Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 24, Pages 3745-3752Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb00267a
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Funding
- NIH [U54CA143837, 1U54CA151668]
- United States-Israel Binational Science Foundation [T-2011-134]
- Engineering and Physical Sciences Research Council [EP/H008683/1] Funding Source: researchfish
- NATIONAL CANCER INSTITUTE [U54CA151668, U54CA143837] Funding Source: NIH RePORTER
- EPSRC [EP/H008683/1] Funding Source: UKRI
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We report on the biological performance of organic nanoparticles formed by a simple method based on rapid solvent removal from a volatile microemulsion. The particular focus of the study was on testing the suitability of the method for substances soluble in partially water-miscible organic solvents as well as on evaluating the therapeutic activity of the resultant nanoparticles. Curcumin was employed as a model for hydrophobic drugs, and, as it is soluble in water-miscible organic solvents, it was successfully incorporated into a new cyclopentanone-water microemulsion system. During rapid solvent removal by spray-drying, the nanometric droplets of the microemulsion were converted into nanoparticles containing amorphous curcumin with an average size of 20.2 +/- 3.4 nm, having a zeta potential of -36.2 +/- 1.8 mV. These nanoparticles were dispersible in water and retained the high loading of the active substance. The therapeutic activity of the resulting nanoparticles was demonstrated in a pancreatic cancer cell line, PANC-1. The effective concentration for reducing the metabolic activity by 50% (EC50) was found to be 11.5 mu M for nanoparticles compared with 19.5 mu M for free curcumin.
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