao, Liying Hu, Ruru Guo, Zhiqing Li, Jian Ji, Wei Liu
Summary: This study reports a BDUMP patient who initially presented with glaucoma. The patient was diagnosed with BDUMP after a series of auxiliary examinations and subsequently underwent cataract surgery. The patient's visual acuity improved after surgery, but declined again at the last follow-up.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Medicine, General & Internal
Nianting Tong, Liangyu Wang, Nan Wang, Zhanyu Zhou
Summary: BDUMP is a rare intraocular syndrome associated with underlying malignancies. In this case, treatment for the primary malignancy resulted in the absorption of subretinal fluid and significant reduction in ciliary body and choroid thickness.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
David Rafei-Shamsabadi, Johanna Schneider, Laura Trefzer, Kristin Technau-Hafsi, Frank Meiss, Thomas Ness
Summary: This case study highlights a patient with BDUMP exhibiting widespread skin and mucosal involvement initially mimicking multifocal melanoma in situ, showing excellent response to plasmapheresis. The improvement of mucocutaneous lesions, which has not been well-documented before, persists for more than a year post-treatment, indicating the beneficial effect of plasmapheresis. In-vitro data supports the hypothesis that plasma exchange eliminates a CMEP factor from patient blood, leading to decreased melanocyte proliferation, both in-vitro and in-vivo clinically. The study emphasizes the importance of considering BDUMP mimicking multifocal melanoma in situ in patients with rapidly evolving melanocytic skin and/or mucosal lesions, requiring a thorough diagnostic workup before establishing a definitive diagnosis and therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Manabu Miyata, Sotaro Ooto, Masayuki Hata, Ayako Takahashi, Akitaka Tsujikawa
Summary: Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare retinal exudative disease with no established treatment standard. In 3 cases of BDUMP, combined anti-VEGF therapy and photodynamic therapy may be an effective option for treatment-resistant exudate. Early diagnosis and prompt administration of combination therapy are crucial for better outcomes.
Letter
Ophthalmology
Manu Sharma, Sonam Yangzes, Simar Rajan Singh, Mohit Dogra
Summary: Bilateral diffuse uveal melanocytic proliferation (B-DUMP) is a complication that may be associated with known malignancies, but is more commonly seen in patients without a history of cancer. Central nervous system meningiomas can cause B-DUMP, and treatment of malignancies may lead to partial resolution of posterior segment manifestations of B-DUMP.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Dermatology
Cristian Navarrete-Dechent, Jilliana Monnier, Nadeem G. Marghoob, Konstantinos Liopyris, Klaus J. Busam, Jasmine H. Francis, Ashfaq A. Marghoob
Summary: Bilateral diffuse uveal melanocytic proliferation (B-DUMP) is a rare paraneoplastic syndrome presenting with bilateral visual loss, often associated with lung cancer in males and uro-gynaecological cancer in females. Cutaneous involvement with proliferation of dermal melanocytes may also be seen in these patients.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2021)
Article
Ophthalmology
Maria Valeria da Silva, Kalpana Rose, Hatem Krema
Summary: This article reports the first case of pigment-induced glaucoma in a patient with bilateral diffuse uveal melanocytic proliferation (BDUMP) syndrome. Despite treatment, the patient's condition worsened, leading to bilateral glaucoma.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Woohyun Chung, So Hee Kim, Youna Choi, Seung Kwon Choi, Jae Jung Lee, Sung Who Park, Ik Soo Byon
Summary: This report describes a case of bilateral diffuse uveal melanocytic proliferation induced by stomach adenocarcinoma, characterized by multiple pigmented subretinal exudates and exudative macular retinal detachment. A systemic evaluation is necessary for such patients.
JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY
(2022)
Review
Oncology
Thomas A. A. Weppelmann, Sabrina Khalil, Nabeel Zafrullah, Sabah Amir, Curtis E. E. Margo
Summary: This article reviews the critical features of bilateral diffuse uveal melanocytic proliferation and autoimmune retinopathies, as well as the recent advancements in treatment. The lack of understanding in pathogenesis and the challenges in evaluating clinical effectiveness are highlighted. The authors suggest establishing a consensus algorithm to improve clinical communications and trials.
Article
Ophthalmology
Lauren C. Kiryakoza, J. Daniel Diaz, Joshua Priluck, Janet Davis, Nicolas A. Yannuzzi
Summary: Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic syndrome that presents with gradual vision loss. This case report describes a 73-year-old man with metastatic urothelial carcinoma who developed visual symptoms. Ophthalmic examination revealed fluid accumulation, subretinal deposits, and irregular hyperpigmentation, consistent with the diagnosis of BDUMP. Despite undergoing multiple plasmapheresis sessions, the patient did not experience sustained clinical improvement.
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2022)
Article
Cell Biology
Haihan Zhang, Yueming Liu, Kai Zhang, Shiqi Hui, Yu Feng, Jingting Luo, Yang Li, Wenbin Wei
Summary: The study investigated the correlation between iris color and prevalence of UM in the Chinese population using deep learning methods, obtaining satisfactory segmentation results. The iris color spectrum was highly consistent with expert ratings, but showed no significant correlation with UM incidence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Etti Katzburg, Dinah Zur, Orit Gutfeld, Ilya Kirgner, Zohar Habot-Wilner
Summary: Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular syndrome driven by an IgG factor associated with an underlying malignancy. Prompt diagnosis and treatment are crucial due to the lack of established therapeutic strategies for this condition.
CASE REPORTS IN OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Hardeep Singh Mudhar, Bashar M. Bata, Hibba Quhill, Tatyana Milman, Sachin M. Salvi
Summary: Two patients with non-small cell lung carcinoma treated with pembrolizumab developed bilateral diffuse uveal melanocytic proliferation (BDUMP) with interesting histopathological features. The first patient developed a right ciliary body mass concurrently with BDUMP.
OCULAR ONCOLOGY AND PATHOLOGY
(2021)
Article
Medicine, General & Internal
Joanna Konopinska, Lukasz Lisowski, Zofia Mariak, Iwona Obuchowska
Summary: Iris cysts are mostly asymptomatic peripheral cysts that do not grow and do not require treatment in the long-term follow-up. The anatomical location of the cysts cannot differentiate them from solid tumors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Ophthalmology
Mohammad Hossein Jabbarpoor Bonyadi, Vahid Ownagh, Ehsan Rahimy, Masoud Soheilian
INTERNATIONAL OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Rahul N. Khurana, Ehsan Rahimy, W. Anthony Joseph, Namrata Saroj, Andrea Gibson, Robert Vitti, Alyson J. Berliner, Karen Chu, Yenchieh Cheng, David S. Boyer
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Rory Sayres, Ankur Taly, Ehsan Rahimy, Katy Blumer, David Coz, Naama Hammel, Jonathan Krause, Arunachalam Narayanaswamy, Zahra Rastegar, Derek Wu, Shawn Xu, Scott Barb, Anthony Joseph, Michael Shumski, Jesse Smith, Arjun B. Sood, Greg S. Corrado, Lily Peng, Dale R. Webster
Article
Ophthalmology
Ehsan Rahimy, Keith Baker, Desmond Thompson, Namrata Saroj
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2020)
Review
Ophthalmology
Baseer U. Ahmad, Judy E. Kim, Ehsan Rahimy
CURRENT OPINION IN OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Amer F. Alsoudi, Nadim Rayess, Suleman Khan, Euna Koo, Ehsan Rahimy
Summary: The majority of Instagram posts analyzed were made by patients, with a positive tone reflecting primarily on daily living activities and rehabilitation efforts. On the other hand, posts by ophthalmologists were mostly focused on colleague education. Retina specialists should consider providing more social media content directed toward patients, particularly regarding their rehabilitation course following retinal detachment repair.
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2021)
Article
Ophthalmology
Ahmad A. Aref, Ingrid U. Scott, Paul C. VanVeldhuisen, Jacquie King, Michael S. Ip, Barbara A. Blodi, Neal L. Oden
Summary: This study investigated IOP related events in participants receiving intravitreal anti-VEGF injections for up to 60 months, with a small percentage experiencing elevated IOP over baseline.
JAMA OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Adrian Au, Jooyeon Jung, Mark W. Johnson, Caroline Baumal, Mark J. Daily, Julius E. S. Gomolin, R. Rishi Gupta, Ehsan Rahimy, Lihteh Wu, Srinivas R. Sadda, David Sarraf
Summary: This study summarizes all reported cases of Henle fiber layer (HFL) hemorrhage in patients with macular telangiectasia type 2 (MacTel2) in the absence of subretinal neovascularization (SRNV), and proposes a mechanism for the right-sided predominance of this unique presentation.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ingrid U. Scott, Neal L. Oden, Paul C. VanVeldhuisen, Michael S. Ip, Barbara A. Blodi
Summary: This study compared the baseline characteristics, treatment burden, and outcomes of macular edema in HRVO and CRVO patients. The study found a higher proportion of Black participants in HRVO group compared to CRVO group, and no significant differences in the frequency of macular edema treatments between the two groups. Although CRVO eyes had worse visual acuity and more macular edema compared to HRVO eyes at baseline, the magnitude of VALS improvement, central retinal thickness response to anti-VEGF therapy, and treatment burden were similar between the groups.
JAMA OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Russel H. Dinh, Edmund Tsui, Matthew S. Wieder, Alexander Barash, Michael M. Park, Ehsan Rahimy, Prithvi Mruthyunjaya, Louise J. Lu, Suzanne M. Michalak, Rohan J. Shah, David Sierpina, Timothy W. Winter, Ryan A. Shields, Eduardo Uchiyama, Gregory D. Lee, Rahul Komati, Eric Lee, Sundeep K. Kasi, Brian K. Do
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Hong-Uyen Hua, Nadim Rayess, Angela S. S. Li, Diana Do, Ehsan Rahimy
Summary: This study assessed the quality, accountability, readability, accessibility, and presence of Spanish translation in online material about macular degeneration. The top 5 websites from a Google search did not have better quality or readability compared to other websites. Improving quality, accountability, and readability can help improve patients' health literacy regarding macular degeneration.
JOURNAL OF VITREORETINAL DISEASES
(2022)
Meeting Abstract
Ophthalmology
M. Ali Ali Khan, Ehsan Rahimy, Allen C. Ho, Ryan Corley, Mark Gallivan, Daniel Jones, Ramiro Ribeiro, Theodore Leng, Nancy M. Holekamp
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Linus Amarikwa, Suzanne M. Michalak, Susan Caul, Prithvi Mruthyunjaya, Ehsan Rahimy
Summary: Vuity (pilocarpine HCL ophthalmic 1.25%) has been approved for treating presbyopia in October 2021. Previous case series reported vitreofoveal traction and retinal detachment after pilocarpine administration, but recent randomized control trials did not report such cases when evaluating the efficacy of Vuity. The authors present a case of vitreomacular traction observed immediately after the first administration of Vuity in a 65-year-old woman, review the literature, and discuss considerations for screening and managing patients starting Vuity. [Ophthalmic Surg Lasers Imaging Retina 2022; 53:410-411.]
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2022)
Article
Ophthalmology
Ismael Chehaibou, Jean-Pierre Hubschman, Sundeep Kasi, Daniel Su, Anthony Joseph, Pradeep Prasad, Ashkan M. Abbey, Alain Gaudric, Ramin Tadayoni, Ehsan Rahimy
Summary: This study investigates the clinical features and surgical outcomes of patients with spontaneous conversion of lamellar macular hole (LMH) to full-thickness macular hole (FTMH). Most FTMHs derived from LMH had a small diameter, showed epiretinal proliferation, and were associated with relatively poor surgical outcomes.
OPHTHALMOLOGY RETINA
(2021)
Article
Ophthalmology
Nadim Rayess, Angela S. Li, Diana Do, Ehsan Rahimy
OPHTHALMOLOGY RETINA
(2020)