Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 35, Pages 5809-5817Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb00676c
Keywords
-
Categories
Funding
- Japan Society for the Promotion of Science [24659013, 25460031]
- Grants-in-Aid for Scientific Research [25460031, 24659013] Funding Source: KAKEN
Ask authors/readers for more resources
Layer-by-layer (LbL) multilayer films were prepared using phenylboronic acid-modified poly(amidoamine) dendrimers and poly(vinyl alcohol) (PVA) in order to investigate the glucose sensitivity of the films. We used dendrimer derivatives modified with 3-carboxyphenylboronic acid (3CPBA-D) and 3-carboxy-5-nitrophenylboronic acid (3C5NPBA-D) to evaluate the effect of electron-withdrawing nitro groups on glucose sensitivity. PVA/3CPBA-D and PVA/3C5NPBA-D films were prepared on the surface of a quartz slide from PVA and 3CPBA-D or 3C5NPBA-D solutions at pH 7.0, 8.0, and 9.0 through boronate ester bonds. The dendrimer-based LbL films were stable at pH 7.0-9.0, whereas they decomposed in acidic media because of the instability of the boronate ester linkages. The pH threshold of decomposition was at pH 6.0-7.0 for both films. The PVA/3C5NPBA-D film was more stable than the PVA/3CPBA-D film in this range. Both films decomposed in response to glucose under physiological conditions (pH 7.4 buffer solution containing 150 mM NaCl at 37 degrees C), and the decomposition depended on the glucose concentration. The PVA/3C5NPBA-D film was more sensitive to glucose than the PVA/3CPBA-D film, probably due to the higher binding affinity of 3C5NPBA-D to glucose under physiological conditions. The higher response of the PVA/3C5NPBA-D film was explained by the electron-withdrawing effect of the nitro substituent on the phenylboronic acid ring. The results suggest that dendrimer-based LbL films could be used for glucose-triggered release systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available