Review
Obstetrics & Gynecology
Kamran Hessami, Jennifer Welch, Anja Frost, Abdelrahman AlAshqar, Sara E. Arian, Ethan Gough, Mostafa A. Borahay
Summary: In this meta-analysis, we examined the quantity and dose of opioids dispensed during the perioperative period for benign hysterectomy, as well as the predictors of persistent opioid use after the procedure. A total of 8 studies involving 377,569 women were included. The findings showed that 83% of women were dispensed opioids during the perioperative period, and the rate of persistent opioid use after benign hysterectomy was 5%.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Otorhinolaryngology
Jaxon W. Jordan, Christopher Spankovich, Scott P. Stringer
Summary: The study showed that implementing opioid stewardship recommendations in endoscopic sinonasal surgery can reduce the volume of opioid prescriptions without increasing patient phone calls or affecting physician satisfaction scores.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Pediatrics
Thais Calderon, Elizabeth Hedges, Michael H. Livingston, Christopher Gitzelmann, Walter Pegoli, Derek Wakeman
Summary: Most children can achieve adequate pain control after pediatric general surgical procedures with scheduled nonopioid medications only, while a limited supply of opioids for analgesia after discharge may benefit a small subset of patients. Accurate assessment of pain levels is crucial for adjusting pain management strategies.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Natalia Janicka, Agnieszka Salek, Magdalena Sawinska, Ernest Kuchar, Anna Wiela-Hojenska, Katarzyna Karlowicz-Bodalska
Summary: This review analyzes the impact of diclofenac, ibuprofen, naproxen, acetylsalicylic acid, and paracetamol on the cell membrane of skin and gastrointestinal cancers. These drugs can modulate membrane components, leading to changes in receptor expression and lipid bilayer composition, and ultimately inhibiting tumor progression and supporting chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Salva N. Balbale, Lishan Cao, Itishree Trivedi, Jonah J. Stulberg, Katie J. Suda, Walid F. Gellad, Charlesnika T. Evans, Bruce L. Lambert, Neil Jordan, Laurie A. Keefer
Summary: In this study, the high-dose opioid use among Veterans with unexplained GI symptoms and structural GI diagnoses was examined using national patient-level data from the VA and CMS. Results showed that approximately 10-15% of patients had high-dose opioid use, with factors such as receiving opioids from both VA and Part D, younger age, and benzodiazepine use associated with high-dose use. Efforts are needed to reduce high-dose opioid use among Veterans with concurrent GI symptoms and diagnoses.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Urology & Nephrology
Guilherme Sawczyn, Louis Lenfant, Alireza Aminsharifi, Soodong Kim, Jihad Kaouk
Summary: This study evaluated perioperative factors associated with opioid-free management after robotic radical prostatectomy. The results showed that using a less invasive approach (SP-EPP), having a shorter length of hospital stay, and having a lower BMI were predictive of being opioid-free after surgery.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Eran Bornstein, Gregg Husk, Erez Lenchner, Amos Grunebaum, Therese Gadomski, Cristina Zottola, Sarah Werner, Jamie S. Hirsch, Frank A. Chervenak
Summary: Transitioning to a standardized multimodal combination analgesic therapy after cesarean delivery significantly reduces opioid use, decreases average opioid dose, increases acetaminophen dose, and improves pain control. This approach can be effectively implemented on a large scale through incorporation of a multimodal order set in the electronic medical record system.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Arash Kalantar, Mahya Rezaei, Aarefeh Jafarzadeh Kohneloo, Maryam Taghizadeh-Ghehi
Summary: The study aimed to determine the consumption trends of opioid analgesics in Iran over 19 years. The results showed a significant increase in opioid analgesic utilization, suggesting sub-optimal pain management. Misuse and abuse contributed to the increase in consumption, indicating the need for better control and distribution measures.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Article
Medicine, General & Internal
Janet M. Currie, Molly K. Schnell, Hannes Schwandt, Jonathan Zhang
Summary: The study shows that existing patients maintained access to opioid analgesics and buprenorphine for opioid use disorder during the COVID-19 pandemic. Prescriptions for opioid-naive patients briefly decreased and rebounded, while initiation of buprenorphine remained at a low rate through August 2020.
Article
Medicine, General & Internal
Natasa Gisev, Luke Buizen, Ria E. Hopkins, Andrea L. Schaffer, Benjamin Daniels, Chrianna Bharat, Timothy Dobbins, Sarah Larney, Fiona Blyth, David C. Currow, Andrew Wilson, Sallie-Anne Pearson, Louisa Degenhardt
Summary: The objective of this population-based cohort study was to identify 5-year trajectories of prescription opioid use and examine the characteristics of each trajectory group. The results suggest that most individuals initiating treatment with prescription opioids had relatively low and time-limited exposure over a 5-year period. A small proportion of individuals had sustained or increasing use, and they were typically older with more comorbidities and higher use of psychotropic and other analgesic drugs.
Review
Clinical Neurology
Brydget Aguilar, Jonathan Penm, Shania Liu, Asad E. Patanwala
Summary: This systematic review and meta-analysis compared the efficacy and safety of Transdermal buprenorphine (TBUP) with other analgesics or placebo for acute postoperative pain. The results showed that there is insufficient evidence to recommend the use of TBUP in this setting. TBUP was associated with less pain compared to celecoxib and placebo, but no significant difference was found compared to fentanyl. Overall, there is insufficient evidence for the use of TBUP in acute postoperative pain management.
Article
Cardiac & Cardiovascular Systems
Timothy M. Markman, Chase R. Brown, Lin Yang, Gustavo S. Guandalini, Matthew C. Hyman, Jeffrey S. Arkles, Pasquale Santangeli, Robert D. Schaller, Gregory E. Supple, Rajat Deo, Saman Nazarian, Sanjay Dixit, David J. Callans, Andrew E. Epstein, Francis E. Marchlinski, Peter W. Groeneveld, David S. Frankel
Summary: This study investigated the incidence of persistent opioid use in patients who were opioid-naive after cardiac implantable electronic device (CIED) procedures. The results showed that 12% of patients continued to use opioids >30 days after surgery, and higher initially prescribed oral morphine equivalent doses were associated with developing persistent opioid use.
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Ken Lund, Floor D. Zegers, Sonia Friedman, Jessica R. Allegretti, Bente Mertz Norgard
Summary: The use of tramadol in patients with inflammatory bowel diseases (IBDs) was associated with lower odds of infection, bowel obstruction/ileus, and mortality compared to traditional opioids (TOs). These findings suggest that tramadol may be a safer option for pain management in IBD patients.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Surgery
Kevin K. Zhang, Kevin M. Blum, Jacqueline J. Chu, Abeba Zewdu, Sarah Janse, Roman Skoracki, Jeffrey E. Janis, Jenny C. Barker
Summary: This study tested the efficacy of a patient-specific opioid prescribing framework for estimating postdischarge opioid consumption and found that it accurately estimates opioid need and risk of persistent use in plastic surgery patients.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Obstetrics & Gynecology
Abdelrahman AlAshqar, Ryota Ishiwata, Chailee Moss, Kathleen M. Andersen, Lisa Yanek, Mark C. Bicket, G. Caleb Alexander, Mostafa A. Borahay
Summary: This study analyzed over 100,000 women who underwent benign hysterectomy and found that 4.6% of patients developed new persistent opioid use after the surgery. Factors such as age, geographic location, preoperative psychiatric and pain disorders, preoperative pain medication use, smoking habits, surgical complications, and perioperative opioid prescriptions were associated with new persistent opioid use.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Gastroenterology & Hepatology
Fabienne G. M. Smeets, Daniel Keszthelyi, Lisa Vork, Jan Tack, Nicholas J. Talley, Magnus Simren, Qasim Aziz, Alexander C. Ford, Jose M. Conchillo, Joanna W. Kruimel, Jim Van Os, A. M. Masclee
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Review
Anesthesiology
Rolf-Detlef Treede, Winfried Rief, Antonia Barke, Qasim Aziz, Michael Bennett, Rafael Benoliel, Milton Cohen, Stefan Evers, Nanna B. Finnerup, Michael B. First, Maria Adele Giamberardino, Stein Kaasa, Beatrice Korwisi, Eva Kosek, Patricia Lavand'homme, Michael Nicholas, Serge Perrot, Joachim Scholz, Stephan Schug, Blair H. Smith, Peter Svensson, Johan W. S. Vlaeyen, Shuu-Jiun Wang
Review
Anesthesiology
Michael Nicholas, Johan W. S. Vlaeyen, Winfried Rief, Antonia Barke, Qasim Aziz, Rafael Benoliel, Milton Cohen, Stefan Evers, Maria Adele Giamberardino, Andreas Goebel, Beatrice Korwisi, Serge Perrot, Peter Svensson, Shuu-Jiun Wang, Rolf-Detlef Treede, Michael Bennett, Nanna B. Finnerup, Michael First, Stein Kaasa, Eva Kosek, Patricia Lavand'homme, Joachim Scholz, Stephan Schug, Blair H. Smith, Johannes Vlaeyen
Review
Anesthesiology
Joachim Scholz, Nanna B. Finnerup, Nadine Attal, Qasim Aziz, Ralf Baron, Michael Bennett, Rafael Benoliel, Milton Cohen, Giorgio Cruccu, Karen D. Davis, Stefan Evers, Michael First, Maria Adele Giamberardino, Per Hansson, Stein Kaasa, Beatrice Korwisi, Eva Kosek, Patricia Lavand'homme, Michael Nicholas, Turo Nurmikko, Serge Perrot, Srinivasa N. Raja, Andrew S. C. Rice, Michael C. Rowbotham, Stephan Schug, David M. Simpson, Blair H. Smith, Peter Svensson, Johan W. S. Vlaeyen, Shuu-Jiun Wang, Antonia Barke, Winfried Rief, Rolf-Detlef Treede
Biographical-Item
Gastroenterology & Hepatology
Qasim Aziz
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Article
Gastroenterology & Hepatology
Kenichiro Nakagawa, Ken Hara, Asma Fikree, Shahab Siddiqi, Philip Woodland, Atsushi Masamune, Qasim Aziz, Daniel Sifrim, Etsuro Yazaki
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Medicine, Research & Experimental
David Gunn, Ron Fried, Rabia Lalani, Amanda Farrin, Ivana Holloway, Tom Morris, Catherine Olivier, Rachael Kearns, Maura Corsetti, Mark Scott, Adam Farmer, Anton Emmanuel, Peter Whorwell, Yan Yiannakou, David Sanders, John Mclaughlin, Kapil Kapur, Maria Eugenicos, Ayesha Akbar, Nigel Trudgill, Lesley Houghton, Phil G. Dinning, Alexander C. Ford, Qasim Aziz, Robin Spiller
Article
Gastroenterology & Hepatology
Adam D. Farmer, Ahmed Albusoda, Gehanjali Amarasinghe, James K. Ruffle, Heather E. Fitzke, Ruqaya Idrees, Ron Fried, Christina Brock, Qasim Aziz
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Gastroenterology & Hepatology
Florencia Carbone, Nick Goelen, Asma Fikree, Qasim Aziz, Jan Tack
Summary: Functional dyspepsia (FD) often co-exists with joint hypermobility syndrome (JHS), characterized by decreased gastric accommodation and lower nutrient tolerance compared to FD patients with JHS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Tim Klaassen, Fabienne G. M. Smeets, Lisa Vork, Jan Tack, Nicholas J. Talley, Magnus Simren, Qasim Aziz, Alexander C. Ford, Joanna W. Kruimel, Jose M. Conchillo, Carsten Leue, Adrian A. M. Masclee, Daniel Keszthelyi
Summary: This study demonstrated the good validity and reliability of a novel ESM-based PROM for assessing gastrointestinal symptoms in FD patients. The novel PROM allows evaluation of individual symptom patterns and interactions between symptoms and environmental/contextual factors. ESM has the potential to increase patients' disease insight, provide tools for self-management, and improve shared decision making, aiding in the transition toward personalized health care for FD patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Ans Pauwels, Jan Tack, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study found that slow, deep breathing can reduce visceral pain intensity, which is not specific to the frequency of slow breathing and is not mediated by autonomic or emotional responses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study did not support the hypothesis that adding an inspiratory load to slow, deep breathing enhances its hypoalgesic effects. While pain intensity was slightly lower during SDB with load compared to normal-frequency controlled breathing, the difference was minimal. Heart rate variability was higher during SDB, but emotional responses were less favorable when using load.
Article
Anesthesiology
Abraham B. Beckers, Lukas van Oudenhove, Zsa Zsa R. M. Weerts, Heidi I. L. Jacobs, Nikos Priovoulos, Benedikt A. Poser, Dimo Ivanov, Ali Gholamrezaei, Qasim Aziz, Sigrid Elsenbruch, Ad A. M. Masclee, Daniel Keszthelyi
Summary: The study found that subjects with abdominal pain had more pronounced brain activation during infusion, while activation at the NTS level was independent of subjective pain ratings. These findings contribute to understanding the fundamental mechanism necessary for developing novel therapies aimed at correcting disturbances in visceral afferent pain processing.
Review
Gastroenterology & Hepatology
Christopher Roberts, Ahmed Albusoda, Adam D. Farmer, Qasim Aziz
Summary: This study aimed to determine whether individuals with irritable bowel syndrome (IBS) have lower pain thresholds compared to healthy individuals. The results showed that reduced rectal pain threshold is more common in IBS patients than in healthy controls. Further research is needed to understand the pathophysiological and therapeutic implications of rectal sensitivity in IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: This study compared four deep breathing techniques and found that loaded breathing was associated with better cardiovascular effects, while pursed-lips breathing had better emotional responses. The findings suggest that different deep breathing techniques may have varying impacts on physiological and emotional states.