Article
Medicine, General & Internal
Jason-Alexander Hoerauf, Christoph Nau, Nils Muehlenfeld, Rene D. Verboket, Ingo Marzi, Philipp Stoermann
Summary: This retrospective study analyzed the injury patterns of severe trauma patients who fell down a flight of stairs, and found that the likelihood of traumatic brain injury and intracranial hemorrhage increased with the number of stairs fallen. There was also a high correlation between staircase falls and alcohol intake. Therefore, it is important to consider the impact of brain injury and alcohol intake in these cases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Shichen Shen, Ming Zhang, Min Ma, Sailee Rasam, David Poulsen, Jun Qu
Summary: This study compared proteomic changes in rat cortex and hippocampus under different TBI and MA treatment conditions, identifying that the protein profile in TSm rats was more similar to TM rats than TS rats. Pathway analysis suggested beneficial roles for acute signaling through IL-6, TGF beta, and IL-1 beta in TSm rats, with potential involvement of fibrinogen in reducing/preventing TBI-induced coagulopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Eujene Jung, Young Sun Ro, Joo Jeong, Hyun Ho Ryu, Sang Do Shin
Summary: This study investigated the association between alcohol intake and outcomes in patients with traumatic brain injury (TBI), and found that alcohol intake before injury was associated with lower odds of poor functional recovery and in-hospital mortality in TBI patients. The effects were more pronounced in male patients.
Article
Pharmacology & Pharmacy
Maria Daglas, Phan H. Truong, Linh Q. Miles, Sydney M. A. Juan, Shalini S. Rao, Paul A. Adlard
Summary: Iron plays a detrimental role in the injured brain, and the use of an iron chelator like deferiprone may be a promising therapeutic approach to improve survival, functional outcomes, and quality of life in TBI patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Mart Kals, Kevin Kunzmann, Livia Parodi, Farid Radmanesh, Lindsay Wilson, Saef Izzy, Christopher D. Anderson, Ava M. Puccio, David O. Okonkwo, Nancy Temkin, Ewout W. Steyerberg, Murray B. Stein, Geoff T. Manley, Andrew I. R. Maas, Sylvia Richardson, Ramon Diaz-Arrastia, Aarno Palotie, Samuli Ripatti, Jonathan Rosand, David K. Menon
Summary: This study is the first genome-and transcriptome-wide association studies of genetic effects on outcome in traumatic brain injury (TBI). While no genetic variants with genome-wide significance were found, the overall heritability estimate is consistent with the hypothesis that common genetic variation substantially contributes to inter-individual variability in TBI outcome.
Article
Critical Care Medicine
Chantal M. Sanchez, David J. Titus, Nicole M. Wilson, Julie E. Freund, Coleen M. Atkins
Summary: Early life stress may contribute to persistent cognitive deficits in individuals with mild traumatic brain injury, including impaired learning and memory function, as well as worsened cortical pathology.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Clinical Neurology
Cassidy Q. B. Mostert, Ranjit D. Singh, Maxime Gerritsen, Erwin J. O. Kompanje, Gerard M. Ribbers, Wilco C. Peul, Jeroen T. J. M. van Dijck
Summary: This systematic review investigated the long-term outcome after severe traumatic brain injury (sTBI) and found limited and heterogeneous literature in this area. Mortality and unfavorable outcome rates were high, but a considerable proportion of survivors achieved favorable outcomes.
ACTA NEUROCHIRURGICA
(2022)
Article
Critical Care Medicine
David A. Zuckerman, Joseph T. Giacino, Yelena G. Bodien
Summary: The outcomes of TBI are diverse and not standardized, with dichotomization of outcomes into favorable and unfavorable categories potentially limiting detection of treatment effects and impacting decision-making processes.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Neurosciences
Teodor Svedung Wettervik, Per Enblad, Anders Lewen
Summary: The study found that pre-injury alcohol abuse was common in severe TBI patients, associated with coagulopathy, worse intracranial hemorrhage/injury evolution, and independently predicted poor clinical outcome. These findings suggest that patients with pre-injury alcohol abuse should receive more attention in care and research to address the specific challenges they face.
Review
Neurosciences
Miyamoto Akira, Takata Yuichi, Ueda Tomotaka, Kubo Takaaki, Mori Kenichi, Miyamoto Chimi
Summary: This paper discusses the importance of traumatic brain injury and its potential long-term consequences for public health professionals, as well as the distinct features of neurorehabilitation for affected individuals. It also addresses common medical issues that may occur at different stages of neurorehabilitation, and the importance of scheduling rehabilitation programs and the availability of comprehensive rehabilitative neuropsychology techniques.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Medical Laboratory Technology
Yun Xie, Zhidong Guo, Fanghui Chen, Chen Xiao, Jianping Xu, Dezhi Bo
Summary: The study found that serum netrin-1 concentrations in TBI patients are closely related to prognosis, and may serve as a potential biomarker for predicting outcomes in TBI patients.
CLINICA CHIMICA ACTA
(2021)
Article
Emergency Medicine
Henry Alexander Leijdesdorff, Juno Legue, Pieta Krijnen, Steven Rhemrev, Sanne Kleinveld, Inger Birgitta Schipper
Summary: The study suggests a correlation between high BAC levels and lower risk of in-hospital mortality and less ICU admissions for TBI patients. Further research into the underlying mechanisms is necessary.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2021)
Article
Psychiatry
James R. Gooden, Vanessa Petersen, Georgia L. Bolt, Ashlee Curtis, Victoria Manning, Catherine A. Cox, Dan I. Lubman, Shalini Arunogiri
Summary: This study investigated the biopsychosocial and neuropsychological profiles of individuals reporting cognitive impairment in MA-polysubstance users compared to an alcohol-using group. The study found that the neuropsychological profiles were largely similar between the two groups, but MA-polysubstance users were more likely to experience overall harm from substance use at a younger age. This highlights the importance of considering factors such as age, emotional distress, and indirect substance-related harms in understanding cognitive difficulties in MA-polysubstance users.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Rehabilitation
Rachel Sayko Adams, Jessica M. Ketchum, Risa Nakase-Richardson, Douglas I. Katz, John D. Corrigan
Summary: This study investigated the prevalence of low-risk drinking after moderate/severe traumatic brain injury (TBI) and found that more than 30% of participants drank at a low-risk level both before and after the injury. Most drinkers continued to consume alcohol within the low-risk level post-injury, indicating the need for further research on the long-term effects of low-risk drinking after more severe TBI.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Critical Care Medicine
Teodor Svedung Wettervik, Erta Beqiri, Anders Hanell, Stefan Yu Bogli, Michal Placek, Mathew R. Guilfoyle, Adel Helmy, Andrea Lavinio, Ronan O'Leary, Peter J. Hutchinson, Peter Smielewski
Summary: The study examined the impact of threshold insults on brain tissue oxygenation (pbtO(2)) in traumatic brain injury (TBI), and found that lower pbtO(2) levels were associated with unfavorable outcomes and mortality. The study also highlighted the importance of considering concurrent disturbances in cerebral physiological variables when assessing the impact of low pbtO(2). Prospective trials are needed to further investigate the potential benefits of pbtO(2)-directed therapy and determine individualized threshold values.
Article
Medicine, General & Internal
Peter S. Tatum, Emily Anderson, Alina Kravtsova, Osamah Alnasser, Thomas Hedges, Deborah M. Green-Laroche, Neel Madan
Summary: This case illustrates a unique situation of rapid cognitive decline caused by spinal cerebrospinal fluid venous fistula (SCVF). Treatment with acetazolamide may serve as prophylaxis for rebound intracranial hypertension, and the presence of a hyperintense paraspinal vein on imaging could potentially aid in the future diagnosis of SCVF.
Article
Oncology
Takahisa Mikami, Bobby Liaw, Mizuho Asada, Takahiro Niimura, Yoshito Zamami, Deborah Green-LaRoche, Lori Pai, Michael Levy, Suriya Jeyapalan
Summary: The use of immune checkpoint inhibitors (ICIs) is associated with a higher risk of neurological complications, with dual ICI therapy posing a higher risk. Older age, sex, or metastasis were not significant risk factors for the incidence of neurologic ICI-related AEs. Patients at older age, with certain cancer types, or on dual ICI therapy may be at higher risk of fatal neurologic AEs.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Review
Critical Care Medicine
Cherylee W. J. Chang, Jose Javier Provencio, Shreyansh Shah
CRITICAL CARE MEDICINE
(2021)
Article
Clinical Neurology
Tyler Miao, Michael Johanis, Taranjit Kaur, Courtney Duong, Russell De Jong, Shelby Willis, Michelle Hong, Prasanth Romiyo, Leslie Hwang, David McArthur, Isaac Yang, Quinton Gopen
Summary: This study compared the thickness of the temporal bone beyond the petrous portion between healthy subjects and those with SSCD, finding that the etiology of SSCD is limited to the petrous portion of the temporal bone and may not be related to a larger process of global temporal bone degeneration. Additional clinical screening for regions outside the petrous temporal bone is not warranted unless SSCD patients present with symptoms characteristic of other temporal bone pathologies.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Christopher C. Giza, Michael McCrea, Daniel Huber, Kenneth L. Cameron, Megan N. Houston, Jonathan C. Jackson, Gerald McGinty, Paul Pasquina, Steven P. Broglio, Alison Brooks, John DiFiori, Stefan Duma, Jaroslaw Harezlak, Joshua Goldman, Kevin Guskiewicz, Thomas W. McAllister, David McArthur, Timothy B. Meier, Jason P. Mihalik, Lindsay D. Nelson, Steven Rowson, Jessica Gill
Summary: The study investigated acute blood protein levels in military cadets after combative training-associated concussions. Results suggest that blood biomarkers have potential for use as research tools to better understand the pathobiological changes associated with concussion and to assist with injury identification and recovery from combative training-associated concussions among military service academy cadets.
Meeting Abstract
Rehabilitation
Shannon S. Westerberg, Madison Harris, Samia Rafeedie, David McArthur, Christopher Giza
AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
(2021)
Article
Neuroimaging
Marianna La Rocca, Giuseppe Barisano, Alexis Bennett, Rachael Garner, Jerome Engel, Emily J. Gilmore, David L. McArthur, Eric Rosenthal, James Stanis, Paul Vespa, Frederick Willyerd, Lara L. Zimmermann, Arthur W. Toga, Dominique Duncan
Summary: The text discusses the heterogeneous injury patterns that can result from traumatic brain injury, and how lesion size, location, and the interaction between contusion number and location may affect the occurrence of seizures. The preliminary report describes the methodologic approach to identifying and segmenting hemorrhagic contusions using early posttraumatic MRI, as well as the association between hemorrhagic contusion and edema location and volume with seizure incidence.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Clinical Neurology
Joel Frohlich, Micah A. Johnson, David L. McArthur, Evan S. Lutkenhoff, John Dell'Italia, Courtney Real, Vikesh Shrestha, Norman M. Spivak, Jesus E. Ruiz Tejeda, Paul M. Vespa, Martin M. Monti
Summary: The study found that sedation-induced burst-suppression (SIBS) was positively associated with outcomes at 6 months in patients with moderate-to-severe traumatic brain injury (TBI), but did not predict outcomes at discharge. These results suggest that burst suppression may have neuroprotective effects in acute patients with TBI etiologies.
FRONTIERS IN NEUROLOGY
(2021)
Letter
Critical Care Medicine
Thomas P. Bleck, Timothy G. Buchman, Cherylee W. J. Chang, R. Phillip Dellinger, Clifford S. Deutschman, Sameer S. Kadri, John C. Marshall, David M. Maslove, Henry Masur, Tiffany M. Osborn, Margaret M. Parker, Bram Rochwerg, Aarti Sarwal, Jonathan Sevransky, Ravi R. Thiagarajan
CRITICAL CARE MEDICINE
(2022)
Article
Neurosciences
Ruyi Huang, Jason Worrell, Eric Garner, Stephanie Wang, Tali Homsey, Bo Xu, Erika L. Galer, Yan Zhou, Sherwin Tavakol, Meelod Daneshvar, Timothy Le, Harry V. Vinters, Noriko Salamon, David L. McArthur, Marc R. Nuwer, Irene Wu, James C. Leiter, Daniel C. Lu
Summary: Cervical spinal cord EES can counteract the respiratory depression caused by opioids and promote respiratory activity.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Critical Care Medicine
Kristi Tempro, Cherylee W. J. Chang
CRITICAL CARE CLINICS
(2023)
Review
Clinical Neurology
Wuwei Feng, Alexis Domeracki, Christine Park, Shreyansh Shah, Pratik Y. Chhatbar, Swaroop Pawar, Cherylee Chang, Po-Chun Hsu, Eric Richardson, David Hasan, Estate Sokhadze, Quanguang Zhang, Hanli Liu
Summary: This article summarizes the results of clinical trials testing near-infrared laser therapy as an acute stroke treatment, discusses the mechanisms of light stimulation, challenges in the translational process, and parameters, dosages, and safety issues of light stimulation, and proposes potential opportunities for using transcranial light stimulation as a cerebroprotective or restorative tool for future stroke treatment.
TRANSLATIONAL STROKE RESEARCH
(2022)
Meeting Abstract
Psychology, Clinical
Kristina E. Smith, Daniel W. Lopez-Hernandez, Alexis Bueno, Rachel A. Rugh-Fraser, Bethany A. Nordberg, Deborah Budding, David A. Hovda, David L. McArthur, David Plurad, Joaquin M. Fuster, Ellen Woo, David J. Hardy, Matthew J. Wright
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2021)
Meeting Abstract
Psychology, Clinical
Winter Olmos, Daniel W. Lopez-Hernandez, Isabel Munoz, Laura Schierholz, Rachel A. Rugh-Fraser, Raelynn B. Munoz, Bethany A. Nordberg, David A. Hovda, David L. McArthur, Paul Vespa, Joaquin M. Fuster, Ellen Woo, Enrique Lopez, David J. Hardy, Matthew J. Wright
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2021)
Meeting Abstract
Psychology, Clinical
Abril Baez, Daniel W. Lopez-Hernandez, Winter Olmos, Rachel A. Rough-Fraser, Kristina E. Smith, Alexis Bueno, Isabel C. Munoz, Sarah Saravia, Deborah Budding, Paul Vespa, David A. Hovda, Pavel Y. Litvin, Nick Graub, David L. McArthur, David Plurad, Sarah Fatoorechi, Ellen Woo, David J. Hardy, Matthew J. Wright
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2021)