Article
Pharmacology & Pharmacy
Yanan Huang, Ziqing Du, Guochen Bao, Guocheng Fang, Matthew Cappadona, Lana McClements, Bernard E. Tuch, Hongxu Lu, Xiaoxue Xu
Summary: In this paper, a two-way controlled drug-release system was designed using near-infrared light and protein coating as external stimuli to promote and prolong drug release. A hierarchical nanostructure was fabricated using upconversion nanoparticles-mesoporous silica as the core-shell structure with protein lysozyme coating. The results demonstrated the uniform core-shell nanostructures and the potential of the designed system for chemotherapy treatment of solid cancers.
Article
Pharmacology & Pharmacy
Muhammad Umair Amin, Sajid Ali, Imran Tariq, Muhammad Yasir Ali, Shashank Reddy Pinnapreddy, Eduard Preis, Christian Woelk, Richard D. Harvey, Gerd Hause, Jana Bruessler, Udo Bakowsky
Summary: The study developed a stimuli responsive drug delivery system based on lipid supported mesoporous silica nanoparticles, enabling triggered drug release at the target site while avoiding premature release. Enhanced drug release by FDA approved US-irradiation, along with improved cellular uptake and reduced premature release effects, makes it a suitable candidate for delivering anticancer drugs.
Article
Pharmacology & Pharmacy
Irene Moroni, Alfonso E. Garcia-Bennett
Summary: In this study, melatonin was encapsulated in mesoporous silica with the addition of a coating of cellulose acetate phthalate. The release kinetics of melatonin and its metabolism were investigated in simulated gastrointestinal fluids and in an in vitro model of the intestinal tract. The presence of the coating affected the release and absorption of melatonin, as well as its catabolism. The confinement of melatonin in the mesopores had a slight impact on its permeability and metabolism.
Article
Materials Science, Multidisciplinary
Ozi Adi Saputra, Windy Ayu Lestari, Wahyu Nur Safitriono, Murni Handayani, Witri Wahyu Lestari, Fajar Rakhman Wibowo
Summary: The study successfully prepared surface-modified magnetic mesoporous silica nanoparticles with high loading capacity, which can prevent premature drug release and achieve controlled release under different pH conditions. The nanoparticles also demonstrated good magnetic properties, potentially extending to magnetic hyperthermia for cancer therapy.
Article
Chemistry, Analytical
Berrin Kucukturkmen, Wali Inam, Fadak Howaili, Mariam Gouda, Neeraj Prabhakar, Hongbo Zhang, Jessica M. Rosenholm
Summary: Microfluidics has been used to coat mesoporous silica nanoparticles (MSNs) with polymeric layers for achieving high protein loading and retention. This study demonstrates the potential of microfluidic technologies in the design of protein delivery systems, allowing for multicomponent systems and preservation of protein stability.
Article
Chemistry, Applied
Rui Li, Xianbin Mei, Xiangfeng Li, Changli Zhang, Liping Ruan
Summary: A novel bolt-like-blocking nanovalve based on mesoporous silica nanoparticles has been developed as a drug carrier. The peptide-modified nanoparticles show no obvious cytotoxicity and can be triggered for release by GSH. In addition, they have shown GSH-responsive capability in inducing cell apoptosis.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Multidisciplinary Sciences
Louis William Rogowski, Min Jun Kim
Summary: A newly discovered propulsion mechanism allows chemically coated microparticles to swim through mucus solution, with certain functionalizations altering propulsion behavior. The relationship between different chemical coatings, microparticle velocity, and controllability was explored, showing potential to enhance drug delivery methods and medical techniques utilizing micro/nanoparticles.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Inorganic & Nuclear
Selvakumari Ulagesan, Madhappan Santhamoorthy, Thi Phan Vy Phan, Krishnapandi Alagumalai, Kokila Thirupathi, Seong-Cheol Kim, Taek-Jeong Nam, Youn-Hee Choi
Summary: In this study, a mesoporous silica material containing amidoxime ligand groups was successfully synthesized through surface modification. The resulting SBA-15@AMI NPs exhibited a high concentration of amidoxime ligands on the surface, making them suitable for pH-responsive drug delivery applications in cancer therapy.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Ping Huang, Daizheng Lian, Hualin Ma, Nansha Gao, Limin Zhao, Ping Luan, Xiaowei Zeng
Summary: Mesoporous silica nanoparticles, with their simple synthesis, biocompatibility, and high surface area, have been developed as drug carriers for targeted and controlled drug release. By designing gated systems using various materials, these nanoparticles offer a new approach for selective delivery of antitumor drugs. Challenges and future prospects of gated mesoporous silica nanoparticles are discussed for their potential in drug delivery systems.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Paul Joyce, Silver Joemetsa, Simon Isaksson, Shakhawath Hossain, Per Larsson, Christel Bergstrom, Fredrik Hook
Summary: This study established a new method to monitor membrane permeation kinetics using mesoporous silica substrate and total internal reflection fluorescence microscopy. By contrasting the permeation behavior of pure felodipine with felodipine coupled to the permeability enhancer caprylate (C8), evidence for C8-facilitated transport across lipid membranes was provided, validating the potential of this approach to quantify carrier system-induced changes to cellular membrane permeation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Ling Cai, Yanqiang Huang, Yuanyuan Duan, Qiao Liu, Qilan Xu, Jia Jia, Jianming Wang, Qian Tong, Peipei Luo, Yujie Wen, Luming Peng, Qian Wu, Xudong Hang, Huijun Jiang, Ping Zhu, Yanmei Yang, Boshen Zhou, Liping Zeng, Hongkai Bi, Jin Chen
Summary: This study introduces a novel Schiff-based silver nanocomplex with broad-spectrum antimicrobial activity, including prevention of drug resistance, and demonstrates superior in vivo fungicidal efficacy compared to traditional antifungal drugs.
Article
Materials Science, Biomaterials
Haruka Hirayama, Saliu Alao Amolegbe, Md Saidul Islam, Mohammad Atiqur Rahman, Nonoka Goto, Yoshihiro Sekine, Shinya Hayami
Summary: In this study, encapsulation and release of antimalarial drug quinine using three nanocarriers were investigated, with pH and thermal optimization effects on drug adsorption and release from the nanocarriers explored.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Pharmacology & Pharmacy
Khatereh Zarkesh, Reza Heidari, Pooya Iranpour, Negar Azarpira, Fatemeh Ahmadi, Soliman Mohammadi-Samani, Fatemeh Farjadian
Summary: This study successfully synthesized a novel pH-responsive mesoporous silica nanoparticle and achieved targeted drug delivery to cancer cells by coating with hyaluronan. The results showed that the nanoparticles had good biocompatibility and biodegradability, and could improve pharmacokinetic parameters.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jingjing Zhu, Ying Zhang, Xiaojie Chen, Yue Zhang, Ke Zhang, Hongyue Zheng, Yinghui Wei, Hangsheng Zheng, Jiazhen Zhu, Fang Wu, Ji-Gang Piao, Zhihong Zhu, Fanzhu Li
Summary: This study developed a novel nanomedicine for treating glioma, which achieved better drug targeting effect and showed significant improvement in treatment efficacy and survival time in animal experiments.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Thorben Fischer, Inga Winter, Robert Drumm, Marc Schneider
Summary: Transporting macromolecular drugs like oligonucleotides into lungs has become increasingly important due to their high potency, but their chemical structure presents challenges including negative charge, membrane impermeability, and instability. A drug delivery system combining anti-inflammatory ingredients showed reduced TNF-alpha release, demonstrating improved activity in inhibiting TNF-alpha in the lungs.
Article
Chemistry, Physical
Anthony Dessalle, Javier Quilez-Bermejo, Vanessa Fierro, Feina Xu, Alain Celzard
Summary: Platinum is an expensive and scarce catalyst, limiting the large-scale commercialization of Pt-based electrochemical devices. The slow oxygen reduction reaction (ORR) with Pt in acidic media has led to the exploration of Pt-free catalysts. This review critically discusses the influence of the physicochemical and electrochemical properties of biomass-derived, carbon-based electrocatalysts for the ORR over the past decade.
Article
Chemistry, Multidisciplinary
Javier Quilez-Bermejo, Sergio Garcia-Dali, Ayoub Daouli, Andrea Zitolo, Rafael L. S. Canevesi, Melanie Emo, Maria T. Izquierdo, Michael Badawi, Alain Celzard, Vanessa Fierro
Summary: In this study, single atoms and nanoclusters of Fe, Ni, Co, Cu, and Mn were embedded in a well-defined C1N1-type material with internal cavities of approximately 0.6 nm. The nucleation of different metal nanoclusters was achieved by forming metal-nitrogen bonds on four N atoms. After pyrolysis, TM@CNx-type structures were obtained, where TM represents the transition metal and x<1. Fe@CNx and Co@CNx showed promising performance in oxygen reduction reaction and hydrogen evolution reaction respectively, with a Pt-like performance, while Ni@CNx exhibited the highest activity in oxygen evolution reaction (OER) with an E-OER of 1.59 V versus RHE, surpassing the commercial IrO2 (E-OER = 1.72 V). This systematic and benchmarking study provides a basis for the future design of advanced multi-functional electrocatalysts by modulating and combining the metallic nature of nanoclusters and single atoms.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Yann Foucaud, Azza Ben Jannet, Stefano Caramori, Rafael Canevesi, Moncef Said, Alain Celzard, Vanessa Fierro, Michael Badawi, Mariachiara Pastore
Summary: WO3 is a fascinating material for photocatalysis due to its properties of UV-vis absorption, charge carrier transport, and stability against photocorrosion. However, the hydration process of WO3 has been rarely studied, mostly from a theoretical perspective. In this study, a combination of gas sorption experiments and molecular dynamics simulations is used to investigate the hydration mechanisms of WO3. It is found that water molecules adsorb onto the WO3 surface in a two-step mechanism, forming molecular sublayers and subsequent hydrogen bonding to form a complete layer.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Pauline Blyweert, Vincent Nicolas, Vanessa Fierro, Alain Celzard
Summary: This paper demonstrates the preparation and characteristics of new 3D-printed porous carbons using stereolithography (SLA) and heat treatment. The physical and textural properties of the carbons can be adjusted by using chemically modified biobased aromatic precursors as monomers. These materials show higher thermal stability and carbonyield. The dense porous carbon materials also exhibit outstanding mechanical properties and resistance to oxidation.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Physical
Sergio Garcia-Dali, Javier Quilez-Bermejo, Raj Karthik, Rafael Luan Sehn Canevesi, Maria T. Izquierdo, Melanie Emo, Alain Celzard, Vanessa Fierro
Summary: The sluggish kinetics of the oxygen evolution reaction (OER) is a major limitation for green electrochemical devices. Expensive ruthenium and iridium oxide electrodes have been used as advanced electrocatalysts, but their rarity limits their global implementation. Transition metal and boron compounds show promise as alternatives due to their high catalytic properties and stability. However, their synthesis routes often involve expensive supports, increasing the cost. This study presents an easy and support-free synthesis of bimetallic borates, showing improved electrocatalytic properties for OER, particularly with nickel as the transition metal. A support-free synthesis route achieved an overpotential of 230 mV, comparable to commercial and state-of-the-art electrocatalysts.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Developmental Biology
Motomu Tanaka, Judith Thoma, Laura Poisa-Beiro, Patrick Wuchter, Volker Eckstein, Sascha Dietrich, Caroline Pabst, Carsten Mueller-Tidow, Takao Ohta, Anthony D. Ho
Summary: Adhesion between hematopoietic stem and progenitor cells (HSPCs) and the bone marrow niche is crucial for the maintenance of primitive HSPCs. The interactions between HSPCs and the bone marrow niche are clinically relevant in acute myeloid leukemia (AML), as adherent leukemia-initiating cells are protected from chemotherapy, and mobilization of HSPCs from healthy donors is essential for stem cell transplantation.
CELLS & DEVELOPMENT
(2023)
Article
Physics, Applied
Pauline Blyweert, Alexander Zharov, Darya Meisak, Artyom Plyushch, Jan Macutkevic, Juras Banys, Vanessa Fierro, Alain Celzard
Summary: 3D-printed carbon structures filled with BaTiO3 nanoparticles were studied for their properties in low and microwave frequency ranges. These structures exhibited high electrical conductivity in the low-frequency range and excellent dielectric properties in the microwave range. The electrical transport was thermally activated and attributed to electron transport through various defects. The investigated structures showed attractive electromagnetic properties in the microwave range, with high absorption rates for BaTiO3-filled structures.
APPLIED PHYSICS LETTERS
(2023)
Article
Chemistry, Physical
Marco Pelanconi, Pauline Blyweert, Giovanni Bianchi, Vincent Nicolas, Davide Vigano, Samuele Bottacin, Vanessa Fierro, Alain Celzard, Alberto Ortona
Summary: This study focuses on the design, additive manufacturing, and characterization of porous carbon-based structures with outstanding mechanical properties and oxidation resistance, combined with good electrical and thermal conductivity. Graphite-carbon black powders were 3D printed using binder jetting to create computational models of three different topologies and geometric porosities. The parts were then densified using infiltration and pyrolysis with furan resin. The resulting composite materials exhibit excellent mechanical properties and high oxidation resistance, making them suitable for applications such as Joule resistors and seasonal thermal storage.
Article
Chemistry, Physical
Sergio Garcia-Dali, Javier Quilez-Bermejo, Jimena Castro-Gutierrez, Niki Baccile, Maria T. Izquierdo, Alain Celzard, Vanessa Fierro
Summary: This study presents efficient electrodes for the hydrogen evolution reaction (HER) based on low-cost and metal-free carbon catalysts. Phytic acid, a biosourced molecule containing carbon (C) and phosphorus (P), is used as a precursor to produce P-doped carbon materials. The conversion of P-O-type groups into P-C-type species is crucial for the catalytic activity of P-doped carbon materials, with P-C-type groups being the key factor in the electrocatalytic activity.
Article
Agricultural Engineering
Pauline Blyweert, Vincent Nicolas, Vanessa Fierro, Alain Celzard
Summary: Greener and more mechanically robust 3D-printed structures were achieved by incorporating tannin into acrylate resin. The addition of tannin particles to the resin improved the resolution control and mechanical properties of the printed structures. The use of tannin as a bio-based ingredient showed promising results in producing accurate and reinforced 3D-printed structures.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Green & Sustainable Science & Technology
R. Morales-Ospino, A. Celzard, V. Fierro
Summary: Liquid hydrogen (LH2) has the highest storage density with no chemical reaction required, but it needs to be cooled to 20 K using energy-intensive refrigeration. LH2 storage results in the evaporation of LH2, known as boil-off, leading to process inefficiency and energy losses. This review discusses the definition, challenges, state-of-the-art, and recovery strategies to minimize hydrogen evaporation, including zero boil-off (ZBO), hydrogen reliquefaction, and compression solutions. The expertise gained in cryogenic storage for spacecraft has potential applications beyond the industry. Proper integration of reliquefaction systems with LH2 tanks and non-mechanical compressors for boil-off hydrogen offer attractive options for advancing LH2 logistics.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Materials Science, Composites
Azamat Taurbekov, Alisher Abdisattar, Meiram Atamanov, Mukhtar Yeleuov, Chingis Daulbayev, Kydyr Askaruly, Bayan Kaidar, Zulkhair Mansurov, Jimena Castro-Gutierrez, Alain Celzard, Vanessa Fierro, Tolganay Atamanova
Summary: This study systematically investigates the efficient production method and electrochemical characteristics of activated carbons derived from rice husk and walnut shell. The results show that CO2 activation exhibits superior rate performance and charge transfer characteristics compared to KOH activation. These findings highlight the significance of activation techniques in tailoring the electrochemical behavior of biomass-derived carbon and provide valuable guidance for the development of high-performance supercapacitor electrodes with less environmental impact.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Review
Materials Science, Multidisciplinary
Motomu Tanaka, Marie Pierre Krafft, Andreea Pasc
Summary: Surfactants with fluorocarbon chains can form unique patterns at the air/water interface, which are different from their hydrocarbon counterparts. This review discusses the relationship between line tension and dipole interaction, which governs the pattern formation of two-dimensional self-assemblies. It also explores experimental and analytical techniques for characterizing hierarchical self-assemblies on water surfaces and highlights biomedical applications of fluorinated self-assemblies in materials science.
NPG ASIA MATERIALS
(2023)
Article
Chemistry, Physical
Felix Weissenfeld, Lucia Wesenberg, Masaki Nakahata, Marcus Mueller, Motomu Tanaka
Summary: The interactions between vesicle and substrate were investigated using simulation and experiment. Polyacrylic acid brushes with cysteine side chains were grafted onto planar lipid membranes. The addition of Cd2+ ions compacted the polymer brushes and influenced the adhesion of lipid vesicles. Wetting of the vesicles occurred at [CdCl2] = 0.25 mM. The shape and adhesion of vesicles were quantitatively evaluated, and simulations revealed that wetting sensitivity was dependent on the interaction range.
Article
Chemistry, Analytical
Claire Dazon, Sebastien Bau, Raphael Payet, Vanessa Fierro, Olivier Witschger
Summary: The relevance of dustiness methods in the evaluation of worker's exposure to nanomaterials and environmental risk is recognized. Current methods based on mass are recommended, but surface area is considered a better determinant of nanoparticle pulmonary toxicity. This study proposes a surface-based dustiness index to assess nanoparticulate matter, demonstrating its superiority over the conventional mass-based index in discrimination and impact on ranking. Further research is needed to support the inclusion of this proposal in European standards.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
