Article
Dermatology
JiHui Chen, Qin Zou, Michael R. Hamblin, Xiang Wen
Summary: The clinical trial involving 58 PV patients showed that wet silver-containing dressings were significantly more effective than wet to dry povidone-iodine dressings in wound healing, with fewer dressing changes, faster healing time, shorter hospital stay, lower pain scores, and higher patient satisfaction. No significant adverse reactions were observed between the two groups.
DERMATOLOGIC THERAPY
(2021)
Article
Dermatology
Paulo J. Alves, Ruben T. Barreto, Brigitte M. Barrois, Luc G. Gryson, Sylvie Meaume, Stan J. Monstrey
Summary: Biofilms play a major role in delaying chronic wounds from healing and pose a significant treatment challenge due to their resistance towards antimicrobial agents. However, there is a window of opportunity post-debridement when biofilms are more susceptible to topical antiseptics. Among commonly used antiseptics, PVP-I stands out for its broad spectrum of antimicrobial activity, potent antibiofilm efficacy, lack of acquired resistance, low cytotoxicity, good tolerability, and wound healing promotion.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Shaydier Argel, Melissa Castano, Daiver Estiven Jimenez, Sebastian Rodriguez, Maria Jose Vallejo, Cristina Isabel Castro, Marlon Andres Osorio
Summary: In this study, bioactive wound dressings were successfully developed by loading the antibacterial povidone-iodine and anti-inflammatory acetylsalicylic acid into bacterial nanocellulose (BNC). The structure and mechanical properties of the dressings were characterized by scanning electron microscopy and mechanical tests. The release assays and histology confirmed the diffusion of the bioactive compounds in porcine skin. Antimicrobial experiments and protein denaturation tests further confirmed the antibacterial and anti-inflammatory properties of the dressings.
Review
Infectious Diseases
Qian Pang, Zilian Jiang, Kaihao Wu, Ruixia Hou, Yabin Zhu
Summary: Nanomaterials have made significant progress in the application of infection control and wound healing. Nanomaterial-based wound dressings with antibacterial properties can effectively prevent and treat bacterial infections. They can kill bacteria and reduce drug resistance. In addition, nanomaterials can act as drug carriers to kill bacteria through photothermal or photodynamic therapy. Intelligent nanomaterial-based wound dressings can detect bacterial infections and provide timely antibacterial therapy for enhanced management of infected wounds.
Article
Food Science & Technology
Esin Yalcinkaya, Mustafa Mert Basaran, Mehmet Emin Tunckasik, Gulce Naz Yazici, Cigdem Elmas, Sinan Kocaturk
Summary: This study compared the safety and efficacy of different topical agents for surgical wound healing. The results showed that HPE had the most advanced healing stage with higher re-epithelialization and collagen accumulation values, as well as lower inflammatory cell count and granulation tissue. TB and PI also demonstrated good healing effects. HPE can be a safe, effective, and cheap agent for surgical wounds.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Anesthesiology
Sue E. Gardner, Jaewon Bae, Bootan H. Ahmed, Linda Abbott, Jessica S. Wolf, Maria Hein, Cheryl Carter, Stephen L. Hillis, LuAnn M. Tandy, Barbara A. Rakel
Summary: This study aims to develop a clinical tool to predict severe pain during dressing changes and evaluate the diagnostic validity of the model. Three predictors have been identified and algorithms based on these predictors have been proposed for predicting patients likely to experience severe pain during a dressing change.
Article
Surgery
Ryo Maemoto, Hiroshi Noda, Kosuke Ichida, Yasuyuki Miyakura, Nao Kakizawa, Erika Machida, Hidetoshi Aizawa, Takaharu Kato, Masahiro Iseki, Taro Fukui, Yuta Muto, Shota Fukai, Shingo Tsujinaka, Yuuri Hatsuzawa, Fumiaki Watanabe, Masakazu Nagamori, Jun Takahashi, Yasuaki Kimura, Shimpei Maeda, Noriya Takayama, Ryotaro Sakio, Rei Takahashi, Tsutomu Takenami, Natsumi Matsuzawa, Makiko Mieno, Toshiki Rikiyama
Summary: This trial evaluated the superiority of intraoperative wound irrigation with povidone-iodine compared with saline for reducing surgical site infection. The results showed that the irrigation with povidone-iodine did not significantly reduce the incidence of incisional SSI, suggesting a need for reconsideration of the current recommendation.
Article
Engineering, Environmental
Yujie Zhang, Donggang Tao, Fei Xu, Ting Li
Summary: In this study, a high-performance rechargeable magnesium battery was developed using low-cost povidone iodine as the cathode material. The povidone iodine cathode demonstrated high reversible magnesium storage capacity, outstanding rate capability, and remarkable cycling durability. The chemical interaction of iodine with the host material effectively improved battery performance and eliminated the shuttle effect.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Phat Tran, Jonathan Kopel, Keaton Luth, Huy Dong, Ameesh Dev, Dilip Mehta, Kelly Mitchell, Keith W. Moeller, Cameron D. Moeller, Ted Reid
Summary: This study aimed to determine if the combination of 5% betadine solution and silver colloidal gel is more effective than either substance alone in inhibiting the growth of gram-negative and gram-positive bacteria. The results showed that silver gel had complete inhibition on all the bacteria species examined except for the Klebsiella pneumoniae clinical isolate strain, while 5% betadine solution did not completely kill any of the tested bacteria. However, when 5% betadine solution and silver gel were used together, they were able to completely eliminate K. pneumoniae. The study concluded that the combination of 5% betadine solution and silver gel was superior at eliminating all tested bacteria.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Polymer Science
Ali Afzal, Mohammed Jalalah, Abid Noor, Zubair Khaliq, Muhammad Bilal Qadir, Rashid Masood, Ahsan Nazir, Sheraz Ahmad, Faheem Ahmad, Muhammad Irfan, Munazza Afzal, Mohd Faisal, Saeed A. Alsareii, Farid A. Harraz
Summary: Nowadays, synthetic polymers with special properties such as biodegradability, biocompatibility, hydrophilicity, and non-toxicity are widely used in medical applications. This study aims to develop and characterize PVA/PCL fibers containing a model drug for controlled drug release in wound dressing. The wet spinning technique was used to produce PVA/PCL fibers from a dope solution, and the fibers were tested for various properties related to wound healing. The results showed that the developed PVA/PCL fibers have respectable tensile properties, adequate liquid absorption, swelling behavior, degradation, and antimicrobial activity, as well as a controlled drug release profile.
Review
Materials Science, Multidisciplinary
Shokoh Parham, Anousheh Zargar Kharazi, Hamid Reza Bakhsheshi-Rad, Mahshid Kharaziha, Ahmad Fauzi Ismail, Safian Sharif, Mahmood Razzaghi, Seeram RamaKrishna, Filippo Berto
Summary: Wound dressings have evolved from using natural materials to customizable electrospun polymers that contain active compounds for wound healing and infection prevention. Electrospun polymeric nanofibers are considered promising for enhancing skin regeneration and controlling wound infection.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Priyadarshani Choudhary, Baskaran Ramalingam, Sujoy K. Das
Summary: Wound dressings with poor antibacterial properties, adhesion to the wound site, weak mechanical strength, and lack of porosity and flexibility lead to blood loss, delayed wound repair, and sometimes death. In this study, a multifunctional graphene-based nanobiocomposite wound dressing was developed, which demonstrated hydrophilic properties, good mechanical strength, antibacterial activity, non-toxicity to cells, and pro-angiogenic potential. In in-vivo studies using a rat model, the nanobiocomposite dressing significantly enhanced wound healing compared to commercially available dressings, achieving complete wound closure in 14 days. Overall, the CGAPL nanobiocomposite dressing offers a novel and efficient solution for faster wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Evi Sulastri, Muhammad Sulaiman Zubair, Ronny Lesmana, Ahmed Fouad Abdelwahab Mohammed, Nasrul Wathoni
Summary: The study found that different concentrations of ulvan in the formula affect the characteristics of the hydrogel films. The SEM showed porous structure, and all hydrogel films can inhibit both gram-positive and gram-negative bacteria. The higher the concentration of ulvan, the higher the viscosity, swelling degree, moisture content, and water vapor transmission rate of the hydrogel films.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Engineering, Biomedical
C. K. Nanditha, G. S. Vinod Kumar
Summary: This study reports the potential application of a nanofibrous mat enriched with bioactive peptides as an effective wound dressing for diabetic wounds. The material, fabricated using electrospinning, promotes accelerated wound healing, cell proliferation, and migration through the incorporation of bioactive peptides.
MATERIALS TODAY BIO
(2022)
Article
Materials Science, Composites
Gul Kumar, Faraz Gaji Khan, Muhammad Ishaque Abro, Umair Aftab, Abdul Wahab Jatoi
Summary: The CuO/AgNP composite nanoparticles were successfully synthesized and electrospun cellulose acetate (CA) nanofiber was fabricated for effective and safer antimicrobial wound dressing. The synthesis of composite nanoparticles was confirmed by XRD, TEM, and EDS analysis. The SEM confirmed the regular morphologies of the composite nanofibers. CA nanofibers with three different concentrations of CuO/AgNPs (3%, 6%, and 10%) were prepared. The Kirby-Buyer disk diffusion test and relative cell viability results confirmed the significant bacteriostatic and bactericidal properties of the nanocomposites. The water absorption/transport, swelling ratio, and tensile strength results revealed the potential application of the nanocomposites. Our findings suggested CA/CuO/AgNP as an effective antimicrobial wound dressing material.
COMPOSITES COMMUNICATIONS
(2023)
