Article
Engineering, Biomedical
D. Cai, S. Chen, B. Wu, J. Chen, D. Tao, Z. Li, Q. Dong, Y. Zou, Y. Chen, C. Bi, D. Zu, L. Lu, B. Fang
Summary: The study developed a dermal extracellular matrix hydrogel loaded with vancomycin as a novel approach for treating skin defects and controlling hemorrhage, showing rapid release of antimicrobial agents, promotion of wound healing, and effective antibacterial and hemostatic effects in in vivo experiments.
MATERIALS TODAY BIO
(2021)
Article
Infectious Diseases
Maria Anna Smolle, Hana Murtezai, Tobias Niedrist, Florian Amerstorfer, Nina Hoerlesberger, Lukas Leitner, Sebastian Martin Klim, Reingard Glehr, Raju Ahluwalia, Andreas Leithner, Mathias Glehr
Summary: This study analysed and compared the vancomycin elution kinetics of four biodegradable, osteoconductive antibiotic carriers used in clinical practice. The results showed different elution rates and antibiotic concentration patterns for each carrier. The carrier made of allogenic bone chips exhibited the highest elution rate, while the carrier with separately added vancomycin showed a more consistent antibiotic-releasing profile.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marina Lopez-Alvarez, Marjolein Heuker, Klaas A. Sjollema, Gooitzen M. van Dam, Jan Maarten van Dijl, Frank F. A. IJpma, Marleen van Oosten
Summary: This study demonstrates the clinical application of fluorescence imaging for the detection of FRI, showing that imaging with vanco-800CW can provide early, accurate, and real-time visual diagnostic information on FRI in the clinical setting, even in the case of low-grade infections.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Microbiology
Ya-Xin Fan, Meng-Ting Chen, Nan-Yang Li, Xiao-Fen Liu, Min-Jie Yang, Yuan-Cheng Chen, Xiao-Yu Liang, Ju-Fang Wu, Bei-Ning Guo, Si-Chao Song, Yong-Qiang Zhu, Feng-Ying Zhang, Jing-Qing Hang, Sheng-Bin Wu, Bo Shen, Hua-Yin Li, Qin Wang, Xu-Ming Luo, Qing-Ge Chen, Hui-Fang Zhang, Rui-Lan Wang, Li-Hua Shen, Feng-Ming Fu, Xiao-Lian Song, Jing Zhang
Summary: This study analyzed risk factors for vancomycin failure in patients with MRSA pneumonia and found that factors such as vancomycin dosage, peak concentration, and specific genes were associated with clinical improvement and eradication of the bacteria. ST5 strains were identified as potential predictors of bacterial persistence and were associated with higher levels of resistance and virulence genes.
MICROBIOLOGY SPECTRUM
(2022)
Article
Critical Care Medicine
Jan Tilmann Vollrath, Cora Rebecca Schindler, Eva Herrmann, Rene D. Verboket, Dirk Henrich, Ingo Marzi, Philipp Stoermann
Summary: This study evaluated the ability of different serum markers to identify polytraumatized patients at risk of developing pneumonia. The study found that individual serum markers were not helpful in accurately identifying the risk of pneumonia, but a combination of IL-6, IL-10, PTX-3, and sRAGE may be useful for identification.
Article
Biochemistry & Molecular Biology
Kristina Macakova, Elzbieta Kaczmarek, Kiyoshi Itagaki
Summary: Our work suggests that mtDAMPs, specifically mtFPs released by tissue injury, play a significant role in the development of nosocomial pneumonia after a serious injury. PMN migrate to the injury site by detecting mtFPs through FPR1 to fight bacterial infection, but the activation of FPR1 by mtFPs leads to desensitization/internalization of chemokine receptors, rendering PMN unresponsive to secondary infections. This allows bacterial growth in the lungs and the development of nosocomial pneumonia. Intratracheal application of exogenously isolated PMN may prevent pneumonia coupled with a serious injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Wei Yan, Sun Xiao Sun, Meng Wang, Fei Fan Zhao, Qing Tao Zhou
Summary: This study aimed to evaluate the clinical benefits of a vancomycin dosage strategy based on a serum trough concentration model in elderly patients with severe pneumonia. The study found that individualized vancomycin therapy with a dosing strategy based on a serum trough concentration model can improve the proportion of patients achieving target trough concentrations in elderly patients.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2023)
Article
Environmental Sciences
Wei Yan, Xiao Yan Sun, Meng Wang, Fei Fan Zhao, Qing Tao Zhou
Summary: The clinical benefits of a vancomycin dosage strategy based on a serum trough concentration model in elderly patients with severe pneumonia were evaluated in this study. Elderly patients were categorized into a study group and a control group. The study group received individualized vancomycin therapy based on the serum trough concentration model, while the control group received vancomycin based on the attending physician's regimen. The results showed that the study group had a significantly higher proportion of patients achieving target trough concentrations compared to the control group.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2023)
Article
Critical Care Medicine
Quanzhi Zhang, Woon Yong Kwon, Barbora Vlkova, Ingred Rica, Elzbieta Kaczmarek, Jinbong Park, Hyo In Kim, Barbora Konecna, Francoise Jung, Garry Douglas, Leo E. Otterbein, Carl J. Hauser, Kiyoshi Itagaki
Summary: Injury-induced mtFPs inhibit the migration of neutrophils to infected alveoli, but instillation of exogenous human neutrophils into the airway prevents the development of post-traumatic pneumonia in recipients.
Article
Immunology
David Henry Greentree, Louis B. Rice, Curtis J. Donskey
Summary: There is an urgent need for surveillance to determine if C. difficile strains with reduced vancomycin susceptibility are circulating in other areas, as high-level phenotypic resistance to vancomycin has recently been reported in multiple geographic regions.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Jang Ho Lee, Myeong Geun Choi, Hyung Jun Park, Ho Cheol Kim, Chang-Min Choi
Summary: This study compared the efficacy and safety of vancomycin and teicoplanin in patients with methicillin-resistant Staphylococcus aureus pneumonia. The results showed that vancomycin had lower clinical failure rates, discontinuation rates due to treatment failure, and mortality rates compared to teicoplanin. However, it had higher rates of side effects. Therefore, clinicians need to consider the efficacy and potential side effects of these drugs before prescribing.
BMC INFECTIOUS DISEASES
(2022)
Article
Immunology
L. Meng, S. Pourali, M. M. Hitchcock, D. R. Ha, E. Mui, W. Alegria, E. Fox, C. Diep, R. Swayngim, A. Chang, N. Banaei, S. Deresinski, M. Holubar
Summary: A pharmacist-led protocol for MRSA nasal PCR testing resulted in a significant reduction in unnecessary vancomycin use and cost savings. The study also found a high concordance between culture-based and PCR-based MRSA nasal screening.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Margaret M. Chapman, Victorine V. Muse, James E. Mojica, Melis N. Anahtar
Summary: A 50-year-old woman with sarcoidosis presented with pain in the left upper quadrant and hypoxemia. Chest radiography revealed consolidations in the middle and lower lobes with diffuse ground-glass opacities. A diagnostic test was performed to further evaluate the condition.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Infectious Diseases
Theresa Maria Wagner, Jessin Janice, Mark Schulz, Susan A. Ballard, Anders Goncalves da Silva, Geoffrey W. Coombs, Denise A. Daley, Stanley Pang, Shakeel Mowlaboccus, Tim Stinear, Kristin Hegstad, Benjamin P. Howden, Arnfinn Sundsfjord
Summary: This study identified eight potential vancomycin variable enterococci (VVE) isolates through whole-genome sequencing of Australian Enterococcus faecium (Efm) isolates. It was found that VVE could convert to a resistant phenotype under vancomycin selection, which was associated with a 44-bp deletion in the vanHAX promoter region and an increased vanA plasmid copy number.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Emergency Medicine
Anthony J. Renzoni, Gary D. Peksa, Joshua M. DeMott
Summary: A study of 116 emergency department patients found that conducting MRSA nasal screening for pneumonia patients did not decrease the duration of anti-MRSA antibiotics. Secondary outcomes showed no significant differences either. Therefore, there is currently no need for ED providers to consider MRSA nasal screening for patients admitted to general medicine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)