Multi-modal delivery of therapeutics using biomaterial scaffolds

Tumor-targeting dual peptides-modified cationic liposomes for delivery of siRNA and docetaxel to gliomas

(2014) Zhen-Zhen Yang et al.   BIOMATERIALS

The effects of co-delivery of BMSC-affinity peptide and rhTGF-β1 from coaxial electrospun scaffolds on chondrogenic differentiation

(2014) Zhentao Man et al.   BIOMATERIALS

Macrophage phenotypes in the collagen-induced foreign body reaction in rats

(2013) Sander M. van Putten et al.   Acta Biomaterialia

Hydrogels in healthcare: From static to dynamic material microenvironments

(2013) Chelsea M. Kirschner et al.   ACTA MATERIALIA

Intramyocardial Injection of a Synthetic Hydrogel with Delivery of bFGF and IGF1 in a Rat Model of Ischemic Cardiomyopathy

(2013) Devin M. Nelson et al.   BIOMACROMOLECULES

Dual-delivery of VEGF and PDGF by double-layered electrospun membranes for blood vessel regeneration

(2013) Hong Zhang et al.   BIOMATERIALS

Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors

(2013) Yevgeny Brudno et al.   BIOMATERIALS

Use of a fibrin-based system for enhancing angiogenesis and modulating inflammation in the treatment of hyperglycemic wounds

(2013) M. Kulkarni et al.   BIOMATERIALS

Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke

(2013) Yuanfei Wang et al.   JOURNAL OF CONTROLLED RELEASE

Multiple release of polyplexes of plasmids VEGF and bFGF from electrospun fibrous scaffolds towards regeneration of mature blood vessels

(2012) Shuhui He et al.   Acta Biomaterialia

Synthetic collagen fascicles for the regeneration of tendon tissue

(2012) S.J. Kew et al.   Acta Biomaterialia

Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation

(2012) Sungwoo Kim et al.   Acta Biomaterialia

Hyaluronan inhibits TLR-4 dependent cathepsin K and matrix metalloproteinase 1 expression in human fibroblasts

(2012) Shinya Hirabara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biocompatible and Biodegradable Dual-Drug Release System Based on Silk Hydrogel Containing Silk Nanoparticles

(2012) Keiji Numata et al.   BIOMACROMOLECULES

The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair

(2012) William T. Daly et al.   BIOMATERIALS

Extended and sequential delivery of protein from injectable thermoresponsive hydrogels

(2012) Devin M. Nelson et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Sequential delivery of TAT-HSP27 and VEGF using microsphere/hydrogel hybrid systems for therapeutic angiogenesis

(2012) Seung-Hwa Shin et al.   JOURNAL OF CONTROLLED RELEASE

A Protective Extracellular Matrix-Based Gene Delivery Reservoir Fabricated by Electrostatic Charge Manipulation

(2012) Shane Browne et al.   MOLECULAR PHARMACEUTICS

Dual Delivery of Hepatocyte and Vascular Endothelial Growth Factors via a Protease-Degradable Hydrogel Improves Cardiac Function in Rats

(2012) Apoorva S. Salimath et al.   PLoS One

What Is the Greatest Regulatory Challenge in the Translation of Biomaterials to the Clinic?

(2012) G. D. Prestwich et al.   Science Translational Medicine

Regenerative Medicine: A Snapshot of the Current Regulatory Environment and Standards

(2011) Michael P. Messenger et al.   ADVANCED MATERIALS

Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials

(2011) Sandra Franz et al.   BIOMATERIALS

Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration

(2011) Chunying Shi et al.   BIOMATERIALS

The role of multifunctional delivery scaffold in the ability of cultured myoblasts to promote muscle regeneration

(2011) Cristina Borselli et al.   BIOMATERIALS

Arteriogenic Therapy by Intramyocardial Sustained Delivery of a Novel Growth Factor Combination Prevents Chronic Heart Failure

(2011) Sébastien Banquet et al.   CIRCULATION

Complementary therapeutic effects of dual delivery of insulin-like growth factor-1 and vascular endothelial growth factor by gelatin microspheres in experimental heart failure

(2011) Antonio Cittadini et al.   EUROPEAN JOURNAL OF HEART FAILURE

Inflammation and wound healing: the role of the macrophage

(2011) Timothy J. Koh et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Vascular endothelial growth factor and fibroblast growth factor 2 delivery from spinal cord bridges to enhance angiogenesis following injury

(2011) Laura De Laporte et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Tunable elastin-like polypeptide hollow sphere as a high payload and controlled delivery gene depot

(2011) Biraja C. Dash et al.   JOURNAL OF CONTROLLED RELEASE

Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene delivery

(2011) Yuguo Lei et al.   JOURNAL OF CONTROLLED RELEASE

Nanomaterials for in situ cell delivery and tissue regeneration☆

(2010) Andrew C.A. Wan et al.   ADVANCED DRUG DELIVERY REVIEWS

Combination of Injectable Multiple Growth Factor–Releasing Scaffolds and Cell Therapy as an Advanced Modality to Enhance Tissue Neovascularization

(2010) Jaimy Saif et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility

(2010) Biraja C. Dash et al.   BIOMATERIALS

Surface functionalization of polyketal microparticles with nitrilotriacetic acid–nickel complexes for efficient protein capture and delivery

(2010) Jay C. Sy et al.   BIOMATERIALS

Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis

(2010) Jillian E. Tengood et al.   BIOMATERIALS

Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization

(2010) Steven M. Jay et al.   BIOMATERIALS

A nanocapsular combinatorial sequential drug delivery system for antiangiogenesis and anticancer activities

(2010) Zhe Wang et al.   BIOMATERIALS

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

(2010) J. Patterson et al.   BIOMATERIALS

Delivery of basic fibroblast growth factor with a pH-responsive, injectable hydrogel to improve angiogenesis in infarcted myocardium

(2010) Jessica C. Garbern et al.   BIOMATERIALS

The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction

(2010) Emil Ruvinov et al.   BIOMATERIALS

Engineering more than a cell: vascularization strategies in tissue engineering

(2010) Edward A Phelps et al.   CURRENT OPINION IN BIOTECHNOLOGY

Biomimetic matrices for myocardial stabilization and stem cell transplantation

(2010) Samuel T. Wall et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A Temporal Gene Delivery System Based on Fibrin Microspheres

(2010) Mangesh M. Kulkarni et al.   MOLECULAR PHARMACEUTICS

Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones

(2010) W. W. Yuen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Delivery of Basic Fibroblast Growth Factor and Platelet-Derived Growth Factor for Angiogenesis

(2010) Jillian E. Tengood et al.   TISSUE ENGINEERING PART A

Hydrogels in Regenerative Medicine

(2009) Brandon V. Slaughter et al.   ADVANCED MATERIALS

Calcium alginate beads embedded in silk fibroin as 3D dual drug releasing scaffolds

(2009) Biman B. Mandal et al.   BIOMATERIALS

The effect of an rhBMP-2 absorbable collagen sponge-targeted system on bone formation in vivo

(2009) Rick Visser et al.   BIOMATERIALS

In-situ crosslinking hydrogels for combinatorial delivery of chemokines and siRNA–DNA carrying microparticles to dendritic cells

(2009) Ankur Singh et al.   BIOMATERIALS

The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization

(2009) Inbar Freeman et al.   BIOMATERIALS

Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration

(2009) Diederik H.R. Kempen et al.   BIOMATERIALS

The ability of a collagen/calcium phosphate scaffold to act as its own vector for gene delivery and to promote bone formation via transfection with VEGF165

(2009) Michael Keeney et al.   BIOMATERIALS

A matrix reservoir for improved control of non-viral gene delivery

(2009) Carolyn Holladay et al.   JOURNAL OF CONTROLLED RELEASE

Local controlled release of VEGF and PDGF from a combined brushite–chitosan system enhances bone regeneration

(2009) Beatriz De la Riva et al.   JOURNAL OF CONTROLLED RELEASE

Assessment of Wound Healing in the Alloxan-Induced Diabetic Rabbit Ear Model

(2009) Ailish Breen et al.   JOURNAL OF INVESTIGATIVE SURGERY

Complexity in biomaterials for tissue engineering

(2009) Elsie S. Place et al.   NATURE MATERIALS

Dose Effect of Dual Delivery of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein-2 on Bone Regeneration in a Rat Critical-Size Defect Model

(2009) Simon Young et al.   TISSUE ENGINEERING PART A

Scleral Reinforcement Through Host Tissue Integration with Biomimetic Enzymatically Degradable Semi-Interpenetrating Polymer Network

(2009) James Su et al.   TISSUE ENGINEERING PART A

Sequential release of bioactive IGF-I and TGF-β1 from PLGA microsphere-based scaffolds

(2008) Ana Jaklenec et al.   BIOMATERIALS

Sequential delivery of dexamethasone and VEGF to control local tissue response for carbon nanotube fluorescence based micro-capillary implantable sensors

(2008) Jaeyun Sung et al.   BIOMATERIALS

Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model

(2008) Zarana S. Patel et al.   BONE

Fabrication of nano-fibrous collagen microspheres for protein delivery and effects of photochemical crosslinking on release kinetics

(2008) O.C.M. Chan et al.   JOURNAL OF CONTROLLED RELEASE

Efficient Modulation of T-cell Response by Dual-mode, Single-carrier Delivery of Cytokine-targeted siRNA and DNA Vaccine to Antigen-presenting Cells

(2008) Ankur Singh et al.   MOLECULAR THERAPY

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction

(2008) Jay C. Sy et al.   NATURE MATERIALS

Design of Biodegradable Hydrogel for the Local and Sustained Delivery of Angiogenic Plasmid DNA

(2008) Hyun Joon Kong et al.   PHARMACEUTICAL RESEARCH

In Vitro and In Vivo Release of Vascular Endothelial Growth Factor from Gelatin Microparticles and Biodegradable Composite Scaffolds

(2008) Zarana S. Patel et al.   PHARMACEUTICAL RESEARCH

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY

Novel scaffolds fabricated from protein-loaded microspheres for tissue engineering

(2007) Ana Jaklenec et al.   BIOMATERIALS