Article
Pediatrics
Marinde van Lennep, Frederique Lansink, Marc A. Benninga, Michiel P. van Wijk
Summary: The study aimed to determine age-specific normal values in healthy infants using the Infant Gastroesophageal Reflux Questionnaire Revised (I-GERQ-R). The results showed that reflux symptoms decrease in the first 24 months of life in healthy infants. Validation as a diagnostic tool for GER-disease using age-appropriate normal values is needed.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Annelies Geeraerts, Livia Guadagnoli, Ans Pauwels, Hannelore Geysen, Thomas Neyens, Lukas Van Oudenhove, Tim Vanuytsel, Jan Tack
Summary: This study aimed to investigate the association between psychological symptoms and reflux phenotype along the GERD spectrum in refractory reflux patients. The findings suggest that psychological symptoms do not differ across reflux phenotypes and do not predict reflux phenotype membership in refractory reflux patients.
Review
Multidisciplinary Sciences
Amanda J. Krause, Erin H. Walsh, Philip A. Weissbrod, Tiffany H. Taft, Rena Yadlapati
Summary: Laryngopharyngeal reflux (LPR) is a syndrome caused by the reflux of gastric contents into the pharynx or larynx, leading to a variety of symptoms. Treatment options for LPR include medical therapies such as proton pump inhibitors and noninvasive treatment options like lifestyle therapy. Due to the complexity of patients with LPR, a treatment algorithm is proposed to assist clinicians in diagnosing and treating patients effectively.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Inyoung Hwang, Sang Chun Ji, Jaeseong Oh, Hyojin Kim, Hyunju Cha, John Kim, Chang-Seok Lee, Kyung-Sang Yu, SeungHwan Lee
Summary: This study investigated the safety, tolerability, pharmacodynamics, pharmacokinetics, and pharmacogenomics of zastaprazan. The results showed that zastaprazan effectively suppressed gastric acid secretion and exhibited favorable pharmacokinetic properties. The evaluation indicated that zastaprazan is safe and suitable for the treatment of acid-related diseases.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Joan W. Chen, Marcelo F. Vela, Kathryn A. Peterson, Dustin A. Carlson
Summary: This article provides practical advice for the clinical management of patients with suspected extraesophageal gastroesophageal reflux disease. The advice is based on available evidence from published studies, clinical trials, and clinical guidelines. It emphasizes the importance of considering extraesophageal manifestations of gastroesophageal reflux disease and the need for a multidisciplinary approach in diagnosis and treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tina L. Samuels, Simon Blaine-Sauer, Ke Yan, Kate Plehhova, Cathal Coyle, Nikki Johnston
Summary: Epithelial barrier dysfunction is a major characteristic of GERD, which is associated with symptom origination, inflammatory remodeling, and carcinogenesis. Alginate-based antireflux medications have been found to protect against peptic barrier disruption, and this study reveals the molecular mechanisms behind the injury and protection. The findings highlight the potential of targeting regulated intramembrane proteolysis and molecular mechanisms induced by weakly acidic reflux to treat GERD and prevent carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Suzanna Hirsch, Joel A. Friedlander, Hayat Mousa, Valeria Cohran, Jose M. Garza, Rinarani Sanghavi, Lusine Ambartsumyan, Paul D. Mitchell, Rachel Rosen
Summary: While some practice patterns were similar between groups, aerodigestive providers pursued more testing than nonaerodigestive providers in several clinical scenarios including infants with respiratory symptoms and GE reflux.
JOURNAL OF PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Magnus Halland, Adil E. Bharucha, Michael D. Crowell, Karthik Ravi, David A. Katzka
Summary: The study showed that diaphragmatic breathing can reduce the number of postprandial reflux events in patients with upright GERD by increasing the difference between LES and gastric pressure. These findings support further investigation of diaphragmatic breathing as a therapy for GERD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Sung-Goo Kang, Hyun Jee Hwang, Youngwoo Kim, Junseak Lee, Jung Hwan Oh, Jinsu Kim, Chul-Hyun Lim, Seung Bae Youn, Sung Hoon Jung
Summary: The study evaluated the association between reflux esophagitis and fatigue, finding no statistically significant association between reflux esophagitis and daytime sleepiness, fatigue, anxiety, or depression. However, fatigue was associated with GERD symptoms, being women, anxiety, and depression. Further research is needed to clarify the relationship between fatigue and reflux esophagitis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Valentinos Sofokleous, Anna-Maria Papadopoulou, Evangelos Giotakis, Alexander Delides, Efthymios Kyrodimos, Pavlos Maragoudakis, Ioannis Psarommatis
Summary: This study reviews the latest developments in pediatric laryngopharyngeal reflux, highlighting the need for further research on diagnostic methods and treatment strategies. The review includes 86 articles and emphasizes the urgency of future studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yung-An Tsou, Sheng-Hwa Chen, Wen-Chieh Wu, Ming-Hsui Tsai, David Bassa, Liang-Chun Shih, Wen-Dien Chang
Summary: This study investigated the clinical assessments and extent of esophageal pressure changes in LRPD patients with varying severities of GERD. It found that patients with more severe GERD had lower esophageal sphincter pressures, with the lowest pressures observed in patients with grade D GERD. No significant differences in esophageal pressures were noted based on age, gender, or BMI among the patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Loren Laine, Kenneth DeVault, Philip Katz, Stefan Mitev, John Lowe, Barbara Hunt, Stuart Spechler
Summary: This study found that vonoprazan, a potassium-competitive acid blocker, was noninferior and superior to the PPI lansoprazole in healing and maintenance of erosive esophagitis, particularly in patients with more severe cases.
Article
Surgery
Hoover Wu, Mikhail Attaar, Harry J. Wong, Michelle Campbell, Kristine Kuchta, Ervin Woodford Denham, John Linn, Michael B. Ujiki
Summary: Previous research has shown that impedance planimetry-based FLIP measurements are associated with patient-reported outcomes after laparoscopic antireflux surgery. This study found that Toupet and Nissen fundoplications have different ideal distensibility ranges, which are associated with improved patient-reported outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Psychology, Developmental
Anna Jones, Katie Rogers, Keith Sullivan, Nina Viljoen
Summary: This study investigated the utility of questionnaires used in adult autism assessment and found that while they showed good sensitivity in detecting a positive diagnosis, their ability to exclude individuals without a diagnosis was poor. These findings have clinical implications for improving the assessment process.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Nutrition & Dietetics
Yang Chen, Xiaohong Sun, Wenjuan Fan, Jiao Yu, Peng Wang, Dong Liu, Mingwei Song, Shi Liu, Xiuli Zuo, Rong Zhang, Yuantao Hou, Shaomei Han, Yanqing Li, Jun Zhang, Xiaoqing Li, Meiyun Ke, Xiucai Fang
Summary: This study compared dietary and lifestyle triggers between non-erosive reflux disease (NERD) and reflux esophagitis (RE) in Chinese patients and provided evidence for practical dietary modifications for GERD.