Chemical modification of inorganic nanostructures for targeted and controlled drug delivery in cancer treatment

Ultrasound, pH, and Magnetically Responsive Crown-Ether-Coated Core/Shell Nanoparticles as Drug Encapsulation and Release Systems

(2013) Siu-Fung Lee et al.   ACS Applied Materials & Interfaces

Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy

(2013) Jing Lin et al.   ACS Nano

Lysosomal Membrane Permeabilization by Targeted Magnetic Nanoparticles in Alternating Magnetic Fields

(2013) Maribella Domenech et al.   ACS Nano

Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide

(2013) Hyunwoo Kim et al.   ACS Nano

Versatile Fluorescence Resonance Energy Transfer-Based Mesoporous Silica Nanoparticles for Real-Time Monitoring of Drug Release

(2013) Jinping Lai et al.   ACS Nano

Iron Oxide @ Polypyrrole Nanoparticles as a Multifunctional Drug Carrier for Remotely Controlled Cancer Therapy with Synergistic Antitumor Effect

(2013) Chao Wang et al.   ACS Nano

Gold Nanocage-Based Dual Responsive “Caged Metal Chelator” Release System: Noninvasive Remote Control with Near Infrared for Potential Treatment of Alzheimer's Disease

(2013) Peng Shi et al.   ADVANCED FUNCTIONAL MATERIALS

Glucose- and pH-Responsive Controlled Release of Cargo from Protein-Gated Carbohydrate-Functionalized Mesoporous Silica Nanocontainers

(2013) Shanshan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold Nanorod-Cored Biodegradable Micelles as a Robust and Remotely Controllable Doxorubicin Release System for Potent Inhibition of Drug-Sensitive and -Resistant Cancer Cells

(2013) Yinan Zhong et al.   BIOMACROMOLECULES

Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

(2013) Kyoung-Ran Kim et al.   CHEMICAL COMMUNICATIONS

Hybrid PLGA-Organosilica Nanoparticles with Redox-Sensitive Molecular Gates

(2013) Manuel Quesada et al.   CHEMISTRY OF MATERIALS

Multifunctional Envelope-Type Mesoporous Silica Nanoparticles for Tumor-Triggered Targeting Drug Delivery

(2013) Jing Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CMCTS stabilized Fe3O4 particles with extremely low toxicity as highly efficient near-infrared photothermal agents for in vivo tumor ablation

(2013) Song Shen et al.   Nanoscale

Hyaluronic acid-conjugated graphene oxide/photosensitizer nanohybrids for cancer targeted photodynamic therapy

(2013) Fangyuan Li et al.   Journal of Materials Chemistry B

Patchy Nanocapsules of Poly(vinylferrocene)-Based Block Copolymers for Redox-Responsive Release

(2012) Roland H. Staff et al.   ACS Nano

Enzyme-responsive nanoparticles for drug release and diagnostics

(2012) Roberto de la Rica et al.   ADVANCED DRUG DELIVERY REVIEWS

Quantum-Dot-Tagged Reduced Graphene Oxide Nanocomposites for Bright Fluorescence Bioimaging and Photothermal Therapy Monitored In Situ

(2012) Shang-Hsiu Hu et al.   ADVANCED MATERIALS

Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

(2012) Fangqiong Tang et al.   ADVANCED MATERIALS

Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease

(2012) Meng Li et al.   ADVANCED MATERIALS

Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment

(2012) Zhenjiang Zhang et al.   ADVANCED MATERIALS

Riboflavin carrier protein-targeted fluorescent USPIO for the assessment of vascular metabolism in tumors

(2012) Jabadurai Jayapaul et al.   BIOMATERIALS

Targeting carbon nanotubes against cancer

(2012) Chiara Fabbro et al.   CHEMICAL COMMUNICATIONS

Graphene oxide–photosensitizer conjugate as a redox-responsive theranostic agent

(2012) Youngnam Cho et al.   CHEMICAL COMMUNICATIONS

Near-infrared light-responsive graphene oxide composite multilayer capsules: a novel route for remote controlled drug delivery

(2012) Rajendra Kurapati et al.   CHEMICAL COMMUNICATIONS

Mesoporous silica nanoparticle facilitated drug release through cascade photosensitizer activation and cleavage of singlet oxygen sensitive linker

(2012) Junseok Lee et al.   CHEMICAL COMMUNICATIONS

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

(2012) Nazila Kamaly et al.   CHEMICAL SOCIETY REVIEWS

Cucurbit[7]uril Pseudorotaxane-Based Photoresponsive Supramolecular Nanovalve

(2012) Yu-Long Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enzyme-Responsive Silica Mesoporous Supports Capped with Azopyridinium Salts for Controlled Delivery Applications

(2012) Núria Mas et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Photoactivated Molecular Gate

(2012) Alessandro Agostini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mesoporous silicananoparticles: A multifunctional nano therapeutic system

(2012) Wilson X. Mai et al.   Integrative Biology

Analysis on the current status of targeted drug delivery to tumors

(2012) Il Keun Kwon et al.   JOURNAL OF CONTROLLED RELEASE

Biocompatibility of engineered nanoparticles for drug delivery

(2012) Sheva Naahidi et al.   JOURNAL OF CONTROLLED RELEASE

Endosomal pH-activatable magnetic nanoparticle-capped mesoporous silica for intracellular controlled release

(2012) Qi Gan et al.   JOURNAL OF MATERIALS CHEMISTRY

Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles

(2012) Limin Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lysozyme as a pH-Responsive Valve for the Controlled Release of Guest Molecules from Mesoporous Silica

(2012) Mengjun Xue et al.   LANGMUIR

Amino/quaternary ammonium groups bifunctionalized large pore mesoporous silica for pH-responsive large drug delivery

(2012) Haoquan Zheng et al.   RSC Advances

Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy

(2012) Peng Huang et al.   Theranostics

Efficient, pH-Triggered Drug Delivery Using a pH-Responsive DNA-Conjugated Gold Nanoparticle

(2012) Lei Song et al.   Advanced Healthcare Materials

Folic Acid-Modified Mesoporous Silica Nanoparticles for Cellular and Nuclear Targeted Drug Delivery

(2012) Fabiola Porta et al.   Advanced Healthcare Materials

Cell-Specific Intracellular Anticancer Drug Delivery from Mesoporous Silica Nanoparticles with pH Sensitivity

(2012) Zhong Luo et al.   Advanced Healthcare Materials

Multifunctional Mesoporous Silica Nanocomposite Nanoparticles for Theranostic Applications

(2011) Ji Eun Lee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Electrochemically Controlled Drug-Mimicking Protein Release from Iron-Alginate Thin-Films Associated with an Electrode

(2011) Zhiyuan Jin et al.   ACS Applied Materials & Interfaces

Controlled Release of Nanoparticles and Macromolecules from Responsive Microgel Capsules

(2011) Hassan Masoud et al.   ACS Nano

Smart Drug Delivery through DNA/Magnetic Nanoparticle Gates

(2011) Eduardo Ruiz-Hernández et al.   ACS Nano

Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide

(2011) Bo Tian et al.   ACS Nano

Release of Photoactivatable Drugs from Plasmonic Nanoparticles for Targeted Cancer Therapy

(2011) Yun-Ling Luo et al.   ACS Nano

Photothermally Enhanced Drug Delivery by Ultrasmall Multifunctional FeCo/Graphitic Shell Nanocrystals

(2011) Sarah P. Sherlock et al.   ACS Nano

Photo- and pH-Triggered Release of Anticancer Drugs from Mesoporous Silica-Coated Pd@Ag Nanoparticles

(2011) Weijun Fang et al.   ADVANCED FUNCTIONAL MATERIALS

Redox-Responsive Molecular Nanoreservoirs for Controlled Intracellular Anticancer Drug Delivery Based on Magnetic Nanoparticles

(2011) Zhong Luo et al.   ADVANCED MATERIALS

Gold Nanoclusters and Graphene Nanocomposites for Drug Delivery and Imaging of Cancer Cells

(2011) Chensu Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Theranostic Applications of Nanomaterials in Cancer: Drug Delivery, Image-Guided Therapy, and Multifunctional Platforms

(2011) Alicia Fernandez-Fernandez et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide

(2011) Wen Zhang et al.   BIOMATERIALS

Gold nanoparticles in biomedical applications: recent advances and perspectives

(2011) Lev Dykman et al.   CHEMICAL SOCIETY REVIEWS

Role of endothelial injury in disease mechanisms and contribution of progenitor cells in mediating endothelial repair

(2011) Sophie P. Toya et al.   IMMUNOBIOLOGY

Targeted drug delivery to tumors: Myths, reality and possibility

(2011) You Han Bae et al.   JOURNAL OF CONTROLLED RELEASE

Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress

(2011) Twan Lammers et al.   JOURNAL OF CONTROLLED RELEASE

The journey of a drug-carrier in the body: An anatomo-physiological perspective

(2011) Nicolas Bertrand et al.   JOURNAL OF CONTROLLED RELEASE

Biocompatibility, MR imaging and targeted drug delivery of a rattle-type magnetic mesoporous silica nanosphere system conjugated with PEG and cancer-cell-specific ligands

(2011) Huixia Wu et al.   JOURNAL OF MATERIALS CHEMISTRY

Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy

(2011) Joshua T. Robinson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Multifunctional Nanocarrier Based on Nanogated Mesoporous Silica for Enhanced Tumor-Specific Uptake and Intracellular Delivery

(2011) Yaohua Gao et al.   MACROMOLECULAR BIOSCIENCE

pH-Disintegrable Polyelectrolyte Multilayer-Coated Mesoporous Silica Nanoparticles Exhibiting Triggered Co-Release of Cisplatin and Model Drug Molecules

(2011) Xuejuan Wan et al.   MACROMOLECULAR RAPID COMMUNICATIONS

A biocompatible drug delivery nanovalve system on the surface of mesoporous nanoparticles

(2011) Li Du et al.   MICROPOROUS AND MESOPOROUS MATERIALS

Cellular toxicity of inorganic nanoparticles: Common aspects and guidelines for improved nanotoxicity evaluation

(2011) Stefaan J. Soenen et al.   Nano Today

Gold nanocages covered with thermally-responsive polymers for controlled release by high-intensity focused ultrasound

(2011) Weiyang Li et al.   Nanoscale

Exchange-coupled magnetic nanoparticles for efficient heat induction

(2011) Jae-Hyun Lee et al.   Nature Nanotechnology

Synthesis of Biomolecule-Modified Mesoporous Silica Nanoparticles for Targeted Hydrophobic Drug Delivery to Cancer Cells

(2011) Daniel P. Ferris et al.   Small

Cytotoxicity Effects of Graphene and Single-Wall Carbon Nanotubes in Neural Phaeochromocytoma-Derived PC12 Cells

(2010) Yongbin Zhang et al.   ACS Nano

Enzyme-Responsive Intracellular Controlled Release Using Nanometric Silica Mesoporous Supports Capped with “Saccharides”

(2010) Andrea Bernardos et al.   ACS Nano

Glutathione-Induced Intracellular Release of Guests from Mesoporous Silica Nanocontainers with Cyclodextrin Gatekeepers

(2010) Hyehyeon Kim et al.   ADVANCED MATERIALS

Polyvalent Nucleic Acid/Mesoporous Silica Nanoparticle Conjugates: Dual Stimuli-Responsive Vehicles for Intracellular Drug Delivery

(2010) Cuie Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Carbon Nanomaterials in Biosensors: Should You Use Nanotubes or Graphene?

(2010) Wenrong Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual-mode probe based on mesoporous silica coated gold nanorods for targeting cancer cells

(2010) Zhuyuan Wang et al.   BIOSENSORS & BIOELECTRONICS

Image-Guided Breast Tumor Therapy Using a Small Interfering RNA Nanodrug

(2010) M. Kumar et al.   CANCER RESEARCH

Interfacing Carbon Nanotubes with Living Mammalian Cells and Cytotoxicity Issues

(2010) Hui-Fang Cui et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Reversible Targeting and controlled release delivery of daunorubicin to cancer cells by aptamer-wrapped carbon nanotubes

(2010) Seyed Mohammad Taghdisi et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Targeting gold nanocages to cancer cells for photothermal destruction and drug delivery

(2010) Claire M Cobley et al.   Expert Opinion on Drug Delivery

Relevance of folic acid/polymer ratio in targeted PEG–epirubicin conjugates

(2010) Fabiana Canal et al.   JOURNAL OF CONTROLLED RELEASE

Single-walled carbon nanotubes in biomedical imaging

(2010) Zhuang Liu et al.   JOURNAL OF MATERIALS CHEMISTRY

pH-Operated Nanopistons on the Surfaces of Mesoporous Silica Nanoparticles

(2010) Yan-Li Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles

(2010) Courtney R. Thomas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Drug-Delivery Behavior of Chitosan-Functionalized Graphene Oxide Hybrid Nanosheets

(2010) Vijay Kumar Rana et al.   MACROMOLECULAR MATERIALS AND ENGINEERING

Graphene in Mice: Ultrahigh In Vivo Tumor Uptake and Efficient Photothermal Therapy

(2010) Kai Yang et al.   NANO LETTERS

In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation

(2010) Qianjun He et al.   Small

Targeted Killing of Cancer Cells in Vivo and in Vitro with EGF-Directed Carbon Nanotube-Based Drug Delivery

(2009) Ashwin A. Bhirde et al.   ACS Nano

Impact of Nanotechnology on Drug Delivery

(2009) Omid C. Farokhzad et al.   ACS Nano

Inorganic Drug-Delivery Nanovehicle Conjugated with Cancer-Cell-Specific Ligand

(2009) Jae-Min Oh et al.   ADVANCED FUNCTIONAL MATERIALS

Using Aptamer-Conjugated Fluorescence Resonance Energy Transfer Nanoparticles for Multiplexed Cancer Cell Monitoring

(2009) Xiaolan Chen et al.   ANALYTICAL CHEMISTRY

Biotin-Avidin as a Protease-Responsive Cap System for Controlled Guest Release from Colloidal Mesoporous Silica

(2009) Axel Schlossbauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modification of Thiol Functionalized Aptamers by Conjugation of Synthetic Polymers

(2009) Chiara Da Pieve et al.   BIOCONJUGATE CHEMISTRY

Specific Targeting of Brain Tumors with an Optical/Magnetic Resonance Imaging Nanoprobe across the Blood-Brain Barrier

(2009) O. Veiseh et al.   CANCER RESEARCH

Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells

(2009) Yu-Fen Huang et al.   CHEMBIOCHEM

Synthesis and Characterization of Biocompatible and Size-Tunable Multifunctional Porous Silica Nanoparticles

(2009) Yu-Shen Lin et al.   CHEMISTRY OF MATERIALS

Current Constructs and Targets in Clinical Development for Antibody- Based Cancer Therapy

(2009) P. Deckert   CURRENT DRUG TARGETS

Characterisation of carbon nanotubes in the context of toxicity studies

(2009) Deborah Berhanu et al.   Environmental Health

Redox- and pH-Controlled Mechanized Nanoparticles

(2009) Niveen M. Khashab et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Nanoparticle-based targeted drug delivery

(2009) Rajesh Singh et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Photoinduced Intracellular Controlled Release Drug Delivery in Human Cells by Gold-Capped Mesoporous Silica Nanosphere

(2009) Juan L. Vivero-Escoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dumbbell-like Au−Fe3O4Nanoparticles for Target-Specific Platin Delivery

(2009) Chenjie Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Controlled-Access Hollow Mechanized Silica Nanocontainers

(2009) Li Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme Responsive Nanocontainers with Cyclodextrin Gatekeepers and Synergistic Effects in Release of Guests

(2009) Chiyoung Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

pH Clock-Operated Mechanized Nanoparticles

(2009) Sarah Angelos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

pH- and Photo-Switched Release of Guest Molecules from Mesoporous Silica Supports

(2009) Elena Aznar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light-Operated Mechanized Nanoparticles

(2009) Daniel P. Ferris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantum dots and their potential biomedical applications in photosensitization for photodynamic therapy

(2009) Elnaz Yaghini et al.   Nanomedicine

Mechanised nanoparticles for drug delivery

(2009) Karla K. Cotí et al.   Nanoscale

Gold nanocages covered by smart polymers for controlled release with near-infrared light

(2009) Mustafa S. Yavuz et al.   NATURE MATERIALS

Noble Metals on the Nanoscale: Optical and Photothermal Properties and Some Applications in Imaging, Sensing, Biology, and Medicine

(2008) Prashant K. Jain et al.   ACCOUNTS OF CHEMICAL RESEARCH

Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery

(2008) Monty Liong et al.   ACS Nano

Gold nanoparticles in delivery applications☆

(2008) P GHOSH et al.   ADVANCED DRUG DELIVERY REVIEWS

Magnetic nanoparticles in MR imaging and drug delivery☆

(2008) C SUN et al.   ADVANCED DRUG DELIVERY REVIEWS

pH-Responsive Supramolecular Nanovalves Based on Cucurbit[6]uril Pseudorotaxanes

(2008) Sarah Angelos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug Delivery with Carbon Nanotubes for In vivo Cancer Treatment

(2008) Z. Liu et al.   CANCER RESEARCH

Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy

(2008) Andrew Z. Wang et al.   ChemMedChem

Emerging application of quantum dots for drug delivery and therapy

(2008) Lifeng Qi et al.   Expert Opinion on Drug Delivery

Wavelength-dependent penetration depths of ultraviolet radiation in human skin

(2008) Merve Meinhardt et al.   JOURNAL OF BIOMEDICAL OPTICS

High-Efficiency Loading and Controlled Release of Doxorubicin Hydrochloride on Graphene Oxide

(2008) Xiaoying Yang et al.   Journal of Physical Chemistry C

Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer

(2008) Yu Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Single-Wall Carbon Nanotube-Mediated Pt(IV) Prodrug Delivery Using Folate as a Homing Device

(2008) Shanta Dhar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer Drugs

(2008) Zhuang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual Aperture Control on pH- and Anion-Driven Supramolecular Nanoscopic Hybrid Gate-like Ensembles

(2008) Rosa Casasús et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme-Responsive Snap-Top Covered Silica Nanocontainers

(2008) Kaushik Patel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tunable Redox-Responsive Hybrid Nanogated Ensembles

(2008) Rui Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Synthesis of Novel Magnetic Core−Shell Polymeric Particles

(2008) Kin Man Ho et al.   LANGMUIR

Preclinical Studies To Understand Nanoparticle Interaction with the Immune System and Its Potential Effects on Nanoparticle Biodistribution

(2008) Marina A. Dobrovolskaia et al.   MOLECULAR PHARMACEUTICS

Nano-graphene oxide for cellular imaging and drug delivery

(2008) Xiaoming Sun et al.   Nano Research

Multifunctional pH-sensitive magnetic nanoparticles for simultaneous imaging, sensing and targeted intracellular anticancer drug delivery

(2008) Shashwat S Banerjee et al.   NANOTECHNOLOGY

Highly water-dispersible PEG surface modified ultra small superparamagnetic iron oxide nanoparticles useful for target-specific biomedical applications

(2008) Ja Young Park et al.   NANOTECHNOLOGY

Nanoparticle-mediated cellular response is size-dependent

(2008) Wen Jiang et al.   Nature Nanotechnology

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Iridium-Complex-Functionalized Fe3O4/SiO2 Core/Shell Nanoparticles: A Facile Three-in-One System in Magnetic Resonance Imaging, Luminescence Imaging, and Photodynamic Therapy

(2008) Chih-Wei Lai et al.   Small

Light-Activated Nanoimpeller-Controlled Drug Release in Cancer Cells

(2008) Jie Lu et al.   Small

Distribution and potential toxicity of engineered inorganic nanoparticles and carbon nanostructures in biological systems

(2008) Eudald Casals et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Does a targeting ligand influence nanoparticle tumor localization or uptake?

(2008) Kathleen F. Pirollo et al.   TRENDS IN BIOTECHNOLOGY

Cytotoxicity of Nanoparticles

(2007) Nastassja Lewinski et al.   Small