Article
Immunology
Ana Carolina Matias Dinelly Pinto, Rodolfo de Melo Nunes, Igor Albuquerque Nogueira, Bernhard Fischer, Rudolf Lucas, Virginia Claudia Carneiro Girao-Carmona, Vivian Louise Soares de Oliveira, Flavio Almeida Amaral, Georg Schett, Francisco Airton Castro Rocha
Summary: TNF inhibitors are commonly used for the treatment of arthropathies like rheumatoid arthritis (RA), but not all patients achieve remission and there is a risk of infection. This study found that the lectin-like domain of TNF has anti-inflammatory effects and can mitigate the development of immune-mediated arthritis in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Winsz-Szczotka, Kornelia Kuznik-Trocha, Iwona Lachor-Motyka, Wojciech Lemski, Krystyna Olczyk
Summary: The joint destruction in juvenile idiopathic arthritis (JIA) can be diagnosed and treated earlier through the determination of circulating cartilage-matrix turnover markers, and the response to treatment is correlated with the levels of these markers. Understanding the changes in type II collagen metabolism may lead to new diagnostic tools and therapeutic strategies for children with JIA.
Article
Rheumatology
Nicolino Ruperto, Hermine Brunner, Cesar Pacheco-Tena, Ingrid Louw, Gabriel Vega-Cornejo, Alberto J. Spindler, Daniel J. Kingsbury, Heinrike Schmeling, Arturo Borzutzky, Ruben Cuttica, C. J. Inman, Victor Malievskiy, Christiaan Scott, Vladimir Keltsev, Maria Teresa Terreri, Diego Oscar Viola, Ricardo M. Xavier, Taciana A. Pedrosa Fernandes, Maria Del Rocio Maldonado Velazquez, Michael Henrickson, Michael B. Clark, Karen A. Bensley, Xiaoming Li, Kim Hung Lo, Jocelyn H. Leu, Chyi-Hung Hsu, Elizabeth C. Hsia, Zhenhua Xu, Alberto Martini, Daniel J. Lovell
Summary: Intravenous golimumab was effective, showed consistent pharmacokinetics, and was relatively safe in pediatric patients with polyarticular-course JIA. Treatment led to significant JIA ACR response rates at 28 and 52 weeks, with steady PK exposure maintained. However, the presence of antibodies in some patients and rare serious infections were noted as potential issues.
Article
Medicine, General & Internal
Alberto Martini, Daniel J. Lovell, Salvatore Albania, Hermine Brunner, Kimme L. Hyrich, Susan D. Thompson, Nicolino Ruperto
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory rheumatic condition of childhood, classified into seven categories. The pathogenesis of JIA involves autoimmune and autoinflammatory mechanisms, and the availability of new drugs has significantly improved treatment options.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Rheumatology
Anna Felis-Giemza, Kornelia Chmurzynska, Beata Kolodziejczyk, Agnieszka Gazda
Summary: The study aimed to assess the classification criteria for adult rheumatic diseases in adult patients with juvenile idiopathic arthritis (JIA) treated with biologics, and to evaluate the course of JIA in adulthood. Among 138 adult patients with JIA treated with biologics, 81 patients remained with JIA diagnosis and 57 patients were rediagnosed with other adult rheumatic diseases. Importance rating of this study: 8/10.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Imane Bardan, Karen M. Fagerli, Joe Sexton, Tore K. Kvien, Gunnstein Bakland, Pawel Mielnik, Yi Hu, Gunhild Lien, Berit Flato, Oyvind Molberg, Eirik K. Kristianslund, Anna-Birgitte Aga
Summary: This study compared the effectiveness of tumor necrosis factor inhibitors (TNFi) and comedication, as well as methotrexate (MTX) monotherapy, in patients with adult juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA). The results showed that JIA patients had lower baseline disease activity compared to RA patients in different treatment groups. After baseline disease activity adjustment, there were no significant differences in disease activity change between JIA and RA patients for both treatment groups. TNFi and MTX monotherapy are both effective in adult JIA, with similar effectiveness to that shown in RA.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Immunology
Aline Alencar M. F. Nicacio, Octavio A. B. Peracchi, Juliana Yamada, Melissa M. Fraga, Maria Sylvia Vitalle, Maria Isabel de Moraes-Pinto, Maria Teresa Terreri
Summary: This study evaluated the immune response and safety after a Tdap booster in JIA patients and healthy adolescents. The results showed that individuals with JIA on or off anti-TNF agents had a good response to the booster dose for the three antigens studied, with no major adverse events or disease reactivation.
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Yu-Jih Su, Hui-Ming Chen, Tien-Ming Chan, Tien-Tsai Cheng, Shan-Fu Yu, Jia-Feng Chen, Chun-Yu Lin, Chung-Yuan Hsu
Summary: This study aimed to investigate whether patients using disease-modifying anti-rheumatic drugs (DMARDs) may have different levels of risk for diabetes and to analyze other risk factors for diabetes. The results showed that certain DMARDs can reduce the risk of diabetes.
Article
Rheumatology
Yongdong Zhao, Erin Sullivan, Mary Beth Son, Timothy Beukelman
Summary: In a large prospective registry study of juvenile idiopathic arthritis patients, a nearly threefold increased risk of psoriasis was observed after TNFi exposure.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Oncology
Leilei Fang, Changqin Liu, Xiaomin Sun, Zhanju Liu
Summary: ICI-induced colitis is a known complication of therapies targeting immune checkpoint proteins. This report highlights a case of a 69-year-old male patient who developed severe colitis after durvalumab treatment and failed to respond to standard therapies, resulting in death. The case emphasizes the need for timely and optimized rescue measures for patients with severe ICI-induced colitis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Masanao Kyuuma, Ayaka Kaku, Chiemi Mishima-Tsumagari, Bunichiro Ogawa, Mayumi Endo, Yunoshin Tamura, Kei-ichiro Ishikura, Masashi Mima, Yutaka Nakanishi, Yasuyuki Fujii
Summary: Biologics are widely used in the treatment of various diseases, but concerns have been raised regarding the immunogenicity and adverse events associated with large immune complexes and aggregates. This study investigated the mechanism underlying the reduced incidence of injection site reactions (ISRs) with ozoralizumab, a trivalent bispecific nanobody compound, compared to other TNF alpha inhibitors. The results showed that ozoralizumab-TNF alpha immune complexes are smaller and lack an Fc portion, mitigating immune responses on neutrophils mediated by Fc gamma receptors. Furthermore, ozoralizumab-TNF alpha immune complexes did not induce significant inflammation at injection sites. These findings suggest that ozoralizumab may be a promising candidate for the treatment of rheumatoid arthritis with a lower risk of unwanted immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Iwona Sudol-Szopinska, Nele Herregods, Andrea S. Doria, Mihra S. Taljanovic, Piotr Gietka, Nikolay Tzaribachev, Andrea Sabine Klauser
Summary: Over the past decade, imaging techniques for inflammatory arthritis in juvenile arthropathies have significantly improved, allowing for more accurate assessment and diagnosis. Ultrasound and magnetic resonance imaging have seen advancements in resolution, sensitivity, and diagnostic possibilities.
Article
Nutrition & Dietetics
Boonyarut Ladda, Chittapon Jantararussamee, Wisuit Pradidarcheep, Anongnard Kasorn, Udomlak Matsathit, Malai Taweechotipatr
Summary: This study examined the properties of three probiotic strains in colorectal adenocarcinoma cells. It was found that the probiotic L. paracasei strain MSMC39-1 significantly suppressed TNF-a secretion in the cells. Further experiments showed that this strain reduced liver enzyme levels, inhibited TNF-a secretion in colon and liver tissues, alleviated colon and liver histopathology, and increased beneficial bacteria in the gut.
Article
Virology
Ulf Martin Geisen, Ruben Rose, Franziska Neumann, Maria Ciripoi, Lena Vullriede, Hayley M. Reid, Dennis Kristopher Berner, Federico Bertoglio, Paula Hoff, Michael Hust, Ann Carolin Longardt, Thomas Lorentz, Gabriela Rios Martini, Carina Saggau, Jan Henrik Schirmer, Maren Schubert, Melike Suembuel, Florian Tran, Mathias Voss, Rainald Zeuner, Peter J. Morrison, Petra Bacher, Helmut Fickenscher, Sascha Gerdes, Matthias Peipp, Stefan Schreiber, Andi Krumbholz, Bimba Franziska Hoyer
Summary: The humoral immune response declines more rapidly with TNF-alpha inhibition in patients with chronic inflammatory disease. The efficacy of current vaccines against Omicron variants, including BA.2, is limited. Alterations in immune cell populations, changes in IgG affinity, and the ability to neutralize the virus were investigated in these at-risk patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Dermatology
Stephanie W. Liu, Mary H. Lien, Neil Alan Fenske
CLINICS IN DERMATOLOGY
(2010)
Letter
Dermatology
Stephanie W. Liu, Joan G. Guitart, Timothy M. Kuzel, Mona Gandhi, Mario Lacouture
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2009)
Article
Rheumatology
Mital Patel, Stephanie W. Liu, Abrar Qureshi, Joseph F. Merola
JOURNAL OF RHEUMATOLOGY
(2014)
Article
Dermatology
Stephanie W. Liu, George F. Cohen
JOURNAL OF COSMETIC DERMATOLOGY
(2010)
Article
Oncology
Rahul D. Tendulkar, Stephanie W. Liu, Gene H. Barnett, Michael A. Vogelbaum, Steven A. Toms, Tao Jin, John H. Suh
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2006)
Article
Oncology
Samuel T. Chao, Gene H. Barnett, Stephanie W. Liu, Alwyn M. Reuther, Steven A. Toms, Michael A. Vogelbaum, Gregory M. M. Videtic, John H. Suh
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2006)