Article
Cell Biology
Yaron Shoham, Eyal Shapira, Josef Haik, Moti Harats, Dana Egozi, Dror Robinson, Leonid Kogan, Rania Elkhatib, Geza Telek, Avshalom Shalom
Summary: Chronic wounds affect over 6 million people annually in the US, with an estimated annual cost of $25 billion. Debridement is crucial for tissue repair, but there is a need for non-surgical debridement agents. EscharEx, a bromelain-based enzymatic debridement agent, has shown to be effective and safe in chronic wounds.
WOUND REPAIR AND REGENERATION
(2021)
Review
Surgery
Nikolaos Arkoulis, Nigel Tapiwa Mabvuure, Alex Smith, David E. Barnes
Summary: The study presented the early experience of using NexobridTM at a tertiary burns center between July 2016 and December 2019. It assessed whether NXB had changed the acute care delivered to the cohort. Results showed that NXB was successful in debriding burnt tissue in 55% of patients, reducing the need for escharotomy in some cases. Further surgery was required for 60% of patients, with 80% of facial burns treated with NXB requiring additional surgery.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Critical Care Medicine
Pablo Pfister, Pedro David Garcia Wendel, Bong Sung Kim, Reto Andreas Schuepbach, Peter Steiger, Giovanni Camen, Philipp Karl Buehler
Summary: This study compared the effects of enzymatic and surgical debridement on coagulation in burn patients. The results showed that enzymatic debridement did not increase the risk of coagulation abnormalities compared to the standard surgical approach.
Article
Medicine, General & Internal
Tomasz Korzeniowski, Ewelina Grywalska, Jerzy Struzyna, Magdalena Bugaj-Tobiasz, Agnieszka Surowiecka, Izabela Korona-Glowniak, Magdalena Staskiewicz, Kamil Torres
Summary: This study aimed to compare the demographic characteristics, surgical treatment, and outcomes of patients treated with Nexobrid(R) and patients who had standard surgical excision. The results showed that enzymatic debridement effectively removed burn eschar without adverse reactions or serious complications. The relative risk of reconstructive procedures was reduced in patients treated enzymatically.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Amal Sharaf, Preetha Muthayya
Summary: This study examines the effect of bromelain-based enzymatic debridement using NexoBrid(R) gel on the microbiological pattern of burn wounds, and finds that it is similar to cases treated without enzymatic debridement.
Review
Dermatology
Yaron Shoham, Konstantinos Gasteratos, Adam J. Singer, Yuval Krieger, Eldad Silberstein, Jeremy Goverman
Summary: In 2012, a pineapple stem-derived Bromelain-based debridement concentrate (NexoBrid & REG;, MediWound Ltd, Yavne, Israel) was approved by the European Medicines Agency for adult deep burns. A systematic review of the literature on Nexobrid & REG; outcomes was conducted, identifying 103 relevant studies, of which 34 were eligible. The studies reported positive effects of Nexobrid & REG; on burn debridement, functional and cosmetic outcomes, scarring, and quality of life, indicating its safety and benefits as a non-surgical eschar removal treatment.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Mihaela Pertea, Vladimir Poroch, Petru Ciobanu, Alexandru Filip, Natalia Velenciuc, Sorinel Lunca, Andrian Panuta, Mihaela Buna-Arvinte, Stefana Luca, Bogdan Veliceasa
Summary: The study aimed to evaluate the use of bromelain in deep burns and found that it has certain advantages in removing eschar. However, early excision followed by coverage with split-thickness skin graft remains the gold standard for the treatment of deep burns.
APPLIED SCIENCES-BASEL
(2021)
Article
Dermatology
Paul J. Kim, Siobhan Lookess, Christine Bongards, Leah Passmore Griffin, Allen Gabriel
Summary: The study examined the effectiveness and cost of negative pressure wound therapy with instillation compared to control therapies for complex acute and chronic wounds. Results showed a potential cost savings with fewer operating room visits and shorter therapy duration in the negative pressure wound therapy with instillation group.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Dermatology
Yaron Shoham, Itai Sabbag, Adam J. Singer
Summary: This study developed a novel porcine eschar model and compared the debridement efficacy of a novel bromelain-based enzymatic agent with collagenase. The results showed that the novel bromelain-based enzymatic agent was more effective than collagenase in removing eschars in this wound model.
JOURNAL OF WOUND CARE
(2021)
Article
Polymer Science
Yasaman Saghafi, Hadi Baharifar, Najmeh Najmoddin, Azadeh Asefnejad, Hassan Maleki, Sayed Mahmoud Sajjadi-Jazi, Alireza Bonkdar, Forough Shams, Kamyar Khoshnevisan
Summary: This study developed gel-based polycaprolactone/chitosan (PCL/CS) nanofibrous dressings containing bromelain (BRO) and silver nanoparticle (Ag NPs) through electrospinning. The resulting nanofibers exhibited uniform morphology without beads, with an average diameter of 176 +/- 63 nm. Adding BRO and Ag NPs improved the tensile strength of the nanofibers and enhanced their antibacterial activity against E. coli and S. aureus bacteria. In vivo experiments demonstrated that the wound healing process was significantly accelerated with the dressings containing BRO and Ag NPs. Therefore, gel-based PCL/CS nanofibrous dressings loaded with BRO and Ag NPs have promising potential for skin wound healing.
Article
Public, Environmental & Occupational Health
Joanna Przybek Mita, Dariusz Bazalinski, Rafal Sztembis, Izabela Kuberka, Pawel Wiech
Summary: Stress is recognized as a key problem in neurological studies, with prolonged stress being detrimental to health. This study assessed the intensity of perceived stress in nurses dealing with wound care. The results showed that there were differences in stress levels among age groups, but they were not statistically significant. The highest differences in stress levels were observed between those who completed treatment courses and those who did not. The higher the stress level, the lower the willingness to undertake such therapy.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Dermatology
Thomas J. Secker, Christopher C. Harling, Chloe Hand, David Voegeli, Charles W. Keevil, Timothy G. Leighton
Summary: This study investigates a device that uses acoustically activated microscopic air bubbles to remove bacterial biofilm from wounds. The results show that the device efficiently removes biofilm without damaging human tissue, suggesting its potential for improving wound healing.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Dermatology
Kazuki Shimada, Yosuke Ojima, Yukiko Ida, Hajime Matsumura
Summary: Hydrosurgery has shown advantages in rapid and high-quality debridement for chronic wounds, saving time compared to conventional methods, and requiring fewer repetitions to achieve adequate wound beds, leading to potential success and cost-effectiveness in subsequent treatments.
INTERNATIONAL WOUND JOURNAL
(2021)
Review
Dermatology
Kevin Syam, Shaheer A. Joiya, Sumayyah Khan, P. Nithin Unnikrishnan
Summary: The analysis of existing randomized controlled trials on maggot debridement therapy (MDT) indicates its effectiveness in diabetic foot ulcers, but its efficacy in chronic peripheral vascular disease ulcers remains inconclusive. Further studies are recommended to evaluate the cost-effectiveness and patient experience.
ADVANCES IN SKIN & WOUND CARE
(2021)
Article
Dermatology
Barakat Abdelreheem Mahmood, Emad Hussein ElSayed, Salah M. Abd Elghany, Dina Farouk Elnaggar, Hoda A. A. Youssef, Saber M. Abdelmaksoud
Summary: A new powder dressing was found to be effective in managing chronic venous ulcers, with higher healing rates, shorter duration to healing, and lower pain.
DERMATOLOGIC SURGERY
(2023)