Article
Clinical Neurology
Nickalus R. Khan, Turki Elarjani, Aria M. Jamshidi, Stephanie H. Chen, Clifford S. Brown, Josh Abecassis, Michael A. Silva, Victor M. Lu, Eva Wu, Monica Diaz-Kanelidis, Rita Bhatia, Michael E. Hoffer, Adrien A. Eshraghi, Christine T. Dinh, Simon I. Angeli, Fred F. Telischi, Jacques J. Morcos
Summary: This study retrospectively evaluated the clinical and surgical outcomes of a large surgical series of vestibular schwannoma in North America over 20 years. The study found that facial nerve outcomes were correlated with cerebellopontine angle extension, tumor volume, facial nerve stimulation threshold, facial nerve consistency, preoperative facial nerve function, and history of a prior resection. The data supports a continuation of a strategy of gross total resection, modifiable by intraoperative findings and judgment.
WORLD NEUROSURGERY
(2022)
Article
Oncology
Michel Heide Talebnasab, Dan Dupont Hougaard
Summary: Vestibular schwannoma is the most common type of intracranial schwannoma, accounting for about 8% of all intracranial tumors in adults with an estimated incidence rate of around 1.3/100,000. The incidence rates of facial nerve schwannomas and cochlear nerve schwannomas are not well-documented. These three types of nerve tumors often present with unilateral hearing loss, tinnitus, and disequilibrium. Facial nerve palsy is common in facial nerve schwannomas but rare in vestibular schwannomas. The symptoms are usually persistent and progressive, leading to interventions that may cause significant morbidity such as deafness and imbalance.
Article
Clinical Neurology
Felix Arlt, Johannes Kasper, Dirk Winkler, Katja Jaehne, Michael Karl Fehrenbach, Juergen Meixensberger, Caroline Sander
Summary: Intraoperative neurophysiological monitoring is crucial in vestibular schwannoma surgery to prevent nerve injury. Repeated direct nerve stimulation and a detected decreased amplitude might show facial nerve function deterioration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Otorhinolaryngology
Catherine Sobieski, Daniel E. Killeen, Samuel L. Barnett, Bruce E. Mickey, Jacob B. Hunter, Brandon Isaacson, Joe Walter Kutz
Summary: Facial nerve outcomes one year after microsurgical resection are poorer in patients with NF2 tumors compared to sporadic tumors, particularly for tumors with a volume greater than 3 cm³ and those classified as NF2 tumors.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Kareem O. Tawfik, Michael Coulter, Thomas H. Alexander, Joe Saliba, Bill Mastrodimos, Roberto A. Cueva
Summary: Identifying clinical factors associated with delayed facial palsy (DFP) after microsurgical resection of vestibular schwannoma and determining whether DFP predicts worse facial nerve (FN) outcomes. Tumor size, preoperative HB2 function, and onset timing of postoperative facial palsy are key factors influencing final FN outcomes. In patients with DFP, a longer time to onset of weakness predicts better long-term FN function.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Clinical Neurology
Bridget MacDonald, Yin Ren, Bita Shahrvini, Kareem O. Tawfik, Omid Moshtaghi, Marc S. Schwartz, Rick A. Friedman
Summary: This study aimed to analyze the characteristics and functional changes of delayed facial nerve palsy following resection of vestibular schwannoma (VS). The results showed that intraoperative electromyographic facial nerve response, tumor size, surgical approach, and extent of resection may play a role in the development of delayed facial nerve palsy. Most patients were able to recover near-normal function after experiencing delayed facial nerve palsy.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Medicine, Research & Experimental
Daniel E. Killeen, Samuel L. Barnett, Bruce E. Mickey, Jacob B. Hunter, Brandon Isaacson, Joe Walter Kutz
Summary: The study revealed that patients with tumor volume >3 cm(3) had worse facial nerve outcomes 12 months following surgical resection. Tumor volume was identified as a key factor affecting facial nerve function outcomes.
Article
Otorhinolaryngology
Yin Ren, Bridget MacDonald, Kareem O. Tawfik, Marc S. Schwartz, Rick A. Friedman
Summary: Clinical predictors of facial nerve outcomes after microsurgical resection of vestibular schwannoma were identified, indicating excellent outcomes can be achieved with this procedure. Gross total resection and >= 100-mu V intraoperative FN electromyographic response were found to predict excellent FN outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Review
Clinical Neurology
Mingbin Bao, Yunsen He, Ye Tao, Li Liu, Yuheng Li, Yongjun Zhu, Qinjiang Huang, Mengjun Zhang, Bo Wu, Hao Wang
Summary: This article reports a case of a giant vestibular schwannoma during pregnancy, highlighting the importance of early diagnosis and treatment, and providing insights into the optimal timing for surgery.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Michael A. Silva, Henry Chang, Ashish H. Shah, Nickalus R. Khan, Clifford S. Brown, Christine T. Dinh, Adrien A. Eshraghi, Fred F. Telischi, Simon Angeli, Jacques J. Morcos
Summary: Intracisternal papaverine irrigation during vestibular schwannoma resection can safely improve immediate postoperative facial nerve outcomes, maintain similar long-term facial nerve outcomes, and is not associated with a significant increase in complications.
WORLD NEUROSURGERY
(2022)
Review
Medicine, General & Internal
Leonardo Franz, Gino Marioni, Antonio Mazzoni, Cosimo de Filippis, Elisabetta Zanoletti
Summary: This narrative review provides an update on the patho-physiological and clinical issues related to facial nerve damage in oto-neurological and skull base surgery. The occurrence of intraoperative facial nerve damage is associated with the anatomical relationship between tumor and nerve, the trajectory of the surgical corridor, and the boundaries of the resection margins. Mechanisms such as stretching, compression, devascularization, and heating may contribute to intraoperative facial nerve damage and nerve regeneration disorders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Gang Xiao, Bin Huang, Ming Guo, Chaoxin Long, Pingan Li, Bin Zhong, Chuncheng Guan
Summary: BRCAT54 is an anti-tumor lncRNA that is downregulated in lung cancer and its role in vestibular schwannoma (VS) is unclear. This study found that BRCAT54 interacts with miR-21 and suppresses cell proliferation in VS.
Article
Clinical Neurology
Xian-hao Jia, Zhen Gao, Nai-er Lin, Ya-sheng Yuan, Wei-dong Zhao
Summary: This study reports the long-term outcome of delayed facial nerve paralysis (DFNP) after surgical resection of vestibular schwannoma and evaluates the influence of various factors on the prognosis of facial nerve function. Among 265 patients who underwent surgical excision of VS through a retrosigmoid approach, 15 (5.7%) developed DFNP. The majority of patients with DFNP had a favorable prognosis, but a small proportion of patients with deteriorated facial nerve function immediately after surgery had poor long-term outcomes, despite confirmation of their facial nerve integrity anatomically and by electrical stimulation.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Robert J. Macielak, Christine M. Lohse, Katherine P. Wallerius, Skye K. Lawlor, Brian A. Neff, Maria Peris Celda, Jamie J. Van Gompel, Colin L. W. Driscoll, Michael J. Link, Matthew L. Carlson
Summary: Younger age and better immediate postoperative HB grade were found to be significantly associated with complete recovery of facial nerve function to HB Grade I after microsurgical resection of sporadic vestibular schwannoma.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Otorhinolaryngology
Zdenek Fik, Josef Kraus, Zdenek Cada, Martin Chovanec, Alzbeta Fikova, Eduard Zverina, Jan Betka, Jan Plzak
Summary: The study demonstrates the utility of electromyographic follow-up in facial nerve reconstruction, with hemihypoglossal-facial anastomosis being an optimal solution for restoring facial function. Electromyography can predict initial reinnervation activity after reconstructive procedures, aiding in identifying insufficiently recovering patients during follow-up.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Review
Otorhinolaryngology
Antonio Moffa, Lucrezia Giorgi, Valeria Fiore, Peter Baptista, Michele Cassano, Manuele Casale
Summary: There is no statistically significant difference in the incidence of otorrhoea between water exposure with and without ear protection in children with VTs, and between water exposure and no water exposure in children with VTs. Therefore, prohibiting water activities may not be necessary and individualized decisions should be made based on the patient's condition and history of otorrhoea. Ear protection should be recommended during the first month after surgery and in cases of recurrent otorrhoea.
ACTA OTORRINOLARINGOLOGICA ESPANOLA
(2022)
Article
Otorhinolaryngology
Manuele Casale, Antonio Moffa, Lucrezia Giorgi, Lorenzo Sabatino, Michelangelo Pierri, Rodolfo Lugo, Peter Baptista, Vittorio Rinaldi
Summary: The Alianza technique is a safe and repeatable surgical procedure for treating concentric pharyngeal collapse in selected OSA patients. It showed significant improvements in post-operative apnea-hypopnea indexes, oxygen desaturation index, ESS scores, and snoring VAS scores, with no major complications observed. Further studies on a larger scale are needed to confirm the effectiveness of Alianza in OSA patients.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Clinical Neurology
Marcello Di Pumpo, Mario Cesare Nurchis, Antonio Moffa, Lucrezia Giorgi, Lorenzo Sabatino, Peter Baptista, Lorenzo Sommella, Manuele Casale, Gianfranco Damiani
Summary: The study compared the cost differences between the multiple-access outpatient pathway and the telemedicine pathway, showing that the telemedicine approach had cost savings from the perspectives of the hospital, patients, and society. The adoption of telemedicine home sleep apnea testing could improve the efficiency of healthcare processes, considering both direct and indirect costs incurred by patients and healthcare providers.
SLEEP AND BREATHING
(2022)
Review
Otorhinolaryngology
Peter M. Baptista, Fabricio Martin, Harry Ross, Carlos O'Connor Reina, Guillermo Plaza, Manuele Casale
Summary: The development of sleep-related smartphone applications and devices offers convenient options for the diagnosis, management, and follow-up of sleep disordered breathing. However, their accuracy is currently not as reliable as traditional options.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Medicine, General & Internal
Peter M. Baptista, Natalia Diaz Zufiaurre, Octavio Garaycochea, Juan Manuel Alcalde Navarrete, Antonio Moffa, Lucrezia Giorgi, Manuele Casale, Carlos O'Connor-Reina, Guillermo Plaza
Summary: This study summarizes the personal experience with Transoral Robotic Surgery (TORS) for treating Obstructive Sleep Apnea (OSA) and provides information on its safety, efficacy, and postoperative complications. TORS appears to be an effective and safe procedure for selected OSA patients seeking alternative therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Analytical
Nunzia Molinaro, Emiliano Schena, Sergio Silvestri, Carlo Massaroni
Summary: This study proposes a technique for estimating heart rate and respiratory rate by processing video frames without physical contact with the subject. The study records videos of healthy volunteers using a multi-ROI spectral analysis method and compares the results with reference data, showing high accuracy.
Review
Clinical Neurology
Antonio Moffa, Lucrezia Giorgi, Michele Cassano, Rodolfo Lugo, Peter Baptista, Manuele Casale
Summary: This systematic review aimed to report the complications and side effects of different barbed pharyngoplasty (BP) techniques. The results showed that short-term and long-term complications included thread/knot extrusion, dysphagia, bleeding, myoresective surgery dehiscence, and foreign body sensation. Overall, BP is a safe technique, but more large-scale studies with long-term follow-up are needed to confirm these results.
SLEEP AND BREATHING
(2023)
Review
Clinical Neurology
Antonio Moffa, Lucrezia Giorgi, Luca Carnuccio, Michele Cassano, Filippo Montevecchi, Peter Baptista, Manuele Casale
Summary: This review discusses the efficacy of new non-invasive electrical stimulation devices in improving snoring by approximately 50%, with conflicting results on their effectiveness in treating OSA. Further studies are needed to support the use of these devices in treating OSA.
SLEEP AND BREATHING
(2023)
Article
Otorhinolaryngology
Felipe Castillo-Farias, Marina Carrasco-Llatas, Gabriela Bosco, Vittorio Rinaldi, Peter Michael Baptista-Jardin, Giovanni Cammaroto, Uri Alkan, Noelia Munoz-Fernandez, Pablo Rosel, Cristian Bachelet, Manuele Casale, Antonio Moffa, Guillermo Plaza-Mayor, Nuria Perez-Martin, Claudio Vicini
Summary: The study evaluated the results of pharyngoplasty with barbed sutures in the treatment of obstructive sleep apnea syndrome. The results showed that this treatment method improved the patients' condition and increased the success rate of the surgery.
EGYPTIAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Octavio Garaycochea, Peter Baptista, Marta Calvo-Imirizaldu, David Terrasa, Antonio Moffa, Manuele Casale, Juan Alcalde, Carlos O'Connor-Reina, Guillermo Plaza, Secundino Fernandez
Summary: This study describes the anatomical relationship between the lingual nerve and the lateral oropharyngeal wall, revealing that the lingual nerve runs laterally to the lateral oropharyngeal wall and is closer to it at its lower third.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Shekh Md Mahmudul Islam, Nunzia Molinaro, Sergio Silvestri, Emiliano Schena, Carlo Massaroni
Summary: Non-contact respiratory monitoring using optical sensors integrated with commercial video cameras is proposed for recognizing different respiratory patterns, including eupnea, tachypnea, bradypnea, and apnea. A hyper-feature algorithm is implemented to extract distinguishable air-flow-related features from videos captured from 24 participants with different respiratory patterns. The system achieved an accuracy of 96.07% in recognizing all respiratory patterns, with the lowest performance (81.81%) in detecting bradypnea and 100% accuracy in detecting apnea events.
IEEE TRANSACTIONS ON HUMAN-MACHINE SYSTEMS
(2023)
Review
Food Science & Technology
Dnyandeo Pawar, Daniela Lo Presti, Sergio Silvestri, Emiliano Schena, Carlo Massaroni
Summary: This article provides a comprehensive overview of various techniques and methods for monitoring physical, chemical, and biological parameters in cultured meat production. It aims to improve the understanding of novel sensing systems and support the development of cultured meat applications.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Engineering, Electrical & Electronic
Nunzia Molinaro, Federico Zangarelli, Emiliano Schena, Sergio Silvestri, Carlo Massaroni
Summary: Continuous estimation of heart rate and respiratory rate can be achieved using images captured with a single digital camera. The study found that the estimation error is smaller during motionless trials and increases during movements.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Nunzia Molinaro, Emiliano Schena, Sergio Silvestri, Carlo Massaroni
Summary: The identification of respiratory patterns based on the movement of the chest wall can assist in monitoring an individual's health status. This study explores the possibility of using a single RGB digital camera to record the kinematics of the thoracic and abdominal regions by placing four non-reflective markers on the torso.
Article
Otorhinolaryngology
Michele Cassano, Eugenio De Corso, Valeria Fiore, Rossana Giancaspro, Antonio Moffa, Manuele Casale, Eleonora Maria Consiglia Trecca, Dario Antonio Mele, Pasquale Cassano, Matteo Gelardi
Summary: This study aimed to update the classification of adenoid hypertrophy (AH) to guide physicians in choosing the best therapeutic option. The study found that patients can be classified into four different levels of AH based on nasal endoscopy results, which provides guidance for selecting medical or surgical treatments. Additionally, surgical treatment is effective in controlling both nasal symptoms and associated comorbidities in patients with important comorbidities.
ACTA OTORHINOLARYNGOLOGICA ITALICA
(2022)