Article
Dermatology
Barakat Abdelreheem Mahmood, Emad Hussein ElSayed, Salah M. Abd Elghany, Dina Farouk Elnaggar, Hoda A. A. Youssef, Saber M. Abdelmaksoud
Summary: A new powder dressing was found to be effective in managing chronic venous ulcers, with higher healing rates, shorter duration to healing, and lower pain.
DERMATOLOGIC SURGERY
(2023)
Review
Medicine, General & Internal
Cibele T. D. Ribeiro, Fernando A. L. Dias, Guilherme A. F. Fregonezi
Summary: The effectiveness of hydrogel dressings for treating venous leg ulcers remains uncertain. More research is needed to determine the efficacy of hydrogel dressings compared to gauze and saline, alginate dressing, manuka honey, or hydrocolloid in promoting the healing of venous leg ulcers.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Hubert Aleksandrowicz, Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Summary: The prevalence of venous leg ulcers (VLUs) ranges from 1.5% to 3% in the general population, with common challenges being recurrence and resistance to healing. New technologies, such as biophysical interventions and advanced wound therapies, have been increasingly used in treating VLUs in recent years.
Review
Medicine, General & Internal
Niamh E. M. McLain, Zena E. H. Moore, Pinar Avsar
Summary: This study aimed to evaluate the effects of wound cleansing, wound cleansing solutions and wound cleansing techniques for treating venous leg ulcers. Four studies including 254 participants were analyzed, but with insufficient evidence to demonstrate the effectiveness of different cleansing solutions in treating venous leg ulcers.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Multidisciplinary Sciences
Quoc Cuong Ngo, Rajna Ogrin, Dinesh Kant Kumar
Summary: This study proposed a computerised prediction framework for healing of venous leg ulcers using thermal images, with textural features from the thermal images at week 0 being used to discriminate between healed and unhealed wounds. The optimal Bayesian neural network achieved 78.57% sensitivity and 60.00% specificity in classifying healing outcomes. This non-contact method incorporating machine learning provides earlier prediction compared to current methods requiring contact digital planimetry.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Debbie X. E. Lim, Toby Richards, Muholan Kanapathy, Thankiah Sudhaharan, Graham D. Wright, Anthony R. J. Phillips, David L. Becker
Summary: The study found a strong correlation between the presence of senescent cells and decreased collagen area in human chronic wounds, aiding in predicting healing trajectory of wounds; higher levels of senescent cells were found in male venous leg ulcer patients, while those under 60 years old with wounds persisting for over 24 months had the lowest levels of collagen.Dispensing method founded by Wang et al. requires less effort and cost and is highly accurate when it comes to protein liquid handling.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Marianne Degerman, Micael Ohman, Bo C. Bertilson
Summary: The study aimed to investigate the effects of laser Photobiomodulation (PBM) on the healing time of hard-to-heal venous leg ulcer, and found that using PBM in addition to traditional dressing significantly reduced the healing time of the ulcer.
Review
Dermatology
Elaine Greene, Pinar Avsar, Zena Moore, Linda Nugent, Tom 'Connor, Declan Patton
Summary: Larval therapy promotes rapid debridement of venous leg ulcers, with similar effects compared to other debridement methods. Combining larval therapy with compression therapy enhances the debridement effect, although it does not improve overall wound healing rates. Further high quality randomized controlled trials are needed to determine the long term effects of larval therapy compared to other debridement methods.
JOURNAL OF TISSUE VIABILITY
(2021)
Article
Dermatology
Olga Krizanova, Adela Penesova, Alica Hokynkova, Andrea Pokorna, Amir Samadian, Petr Babula
Summary: Chronic venous disease is a condition that affects the veins in the lower extremities, characterized by impaired blood return. This review discusses the etiology, risk factors, and pathophysiology of venous leg ulcers (VLU), and compares the treatment options.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Engineering, Biomedical
Gustavo Coelho Rezende, Brendan O'Flynn, Conor O'Mahony
Summary: Venous leg ulcers are commonly treated by applying compression to the lower limb, but traditional compression therapies have issues. The development of smart compression therapy devices using microtechnologies and new materials has the potential to improve patient comfort and treatment outcomes.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Medicine, General & Internal
Olivia Boerman, Zahidur Abedin, Rose Ann DiMaria-Ghalili, Michael S. Weingarten, Michael Neidrauer, Peter A. Lewin, Kara L. Spiller
Summary: This study aimed to explore the mechanisms of low-frequency, low-intensity ultrasound on the healing of chronic wounds in humans. Gene expression analysis showed that ultrasound treatment affected genes related to cell metabolism, proliferation, and immune cell signaling. These findings contribute to the understanding and improvement of ultrasound therapy for chronic wound healing.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Klaus Kirketerp-Moller, Petra Doerfler, Nicole Schoefmann, Barbara Wolf-Winiski, Omid Niazi, Vibeke Pless, Tonny Karlsmark, Magnus Agren
Summary: This exploratory study aimed to investigate the association between biomarkers in wound fluid and the healing of split-thickness skin grafts in venous leg ulcers. The study found that the concentration of matrix metalloproteinase-9 in wound fluid was higher in venous leg ulcers showing good healing compared to those with poor healing.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Materials Science, Textiles
Abdelhamid R. Aboalasaad, Muhammad Z. Khan, Brigita K. Sirkova, Jakub Wiener, Irena Slamborova, Amany S. Khalil, Ahmed Hassanin
Summary: The proposed study aims to discuss the structure and behavior of a specific type of compression bandage called short-stretch cotton woven compression bandage (WCB). It also focuses on the production and properties of a multifunctional WCB with adjustable compression and antibacterial properties. The study uses integrated tension sensors and nanotechnology to enhance the functionality of the bandage. The results show that the WCB with silver nanoparticles coating exhibits high antibacterial activity, and the bandage can achieve a significant reduction in bacteria. However, there are deviations between the actual bandage pressure and the theoretical pressure calculated.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Medical Laboratory Technology
Serhat Sirekbasan, Erdal Polat, Ugur Cangel
Summary: This study aimed to evaluate the efficacy of Maggot Debridement Therapy (MDT) in the treatment of venous leg ulcers. The results demonstrated significant improvements in wound healing in venous leg ulcers treated with MDT, with a quick debridement process observed.
CLINICAL LABORATORY
(2021)
Article
Multidisciplinary Sciences
Mahta Monshipouri, Behzad Aliahmad, Rajna Ogrin, Kylie Elder, Jacinta Anderson, Barbara Polus, Dinesh Kumar
Summary: Textural analysis of thermal images can effectively predict which venous leg ulcers among older people being managed at home will not heal by week 12 as early as week 2.
SCIENTIFIC REPORTS
(2021)