Review
Clinical Neurology
Massimo Filippi, Paolo Preziosa, Douglas L. Arnold, Frederik Barkhof, Daniel M. Harrison, Pietro Maggi, Caterina Mainero, Xavier Montalban, Elia Sechi, Brian G. Weinshenker, Maria A. Rocca
Summary: The use of MRI in the diagnosis of MS has evolved considerably, with the introduction of the 2017 McDonald criteria and new MRI markers. Artificial intelligence tools may complement human assessment in improving diagnosis and patient classification.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Feiyue Mi, Yingchun Wang, Wenqiang Chai, Ya Chen, Xuhua Yin
Summary: This study compared the levels of plasma neurofilament light (NfL) in patients with multiple sclerosis (MS) at acute and remission stages and healthy individuals, and found that plasma NfL levels could be a potential biomarker for monitoring disease activity and severity, as well as predicting disease prognosis.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Christopher Hollen, Lee E. Neilson, Ramon F. Barajas, Ian Greenhouse, Rebecca I. Spain
Summary: Conventional MRI is important for evaluating patients with multiple sclerosis, but its role in detecting the underlying pathophysiology of neurodegeneration is limited. Biomarkers that identify processes underlying neurodegeneration before irreversible damage occurs are needed. Oxidative stress is believed to play a major role in the pathogenesis of multiple neurodegenerative diseases, including multiple sclerosis. Non-invasive imaging techniques offer real-time assessment of oxidative stress within the brain, which is an area of unrealized potential.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Kelly A. Clark, Abby R. Manning, Luyun Chen, Fang Liu, Quy Cao, Amit Bar-Or, Russell T. Shinohara, Elizabeth Sweeney, Matthew K. Schindler
Summary: This study aimed to identify early MRI features of new multiple sclerosis (MS) lesions that would develop into paramagnetic rim lesions (PRLs) associated with progressive tissue injury in MS. Contrast-enhancing lesions in MS patients were imaged at 7 T within 4 weeks of observation and 3 and 6 months later. The study found that certain characteristics of early lesions were predictive of subsequent PRL status.
ANNALS OF NEUROLOGY
(2023)
Article
Genetics & Heredity
Jakob Rath, Olivia Foesleitner, Lukas Haider, Hubert Bickel, Fritz Leutmezer, Stephan Polanec, Michael A. Arnoldner, Gere Sunder-Plassmann, Daniela Prayer, Thomas Berger, Paulus Rommer, Gregor Kasprian
Summary: The aim of this study was to evaluate the interrater reliability in differentiating white matter lesions (WML) between multiple sclerosis (MS) and Fabry disease (FD) patients. The results showed that the interrater reliability was only moderate, indicating that visual differentiation of these lesions based on standard axial FLAIR images alone is not consistent among raters.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Tranfa, Mario Tortora, Giuseppe Pontillo, Valentina Iuzzolino, Eleonora Riccio, Simona Caccavallo, Teodolinda Di Risi, Serena Monti, Roberta Lanzillo, Vincenzo Brescia Morra, Giuseppe Palma, Maria Petracca, Antonio Pisani, Arturo Brunetti, Sirio Cocozza
Summary: This study aims to evaluate the incidence of the central vein sign (CVS) as a neuroradiological biomarker highly suggestive of multiple sclerosis (MS). The results showed a high prevalence of CVS in MS patients, especially in the early phases of the disease, while it was absent in conditions with a different etiology.
EUROPEAN RADIOLOGY
(2022)
Review
Clinical Neurology
Fabio Giuseppe Masuccio, Giulia Gamberini, Massimiliano Calabrese, Claudio Solaro
Summary: The study reveals a link between brain pathology and depressive symptoms in patients with multiple sclerosis, supporting the hypothesis that structural and functional brain impairment might substantially contribute to the development of depression in these patients. This suggests that depression in multiple sclerosis patients may have a neuro-biological basis and is not merely a consequence of neurological impairment.
NEUROLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jerome Hodel, Meike W. Vernooij, Mona K. Beyer, Mariasavina Severino, Xavier Leclerc, Alain Creange, Abir Wahab, Neesmah Badat, Sarah Toledano, Luc van den Hauwe, Ana Ramos, Antonella Castellano, Alexandre Krainik, Tarek Yousry, Alex Rovira
Summary: This study evaluated compliance with recommendations in imaging for multiple sclerosis (MS). The results showed that while MS imaging practices are relatively consistent across Europe, there is still partial adherence to recommendations.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Isabelle Riederer, Mark Muehlau, Claus Zimmer, Magaly Gutbrod-Fernandez, Nico Sollmann, Jan S. Kirschke
Summary: The study found that pre-contrast T1-w imaging does not significantly increase diagnostic confidence or detection rate of contrast-enhancing lesions in spinal cord MRI follow-up exams for patients with multiple sclerosis (MS).
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Guillaume Mathey, Thomas Ancel, Teresa Garot, Marc Soudant, Sophie Pittion-Vouyovitch, Francis Guillemin, Marc Debouverie, Jonathan Epstein
Summary: Research shows that a significant proportion of patients with secondary progressive multiple sclerosis may experience clinical and/or radiological activity during disease progression. Factors such as a young age, a high relapse rate in the 5 years before progression, and the first year of progression are associated with disease activity in a given year. Further studies should assess the impact of disease-modifying treatments on these patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Agnes Perez-Millan, Jose Contador, Jordi Junca-Parella, Beatriz Bosch, Laia Borrell, Adria Tort-Merino, Neus Falgas, Sergi Borrego-Ecija, Nuria Bargallo, Lorena Rami, Mircea Balasa, Albert Llado, Raquel Sanchez-Valle, Roser Sala-Llonch
Summary: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are common causes of dementia with overlapping symptoms and brain signatures. This study used brain magnetic resonance imaging (MRI) and machine learning to accurately diagnose and classify AD and FTD. The algorithm achieved good accuracy in cross-sectional and longitudinal data.
HUMAN BRAIN MAPPING
(2023)
Review
Neurosciences
Amir Valizadeh, Mana Moassefi, Elham Barati, Mohammad Ali Sahraian, Faezeh Aghajani, Mohammad-Reza Fattahi
Summary: A meta-analysis of 27 studies involving 1919 participants revealed a correlation coefficient of 0.32 (95% CI 0.26-0.37) between T1 hypointense lesions' mean volume and EDSS score. The correlation was interpreted as low to slightly moderate, with high certainty of evidence.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Computer Science, Artificial Intelligence
Orcan Alpar, Ondrej Soukup, Pavel Ryska, Radka Dvorakova, Jiri Jandura, Martin Valis, Ondrej Krejcar
Summary: Monitoring and tracking the size and number of MS lesions is crucial in clinical medicine. MRI technology, especially FLAIR sequence, is used to identify the lesions. However, not all MRI scans are continuous or overlapping, leading to gaps between slices and affecting accuracy.
EXPERT SYSTEMS WITH APPLICATIONS
(2024)
Article
Clinical Neurology
Ferdinando Clarelli, Maria Assunta Rocca, Silvia Santoro, Ermelinda De Meo, Laura Ferre, Melissa Sorosina, Filippo Martinelli Boneschi, Federica Esposito, Massimo Filippi
Summary: The study assessed the association between genetic factors and neuroimaging measures in multiple sclerosis patients using gene set analysis and SNP regression analysis, revealing different patterns of associations between types of lesions and functional processes, providing new insights into the pathophysiological mechanisms of MS.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mohamed A. Abdelatty, Noha Elmansy, Mahmoud M. Saleh, Amany Salem, Sara Ahmed, Amr A. Gadalla, Mohamed F. Osman, Shady Mohamed
Summary: This study evaluated the agreement among radiologists in assessing the features of natal cleft pilonidal sinus disease (PSD) on MRI and proposed a standardized checklist for reporting these features. The results showed that MRI can accurately describe the deep extensions and branching of PSD. However, the reliability of assessing the number and site of external openings was lower. The study highlights the importance of consensus among experts in establishing the necessary MRI features for optimal reporting of PSD.
EUROPEAN RADIOLOGY
(2023)