Article
Nutrition & Dietetics
Chia-Ling Kuo, Ben Kirk, Meiruo Xiang, Luke C. C. Pilling, George A. A. Kuchel, Richard Kremer, Gustavo Duque
Summary: This study examined the relationship between vitamin D levels and leukocyte telomere length (LTL) in older participants. It found that low or extremely low vitamin D levels were associated with shorter LTL, as well as high vitamin D levels. However, these associations may be influenced by unmeasured confounders.
Article
Multidisciplinary Sciences
A. Yun, Shangli Shi, Shoujiang Sun, Yuanyuan Jing, Zili Li, Xiaoyan Zhang, Xiaolong Li, Fang Wu
Summary: In this study, we conducted a longitudinal analysis of telomerase activity and relative telomere length in different varieties of alfalfa. We found significant differences in telomerase activity and relative telomere length between plants of different ages and varieties. The relative telomere length is influenced by genetic variation and age, with age exerting a greater effect.
Review
Sport Sciences
Marlies Schellnegger, Alvin C. Lin, Niels Hammer, Lars-Peter Kamolz
Summary: Healthy life expectancy lags behind overall life expectancy, and increasing overall fitness through physical activity can attenuate the impact of aging. Telomere biology is a key factor in understanding the relationship between exercise and aging, but there is still uncertainty regarding the optimal intensity, duration, and type of physical activity.
SPORTS MEDICINE-OPEN
(2022)
Article
Medicine, General & Internal
Zhenfei Chi, Xuesong Bai, Zhe Zhang
Summary: This study used a two-sample Mendelian randomization analysis to investigate the association between aging and constipation using leukocyte telomere length (LTL) as a marker. The results showed that LTL does not necessarily indicate an increased likelihood of constipation.
FRONTIERS IN MEDICINE
(2023)
Article
Cell Biology
Hyuk-Joon Jeon, Minsung Kang, Jae-Sung Kim, Jeong Su Oh
Summary: The study found that telomeres in oocytes experience shortening during postovulatory aging, but overexpression of Translationally Controlled Tumor Protein (TCTP) can reverse this shortening by upregulating telomerase activity. TCTP prevents telomere attrition during postovulatory aging in mouse oocytes by increasing telomerase activity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Myung-Hoon Han, Eun-Hye Lee, Hyun-Hee Park, Seong Hye Choi, Seong-Ho Koh
Summary: This study found that early subjective depressive symptoms and cognitive complaints are associated with relatively shorter telomere length in relatively healthy elderly individuals. The study also found that interleukin-6 plays an important role in the relationship between telomere shortening and early subjective depressive symptoms and cognitive complaints.
Article
Medicine, General & Internal
Meric Coskun, Alev Eroglu Altinova, Afruz Babayeva, Aydin Tuncer Sel, Dilek Yapar, Mine Karaca, Mehmet Muhittin Yalcin, Mujde Akturk, Fusun Balos Toruner, Mehmet Ayhan Karakoc, Ilhan Yetkin
Summary: The study aimed to investigate the relationship between leukocyte telomere length (LTL) and serum neuregulin-4 levels and their association with disease activity, co-morbidities, and body fat distribution in female acromegaly patients. The results showed that there was no significant difference in LTL between acromegaly and control groups, but neuregulin-4 levels were significantly higher in acromegaly patients. There were no differences in LTL, T/S ratio, and neuregulin-4 levels between active and controlled acromegaly groups. Neuregulin-4 was positively correlated with fasting glucose, triglyceride, and lean body mass in the acromegaly group, and there was a negative correlation between LTL and neuregulin-4 in the control group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Genetics & Heredity
Alexander Vaiserman, Dmytro Krasnienkov
Summary: Telomere length has long been considered one of the best biomarkers of aging, but recent research suggests that it can only provide a rough estimate of aging rate. Other indicators such as immune parameters and epigenetic age may be stronger predictors of health status and risk for chronic diseases.
FRONTIERS IN GENETICS
(2021)
Article
Geriatrics & Gerontology
Sara Pudas, Maria Josefsson, Annelie Nordin Adolfsson, Mattias Landfors, Karolina Kauppi, Line Marie Veng-Taasti, Magnus Hultdin, Rolf Adolfsson, Sofie Degerman
Summary: Shorter baseline LTL is associated with subsequent memory decline, but intra-individual changes in LTL may not be as informative of cognitive outcomes in aging. Long-term longitudinal evaluation of outcomes in biomarker research is essential.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xuesheng Han, Alice Hirschel, Menelaos Tsapekos, Diego Perez, David Vollmer
Summary: This study provides preliminary evidence that gold nanoparticles may increase telomerase activity and slow down telomere shortening in human fibroblasts, suggesting potential anti-aging effects. However, the effects may vary in different types of fibroblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Nhat Quang Thai, Andrea Lacroix, Bernhard Haring, Jean Wactawski-Wende, JoAnn Manson, Alexander Ivan Posis, Aladdin Shadyab
Summary: This prospective cohort study found that leukocyte telomere length (LTL) was associated with higher odds of survival to age 90 among older women.
Review
Reproductive Biology
Betul Tire, Saffet Ozturk
Summary: Telomeres are repetitive DNA sequences that protect the ends of eukaryotic chromosomes and play a crucial role in maintaining the integrity and stability of the genome. Shortening of telomeres can occur due to factors such as aging, DNA replication, oxidative stress, and genotoxic agents. However, telomeres can be lengthened by telomerase and alternative lengthening mechanisms. If telomeres become critically short, it can lead to genomic instability and abnormalities in cell division. The effects of assisted reproductive technologies (ARTs), such as ovarian stimulation, culture conditions, and cryopreservation procedures, on telomere length and telomerase activity in oocytes and embryos have been extensively studied. These parameters could potentially serve as biomarkers for assessing the quality of oocytes and embryos in ART centers.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Cell Biology
Zhu Lin, Hongmei Gao, Bing Wang, Yongqiang Wang
Summary: Previous CMV infection is associated with shorter leukocyte telomere length, independently of CRP levels.
MEDIATORS OF INFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Gabriela del Carmen Lopez-Armas, Martha Eloisa Ramos-Marquez, Monica Navarro-Meza, Miguel Angel Macias-Islas, Ana Miriam Saldana-Cruz, Abraham Zepeda-Moreno, Fernando Siller-Lopez, Jose Alfonso Cruz-Ramos
Summary: This study evaluated the peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNA-CN) in patients with relapsing-remitting multiple sclerosis (RRMS). The results showed a linear correlation between LTL and mtDNA-CN in mild-moderate disability RRMS patients. Moreover, LTL can predict the severity of disability in RRMS patients, and the prediction accuracy can be improved by combining LTL with age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Nihal Inandiklioglu, Ayca Tas, Tugba Agbektas, Zuhal Tuncbilek, Kayode Yomi Raheem, Gulcihan Cinar, Yavuz Silig
Summary: This study aimed to determine the anticancer activity of the chemotherapeutic agent docetaxel in neuroblastoma cell line (SH-SY5Y) and investigate its effect on hTERT gene expression level and telomere length. The results showed that docetaxel reduced the expression level of the hTERT gene in SH-SY5Y cells and significantly shortened telomere length. Molecular docking analysis confirmed the interaction between docetaxel and the active site of telomerase.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
